Mechanism of aging. Medical search. Frequent questions

Our sense from the start was that progeria had a lot to teach us about the normal aging process and clues about more general biochemical and molecular mechanisms. (sciencedaily.com)
To develop novel therapeutic interventions for prevention of age-related vascular pathologies, it is crucial to understand the cellular and molecular mechanisms of vascular aging. (northwestern.edu)
In this review, shared molecular mechanisms of aging are considered in terms of their contribution to the pathogenesis of macrovascular and microvascular diseases associated with old age. (northwestern.edu)
An increased understanding of the molecular mechanisms behind brain aging and how it contributes to the disease process is the key to the development of new therapies. (lu.se)
Proposed molecular mechanisms of oxidative stress-induced Nrf2 activation. (hindawi.com)
But the underlying molecular mechanisms of Rhizoma coptidis are still far from being fully elucidated. (springer.com)
In this review, we studied on the effects and molecular mechanisms of Rhizoma coptidis on NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways. (springer.com)
There are many researches on Rhizoma coptidis, but most of them are only a small part of the whole molecular mechanisms. (springer.com)
As a traditional Chinese medicine, Rhizoma coptidis has excellent therapeutic effects on various diseases, but the underlying systematic molecular mechanisms are still far from being fully elucidated. (springer.com)

Intrinsic aging is associated with programmed aging and cellular senescence, which are caused by endogenous oxidative stress and cellular damage. (qxmd.com)
The new results suggest that the mechanism by which oxidative stress accelerates telomere shortening is by damaging the DNA precursor molecules, not the telomere itself. (upmc.com)
This review focuses on the effects of oxidative stress and the role of a particular antioxidant system-the Keap1-Nrf2-ARE pathway-on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. (hindawi.com)
Radical-induced oxidative stress and inflammation can be modulated by Tempol (TP)-based nitroxide drugs to prevent or treat vascular, ocular, and other pathological conditions and aging associated disease. (frontiersin.org)

The aim of this cross-fertilization is to accelerate our understanding of the mechanisms involved in aging and degeneration of the muscle-tendon unit and its innervation and to explore the therapeutic potential of pharmacological and physical therapy interventions. (frontiersin.org)
The role of cellular senescence in development of vascular aging phenotypes is highlighted, and potential interventions to prevent senescence and to eliminate senescent cells for prevention of vascular pathologies are presented. (northwestern.edu)
Skin aging from mechanisms to interventions: focusing on dermal aging. (qxmd.com)
The National Institute on Aging (NIA), a major research component of the National Institutes of Health (NIH) and the Department of Health and Human Services (DHHS), is seeking exceptional candidates for Full-Time Remote eligible position of Senior Program Advisor for Development and Testing of Interventions Targeting Aging Mechanisms ($155,700 - $235,600). (acs.org)
Such interventions may offer novel preventive and therapeutic strategies for multiple age-related conditions. (acs.org)
Stem cell therapy leverages the body's natural healing mechanism, offering more subtle and natural-looking results compared to synthetic fillers or surgical interventions. (corporatewellnessmagazine.com)
The enormous growth in the elderly population is posing a socioeconomic challenge to societies worldwide, and necessitates new sweeping interventions for age-associated diseases. (fightaging.org)

note = "Funding Information: This work was supported by grants from the American Heart Association (Dr. Tarantini), the Oklahoma Center for the Advancement of Science and Technology (to Dr. Csiszar and Dr. Ungvari), the Presbyterian Health Foundation (to Dr. Unvari and Dr. Csiszar), the National Institute on Aging-supported Geroscience Training Program in Oklahoma (T32AG052363), and the Cellular and Molecular GeroScience CoBRE (1P20GM125528). (northwestern.edu)
V.N.G. is supported by grants from the National Institute on Aging. (psu.edu)

to talk about her work on epigenetic mechanisms of aging and longevity. (activemotif.com)
Aging is a progressive process influenced by genetic and environmental factors that have recently been linked to epigenetic mechanisms. (lu.se)

The results of the study has encouraged Imai to believe that they may soon be able to pinpoint and ultimately manipulate the brain's "control center of aging and longevity" in order to preserve youth and extend life spans in mammals other than mice. (goldsea.com)
The meeting covered topics related to new methodologies to study aging, knowledge about basic mechanisms of longevity, latest interventional strategies to target the aging process as well as discussions about the impact of aging research on society and economy. (psu.edu)
Most of the best conferences relating to aging research, and the longevity industry that has emerged from that research, feature an even mix of entrepreneurs, scientists, and investors. (fightaging.org)

Aging gradually decreases cellular biological functions and increases the risk of age-related diseases. (nih.gov)
Cancer, type 2 diabetes mellitus, cardiovascular disease, and neurological disorders are commonly classified as age-related diseases that can affect the lifespan and health of individuals. (nih.gov)
This review summarizes the most important biological mechanisms of aging, and the ability of resveratrol to prevent age-related diseases. (nih.gov)
Aging is the biggest risk factor for neurodegenerative diseases, such as Alzheimer's disease. (lu.se)
Interestingly, the rates of these "epigenetic clocks" change in various human diseases, suggesting that changes in the epigenetic patterns contribute to age-related disease processes by altering an individual's "biological age. (lu.se)
Suicide deaths were categorized by mechanism of injury using the following International Classification of Diseases, Tenth Revision codes: firearm (X72-X74), suffocation (X70), poisoning (X60-X69) and other mechanisms (U03, X71, X75-X84, and Y87.0). (cdc.gov)
New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead to novel discoveries to treat age-related diseases. (psu.edu)
Then we summarized the mechanisms of these alkaloid components of Rhizoma coptidis on cardiovascular and cerebrovascular diseases, diabetes and diabetic complications. (springer.com)
Here we discuss current progress and challenges in understanding the stressors that induce senescence in vivo, the cell types that are prone to senesce, and the autocrine and paracrine properties of senescent cells in the contexts of aging and age-related diseases as well as disease therapy. (elsevierpure.com)
Nitroxide small molecule agents are in development as preventative or therapeutic pharmaceutical drugs for age-related macular degeneration (AMD) and cardiovascular disease, which are two major diseases of aging. (frontiersin.org)
Certain age- and environmental-related pathophysiological changes, degenerative conditions, and diseases are driven and accelerated by radical- (i.e. (frontiersin.org)
Pharmaceutical nitroxide drug candidates for treatment and/or prevention of aging-related and smoking-related diseases are in various different stages of development. (frontiersin.org)
We are delighted to announce the fifth Ending Age-Related Diseases conference on August 11-14, 2022! (fightaging.org)
It aims to prevent and reverse diseases of aging by addressing their common root cause, the aging process itself. (fightaging.org)

The evidence supporting a role for interorgan communication and circulating progeronic and antigeronic factors in vascular aging is discussed. (northwestern.edu)
The aortic histological mechanisms mediating increased vascular stiffness, i.e., collagen/elastin ratio, elastin, and collagen disarray, and the number of breaks in elastin and collagen fibers were greater in the old premenopausal versus young monkeys and greater in the abdominal versus the thoracic aorta and greatest in the iliac artery. (researchwithrutgers.com)
NEW & NOTEWORTHY This is the first study to examine vascular stiffness down the aortic tree in aging premenopausal females (24 ± 0.7 yr old), whereas prior work studied mainly rodents, which are short-lived and do not undergo menopause. (researchwithrutgers.com)
Histological mechanisms mediating vascular stiffness in older premenopausal females increased progressively down the aortic tree, with greater increases in the abdominal aorta compared with the thoracic aorta and with the greatest increases and differences observed in the iliac artery. (researchwithrutgers.com)
Differentiating these closely coupled mechanisms is important to understanding vascular aging . (bvsalud.org)

Cells age as part of the normal cell cycle process called senescence, which progressively advances through a limited number of divisions in the cell lifetime. (sciencedaily.com)

Noting that there is also a link between other viral infections including COVID-19 and cardiovascular disease, Shah said that there was still little understanding on the mechanisms involved. (medscape.com)
Changes in carotid artery stiffness mechanisms over 10 years were compared by age groups with ANCOVA models adjusted for baseline cardiovascular disease risk factors . (bvsalud.org)
Heterogeneity in arterial stiffening mechanisms with aging may influence cardiovascular disease development. (bvsalud.org)
For example, chronic exposure to cigarette tobacco smoke can cause and accelerate microvascular dysfunction in cardiovascular disease (CVD) and age-related macular degeneration (AMD). (frontiersin.org)

Several studies showed that myocardial fibrosis was common in HIV infection, with prevalence of myocardial fibrosis among those with HIV ranging from 5% to 84% compared with 0% to 68% for those without HIV, suggesting that myocardial fibrosis is likely to be a key pathogenic mechanism in the cardiovascular morbidity and mortality observed in people living with HIV, the researchers say. (medscape.com)

Altogether, these data will establish the molecular and cellular mechanisms leading to the successful recovery of spinal cord function after injury, paving the way to improve neuronal regeneration in mammals. (findaphd.com)

This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)
The present review summarizes presentations from the 7th Annual Aging Research and Drug Discovery (ARDD) meeting, held online on the 1st to 4th of September 2020. (psu.edu)

Research has shown that overuse degeneration and aging also share some pathophysiological mechanisms including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and modification of signalling and stress response pathways. (frontiersin.org)
Extrinsic aging is the result of environmental factors, such as ultraviolet (UV) radiation and pollution, and leads to the production of reactive oxygen species, ultimately causing DNA damage and cellular dysfunction. (qxmd.com)

In aged skin, senescent cells accumulate and contribute to the degradation of the extracellular matrix, which further contributes to the aging process. (qxmd.com)
Furthermore, newly recognized beneficial signaling functions of senescence suggest that indiscriminately targeting senescent cells or modulating their secretome for anti-aging therapy may have negative consequences. (elsevierpure.com)

The successful applicant will assess the status of pertinent aging translational research, identify steps to improve coordination among various ongoing activities, identify needs and opportunities for new therapeutics development, identify bottlenecks in the pipeline through clinical testing, and develop activities by which NIA could enhance therapeutics discovery, development, and clinical testing in this field. (acs.org)

The goal of the current investigation was to quantitate differences in stiffness down the aortic tree and the mechanisms mediating those differences in older, premenopausal (24 ± 0.7 yr) versus young adult (7 ± 0.7 yr) female nonhuman primates. (researchwithrutgers.com)
Histological mechanisms mediating the increased aortic stiffness were augmented in the old premenopausal females, greater in the abdominal versus the thoracic aorta, and greatest in the iliac artery. (researchwithrutgers.com)

Nitroxide drugs preventing aging-, smoking-, high sugar or high fat diet-, or radiation- and other environmental-induced pathophysiological conditions in aging disease are reviewed. (frontiersin.org)

On the other hand, the disturbances in the proper HO-1 level are associated with the pathogenesis of some age-dependent disorders, including neurodegeneration, cancer or macular degeneration. (springer.com)

We have previously shown that isoflurane induces activation of NLRP3, cleavage of caspase 1, and increase of IL-1β and TNF-α levels in the hippocampus of aging mice and supposed that inhibiting the NLRP3 inflammasome might have therapeutic merit for ameliorating general anesthesia-induced cognitive deficits [ 5 ] as cited in Wang's study. (biomedcentral.com)
Expertise in research on aging mechanisms, therapeutic target identification, design and testing of candidate lead compounds, pre-clinical testing, or Phase 1 or 2 clinical trials. (acs.org)
Cellular senescence, a process that imposes permanent proliferative arrest on cells in response to various stressors, has emerged as a potentially important contributor to aging and age-related disease, and it is an attractive target for therapeutic exploitation. (elsevierpure.com)

abstract = "Aging is emerging as a druggable target with growing interest from academia, industry and investors. (psu.edu)

The new information will be useful in designing new therapies to preserve telomeres in healthy cells and ultimately help combat the effects of inflammation and aging. (upmc.com)
This virtual conference will bring together the leading experts in rejuvenation biotechnology and investment in order to foster scientific and business collaborations to develop rejuvenation therapies that target the root causes of aging. (fightaging.org)
Rejuvenation therapies aim to reverse or repair age-related cellular changes such as molecular waste, calcification , tissue stiffening , loss of stem cell function , genetic alterations, and impaired energy production . (fightaging.org)

Data on TBI-related deaths were stratified by year, race/ethnicity, sex, and principal mechanism of injury. (cdc.gov)
In 2011, firearm was the leading mechanism for suicide deaths for all age groups, ranging from 44% of suicides among persons aged 5-24 years to 72% of suicides among persons aged ≥65 years. (cdc.gov)
The figure above is a bar chart showing the percentage of suicide deaths, by mechanism and age group, in the United States during 2011. (cdc.gov)

Models were adjusted for potential maternal, socioeconomic, and child confounders such as maternal education, deprivation, and gestational age. (biomedcentral.com)
To participate in this study, you must have a newborn who is less than 32 weeks' gestational age, has a birth weight greater than 500 grams, and has a platelet count less than 100 × 109/L. This study takes place in multiple locations in the United States, the Netherlands, and Sweden. (nih.gov)

The cellular mechanisms behind stroke are seen in the image below. (medscape.com)

Injuries were also categorized by intent, and unintentional injuries were further categorized by mechanism of injury. (cdc.gov)
Unintentional injuries were further categorized by mechanism of injury (motor vehicle crashes, falls, being struck by or against an object, or unspecified). (cdc.gov)

Evidence of powerful individual differences in cognitive aging has sharpened focus on identifying biological factors underlying relative preservation versus vulnerability to decline. (jneurosci.org)
Imai has received many awards and honors in the field of aging research, including the Ellison Medical Foundation Senior Scholar in Aging Award (2008-2012), the Longer Life Foundation Pilot & Feasibility Award (2008-2010), the WUSM 2008 Distinguished Investigator Award, and the Glenn Award for Research in Biological Mechanisms of Aging (2007-2008). (goldsea.com)
Aging is a complicated and sophisticated biological process involving damage to biochemical macromolecules including DNA, proteins, and cellular organelles such as mitochondria. (nih.gov)
Aging causes multiple alterations in biological processes including energy metabolism and nutrient sensing, thus reducing cell proliferation and causing cellular senescence. (nih.gov)
Among the polyphenolic phytochemicals, resveratrol is believed to reduce the negative effects of the aging process through its multiple biological activities. (nih.gov)
Well, an anti-aging supplement undoubtedly the most reliable option of reversing your biological clock. (articlecity.com)
Outcomes can differ widely among individuals due to variations in age, lifestyle, and individual biological responses. (corporatewellnessmagazine.com)

Age-related pathological alterations of the vasculature have a critical role in morbidity and mortality of older adults. (northwestern.edu)

Shinichiro Imai of the Washington University School of Medicine ( WUSM ) has led a study that identifies the brain region in which a specific protein can trigger a delay in the onset of the aging process. (goldsea.com)
Imai's team traced Sirt1's impact on aging to the hypothalamus, specifically the dorsomedial and lateral hypothalamic nuclei, and identified genes related to those areas that respond to elevated levels of the Sirt1 protein by sending nerve signals that delay the onset of the aging process. (goldsea.com)
University of Washington Medical School professor Shinichiro Komai has identified a brain mechanism that delays the onset of the aging process. (goldsea.com)
Skin aging is a multifaceted process that involves intrinsic and extrinsic mechanisms that lead to various structural and physiological changes in the skin. (qxmd.com)
Damage from free radicals, which can be generated by inflammation in the body as well as environmental factors, is thought to build up throughout the aging process. (upmc.com)
However, there's potential for reversing the aging process using Nicotinamide Mononucleotide . (articlecity.com)
By addressing the underlying causes of aging, stem cell therapy can offer lasting benefits, slowing down the aging process. (corporatewellnessmagazine.com)
This year we have an incredibly exciting program with global thought-leaders sharing their latest insights into aging and how we target aging process ensuring everyone lives a healthier and longer life. (fightaging.org)
According to the World report on ageing and health, healthy ageing is defined as "the process of developing and maintaining the functional ability that enables well-being in older age. (who.int)

Welcome to the 9th Aging Research and Drug Discovery (ARDD) Meeting. (fightaging.org)

To identify targetable mechanisms and pathways underlying initiation and progression of MARD and CVD. (lu.se)

Firearm injury was the underlying mechanism of injury in nearly all (97%) TBI-related suicides among all groups. (cdc.gov)
Suffocation was the second leading mechanism in the two younger age groups (41% of suicides among persons aged 5-24 years and 32% of suicides among persons aged 25-44 years). (cdc.gov)

However, the underlying genetic mechanisms and brain structural changes are unknown. (nature.com)
This indicates that possible genetic mechanisms and brain structural changes may underlie the nonlinear relationship between sleep duration and cognition and mental health. (nature.com)
Carotid Artery Stiffening With Aging: Structural Versus Load-Dependent Mechanisms in MESA (the Multi-Ethnic Study of Atherosclerosis). (bvsalud.org)
Elastic arteries stiffen via 2 main mechanisms (1) load-dependent stiffening from higher blood pressure and (2) structural stiffening due to changes in the vessel wall. (bvsalud.org)
antihypertensive medication were predictive of structural stiffening, whereas age, race / ethnicity , education , blood pressure , cholesterol , and antihypertensive medication were predictive of increased load-dependent stiffening. (bvsalud.org)
Rates of structural and load-dependent carotid artery stiffening increased with age. (bvsalud.org)

In preclinical studies, Nicotinamide Mononucleotide work on mice has proved to be handy in cellular biochemical activities, management of Alzheimer's disease, age-related diabetes, complications that arise from obesity, and cardioprotection. (articlecity.com)

The common pathologic mechanism is likely to be inflammation, but we don't really understand how exactly this affects the heart and blood vessels. (medscape.com)
Pups begun on daily lead feedings for two weeks between 10-18 days of age show similar pathologic changes almost entirely confined to the cerebellum. (nih.gov)

SIGNIFICANCE STATEMENT Few studies have combined measurement of brain dopamine with examination of the neural basis of cognition in youth and aging to delineate the underlying mechanisms of these associations. (jneurosci.org)
We found that only the mice that overexpressed Sirt1 in the brain had significant lifespan extension and delay in aging, just like normal mice reared under dietary restriction regimens," said Imai. (goldsea.com)
Using data from the UK Biobank for participants primarily of European ancestry aged 38-73 years, including 94% white people, we identified a nonlinear association between sleep, with approximately 7 h as the optimal sleep duration, and genetic and cognitive factors, brain structure, and mental health as key measures. (nature.com)
As in man, the sensitivity of the brain to lead toxicity is age-dependent. (nih.gov)
In 2015 I moved to the University of Oxford where I worked for 4 years on my personal research grant investigating the brain mechanisms underlying action control. (essex.ac.uk)
Changing and adapting brain mechanisms of self-control. (essex.ac.uk)

A team of University of Pittsburgh researchers has uncovered new details about the biology of telomeres, "caps" of DNA that protect the tips of chromosomes and play key roles in a number of health conditions, including cancer, inflammation and aging. (upmc.com)
Here, we propose that NLRP3 inflammasome-dependent pyroptosis may be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment and discuss that inhibiting NLRP3 inflammasome activation with a novel inhibitor MCC950 may ameliorate age-dependent isoflurane-induced neuro-inflammation. (biomedcentral.com)
Wang's study found that isoflurane activated NLRP3-caspase-1 pathway and increased the secretion of IL-18 and IL-1β in cells pretreated with lipopolysaccharide and suggested that isoflurane induces age-related hippocampal inflammation through NLRP3-caspase-1 pathway. (biomedcentral.com)

Jeffrey Magee, M.D., Ph.D., of Washington University in St. Louis, discusses how mechanisms that regulate hematopoietic stem cells change with age and how this shapes the biology of pediatric leukemia. (uctv.tv)
The field of aesthetic medicine has been revolutionized by the advent of stem cell therapy, offering novel approaches to address signs of aging. (corporatewellnessmagazine.com)
Stem cell therapy emerges as a revolutionary, non-invasive solution for neck rejuvenation, promising to counteract the signs of aging by leveraging the body's inherent regenerative potential. (corporatewellnessmagazine.com)

Together, these findings define striatal dopamine's association with cognitive flexibility and its neural underpinnings in young adults, and reveal the alteration in dopamine-related neural processes in aging. (jneurosci.org)
Third, we demonstrate alteration of these relationships in older adults, suggesting neurochemical modulation of cognitive flexibility changes with age. (jneurosci.org)
The number of increasing people & in the present study attempt as been made to indentify the variable associated with older adults ability to cope with that retirement years & coping mechanisms in this study 56 community dealing men & women between group of 60-70, 70-75 was taken & correlation was found between two variable &life coping. (homesciencejournal.com)
3. cerebellar mitochondria from animals fed lead from 14 days of age contain much more lead than cerebral mitochondria from these animals and cerebellar mitochondria from lead-fed adults. (nih.gov)
Included in the study correlation of low zinc levels and active were 30 children in the age range 2-12 years pulmonary TB in adults [7,8]. (who.int)

This report analyzes and compares data from the 1995 Behavioral Risk Factor Surveillance System (BRFSS) and previously reported 1991 BRFSS data for women aged 18-44 years (3), and presents the prevalence of alcohol consumption among pregnant women and overall and state-specific prevalence rates among women of childbearing age. (cdc.gov)
BRFSS is an ongoing, state-based, random-digit-dialed telephone survey of the U.S. civilian, noninstitutionalized population aged greater than or equal to 18 years. (cdc.gov)
A total of 33,585 women aged 18-44 years were interviewed about their amount and frequency of alcohol consumption during the month preceding the survey. (cdc.gov)
In 1995, 4.7% of women aged 18-44 years reported being pregnant at the time of the interview. (cdc.gov)
The estimated state-specific prevalence of alcohol consumption among women aged 18-44 years varied substantially by state for both any drinking (from 26.1% in Utah to 68.2% in Wisconsin) and for frequent drinking (from 4.0% in Tennessee to 19.4% in Wisconsin) ( Figure 1 ). (cdc.gov)
In Africa, it is estimated that the number of people aged 60 years or over (called older people or the elderly) will increase from 46 million in 2015 to 147 million by 2050. (who.int)
In Africa, it is estimated that the number of people aged 60 years or over (called older people or the elderly) will increase from 46 million in 2015 to 147 million by 2050.1 Member States are yet to prioritize healthy ageing in their national health and development agenda and address it through a comprehensive multisectoral approach because programming for healthy ageing still remains a major challenge for the Region. (who.int)
Cases were limited to those 15 years of age and older. (cdc.gov)

Some scholars extend the end date of the golden age to around 1350, including the Timurid Renaissance within it, while others place the end of the Islamic Golden Age as late as the end of 15th to 16th centuries, including the rise of the Islamic gunpowder empires. (wikipedia.org)

The researchers have found that short or dysfunctional telomeres activate production of progerin, which is associated with age-related cell damage. (sciencedaily.com)
Telomeres, composed of repeated sequences of DNA, are shortened every time a cell divides and therefore become smaller as a person ages. (upmc.com)
On the flip side, we hope to develop mechanisms to selectively deplete telomeres in cancer cells to stop them from dividing," said Dr. Opresko. (upmc.com)

Early in the course of lead feedings begun at 14 days of age, isolated cerebellar mitochondria show a loss of respiratory control. (nih.gov)

Muscle-tendon unit and its innervation has a pivotal role in motor function performance that can be disrupted by overuse degeneration and aging. (frontiersin.org)

This study uses a cohort sample of 12,644 to 13,832 mother-child pairs from the UK Born in Bradford Study to examine the associations between maternal metabolic syndrome classification (MetS) and child development outcomes at age 5, using cord blood markers as candidate mediators. (biomedcentral.com)
The results support the hypothesis that maternal metabolic syndrome classification during pregnancy is associated with some child developmental outcomes at age 5. (biomedcentral.com)

According to the United Nations, the proportion of people aged over 65 now outnumber children younger than 5. (fightaging.org)

In this regard, we present a hypothesis that pyroptosis plays a critical role in the mechanism of isoflurane-induced cognitive impairment and MCC950 inhibits the NLRP3 inflammasome-dependent pyroptosis in isoflurane anesthesia to improve the cognition. (biomedcentral.com)

As you age, cellular energy decreases due to the low levels of nicotinamide mononucleotide and subsequent reduction of NAD+. (articlecity.com)
ustekinumab decreases effects of adenovirus types 4 and 7 live, oral by Mechanism: pharmacodynamic antagonism. (medscape.com)
ustekinumab decreases effects of influenza virus vaccine quadrivalent, intranasal by Mechanism: pharmacodynamic antagonism. (medscape.com)

Aging is accompanied by profound changes in the brain's dopamine system that affect cognitive function. (jneurosci.org)
Dopamine therefore represents a prime target for investigating the neurochemical basis of variability in executive function in youth, and may represent a driver of powerful individual differences in cognitive aging. (jneurosci.org)
What is more, aging affects both physical and cognitive functions. (articlecity.com)
Recently, we read with great interest the article titled "Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment" by Dr. Wang Z et al. (biomedcentral.com)
This finding is a very important evidence for supporting that NLRP3-caspase-1 pathway is involved in the mechanism of general anesthesia-induced cognitive impairment. (biomedcentral.com)

Shinichiro Imai is an associate professor in WUSM 's departments of developmental biology and medicine and a noted expert in aging research. (goldsea.com)
This Research Topic is intended to bring together basic researchers and clinicians working in the area of neuroscience, aging, sarcopenia and orthopedics in human and in animal models. (frontiersin.org)
D.W.L. is supported in part by research grants and funds from the National Institutes of Health (AG041765, AG050135, AG051974, AG056771 and AG062328), the Wisconsin Partnership Program, the Progeria Research Foundation, the American Federation for Aging Research, and the University of Wisconsin-Madison School of Medicine and Public Health and Department of Medicine. (psu.edu)
The advisor will provide expertise and advice to NIA on activities to improve discovery and development of therapeutics targeting aging mechanisms, and subsequent research pipeline of preclinical and clinical assessment. (acs.org)

The lack of proper bending materials, the homogeneous deformation of the existing bendable surfaces and the need for folding to create some deformation mechanisms are the limitations of the work. (researchgate.net)

The mild age-related diabetes (MARD) cluster, together with the mild obesity-related diabetes (MOD) and the severe insulin-resistant diabetes (SIRD) has the highest risk of developing CVD. (lu.se)

These procedures address different symptoms of aging, but to devise an effective anti-aging treatment protocol, it is essential to thoroughly understand the mechanisms of skin aging. (qxmd.com)
This review provides an overview of the mechanisms of skin aging and their significance in the development of anti-aging treatments. (qxmd.com)
Learn more about Anti-Aging Mechanisms and enrich the skin with the essential ingredients of daily care. (frezyderm.mt)
Is rose hip oil good for skin lightening, scar treatment, and other anti-aging benefits? (thebeautybrains.com)
The key take away here is that rosehip oil contains a large concentration of linoleic acid which is really good for skin and a lesser concentration of some other known anti-aging actives. (thebeautybrains.com)
The neck is susceptible to aging due to its delicate skin and constant exposure to environmental factors. (corporatewellnessmagazine.com)

The leading mechanism of injuries was unintentional fall-related (46.9%), with a mean fall height of 12.8 feet. (cdc.gov)

Connecting this rare disease phenomenon and normal aging is bearing fruit in an important way," said NIH Director Francis S. Collins, M.D., Ph.D., a senior author of the current paper. (sciencedaily.com)
This mechanism appears to be altered by telomere shortening, and affects protein production for multiple proteins that are important for cytoskeleton integrity. (sciencedaily.com)
In epidemiological studies, age is the single most important cardiovascular risk factor that dwarfs the impact of traditional risk factors. (northwestern.edu)
Ongoing surveillance for alcohol consumption among pregnant and childbearing-aged women is important for monitoring the impact of efforts to prevent this risk behavior. (cdc.gov)

The HCAP enables researchers to measure and understand dementia risk in ongoing longitudinal studies of aging around the world using methods and content that are as similar as possible across studies. (nih.gov)

Here we use our well-characterized stroke model in aged female rats subjected to repeated daily sleep restriction (8 h/day) or normal sleep for the 6 days prior to MCAO to better characterize how chronic sleep restriction exposure impacts stroke. (cdc.gov)

The available studies of cardiac imaging involved mainly men aged between 50 and 60, whereas the global HIV population is made up of mostly women who are typically aged at least a decade younger," Shah said. (medscape.com)

Although chemotherapy treatment-induced side effects occur in 16-75% of all patients, the mechanisms of these effects are not well understood. (scite.ai)
The treatment of aging mice with NLRP3 inflammasome inhibitor will be needed. (biomedcentral.com)
The DOTS (directly ob- these nutrients may affect the host's defence served treatment, short-course) regimen mechanisms [5,6]. (who.int)

The effect of age on neutrophil and monocyte responses to $S.$ $pneumoniae$ and on CD4+ T cell polarisation during health, pneumococcal carriage and clinical pneumonia infection were determined. (bham.ac.uk)

In mediation models, significant total effects were found for MetS associations with children's development in the LIT domain at age 5. (biomedcentral.com)
The various Quranic injunctions and Hadith (or actions of Muhammad), which place values on education and emphasize the importance of acquiring knowledge, played a vital role in influencing the Muslims of this age in their search for knowledge and the development of the body of science. (wikipedia.org)

Progeria is an extremely rare disease in which children experience symptoms normally associated with advanced age, including hair loss, diminished subcutaneous fat, premature atherosclerosis and skeletal abnormalities. (sciencedaily.com)
The current study shows that the mutation that causes progeria strongly activates the splicing of lamin A to produce the toxic progerin protein, leading to all of the features of premature aging suffered by children with this disease. (sciencedaily.com)

Neuroproteomic profiling of the sleep-restricted aged female rat after ischemic stroke using iTRAQ LC-MS/MS. (cdc.gov)

Molecular mechanisms9

Oxidative Stress4

Interventions7

National Insti2

Epigenetic mechanisms2

Longevity3

Diseases14

Vascular5

Called senescence1

Cardiovascular disease4

Pathogenic mechanism1

Regeneration1

Review summarizes2

Dysfunction2

Senescent cells2

Translational Research1

Stiffness2

Pathophysiological1

Macular degeneration1

Therapeutic3

Abstract1

Therapies3

Deaths3

Gestational age2

Cellular mechanisms1

Categorized by mechanism of injury2

Biological7

Morbidity and morta1

Process9

ARDD1

Pathways1

Suicides among2

Structural6

Biochemical1

Pathologic2

Brain6

Inflammation3

STEM3

Adults5

Years8

16th1

Telomeres3

Mitochondria1

Degeneration1

Metabolic syndrome2

People aged1

Cognition1

Decreases3

Cognitive5

Research4

Limitations1

Obesity1

Skin6

Unintentional1

Important4

Methods1

Rats1

Younger1

Treatment3

Infection1

Development2

Disease2

Stroke1