Mechanism cell transformation neoplastic. Medical search. Frequent questions

High-efficiency neoplastic transformation of mouse mammary epithelial cells in primary collagen gel culture was induced by N-methyl-N-nitrosourea (MNU). (eurekamag.com)
Mammary epithelial cells, isolated from virgin BALB/c mice, were embedded within collagen gels and grown in a serum-free medium containing prolactin, progesterone, and linoleic acid. (eurekamag.com)
Although estrogens have been shown to play a central role in breast cancer development, their carcinogenicity on human breast epithelial cells (HBECs) has not yet been clearly demonstrated. (eurekamag.com)
During concurrently enhanced epithelial cell proliferation such mutations may then be fixed in dividing cells and clonally expressed. (ecetoc.org)
Driscoll et al (1996) demonstrated for the first time a dose-dependent increase of mutation frequency in alveolar epithelial cells following exposure of rats for 13 weeks against 1.1, 7.1 and 52.8 mg/m3 carbon black particulate including 3 and 8 months of recovery. (ecetoc.org)
Measured endpoints included mutations in the HRPT gene of alveolar epithelial cells, changes in bronchi alveolar lavage fluid markers, expression of mRNA for chemokines as well as histopathology. (ecetoc.org)
especially no inflammatory responses, increased mutation frequencies in the presence of significant pulmonary inflammation and epithelial cell hyperplasia were observed immediately after the exposure period in the mid and high dose groups. (ecetoc.org)
Subsequent studies (Driscoll et al, 1997) revealed a relationship between the severity of pulmonary inflammation and ex vivo induced mutations by co-incubating lung lavage inflammatory cells (macrophages, neutrophils, lymphocytes) from carbon black exposed rats with rat lung epithelial cells. (ecetoc.org)
We have previously reported a mouse model in which Brca1 exon 11 is eliminated in mammary epithelial cells through Cre-mediated excision. (nih.gov)
since Mycobacterium tuberculosis (MTb) is an intracellular organism, bacterial DNA could integrate to bronchial epithelial cells inducing neoplastic transformation. (bvsalud.org)
Researchers also found that oral cancer cells have undergone epithelial-mesenchymal transformation (EMT). (qsstudy.com)
Background: The molecular mechanisms of differentiation of intestinal epithelial cells, is poorly understood and disruption of this balance may result in neoplastic transformation and malignant growth. (metu.edu.tr)
Recently, it was reported that miR-200a plays a crucial role in the development of cancer through its regulation of epithelial to mesenchymal transition (EMT), cell migration, proliferation and metastasis [ 11 , 12 , 13 ]. (oncotarget.com)
EMT is a process by which epithelial cells lose their cell-cell adhesion and gain invasive properties, which leads to the acquisition of mesenchymal stem cell characteristics [ 17 , 18 ]. (oncotarget.com)
Our current studies focus on how the tumor susceptibility gene 101 (TSG101) prevents tumorigenesis in mammary epithelial cells. (grantome.com)

A single exposure or multiple exposures of these cells to MNU was effective in inducing tumorigenic cells that produced palpable tumors as early as 6 weeks after transplantation. (eurekamag.com)
Two treatments with MNU (100 micrograms/ml) were optimal for neoplastic transformation and produced tumors in 79% of the injected fat pads. (eurekamag.com)
They have complementary mechanisms to hinder the carcinogenic process by searching free radicals, inhibiting survival and multiplication of malignant cells, as well as reducing invasiveness and angiogenesis of tumors. (researchsquare.com)
More in detail, both conditions have been widely associated with the accumulation of genetic and epigenetic alterations responsible for the alteration of cell proliferation and apoptosis responsible for the neoplastic transformation of cells and the development of tumors (Candido et al. (researchgate.net)
All the mice injected with transformed cells developed tumors indicating the tumorigenic potential of TCE. (cdc.gov)
2017. Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors. . (oregonstate.edu)
These tumors arise from squamous cell embryologic rests found along the path of the primitive adenohypophysis and craniopharyngeal duct. (medscape.com)
Cancer cells inside individual tumors sometimes reside in distinct phenotypic states that vary in function attributes. (qsstudy.com)
Researchers from Tokyo Medical and Dental University (TMDU) and Niigata University identify a novel mechanism by which tumors progress. (qsstudy.com)
Because tumors are often infiltrated by inflammatory cells, the tumor microenvironment contains high levels of TNF-α. (qsstudy.com)
The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. (mdpi.com)
For studies of the role of NK cells in vivo, we will examine primary mouse and human tumors and metastases from the same individual for susceptibility to NK cells in both beige mice and nude mice immunosuppressed for NK activity and will characterize mechanism of resistance to the growth tumors and metastases by adoptive transfers with defined lymphocyte subpopulations. (grantome.com)
Small tumors have a greater percentage of actively dividing cells than do large tumors. (msdmanuals.com)
Chronic exposure of rats resulted in increased thyroid follicular cell tumors from sustained perturbation of thyroid hormone homeostasis. (cdc.gov)

In oncogenic polyomaviruses, the tumor antigens are responsible for the transformation activity, although the exact molecular mechanisms vary from one virus to another. (wikipedia.org)
We are interested in understanding the underlying molecular mechanisms of senescence regulation by these genes. (umassmed.edu)
OBJECTIVE: To describe the epidemiological studies about the relationship between lung cancer (LC) and pulmonary tuberculosis (Tb) and its possible molecular mechanisms. (bvsalud.org)
Subsequently, we systematically explored the relationships of ANLN expression with patient prognosis, genetic alterations, phosphorylation, the immune microenvironment, and gene function in order to uncover the molecular mechanisms of ANLN in cancer. (biomedcentral.com)
However, we do not know much about the molecular mechanisms underlying these interactions," says the corresponding author of the study Tetsuro Watabe (TMDU). (qsstudy.com)
Our research is aimed to dissect the molecular mechanisms in which mutations in cohesin affect tumorigenesis. (onnlab.org)
In this book the molecular mechanisms and biological processes in which epigenetic modifications play a primordial role are described in detail. (caister.com)

Phenotypic and genotypic changes during carcinogenesis may be demonstrated by the cell transformation and tumorigenesis assays and by molecular analyses. (cdc.gov)
These findings provide a mechanism for BRCA1-associated breast carcinogenesis. (nih.gov)
This review's focus is on the basic mechanism and metabolism of chemical carcinogenesis. (matjournals.co.in)
Thus, this review deals with the basic mechanism and metabolism of chemical carcinogenesis. (matjournals.co.in)
reported that ANLN may be a therapeutic target in patients with hepatocellular carcinoma HCC owing to its effects on carcinogenesis in HCC cell lines [ 12 ]. (biomedcentral.com)
Our exploration of the multistep process of carcinogenesis has provided substantial insights into the mechanisms by which chemopreventive agents modulate these events. (aacrjournals.org)
Choline kinase alpha (ChoKalpha) is an enzyme involved in the metabolism of phospholipids recently found to play a relevant role in the regulation of cell proliferation, oncogenic transformation and human carcinogenesis. (nih.gov)
Many mechanisms have been proposed for the inhibition of carcinogenesis by tea, including the modulation of signal transduction pathways that leads to the inhibition of cell proliferation and transformation, induction of apoptosis of preneoplastic and neoplastic cells, as well as inhibition of tumor invasion and angiogenesis. (indexindex.com)
However, the mechanism by which C. sinensis promotes carcinogenesis is unclear. (yonsei.ac.kr)
Molecularly, Cr(VI) carcinogenesis involves dysregulation of cell cycle signaling resulting in cells that become death resistant. (gwu.edu)
The aim of the Monographs has been, from their inception, to evaluate evidence of carcinogenicity at any stage in the carcinogenesis process, independently of the underlying mechanisms. (who.int)

Symmetric cell division prompts multiplication and asymmetric cell division is an enlightening advance for differentiation. (researchsquare.com)
The family of CCAAT/Enhancer Binding Protein (C/EBP) transcription factors is implicated in cellular growth, differentiation, inflammation and development and control differentiation in several cell types. (metu.edu.tr)
The degree of differentiation of mast cell tumours (MCTs) is the most important feature and reflects the morphological characteristics and metastatic potential of the tumour and its likely response to treatment and the prognosis. (biomedcentral.com)
Where appropriate we will attempt to develop continuous murine and human NK cell lines of vrious NK phenotypes, study their regulation by IFN and IL-2, and attempt to delineate which subsets produce interferon and the pathways of differentiation as determined by cell surface markers. (grantome.com)
Cancer is a disease characterized by a shift in the control mechanisms that govern cell survival, proliferation, and differentiation. (ideviate.org)
The following chapters cover the epigenetic systems of plants, the epigenetic profile of embryonic stem cells, cell differentiation, imprinting marks, and random X chromosome inactivation. (caister.com)
Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)

Heterozygous mutation of Trp53 decreases p53 and results in attenuated apoptosis and G1-S checkpoint control, allowing Brca1Delta11/Delta11 cells to proliferate. (nih.gov)
Role of PDL-1 in NSCLC chemoresistance was assessed using CRISPR/Cas9 knockdown and various functional assays including MTT, cell invasion, sphere formation, and cell apoptosis. (cdc.gov)
Mechanistically, an upregulation of PDL-1 in chemotherapy-treated CAFs led to an increase in hepatocyte growth factor (HGF) secretion, which stimulates cancer progression, cell invasion, and stemness of lung cancer cells, while inhibiting apoptosis. (cdc.gov)
In this study, mechanisms of resistance to imatinib-induced apoptosis in human K562 cells were examined. (metu.edu.tr)
These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)

Malignant transformation in vitro was determined by using the anchorage- independent growth assay on soft agar. (scirp.org)
Pseudolymphoma is characterized by a benign infiltration of lymphoid cells or histiocytes which microscopically resembles a malignant lymphoma. (lookformedical.com)
Excessive reactive oxygen species (ROS) generated by UVR have been shown to contribute to malignant transformation of keratinocytes into cancerous cells including BCC probably through oxidative DNA damage, defects in DNA repair, and interference with cellular signaling [ 6 , 7 ]. (hindawi.com)

Eleven to 14 days after the final carcinogen treatment, the cells were removed from the collagen gels and injected into the cleared mammary fat pads of syngeneic hosts to assay for transformed cell populations. (eurekamag.com)
Control cells cultured for the same periods of time as MNU-treated cells produced only ductal outgrowths that were morphologically similar to those found in the mammary glands of adult virgin hosts. (eurekamag.com)
This system provides a distinct means to study the mechanism of mammary neoplastic transformation at cellular and molecular levels. (eurekamag.com)
Experimental studies have demonstrated that mammary cancer is a hormone-dependent multistep process that can be induced by a variety of compounds and mechanisms, that is, hormones, chemicals, radiation, and viruses, in addition to or in combination with genetic factors. (eurekamag.com)
This mutation is often accompanied by alterations in transformation-related protein 53 (Trp53, encoding p53), which substantially accelerates mammary tumor formation. (nih.gov)

A) Lymphomas found in Smurf2-deficient mice have the characteristics of diffuse large B-cell lymphoma (DLBCL) and enhanced cell proliferation. (umassmed.edu)

Cancer cells and tissues, regardless of their origin and genetic background, have an aberrant regulation of hydrogen ion dynamics leading to a reversal of the intracellular to extracellular pH gradient (ΔpHi to ΔpHe) as compared to normal tissues. (benthamscience.com)
In normal tissues, cellular mechanisms are firmly regulated, through coordinated efforts of many cellular factors, to prevent neoplastic transformation and tumorigenesis. (onnlab.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)

Furthermore, aberrant oncogenic activation, DNA damage or oxidative stress activates senescence, providing a failsafe mechanism that prevents the proliferation of cells at risk of neoplastic transformation. (umassmed.edu)

The mechanism for Epstein-Barr virus infection of progenitor cells and neoplastic transformation has been an area of interest and conjecture. (allenpress.com)
By limiting cell proliferation and consequently depleting the renewal capacity of stem or progenitor cells, senescence is thought to contribute to the aging process. (umassmed.edu)

Consistent with this notion, we have found that Smurf2-deficient mouse embryonic fibroblasts exhibit delayed senescence entry and enhanced potential to become immortalized in culture, while Smurf2-deficient mice show increased susceptibility to various types of cancer, including B-cell lymphoma, hepatocellular carcinoma, adenocarcinoma in small intestine and soft tissue sarcoma. (umassmed.edu)
Further, nude mice were injected with TCE-transformed cells. (cdc.gov)
In aged mice, the self-renewal capacity of long-term hematopoietic stem cells (LT-HSC) diminishes. (umassmed.edu)
Our ongoing studies have found that LT-HSC population, which give rise to all lineages of blood cells, increases in Smurf2-deficient mice, suggesting a beneficial effect of Smurf2 deficiency. (umassmed.edu)
Here, we sought to elucidate the underlying mechanism(s) using mice deficient in the Brca1 exon 11 isoform (Brca1Delta11/Delta11). (nih.gov)
Swiss scientists that research on mice, found that, without existence of periostin protein, cancer cells cannot spread from original organ (metastasis) to others. (ideviate.org)
IEL, a nontoxic ineffective compound in the RTE transformation system ( 20% inhibition), potentially inhibited the activity of iNOS in primary macrophage of intact cells and during the contamination of mice with a NO sensitive parasite, Leishmania major [30]. (e-core.org)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

Cytogenetics and Cell Genetics, 69, 15-17. (scirp.org)
Cytogenetics and Cell Genetics, 71, 94-95. (scirp.org)
Cytogenetics and Cell Genetics, 68, 122-124. (scirp.org)
Cytogenetics and Cell Genetics, 72, 294-296. (scirp.org)

A tumor is a highly complex tissue composed of neoplastic and stromal cells. (qsstudy.com)
It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)
These Fgfr3-creER -marked endosteal stromal cells contribute to a stem cell fraction in young stages, which is later replaced by Lepr-cre -marked stromal cells in adult stages. (nature.com)
Further, Fgfr3 + endosteal stromal cells give rise to aggressive osteosarcoma-like lesions upon loss of p53 tumor suppressor through unregulated self-renewal and aberrant osteogenic fates. (nature.com)
These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
Overall, our findings indicate that Fgfr3 + endosteal stem/stromal cells with OCT identities dictate active and aggressive osteogenesis, identifying these cells as an important regulator of long-term bone homeostasis. (nature.com)

This protocol was adapted for studying the inhibition of chemically induced transformation and has been expanded to test potential chemopreventive compounds belonging to different chemical classes and biologic activity [6C8]. (e-core.org)

SV40 and murine polyomavirus STags appear to have a role in promoting host cell expression of genes under the control of certain types of promoters. (wikipedia.org)
Tumorigenesis is a multi-step process in which a normal cell acquires changes in a number of critical cancer causing genes. (umassmed.edu)
DNA from transformed cells were subjected to differential PCR to detect changes in gene copy number and gene expression of six protooncogenes (K-ras, c-fos, c-jun, c-myc, c-sis, erb-B2) and two tumor suppressor genes (p53, p16). (cdc.gov)
The total chromosomal content of a cell involves approximately 105 genes in a specialized macromolecule of deoxyribonucleic acid (DNA). (cdc.gov)
Transformation of normal cells into neoplastic ones likely involves multiple genomic changes, including loss of tumor-suppressor genes, activation of oncogenes, and alterations in DNA repair and methylation mechanisms. (medscape.com)
Using differential microarray analysis, we identify target genes that provide the basis for the understanding of the molecular mechanism for the regulation of cell proliferation and transformation mediated by over-expression of the human ChoKalpha. (nih.gov)

Further studies are in progress to investigate the epigenetic mechanism(s) of TCE-induced cell transformation and tumorigenesis. (cdc.gov)
Current Research and Scholarly Interests The Wang lab takes an interdisciplinary approach to studying fundamental mechanisms controlling gene expression in mammalian cells, and how epigenetic mechanisms such as DNA methylation, chromatin modifications, and RNA influence chromatin dynamics to affect gene regulation. (stanford.edu)
The first seven chapters describe the different biological mechanisms of the epigenetic machinery including: DNA methylation, histone tails, chromatin structure, nucleosome occupancy, Polycomb group proteins, siRNAs and miRNAs. (caister.com)

STag is known to interact with host cell proteins, most notably protein phosphatase 2A (PP2A), and may activate the expression of cellular proteins associated with the cell cycle transition to S phase. (wikipedia.org)
Because polyomavirus genome replication relies on the DNA replication machinery of the host cell, the cell must be in S phase (the part of the cell cycle in which the host cell's genome is normally replicated) in order to provide the necessary molecular machinery for viral DNA replication. (wikipedia.org)
Viral proteins therefore promote dysregulation of the cell cycle and entry into S phase. (wikipedia.org)
Cell division is a simple cycle from the earliest starting point of life in the universe. (researchsquare.com)
Thus, although PyV-induced oncogenesis in laboratory animals has been a prolific model for the study of the cell cycle and cell transformation, natural infections rarely result in tumor formation, so the steps in cell transformation after natural infection are being revealed more slowly. (cdc.gov)
The molecular basis to understand the connection between phospholipids metabolism and cell cycle regulation through choline kinase is reported. (nih.gov)
During the cell cycle the helix unwinds and clones itself. (whale.to)
In the second half of the cell cycle the chromosomes clone themselves so that at mitosis, cell division, each cell has a full set of chromosomes. (whale.to)
Some drugs work only during a specific phase of the cell cycle, requiring prolonged administration to catch dividing cells during the phase of maximal sensitivity. (msdmanuals.com)

Sensitization of cancer cells to conventional drugs using multi-target agents that block survival and oncogenic pathways, alone or in combination, is an emerging strategy to overcome drug resistance. (researchsquare.com)
Senescence, a process by which cells enter an irreversible growth arrest state, is activated by many stimuli, including telomere attrition, aberrant oncogenic signaling, DNA damage or oxidative stress. (umassmed.edu)
For studies of the nature of target cell recognition we will use target cells infected by a variety of viruses and viral mutants, and target cells transformed with fragments of oncogenic viral DNA to establish the relationship between events in neoplastic transformation and recognition by NK cells. (grantome.com)

Since then, various additional studies investigating the mechanisms for mutagenicity induction following particulate exposures have demonstrated that reactive oxygen/nitrogen species generated during particle-induced pulmonary inflammation can oxidatively attack DNA resulting in structural alterations of the DNA and ultimately in fixed mutations (Weitzman and Gordon 1990, Risom et al, 2005, Singh et al, 2009). (ecetoc.org)

In other polyomaviruses, such as Merkel cell polyomavirus, which causes Merkel cell carcinoma in humans, STag appears to be important for replication and to be an oncoprotein in its own right. (wikipedia.org)
These mechanisms need to be evaluated and verified in animal models or humans in order to gain more understanding on the effect of tea consumption on human cancer. (indexindex.com)
The yeast model's translational value in research lies in the high conservation between yeast and humans in processes governing genome stability, cell proliferation, gene expression, and DNA damage responses. (onnlab.org)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

This lack of association implies the involvement of a secondary mechanism leading to the genetic changes necessary for neoplastic transformation of cells. (ecetoc.org)
When the genetic information containing the "blueprint" for these substances is disrupted, cell homeostasis is disrupted, resulting in a wide-range of immediate and/or delayed toxicological effects. (cdc.gov)
In assessing genotoxicity, any evidence of genetic damage, cell death or neoplastic transformation is evidence of genotoxicity. (whale.to)
In contrast, accumulation of genetic alterations can drive a normal cell into a pre-cancerous state. (onnlab.org)
Somatic cell genetic approaches in murine macrophage cell lines to mechanisms of growth inhibition, the oxidative burst, and expression of the chronic granulomatous disease gene. (grantome.com)

Each cell (except for red blood cells) contains a nucleus that houses these chromosomes. (cdc.gov)
Mitotic chromosomes from uninfected and HCV infected human liver cells. (onnlab.org)

Cell migration was evaluated by using the wound-healing assay and by measuring transendothelial migration of cancer cells. (scirp.org)
Moreover, the migration of MDA-MB231/S283E/Tm1 cells in a wound closure assay is reduced compared to parental cells or those expressing the non-phosphorylatable form of Tm1 (S283A). (scirp.org)
Transformation assay of established cell lines : mechanisms and application, proceedings of a workshop organized by IARC in collaboration with the US National Cancer Institute and the US Environmental Protection Agency, held in Lyon, 15-17 February 1984 / editors, T. Kakunaga, H. Yamasaki. (who.int)
The RTE cell focus inhibition assay has been shown to be sensitive to several classes of chemopreventive brokers. (e-core.org)
Open in a separate window Physique 1 Efficacy of thiourea class of iNOS inhibitors in the RTE transformation assay. (e-core.org)
Table 1 Efficacy Ranking of NOS Inhibitors in Primary (RTE) Cell Transformation Assay. (e-core.org)
Open in a separate window Physique 3 Unfavorable response of nonselective JTK12 NOS inhibitors in the RTE transformation assay. (e-core.org)

2019). In the last decades, it was widely demonstrated how these two pivotal determinants of human pathologies are strongly associated with each other in a dual relationship where aging induces a pro-inflammatory state in the organism and inflammation, in turn, leads to the activation of cellular and molecular pathways involved in cell senescence and aging (Chung et al. (researchgate.net)
These results indicate that TCE is capable of inducing cellular and molecular changes in BALB/c-3T3 cells and that these cells then possess neoplastic potential. (cdc.gov)

MTb could play an active role in cellular transformation and it is important to elucidate the mecha- nism involved. (bvsalud.org)

Senescence limits proliferative capacity of cells and thus impedes the accumulation of multiple mutations necessary for tumorigenesis. (umassmed.edu)
By limiting cell proliferation, senescence impedes the accumulation of multiple mutations that are necessary for tumorigenesis. (umassmed.edu)

We are interested in whether age-dependent accumulation of senescent cells leads to alterations in tissue microenvironment that is favorable for oncogenesis. (umassmed.edu)
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill. (bvsalud.org)

The mouse models we have generated to modulate senescence response in vivo are also used in our studies of senescence regulation in aging, with an emphasis on adult stem cells. (umassmed.edu)
In vivo experiments were conducted using a co-implantation xenograft mouse model with live cell imaging and immunohistochemistry. (cdc.gov)
The discovery of this new class of SSCs is based on the conjunction of evidence from unbiased single-cell molecular profiling and functional dissection of the BMSC lineage hierarchy using in vivo cell lineage analysis. (nature.com)
and ultimately their functional role of resistance to virus infection and tumor cells in vivo. (grantome.com)
Despite its important role for the maintenance of genome integrity in cultured cells, the biological function of TSG101 in vivo is largely unknown. (grantome.com)

Many factors are involved in causing and permitting the unregulated proliferation of cells that occurs in cancer. (msdmanuals.com)
Overview of Cancer Cancer is an unregulated proliferation of cells. (msdmanuals.com)

Dose response relationships for epidemiological studies of cancer are likely to be linear because of the cumulative cell damage/repair/mistake mechanism. (whale.to)
Some epidemiological and experimental studies indicate that different agents may act at different stages in the carcinogenic process, and several different mechanisms may be involved. (who.int)

Normal and neoplastic hematopoiesis : proceedings of the UCLA Symposium held at Steamboat Springs, Colorado, March 27-April 1, 1983 / editors, David W. Golde, Paul A. Marks. (who.int)

RTE cells provide a relevant model for studying the effectiveness Ombrabulin hydrochloride of chemopreventive brokers that inhibit the neoplastic process by different mechanisms. (e-core.org)

Increasing evidence suggests that senescence acts as a tumor suppression mechanism. (umassmed.edu)
The best available evidence suggests that glioblastomas originate from cells that give rise to glial cells. (bmj.com)
Strength of evidence for public health has a classical hierarchy that has dose-response relationship at the top and biological mechanism at the bottom, Hill (1965). (whale.to)

Misregulation of oncogenes, leading to altered cell proliferation and development, is another key factor in the progression of tumorigenesis. (onnlab.org)

2021). Besides these well-known pathogenetic mechanisms related to inflammaging, other processes are involved in age-related and inflammatory-related diseases including enzyme dysfunctions, cell death, impaired tissue renewal and tissue degeneration (Li, 2013). (researchgate.net)
However, cell proliferation is critical for renewal, repair and regeneration to maintain normal tissue homeostasis and functions. (umassmed.edu)
An increase in the number of cells in a tissue or organ without tumor formation. (lookformedical.com)
Our long-term objective is to determine the mechanisms that regulate cellular growth and neoplastic transformation in breast tissue. (grantome.com)

Clinically, grade 3B follicular lymphoma is treated like diffuse large B-cell lymphoma . (medscape.com)

Cancerous growth is characterized as the uncontrolled multiplication and spread of the body's particular cells causing infection and addresses one of the greatest medical care issues for humanity and requests a proactive procedure for fix. (researchsquare.com)
Demonstration of Epstein-Barr virus infection by in situ hybridization within tumor cell remains critical for the diagnosis. (allenpress.com)
This change in the cells of the cervix often occurs from cervical cap or diaphragm use or from infection. (com.ng)

Reverse transcription quantitative polymerase chain reaction and immunohistochemistry were used to determine ANLN mRNA and protein expression in colorectal cancer (CRC), gastric cancer (GC), and hepatocellular carcinoma (HCC) cell lines. (biomedcentral.com)

Our recent studies as well as others indicate that senescent cells change their secretory patterns of cytokines, chemokines, growth factors, extracellular matrix proteins and proteases. (umassmed.edu)
Current Research and Scholarly Interests We employ an interdisciplinary approach to studies of biological systems, combining synthetic chemistry with biochemistry, cell biology, and structural biology. (stanford.edu)
Recent advances have been made by an accumulation of studies on Merkel cell polyomavirus (MCPyV), which is highly associated and integrated in most Merkel cell carcinomas ( 5 ). (cdc.gov)
Recent studies have suggested that SP cells in human pancreatic cancer are characteristically chemoresistant [ 5 ]. (oncotarget.com)
and studies with a pulmonary metastasis model have indicated that l-NAME, a methyl ester of NNLA, increased the number of metastases induced by Lewis lung carcinoma and B16 melanoma cells [29]. (e-core.org)
cell for the virus is placed in a mu- studies costly and difficult. (who.int)

Taken together, these data indicate that Plk1 is involved in the override of Cr(VI)-induced G2/M arrest, increased survival and mutagenesis at the expense of proper DNA repair which may promote neoplastic transformation. (gwu.edu)

Nonetheless, this data remains controversial, and the mechanism which could underlie the association remains largely unexplored. (bvsalud.org)
This reversed proton gradient is driven by a series of proton export mechanisms that underlie the initiation and progression of the neoplastic process. (benthamscience.com)

This goal, however, cannot be accomplished until the specific agent(s) or mechanisms that initiate the neoplastic process are identified. (eurekamag.com)
The process involves numerous molecular and cellular changes that turn normal cells into plastic cells. (matjournals.co.in)
Numerous molecular and cellular events causing the transformation of normal cells into neoplastic cells occur in the process. (matjournals.co.in)
developed to analyze and quantitate the process of transformation in the respiratory system [1C5]. (e-core.org)

These are believed to bind zinc in the SV40 STag and confer improved protein stability, but in Merkel cell polyomavirus STag, they have been reported to bind iron-sulfur clusters. (wikipedia.org)
Anillin (ANLN) is an actin-binding protein that is essential for cell division and contributes to cell growth and migration. (biomedcentral.com)
Background: Tropomyosin 1 alpha chain (Tm1) is an actin-binding protein that regulates the endothelial cell response to oxidative stress following its phosphorylation at Serine 283 (S283). (scirp.org)
The multifunctional nuclear protein large T-antigen was detectable by immunohistochemical analyses in a subset of neoplastic cells. (cdc.gov)
The NHE1 is an integral membrane transport protein involved in regulating pH and in tumor cells is a major contributor to the production and maintenance of their reversed proton gradient. (benthamscience.com)
To achieve their goal, the researchers focused on the protein TNF-α, a known cytokine secreted by inflammatory cells. (qsstudy.com)
Overexpression of the single C-terminal kinase domain in JB6 cells resulted in tumor-promoter-induced neoplastic transformation in a manner similar to that induced by the full-length MSK1 protein. (cornell.edu)
The overall results suggest that the C-terminal kinase domain of MSK1 is regulated by a novel alphaL-helix-independent mechanism, suggesting that a diverse mechanism of autoinhibition and activation might be adopted by members of a closely related protein kinase family. (cornell.edu)
Methodology Using the human cholangiocyte line H69, we investigated cell proliferation and gap junction protein expression after stimulation with the hepatotoxin N-nitrosodimethylamine (NDMA) and/or excretory-secretory products (ESP) of C. sinensis, which induce inflammation. (yonsei.ac.kr)
Moreover, the expression of the cell proliferation-related proteins E2F1, Ki-67, and cancer related protein cytokeratin 19 and Cox-2 increased in response to combined treatment with NDMA and ESP. (yonsei.ac.kr)

Current Research and Scholarly Interests The main focus of our research is to understand how cells maintain genome integrity by checkpoint mechanisms during chromosome replication. (stanford.edu)
TSG101 has been recently identified as an important factor for growth restriction and maintenance of genome stability in murine cell lines. (grantome.com)

In the present study the mechanism of action of M2-type pyruvate kinase from human meningioma in the simultaneous presence of fructose 1,6 diphosphate and L-alanine was investigated. (metu.edu.tr)

Radiation can disrupt the structure of the DNA (and other macromolecules), thereby disrupting normal cell and organ functions. (cdc.gov)
The nodule, poorly encapsulated, consists of a central stellate fibrous scar and normal liver elements such as HEPATOCYTES, small BILE DUCTS, and KUPFFER CELLS among the intervening fibrous septa. (lookformedical.com)
A 50 Hz magnetic field blocks melatonin-induced enhancement of junctional transfer in normal C3H/10T1/2 cells [med. (emf-portal.org)

RESULTS: We demonstrated that chemotherapy-stimulated CAFs promoted tumorigenic and stem cell-like properties of NSCLC cells, which contribute to their chemoresistance. (cdc.gov)
Silencing PDL-1 expression suppressed CAFs' ability to promote stem cell-like properties and invasiveness of lung cancer cells, favoring chemoresistance. (cdc.gov)
CONCLUSION: Our results show that PDL-1-positive CAFs modulate stem cell-like properties of NSCLC cells by secreting elevated HGF, thereby promoting chemoresistance. (cdc.gov)
Cancer stem cells (CSCs) are tumor cells with the key characteristics of self-renewal, clonal tumor initiation capability, and long-term clonal repopulation capacity. (qsstudy.com)
The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
Cancer stem cells (CSCs) are characterized by their capacity for indefinite self-renew and by their relative quiescence [ 2 , 3 ]. (oncotarget.com)
Other reports have indicated that SP cells may serve as an ideal model for stem cell for research [ 7 ]. (oncotarget.com)
It will quite effectively cater to the needs of molecular biologists, molecular geneticists, cell and molecular biologists, animal, plant, and crop geneticists, synthetic biologists, biotechnologists, and researchers involved with the fields of stem cell and molecular aspects of cancer research. (caister.com)
A subpopulation of cells within a cancer has the properties of stem cells. (msdmanuals.com)

ANLN is mainly localized in the nucleus during interphase and in the cell cortex during mitosis [ 8 ]. (biomedcentral.com)

BACKGROUND: Few trials have evaluated the utility of liquid biopsies to detect epidermal growth factor receptor mutations (EGFRm) at the time of response evaluation and its association with the clinical characteristics and outcomes of non-small-cell lung cancer (NSCLC) patients. (bvsalud.org)

Since one of the key biological roles of CAFs is to secrete proteins into the tumor microenvironment and to promote tumor progression, the researchers next cultured human oral cancer cells in the presence of proteins from EndMT-derived CAFs. (qsstudy.com)

However, the role and mechanisms of cohesin in cancer etiology and its impact on treatment are poorly understood. (onnlab.org)

A number of direct and indirect radiation interaction pathways can produce damage to the DNA of irradiated cells. (cdc.gov)

2021). Similarly, cell senescence due to aging has been widely associated with the impairment of mitochondrial as well as proteosome and lysosome functions responsible for the accumulation of aberrant or misfolded proteins often observed in different neurodegenerative disorders (Sikora et al. (researchgate.net)

We are generating conditional Smurf2 knockout and transgenic mouse models to dissect the precise mechanism of Smurf2-mediated tumor suppression. (umassmed.edu)

2017. Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism. . (oregonstate.edu)

These findings support the discussed mechanism that inflammatory cell-derived reactive oxidants and increased cell proliferation play a key role in the pathogenesis of rat lung tumours in response to PSP and are consistent with the existence of a threshold (Oberdörster 1996, Greim et al, 2001). (ecetoc.org)
Oxidative damage has been suggested to play a role in the pathogenesis of basal cell carcinoma (BCC). (hindawi.com)

While none of the transformed cells showed changes in gene amplification, altered gene expression was observed in c-jun, c-sis and p16. (cdc.gov)

These new techniques may also provide a window into mechanisms involved in maintaining cellular homeostasis. (stanford.edu)

Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion. (mayo.edu)

During particle exposure, ROS and RNS are mainly generated from the oxidative burst of pulmonary inflammatory cells, i.e. neutrophils and AMs. (ecetoc.org)
The influx and subsequent activation of such inflammatory cells into the lung therefore may lead to an oxidative burst which overwhelms the pulmonary antioxidative defences, resulting in oxidative DNA damage. (ecetoc.org)

MCTs with a high malignancy grade are transformations involving at least 7 mitotic division figures, three multinucleated cells, three cells with bizarre nuclei per 10 high-power fields, and 10% of cells with karyomegaly. (biomedcentral.com)

Inflammatory cells, like neutrophils, eosinophils and macrophages, possess a NADPH oxidase, which is induced during cell activation to produce superoxide anions. (ecetoc.org)
Furthermore, a recent study reported that SP cells possess the ability to self-renew, and to divide asymmetrically into SP and non-SP cells [ 6 ]. (oncotarget.com)

Simoneau, B., Houle, F. and Huot, J. (2012) Regulation of Endothelial Permeability and Transendothelial Migration of Cancer Cells by Tropomyosin-1 Phosphorylation. (scirp.org)
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina. (lookformedical.com)
Solitary or multiple benign cutaneous nodules comprised of immature and mature vascular structures intermingled with endothelial cells and a varied infiltrate of eosinophils, histiocytes, lymphocytes, and mast cells. (lookformedical.com)
One such molecule is TGF-β, which is known to cause endothelial-mesenchymal transformation (EndMT), a mechanism that includes transforming endothelial cells that form the inner lining of blood vessels to CAFs that modulate tumor progression. (qsstudy.com)
To understand the roles of TNF-α in TGF-β-induced EndMT, the researchers treated human endothelial cells with TGF-β, TNF-α, or both. (qsstudy.com)
TGF-β robustly induced EndMT as shown through increased expression of various markers of CAFs as well as a transition towards a CAF morphology of the human endothelial cells. (qsstudy.com)

Anatomy26

Organisms28

Diseases8

Chemicals and Drugs110

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes62

Disciplines and Occupations1

Information Science3

Health Care1

Epithelial15

Tumors14

Molecular mechanisms7

Carcinogenesis11

Differentiation7

Apoptosis5

Malignant3

Mammary5

Enhanced cell proliferation1

Tissues5

Failsafe mechanism that prevents1

Progenitor cells2

Mice9

Genetics4

Stromal cells6

Chemically induced1

Genes6

Epigenetic3

Cycle9

Oncogenic3

Induction1

Humans4

Genetic5

Chromosomes2

Assay7

Cellular and molecular2

Elucidate1

Impedes the accumulation of multiple mutations2

Alterations2

Vivo5

Proliferation of cells2

Epidemiological2

Hematopoiesis1

Chemopreventive1

Evidence3

Oncogenes1

Tissue4

Diffuse large B-1

Infection3

Hepatocellular carcinoma1

Studies6

Survival1

Underlie2

Process4

Protein10

Genome2

Study the mechanism1

Normal3

Stem9

Mitosis1

Mutations1

Biological1

Cancer etiology1

Pathways1

Accumulation1

Tumor suppression1

Senescent cells1

Role in the pathogenesis2

Gene1

Homeostasis1

Invasion1

Oxidative burst2

Mitotic1

Possess2

Endothelial6