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  • MAPK
  • Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells. (springer.com)
  • residues
  • The solution structure of the C-terminal domain, consisting of residues N130-L226 plus a 13-residue N-terminal extension, has been determined by using NMR spectroscopy. (pnas.org)
  • Residues before A147 are highly mobile and adopt a random coil conformation, but residues A147-L226 form a single structured domain consisting of five β-strands and three helices arranged into a partially orthogonal, two-sheet β-barrel, similar to the structure observed in the crystalline Co 2+ complex of full-length DtxR. (pnas.org)
  • From the sequential assignment of resonances in heteronuclear NMR spectra of a recombinant C-terminal domain (residues N130-L226), we have shown that this isolated domain contains five β-strands and three helices ( 14 ). (pnas.org)
  • Three-dimensional domain swapping in p13suc1 occurs in the unfolded state and is controlled by conserved proline residues. (embl-heidelberg.de)
  • Detailed amino acid sequence comparisons identified both putative key residues conserved in characteristic domains and previously unidentified conserved regions. (biomedcentral.com)
  • expression
  • The diphtheria toxin repressor (DtxR) regulates the expression of several iron-sensitive genes in Corynebacterium diphtheriae , including the iron-response protein genes ( irp ), a heme oxygenase, and the diphtheria toxin gene ( tox ) ( 1 - 3 ). (pnas.org)
  • Leptin also induced mRNA expression of the JAK-STAT inhibitor suppressor of cytokine signaling (SOCS)3 in INS-1 β-cells and human pancreatic islets in vitro and in pancreatic islets of ob/ob mice in vivo. (diabetesjournals.org)
  • Expression of these domains in E. coli as GST-fusion proteins has allowed definition by nuclear magnetic resonance (NMR) of three-dimensional structures for the SH2 and SH3 domains. (royalsocietypublishing.org)
  • Motif
  • Dip1 contained a PPXY motif, and its domain organization was similar to that of the splicing factor FBP21 in that it possessed one zinc finger and two WW domains. (embl-heidelberg.de)
  • characteristic
  • Analysis of characteristic domains of regulatory subunits suggests a novel view of the evolution of Nox: in fish, p40 phox participated in regulating both Nox1 and Nox2, but after the appearance of mammals, Nox1 (but not Nox2) became independent of p40 phox . (biomedcentral.com)
  • C3G is a GEF having CDC25 homology domain characteristic to GEFs for Ras family GTPases. (springer.com)
  • membrane
  • These data suggest that the cation channel-PKC association may require SH3 domain-mediated interactions to bring about modulation, promote membrane depolarization, and initiate prolonged changes in bag cell neuron excitability. (jneurosci.org)
  • Csk is primarily regulated through its SH2 domain, which is required for membrane translocation of Csk via binding to scaffold proteins such as Cbp/PAG1. (ijbs.com)
  • Dynamic changes in the cell membrane are prominent during cell adhesion and spreading in response to extracellular stimuli [ 2 , 3 ]. (ijbs.com)
  • Thus, it is of interest to understand the mechanism by which these proteins are activated as well as the membrane dynamics that occur during cell adhesion and spreading. (ijbs.com)
  • On the molecular level, the Arp2/3 complex might provide the driving force for formation of membrane protrusions by nucleating actin polymerization from the sides of existing filaments. (biologists.org)
  • Structures
  • Structures have shown that despite a lack of sequence homology, both the small type II and Ib CBPs contain ribbon-helix-helix (RHH) DNA-binding folds ( 10-13 ). (pubmedcentralcanada.ca)
  • Structures were determined separately for the KorB HTH-containing DNA-binding domain and the C-terminal dimer-domain, which has an SH3-like fold ( 15 , 16 ). (pubmedcentralcanada.ca)
  • Cell
  • In this study, we tried to investigate the role of SH3GL2 in glioma cell migration and invasion and explore its underlined molecular mechanism. (sigmaaldrich.com)
  • The WW domain-containing iso-prolyl isomerase named Pin1, a protein known to be essential for cell cycle progression, was shown to be active in restoration of the microtubule-binding activity of Tau, a protein of neurofibrillar tangles found in the brains of Alzheimer's patients. (embl-heidelberg.de)
  • Dinap1 is a dinoflagellate nuclear protein that has a WW domain and is synthesized mainly in G1 and S phases of the cell cycle. (embl-heidelberg.de)
  • In previous experiments, we and others have demonstrated that ObR isoforms, including ObRb, are expressed and functional in pancreatic β-cell lines and primary pancreatic islets ( 3 , 13 ). (diabetesjournals.org)
  • Cell adhesion and spreading also activate cell adhesion components and cytoskeletal proteins, including FAK (focal adhesion kinase), Src, paxillin, p130CAS (Crk-associated substrate), vinculin, and other signaling molecules [ 5 ]. (ijbs.com)
  • several
  • Several of the SFKs, c-Src, c-Yes, and c-Fgr, were originally discovered as prototypes of avian retroviral oncogene products (v-Src, v-Yes and v-Fgr) [ 6 - 11 ]. (ijbs.com)
  • These data combined with biochemical studies indicate that these proteins have several domains, including a flexible N-terminal NTPase-binding domain, a central HTH-domain, which is the only conserved domain among these proteins and a C-terminal dimer-domain ( 3 ). (pubmedcentralcanada.ca)
  • function
  • The results of this study, combined with previous x-ray studies of intact DtxR, provide insights into a possible biological function of the C-terminal domain in regulating repressor activity. (pnas.org)
  • To obtain a more complete understanding of the function of the intact repressor protein, we are focusing on the C-terminal domain. (pnas.org)
  • The carboxy-terminal domain (CTD) of RNA polymerase II acts as an assembly platform for distinct WW domain-containing proteins that affect the function of the RNA polymerase II. (embl-heidelberg.de)
  • The relationship of structure to function for these domains is discussed. (royalsocietypublishing.org)
  • Possible clues to the function of PI 3-kinase derived from this and other observations are presented. (royalsocietypublishing.org)
  • indicate
  • These findings indicate that different domains of the same protein may contribute selectively to different pain states. (bl.uk)
  • linker
  • DtxR contains two domains that are separated by a short, unstructured linker. (pnas.org)
  • Pax6 contains two DNA binding domains (paired domain and homeodomain), a glycine-rich linker connecting these two domains and a C-terminal proline-, serine-, and threonine-rich transactivation domain. (genes2cognition.org)
  • The newly isolated isoform, named Pax6(S), retains the paired domain, linker, and homeodomain of Pax6, but its C terminus is composed of a truncated classic proline, serine, and threonine domain and a unique S tail. (genes2cognition.org)