• Knowledge of these regulatory mechanisms allowed us to develop synthetic corrinoid riboswitches that convert repressing riboswitches to riboswitches that robustly induce gene expression in response to corrinoids. (bvsalud.org)
  • Transcription factor binding motifs help to elucidate regulatory mechanism. (systemsbiology.net)
  • The corrinoid riboswitch class, which responds to adenosylcobalamin (coenzyme B12) and related metabolites, is among the most widespread in bacteria. (bvsalud.org)
  • magadii also contained a set of genes that have been predicted to get involved in the conversion of cobyrinic acid into adenosylcobalamin, like a gene that's certain for the archaeal corrinoid salvage pathway. (others-signal.com)
  • The use of a chemically-defined medium (CDM) supporting the growth of both groups of bacteria would facilitate the identification of the molecular mechanisms for the metabolic interactions between them. (bvsalud.org)
  • The mechanism of water oxidation: from electrolysis via homogeneous to biological catalysis. (fu-berlin.de)
  • A thorough understanding of various factors governing the metabolism, in particular energy conservation mechanisms, is critical for metabolic engineering of acetogens for targeted production of desired chemicals. (biomedcentral.com)
  • Analysis of the iHN637 metabolic model revealed that flavin based electron bifurcation played a key role in energy conservation during autotrophic growth and helped identify genes for some of the critical steps in this mechanism. (biomedcentral.com)
  • The structural elements for corrinoid binding and the requirement for a kissing loop interaction between the aptamer and expression platform domains have been established for several corrinoid riboswitches. (bvsalud.org)
  • Structural approach to uncover the photoprotective mechanisms adopted by plants and algae. (berkeley.edu)
  • Semaglutide reduces blood glucose through a mechanism where it stimulates insulin secretion and lowers glucagon secretion, both in a glucose-dependent manner. (godschosenministry.com)
  • Here, we employ an in vivo GFP reporter system in Bacillus subtilis to define alternative secondary structures in the expression platform of a corrinoid riboswitch from Priestia megaterium by disrupting and restoring base-pairing interactions. (bvsalud.org)
  • The individual research project grants support problem-solving research on the mechanisms of biogeochemical interactions that may impact remediation of contaminated soil, sediment, surface water, or groundwater. (clu-in.org)
  • Here we determine the mechanism of regulation in a riboswitch that responds to corrinoids-a family of coenzymes related to vitamin B12. (bvsalud.org)
  • Background: Rare plants that contain corrinoid compounds mostly comprise cobalamin analogues, which may compete with cobalamin (vitamin B 12 (B 12 )) metabolism. (mdpi.com)
  • Oral vitamin B12 supplement is delivered to the distal gut, altering the corrinoid profile and selectively depleting Bacteroides in C57BL/6 mice. (colorado.edu)
  • Cyanocobalamin is a vitamin of the B-complex family, commonly known as cobalamins (corrinoids). (godschosenministry.com)
  • Historically, vitamin B-12 was discovered from its relationship to the disease pernicious anemia , which was eventually discovered to result from an effective lack of this vitamin due to problems with the mechanisms in the body which normally absorb it. (wikidoc.org)
  • In both cases, mutually exclusive RNA secondary structures are responsible for promoting or preventing the formation of an intrinsic transcription terminator in response to the corrinoid binding state of the aptamer domain. (bvsalud.org)
  • This study demonstrates that specific Fe(III)-reduction mechanisms in mixed Fe(III)-reducer populations are uniquely sensitive to the rate of O 2 influx, likely mediated by shifts in soil Fe(III)-(oxyhydr)oxide crystallinity. (biomedcentral.com)
  • At the University of Tennessee, Frank Loeffler, Ph.D., and his research team are investigating the role of the microbial community for supplying specific nutrients called corrinoids, which organohalide-respiring Dehalococcoidia require to dechlorinate and detoxify solvents such as tetrachloroethene (PCE) and trichloroethene (TCE). (clu-in.org)
  • 10. Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin. (nih.gov)
  • 13. A new principle for measurement of cobalamin and corrinoids, used for studies of cobalamin analogs on serum haptocorrin. (nih.gov)
  • The term vitamin B12 is used ubiquitously to refer to the different forms of cobalamin, such as Me-Cbl and Ado-Cbl, and they are also referred to as complete corrinoids. (vitamindwiki.com)
  • The bacterium Salmonella enterica produces the corrin ring only under anaerobic conditions, but it can form 'complete' corrinoids aerobically by importing an 'incomplete' corrinoid, such as cobinamide (Cbi), and adding appropriate alpha- and beta-axial ligands. (nih.gov)
  • On the basis of available structural data, a model for the proton-dependent drug efflux mechanism of EmrE was proposed. (tcdb.org)
  • PMID- 5097483 TI - Increase in collagen level by diphenylhydantoin as possible mechanism of drug induced gingival hyperplasia. (nih.gov)