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  • genotype
  • We published the first molecular HLA association study in childhood ALL and showed a convincing association for a homozygous genotype of the DQA1 locus by RFLP analysis 4 . (dorak.info)
  • This genotype more or less corresponds to homozygosity for HLA-DR53 and the current research specifically examined this genotype by PCR analysis against a newborn control group (as opposed to an adult control group in the previous RFLP study). (dorak.info)
  • allele
  • The first childhood leukaemia studies examined HLA class-II antigen frequencies found an increased allele frequency of DR7 in Switzerland where DR7 is the most common DR53 group antigen 8;9 . (dorak.info)
  • The increased HLA-DR53 allele frequency in adult ALL (66.7% vs 52.3%) could have been significant if homozygosity had been considered 11 . (dorak.info)
  • In fact, the null allele of the HLA-DRB4 gene ( DRB4*0103102N ) is transcribed, but it is an aberrant protein due to the lack of splicing out of the first exon 11 . (dorak.info)
  • For example, hypersensitivity to abacavir, a drug used for treating of human immunodeficiency virus (HIV) infection, has been proposed to be associated with allele 57:01 of HLA-B gene (terms HLA-B 57:01 ). (hindawi.com)
  • susceptibility
  • Can HLA-DRB4 be a susceptibility locus? (dorak.info)
  • As a test of our original hypothesis that the HLA-associated susceptibility to childhood leukaemia is a recessive trait and not a simple allelic association 5;6 , we examined the homozygosity rates. (dorak.info)
  • It has been suggested that these associations among CD and other AD may be explained by the sharing of a common pathogenic basis involving genetic susceptibility, similar environmental triggers, and the loss of intestinal barrier secondary to dysfunction of intercellular tight junctions with increased intestinal permeability, and possibly by other undiscovered mechanisms [ 7 , 11 - 16 ]. (hindawi.com)
  • haplotype
  • HLA-DR53 is not expressed on the HLA-B57DR7Dw11DQ9 (DQA1*02:01, DQB1*03:03) haplotype (as in the cell line DBB (IHW 9052) representing the conserved extended haplotype (CEH) 57.1) due to a base substitution at the 3' end of the first intron of the gene 9;10 . (dorak.info)
  • epitope
  • The most convincing association study in leukaemia is the one which used a monoclonal antibody recognising HVR3 epitope of the DR53 antigen 13 . (dorak.info)
  • We review and update the role of immunogenic TSHR epitopes and HLA in GD, and offer perspectives on TSHR epitope specific treatments. (frontiersin.org)
  • Interaction by the complex of TSHR epitope, HLA-class II molecule, and T-cell receptor (TCR) is modified through binding of CD40 ligand to CD40 and of CTLA-4 to B7 ( 3 - 6 ). (frontiersin.org)
  • DR53
  • Two British studies examined HLA-DR antigens in adult leukaemias and reported the involvement of HLA-DR53 or its members in adult ALL 11 and chronic lymphoid leukaemia (CLL) 12 . (dorak.info)
  • An exception has been reported as an unexpected expression of HLA-DR53 in a DR7 (Dw11) : DQ9 - positive leukemia patient 12 . (dorak.info)
  • DQA1
  • The data available on DQ2-negative CD patients indicate that they almost invariably are HLA-DQ8 positive (DQA1 ∗ 0301/DQB1 ∗ 0302). (biomedcentral.com)
  • adaptive
  • It is now suspected that metabolic diseases, such as obesity, type 2 diabetes and their related complications, are linked to defects in these adaptive mechanisms. (univ-lyon1.fr)
  • To this aim, we investigate the adaptive mechanisms to metabolic stress and pollutant exposure under different experimental conditions reflecting as much as possible normal life. (univ-lyon1.fr)
  • humans
  • The main objectives of Team 1 of CarMeN laboratory are to define the mechanisms involved in the physiological response to metabolic stress in humans, to identify potential defects in these processes and to develop new strategies to fight metabolic and nutritional diseases. (univ-lyon1.fr)
  • In collaboration with the CRNH-RA, we are developing an ambitious research program to characterize these mechanisms usinga overfeeding protocols in humans and in animal models. (univ-lyon1.fr)
  • donors
  • they are also critical in the field of transplant surgery where the donors and the recipients must be HLA-compatible [ 3 ]. (hindawi.com)
  • strongest
  • P = 0.000003), this association remains one of the strongest HLA - cancer associations ever reported. (dorak.info)
  • inflammation
  • In addition, exposure to airborne endotoxins, which is common in workplaces associated with HP, potentiates antigen-specific airway inflammation and allergen responses . (worldallergy.org)
  • proteins
  • It was found that of the structural proteins, El glycoprotein was the dominant antigen recognized by the study population sampled from normal individuals with no history of rubella associated conditions. (ubc.ca)
  • frequency
  • In this study, the frequency of s of HLA-DR, HLA-DQ, and HLA-DP antigens was evaluated by means of the PCR- RFLP method. (healthdocbox.com)
  • Intensity (concentration) and duration of exposure to the antigen, frequency of exposure, particle size, and antigen solubility may influence disease latency, prevalence, severity and course [6, (worldallergy.org)
  • exposure
  • In general, there appears to be a direct relationship between the intensity of antigen exposure and the development of HP. (worldallergy.org)
  • It is believed that acute HP usually results from intense intermittent exposure to inhaled antigens and that subacute HP results from a less intense but more persistent exposure. (worldallergy.org)
  • disease
  • Why, then, in a disease which has attracted much attention for an HLA association since Lilly's original paper on mouse leukaemia in 1964 (Ref.2), and the first HLA association paper in childhood leukaemia 3 , no other strong HLA association has been reported? (dorak.info)
  • Tang et al.333 identied, by chromosomal mechanisms in individuals at increased risk was found.224 there was weak evidence of disease. (arrowheadpharma.com)
  • We’ve identified a previously unknown mechanism for iron absorption that could help in the eradication of global iron deficiency, demonstrated a novel use of statin therapy in the treatment of sickle cell disease pain crises and developed a new translational research and prevention program that identifies and works with children in our local community who are at risk for cardiovascular disease, diabetes and obesity. (paperzz.com)
  • The study of genetic polymorphisms promises to help define pathophysiologic mechanisms, to identify individuals at risk for disease and to suggest novel targets for drug treatment. (biomedcentral.com)
  • study
  • HLA-DR7 was also found increased in childhood ALL in another study 10 . (dorak.info)
  • OBJECTIVE- The aim of our study was to explore the immunomodulatory activity of soluble immunoglobulin (Ig)-like transcript (ILT) 3-Fc in pancreatic islet transplantation and to determine its mechanism of action. (diabetesjournals.org)
  • occur
  • HP develops as a result of the immunologically mediated events and the physiologic consequences that occur in the lung after inhalation of the responsible antigen in a sensitized individual. (worldallergy.org)
  • In HLA-DRB4, allelic differences occur and are not limited to exon 2 ( b 1 domain) but involve exon 3 ( b 2 domain) too. (dorak.info)
  • main
  • In this paper, we presented the main etiopathogenetic factors of RAS with a special emphasis on the mechanisms of the immune response modification. (springer.com)
  • expression
  • The HLA-DRB4 promoter polymorphism is associated with differential expression of this locus 4 and this occurs at the level of mRNA production 3 . (dorak.info)