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  • regimens
  • We also discuss how the translation of these new findings might further improve the efficacy of adoptive cell transfer through the use of vaccines, haematopoietic-stem-cell transplantation, modified preconditioning regimens, and alternative methods for the generation and selection of the T cells to be transferred. (nih.gov)
  • transfer
  • Lymphodepletion enhances adoptive T cell transfer (ACT) therapy by activating the innate immune system via microbes released from the radiation-injured gut. (springer.com)
  • Adoptive cell transfer after host preconditioning by lymphodepletion represents an important advance in cancer immunotherapy. (nih.gov)
  • Perhaps, the most promising specific therapy is the adoptive transfer of genetically engineered tumour‐reactive T cells, an approach that has already proven curative in some patients with metastatic disease. (els.net)
  • Generalized scheme of adoptive cell transfer (ACT) of genetically modified T cells. (els.net)
  • In vivo, the adoptive transfer of CMS4-reactive CTL (≥1 × 10 6 ) resulted in nearly the complete regression of 3-day established lung metastases. (jimmunol.org)
  • Furthermore, mice that rejected CMS4 following a single adoptive transfer of CTL displayed antitumor activity to a rechallenge 45 days later, not only in the lung, but also at a s.c. distal site. (jimmunol.org)
  • Here, we tested in mice several cancer vaccines and an adoptive T cell transfer approach to cancer immunotherapy in combination with several widely used chemotherapeutic drugs. (jci.org)
  • The treatment protocol for the treatment with TAX and adoptive transfer is described in Methods. (jci.org)
  • Adoptive transfer of CD4 + T-cells is another promising target as this cell type can orchestrate the adaptive immune response. (dovepress.com)
  • TILs
  • Utilizing TILs for adoptive T cell therapy has the advantage of providing broad T-cell recognition for many tumor antigen types rather than the single specificity capacity of other techniques. (news-medical.net)
  • Current studies are attempting to minimize the time taken to culture TILs, improve the effector characteristics of T cells and identify biomarkers that allow for the selection of the most suitable patients that will respond well to this type of immunotherapy. (news-medical.net)
  • Adoptive T cell therapies with TILs can overcome this problem. (eppendorf.com)
  • inhibition
  • To target mechanisms important for cancer cell adaptation to genotoxic stress and thereby to achieve cancer cell-specific killing, we combined inhibition of the kinases ATR and Wee1. (jci.org)