• Studies focus on understanding mechanism and regulation in the pathway toward the development of selective inhibitors of isoprenoid biosynthesis. (hopkinsmedicine.org)
  • This research sheds light into the mechanistics of glioma adaptation in the hypoxic tumor microenvironment and motivates further studies aimed at establishing therapeutic strategies targeted at the endocytic machinery that should be combined with available inhibitors of lipid biosynthesis. (lu.se)
  • Our lab studies the roles of lipid biosynthesis in this process, using pharmacological, genetic, and molecular approaches. (csun.edu)
  • Lipid biosynthesis is essential for cell viability and bacterial fatty acid synthetic enzymes have been suggested as antibiotic targets. (csun.edu)
  • p)ppGpp modulates cell size and the initiation of DNA replication in Caulobacter crescentus in response to a block in lipid biosynthesis. (csun.edu)
  • We also investigated four oxidoreductase (OX1-4) genes in the HSAF biosynthetic gene cluster, to define the minimal gene cluster required for HSAF biosynthesis. (unl.edu)
  • The researchers wanted to identify the enzymes and corresponding genes underlying this detoxification mechanism. (mpg.de)
  • Many bioY genes are located at loci encoding biotin biosynthesis or are unlinked to either biotin synthesis or other biotin transport genes. (tcdb.org)
  • The data provided herein suggest that B. fragilis uses N-succinyl-L-ornithine rather than N-acetyl-L-ornithine for de novo arginine biosynthesis and therefore that this pathway in Bacteroides is different from the canonical arginine biosynthetic pathway of most organisms. (nih.gov)
  • The molecular mechanism of this pathway remains unclear. (nih.gov)
  • This review examines pantothenate and the CoA biosynthesis pathway in the human-mosquito-malaria parasite triad and explores possible approaches to leverage the CoA biosynthesis pathway to limit malaria parasite development in both human and mosquito hosts. (mdpi.com)
  • Transcription regulation of taxol biosynthesis. (frontiersin.org)
  • The biosynthesis and regulation of the production of antibiotics in microorganisms. (lu.se)
  • The biosynthesis of gliotoxin, a virulence factor of the human pathogenic fungus Aspergillus fumigatus , involves attachment of two GSH molecules and their sequential decomposition to yield two reactive thiol groups. (cipsm.de)
  • Cytochrome P450c17 is the single enzyme that mediates the 17α-hydroxylase and 17, 20 lyase activities during the biosynthesis of steroid hormones in the gonads and adrenal gland. (amrita.edu)
  • The biosynthesis of steroid hormones. (muni.cz)
  • However, the last decade has witnessed remarkable progress in understanding the molecular mechanisms of cellulose biosynthesis using Arabidopsis, a small herb that has been a sweetheart to many plant scientists. (mtu.edu)
  • Carrier, M.-C., Lalaouna, D. & Massé, E. Broadening the definition of bacterial small RNAs: characteristics and mechanisms of action. (nature.com)
  • Only by further elucidating the control mechanisms of bacterial cell division can we advance the development of new antimicrobial compounds. (csun.edu)
  • We are presently mainly working on the biosynthesis of glycosaminoglycans and bacterial sialic acid uptake mechanisms. (lu.se)
  • Flavonoids: a review on biosynthesis and transportation mechanism in plants. (bvsalud.org)
  • Biosynthesis and antifungal activity of fungus-induced O-methylated flavonoids in maize. (mpg.de)
  • The protection provided by FRF probably involved an antisecretory mechanism mediated by flavonoids which were absent in FDF. (who.int)
  • Other research in the lab examines the molecular mechanism of how skin mast cells sensitize sensory nerves under inflammatory states. (hopkinsmedicine.org)
  • The biosynthesis of lignin involves the polymerization of monolignol building blocks through oxidative radical coupling reactions. (nyu.edu)
  • A strategy for lignin degradation leverages photoredox deoxygenative radical formation to trigger reverse biosynthesis, which cleaves model compounds of the β-O-4 and β-5-β-O-4 linkages to produce monolignols, precursors to flavoring compounds. (nyu.edu)
  • Scientists at the Max Planck Institute for Chemical Ecology in Jena have long been studying the glucosinolates and isothiocyanates that constitute the special defense mechanism of cabbage family plants, which include rapeseed, radishes and mustard. (mpg.de)
  • These findings provide new information on the putative role of succinylated intermediates in arginine biosynthesis and on the evolution of transcarbamylases. (nih.gov)
  • Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
  • In subsequent chapters, we present original research on the biosynthetic mechanisms of dihydromaltophilin, a heat stable antifungal factor (HSAF). (unl.edu)
  • i.e. mechanisms at the molecular level and origin, dispersal and limitation of resistance to antibiotics · understand how antibiotics are developed and produced industrially · recognise applications for antibiotics · understand clinical problems concerning antibiotics · understand how resistance to antibiotics can be tested in bacteria. (lu.se)
  • Understanding the Modus Operandi of Class II KNOX Transcription Factors in Secondary Cell Wall Biosynthesis. (mtu.edu)
  • MYC2 is one of the key regulators of JA signal transfer and the biosynthesis of various secondary metabolites. (frontiersin.org)
  • Traditionally, natural products, a key resource from secondary metabolism, have been studied at a chemical level before the gene clusters or enzymes responsible for their biosynthesis were known. (drexel.edu)
  • However, resistance mechanisms related to the biosynthesis of secondary metabolites remain unknown. (unboundmedicine.com)
  • Jasmonate acid (JA) is a vital endogenous hormone that regulates taxol biosynthesis and other biological processes, especially (a)biotic stress tolerance in various plants ( Roberts, 2001 ). (frontiersin.org)
  • the pathophysiological mechanisms underlying the development of these complications are yet to be determined. (elsevierpure.com)
  • Most interestingly, the genetic feature of HSAF biosynthesis suggests that the same polyketide synthase (PKS) module acts not only iteratively, but also separately. (unl.edu)
  • In the thesis, we demonstrated the in vitro and in vivo production of the polyene tetramate, providing direct evidence for this highly unusual iterative polyketide biosynthetic mechanism that is likely general for this type of hybrid polyketide-peptides. (unl.edu)
  • The biosynthesis of nargenicin is believed to be closely related to fatty acid biosynthesis to produce a polyketide chain. (wikipedia.org)
  • Our approach is to intervene the biosynthesis and transportation of natural compounds with the long-term goal to design pharmaceuticals. (lu.se)
  • The cellular mechanisms that enable this remarkable process are just beginning to be elucidated. (lu.se)
  • Cabbage plants defend themselves against herbivores and pathogens by deploying a defensive mechanism called the mustard oil bomb: when the plant tissue is damaged, toxic isothiocyanates are formed and can effectively fend off attackers. (mpg.de)
  • In this study, evidence shows that EVs can fuel hypoxic glioma cells to acquire a lipid droplet (LD+) phenotype and such effect is associated with increased EV internalization through a hypoxia-sensitive mechanism dependent on heparan sulfate proteoglycan (HSPG) receptor and lipid raft-mediated endocytosis. (lu.se)
  • They may play a role in plant defense mechanisms. (bvsalud.org)
  • The eicosanoid family encompasses thromboxanes, prostacyclins, leukotrienes, hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienic acids (EETs), lipoxins, and isoprostanes, the last of which can be generated by nonenzymatic oxidative mechanisms and may serve as markers of oxidative stress in humans. (jci.org)
  • However, the pathogen uses at least two different detoxification mechanisms that enable the fungus to successfully spread on plants defended in this way. (mpg.de)
  • Cellulose biosynthesis is also one of the most ancient and essential life processes of plants. (mtu.edu)
  • Taxol biosynthesis is significantly regulated by jasmonate acid (JA), one of the most important endogenous hormones in land plants. (frontiersin.org)
  • The molecular mechanisms of resistance to antibiotics, and the origin, occurrence, and spread of resistance. (lu.se)
  • Two tightly regulated biochemical processes, metallation of porphyrin at the last stage of heme biosynthesis and the generation of iron-sulphur clusters (ISC), take place inside the mitochondrial matrix and utilise around 80% of the iron acquired by organisms. (lu.se)
  • The mechanism for activating and introducing the 3-hydroxy fatty acid chain into the peptide is unclear. (unl.edu)
  • He is currently investigating the biological roles, mechanism and biotechnological applications of the fatty acid photodecarboxylase he has discovered a few years ago in microalgae. (rsc.org)
  • In fact, our study offers the first evidence that stem cells employ multiple mechanisms -- not just cell replacement - which collaborate to benefit disease. (sciencedaily.com)
  • Rational strategies can then be devised to correct dysfunction during the progression of disease through a comprehensive understanding of basic mechanisms. (hopkinsmedicine.org)
  • In addition, we evaluated whether the effects of HPTE on rat ovarian cell progesterone biosynthesis were mediated through the estrogen or androgen receptors. (cdc.gov)
  • Although highly preliminary, the findings suggest that different tumor biological factors may predict response to different chemotherapy regimens with distinct mechanisms of action. (lu.se)
  • It is thought that by better understanding the mechanisms involved in Nitric Oxide signaling that we can design appropriate pharmacological interventions for human diseases in which Nitric Oxide metabolism is disrupted. (rutgers.edu)
  • Gaining a deeper understanding of the mechanisms underlying these transport models holds immense potential for various fields such as metabolic engineering , biotechnological approaches, plant protection , and human health . (bvsalud.org)
  • Aggressive tumors typically demonstrate a high glycolytic rate, which results in resistance to radiation therapy and cancer progression via several molecular and physiologic mechanisms. (springer.com)
  • Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)
  • This imbalance in the biosynthesis of vasoactive eicosanoids may account for the rapid progression of PVOD in DS infants with a left-to-right shunt. (elsevierpure.com)
  • Together, the results support a new biosynthetic mechanism: a single set of domains of an iterative PKS-NRPS, in cooperating with a cascade of redox enzymes, to synthesize a complex and highly modified polycyclic tetramate macrolactam. (unl.edu)
  • An experience of TiO 2 NPs (20%, 40%, 80% and 100%), as well as mechanisms that instigated momentous alterations in seed germinations, roots interval, shoot lengths, and antioxidant enzymes, were investigated. (nature.com)
  • Recycling upstream redox enzymes expands the regioselectivity of cycloaddition in Pseudo-Aspidosperma alkaloid biosynthesis. (mpg.de)
  • Two bi-functional cytochrome P450 CYP72 enzymes from olive (Olea europaea) catalyze the oxidative C-C bond cleavage in the biosynthesis of secoxy-iridoids - flavor and quality determinants in olive oil. (mpg.de)
  • To demonstrate that a better understanding of the fundamental mechanisms of stem cell action may permit the development of rational combined synergistic therapies, the investigators then gave the mice a simple oral drug that permitted the amount of enzyme provided by the engrafted stem cells to work even more efficiently by presenting them with a smaller burden of material to metabolize. (sciencedaily.com)
  • We seek to understand the molecular mechanisms involved in controlling Nitric Oxide signaling and answer the question as to how nature uses such a simple molecule to control a multitude of biological processes and in almost every organism. (rutgers.edu)
  • Collaborations are in place with the School of Public Health to explore mechanisms of anti-viral immunity in influenza and COVID-19. (hopkinsmedicine.org)
  • Ferrochelatase catalyses iron insertion into protoporphyrin IX at the terminal step of heme biosynthesis, while IscU assists in the formation of iron-sulphur clusters. (lu.se)
  • In this research project we aimed to investigate the final steps of the biosynthesis of teicoplanin by a. (europa.eu)
  • Other workshop critical review papers are addressing aspects related to homology (the nature of the rat lung tumors and their potential counter- part in humans) as well as the types of nonneoplastic responses seen in laboratory animals and the potential mechanisms responsible for these effects. (cdc.gov)
  • Frataxin may either make iron available to ferrochelatase and IscU, thereby acting as an iron chaperone, or convert surplus iron in the mitochondrion to a mineral, providing a mechanism for iron storage and detoxification, similar to the mechanism of ferritin. (lu.se)
  • In the first chapter, we give a short review of the biosynthesis of polyketides, focusing on those which exhibit new biosynthetic features. (unl.edu)
  • Therefore, this review aims to provide a comprehensive overview of recent advancements in the understanding of flavonoid transport mechanisms. (bvsalud.org)
  • In this review, we summarized the most relevant evidence related to FLAs and the possible mechanism, which could explain their adaptative capacity to several extreme environments. (hindawi.com)
  • The current studies examined the mechanism of action of HPTE on progesterone production by cultured ovarian cells (granulosa and theca-interstitial) from pregnant mare serum gonadotropin-primed immature rats. (cdc.gov)
  • The latter results suggest a reaction mechanism in which the two scissile peptide bonds of one gliotoxin precursor molecule are hydrolyzed sequentially and in a given order. (cipsm.de)
  • All these results revealed that TcMYC2a can regulate taxol biosynthesis either directly or via ERF regulators depending on JA signaling transduction. (frontiersin.org)
  • John Ohlrogge at the Plant Biology Department of Michigan State University as a postdoctoral fellow to work on the biosynthesis of the plant lipid polyesters cutin and suberin. (rsc.org)
  • These mechanisms are discussed in the framework of animal and human studies, taking into account the commonalities and differences between CR and KDs. (springer.com)
  • Human embryonic stem cells (hESCs) can treat degenerative diseases safely and effectively, and do so by invoking multiple mechanisms. (sciencedaily.com)
  • Human embryonic stem cells (hESCs) hold great promise for benefiting degenerative diseases, and do so by invoking multiple mechanisms. (sciencedaily.com)
  • Mechanism of hormone and neurotransmitter action. (muni.cz)
  • My lab is interested in all aspects of these metabolites, ranging from their biosynthesis and their microbiological role in nature to applications in the clinic. (drexel.edu)
  • Here, we summarize current progress on understanding the mechanisms and bioactive components of Pu-erh's weight-cutting effects as well as highlighting current weaknesses in the field in order to suggest possible solutions for future research on Pu-erh tea. (researchgate.net)