Mechanism and regulation. Medical search. Frequent questions

We are interested in the study of the underlying molecular mechanisms of higher organisms that ensure the proper segregation of the genetic material upon cell division. (brookes.ac.uk)
It has been recognized for some time that the stability of neuronal activity in the nervous system hinges on a coordinated action of different molecular mechanisms that respond to changes in synaptic activity. (neurodegenerationresearch.eu)
We propose to use the powerful genetic tools available in Drosophila to unravel the molecular mechanisms that participate in the regulation of this process. (neurodegenerationresearch.eu)
Although the molecular mechanisms that regulate autophagy are not fully understood, recent work indicates that dysfunctional/impaired autophagic functions are associated with the development and progression of nonalcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease (AFLD), and hepatocellular carcinoma (HCC). (hindawi.com)
However, the molecular mechanisms underlying the integration of sugar signaling, nutrient metabolism and stress response in plants remain unclear. (chinbullbotany.com)
In this Review, we discuss the multiple molecular mechanisms of p53 regulation and how they modulate the induction of apoptosis or cell cycle arrest following DNA damage. (nih.gov)
Molecular mechanisms employed by individual multipotent cells at the point of lineage commitment remain largely uncharacterized. (lu.se)

Section 5 provides an example based on the models introduced in Section 4, and compares the effectiveness of various regulatory mechanisms by analyzing each player's behaviors. (scirp.org)
Although much has been known about the TGF-β signaling pathway since the discovery of Smads 15 years ago, remarkable progress has been made in revealing details of different regulatory mechanisms that afford a full range of control of the biological functions of these factors in the TGF-β family. (biomedcentral.com)
Transcriptional regulatory mechanisms drive the maturation of B cells to plasma cells, with a dramatic transcriptional rewiring taking place during the transition. (rais.is)

This rewiring is dependent on a number of factors, including the transcription factor B lymphocyte induced maturation protein 1 (BLIMP1), and epigenetic mechanisms, amongst others. (rais.is)

We then examine how these mechanisms could modulate synaptic function by focusing on three key features of synaptic information transmission: synaptic strength, synaptic variability, and short-term plasticity. (frontiersin.org)
Finally, we describe how the Hfq CTD and its acidic tip residues provide a mechanism to modulate annealing activity and substrate specificity in various bacteria. (johnshopkins.edu)

More recently we have probed the allosteric regulation of class II and class III RNRs by solving the structures of complexes with several combinations of allosteric effector and substrate [2,5]. (lu.se)
We are also determining the structure of other class III RNRs which have overall activity regulation (the T4 enzyme does not), as well as of mutants of the T4 RNR which affect the catalytic mechanism and the allosteric regulation. (lu.se)

This transcriptional control, described for the first time in Plasmodium, provides a mechanism by which single-copy genes can be differently modulated during parasite development. (gla.ac.uk)
These complexes have important biological roles in replication of RNA viruses, cellular transcription and translation, post-transcriptional and post- translational modification and also regulation of these processes. (mdpi.com)
In this thesis, I present two projects investigating mechanisms of transcriptional regulation in antibody-secreting cell malignancies. (rais.is)
Despite this, BLIMP1 and EZH2 bind to the genome at mostly distinct sites, although often on the same genes, indicating that the functional overlap of the two factors is mostly due to parallel transcriptional regulation and through maintenance of EZH2 by BLIMP1, rather than through co-binding to chromatin. (rais.is)

The first study to show, in C. elegans , that sensory neurons have a role in lifespan regulation. (nature.com)

The article presents analysis of the function of supranational mechanism to regulate economic and political relations between states. (hse.ru)
The anticipated outcome is a deeper understanding of mechanisms that regulate telomere DNA synthesis, which should inform the development of telomere-based clinical applications. (grantome.com)

On 19 December 2022 the European Union (EU) Member States agreed their position on a Proposal for a Council Regulation establishing a market correction mechanism . (regulationtomorrow.com)

The Council Regulation is due to enter into force on 1 February 2023 and the correction mechanism in respect of TTF derivatives can apply as of 15 February 2023. (regulationtomorrow.com)
By 23 January 2023, ESMA and ACER are required to publish a preliminary data report concerning the introduction of the market correction mechanism. (regulationtomorrow.com)
By 1 March 2023 both authorities are required to submit a report to the Commission assessing the effects of the market correction mechanism on financial and energy markets and on security of supply and verifying whether the key elements and the scope of the market correction mechanism are still appropriate in the light of financial and energy market and security of supply developments. (regulationtomorrow.com)
Taking into account the said reports, by 31 March 2023 the Commission will propose amendments to exclude hubs other than the TTF from the regulation in case their inclusion has negative effects on the functioning of the mechanism. (regulationtomorrow.com)
By 1 November 2023, the Commission will carry out a review of the regulation in view of the general situation of the gas supply and based on that report, it may propose to extend its validity. (regulationtomorrow.com)

In this review, we summarize our current understanding of the mechanisms of NLRP3 inflammasome activation by multiple signaling events, and its regulation by post-translational modifications and interacting partners of NLRP3. (nih.gov)
This thesis aimed to further our understanding on the mode and regulation of NLRP3 inflammasome activation. (manchester.ac.uk)

Taken together, these results identify a novel TLR-TRIF-IRF3 pathway that regulates the expression of GLI3 that regulates inflammatory cytokines and expands our understanding of the non-canonical signaling pathways involved in the regulation of GLI transcription factors. (oncotarget.com)
Here, we review cellular mechanisms and signaling pathways involved in axonal ion channel modulation and examine how changes to ion channel function affect AP initiation, AP propagation, and the release of neurotransmitter. (frontiersin.org)

The complex pathogenesis of SIC involves a combination of dysregulation of inflammatory mediators, mitochondrial dysfunction, oxidative stress, disorder of calcium regulation, autonomic nervous system dysregulation, and endothelial dysfunction. (frontiersin.org)
The mechanism of oxidative phosphorylation is based on chemiosmotic theory , which states that the difference in proton concentration between the membranes of mitochondria acts as the reservoir for the energy generated from biological oxidation reactions. (microbeonline.com)

A Novel Mechanism of Regulation of the Oncogenic Transcription Factor. (oncotarget.com)

Characterising these mechanisms will provide new insight into reducing or halting cellular migration and invasion of Fn14-positive cancers. (otago.ac.nz)
This global mechanism to cope with overlapping transcription could be co-opted for specific epigenetic processes, such as cellular memory of responses to the environment 10 . (nature.com)
Viewing these cellular mechanisms of neuromodulation from a functional perspective may assist in extending these findings to theories of neural circuit function and its neuromodulation. (frontiersin.org)
Cellular mechanisms of neuromodulation of axonal ion channels. (frontiersin.org)
Mechanisms of toxicity are discussed, focusing on the effect of amyloid interactions with cellular components, and the association of aggregation with healthy ageing and pathology. (nature.com)
These multiple layers of regulation enable p53 to execute cellular responses that are appropriate for specific cellular states and environmental conditions. (nih.gov)

In this study, we performed a literature review in order to investigate the relationship between auditory mechanisms and cardiac autonomic regulation. (bvsalud.org)
It was hypothesized that dopamine release in the striatal system induced by pleasure songs are involved in the cardiac autonomic regulation. (bvsalud.org)

The dynamic stability of homeostasis is mostly maintained by physiologic processes called negative feedback mechanisms Body fluid structure and other physiological variables vary near a regular worth, called a set point, and negative-feedback mechanisms are utilized to keep these variables within their regular range For a negative-feedback mechanism to work, it has to have the ability to keep track of and react to any modifications in homeostasis. (earthslab.com)
For example, excessive inhibition by which tissue remodeling takes place during normal of apoptosis is an underlying mechanism of cancer, while growth and development and the physiologic mechanism an inappropriate increase is seen in some neurodegenera- by which labile cell populations such as gastrointestinal tive diseases and other conditions. (cdc.gov)

Inflammatory mechanisms in the regulation of insulin resistance. (qxmd.com)

Gametocyte/gamete differentiation requires controlled patterns of gene expression and regulation not only of stage and gender-specific genes but also of genes associated with DNA replication and mitosis. (gla.ac.uk)
Moreover, this regulation relies on insulin gene expression through the activation of CaMKII and MafA. (lu.se)
The epigenetic code is determined by several mechanisms that affect gene expression, the most well-known of which is DNA methylation (See Figure 1). (cdc.gov)

Identification and regulation of the rate-limiting step in the overall system for cisplatin detoxification is of crucial importance for sensitization of human tumor cells to cisplatin. (aspetjournals.org)
In this study, the GSH content, GST activity, and GS-X pump activity were regulated separately to examine effects of the regulation on cisplatin cytotoxicity and cisplatin-induced DNA interstrand cross-links (ICL) in HepG2 cells. (aspetjournals.org)
The results showed that of the parameters measured, intracellular GSH seems to be the rate-limiting factor, and its regulation would provide a more promising strategy for sensitization of human liver tumor cells to cisplatin. (aspetjournals.org)
Cells constitutively utilize several distinct mechanisms of endocytosis, including clathrin-mediated endocytosis (CME) for the internalization of receptor-bound macromolecules such as Transferrin Receptor (TfR), and distinct mechanism(s) that mediate the majority of fluid-phase endocytosis. (plos.org)
An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells. (ox.ac.uk)
However, FOXO-mediated mechanisms can also support the survival of cancer and other dysfunctional cells, thereby complicating the link between FOXOs and lifespan extension. (nature.com)

Karoly, P 1993, ' mechanisms of self-regulation: A systems view ', Annual Review of Psychology , vol. 44, no. 1, pp. 23-52. (elsevierpure.com)

In summary, we investigate the mechanisms regulating insulin production and secretion through Cav channels and DEGs. (lu.se)

Finally, I uncover novel roles for BLIMP1 and EZH2 in evasion from natural killer (NK) cell mediated cytotoxicity and regulation of the cell cycle. (rais.is)

Neuromodulatory regulation of ion channels affects how ion channels respond to voltage deflections on short and long time scales, thus affecting how certain features of synaptic input are transformed into neuronal output. (frontiersin.org)
Mechanism of SNARE protein binding and regulation of Cav2 channels by phosphorylation of the synaptic protein interaction site. (bvsalud.org)

Furthermore, the effect of FLD on transcription dynamics is antagonized by DNA topoisomerase I. Our study reveals chromatin-based mechanisms to cope with overlapping transcription, which may occur by modulating DNA topology. (nature.com)
The structure reveals that the CTD of neighboring hexamers pack in crystal contacts, and that the acidic residues at the C-terminal tip of the protein interact with positive residues on the rim of Hfq, as has been recently proposed for a mechanism of modulating RNA binding. (johnshopkins.edu)

The mechanism of action is based on the binding of cholesterol at specific high-affinity sites located near the transmembrane helices 5-7 of the receptor. (helsinki.fi)
To keep track of a physiological variable, a negative-feedback mechanism makes use of a receptor to spot discrepancy from the set point and send out a signal alerting the integrating center about the discrepancy. (earthslab.com)

The purpose of this thesis is to investigate what effects a rule of law-based financial conditionality mechanism may have upon the EU legal framework for the protection of the rule of law. (lu.se)

The roles and mechanisms of antioxidants are complex and context-dependent, necessitating better understanding of their actions in vivo and warranting caution with their use as therapeutic agents. (nature.com)
This research will offer greater understanding of the mechanisms of telomere DNA synthesis, which will in turn catalyze the development of new diagnostics and therapies for telomere-related disorders. (grantome.com)

We are interested the recent advances in the area of structural organization, mechanisms of function, assembly and transport RNPs, and also regulation of processes involving ones. (mdpi.com)
A fusion mechanism is any mechanism by which cell fusion or virus-cell fusion takes place, as well as the machinery that facilitates these processes. (wikipedia.org)
An alternative infectious processes and may contribute to high case fatal- approach attempts to identify mechanisms shared by most ity rates by impairing adaptive immune function. (cdc.gov)

Our Centre for Digital Policy, alongside the DCU Anti-Bullying Centre (ABC) and the Irish Society for the Prevention of Cruelty to Children (ISPCC) submitted replies to an Oireachtas-appointed expert group's questions regarding the potential operation of an individual complaints mechanism as it pertains to the Online Safety and Media Regulation (OSMR) Bill 2022. (digitalpolicy.ie)

role of ubiquitin ligases in autophagy and of ubiquitin-modifying enzymes in the regulation of the immune response. (brookes.ac.uk)

This failure of calcium regulation within myocytes can trigger the abnormal heart rhythm characteristic of ARVC. (medlineplus.gov)

Note: for a further reading on the topic, based on the draft of the Regulation, Jan Kleinheisterkamp, 'Financial Responsibility in the European International Investment Policy', (2014) 63-2 International and Comparative Law Quarterly 449-476 (summary here ). (conflictoflaws.net)
The draft Council regulation introduces a market correction mechanism that will apply to "TTF derivatives" and "derivatives linked to other Virtual Trading Points", both being defined terms under the draft law. (regulationtomorrow.com)
The comments, their assessment and the ensuing amendments to the draft ECB Regulation are published on the ECB's banking supervision website. (europa.eu)

Mechanisms leading to aberrant activation of the Fn14/TWEAK signaling axis are poorly understood. (otago.ac.nz)

We integrate structural biology methods, including NMR (nuclear magnetic resonance) spectroscopy and protein X-ray crystallography, to study the protein-protein interactions underpinning cell division regulation. (brookes.ac.uk)
However, there are no data showing how exactly the regulation emerges from specific lipid-protein interactions. (helsinki.fi)
Þessar breytingar eru háðar fjölmörgum þáttum, en þar á meðal er umritunarþátturinn "B lymphocyte- induced maturation protein-1" (BLIMP1), auk ferla sem stjórna umframerfðamörkunum. (rais.is)
Figure 1 The mechanism of coordinated regulation of plant growth by nutrition and ethylene signaling Protein kinases CTR1 and TOR can interact and phosphorylate EIN2, respectively, in nutrition-rich medium or ethylene- free environment. (chinbullbotany.com)

The TGFβ and Ras-MAPK pathways play critical roles in cell development and cell cycle regulation, as well as in tumor formation and metastasis. (biomedcentral.com)

The Mechanisms of Regulation of Cell Division Group (MRCDG) undertakes both basic and applied research in the field of cell division control. (brookes.ac.uk)
For the Special Issue "Molecular Regulation and Mechanism of Ribonucleoprotein Complexes" of the International Journal of Molecular Sciences we accept original research manuscripts and reviews highlighting different structural and functional aspects of any ribonucleoprotein сomplex. (mdpi.com)
Research progress of neogenin regulation mechanism on osteogenesis[J]. , doi: 10.3969/j.issn.1674-8115.2014.05.034 . (shsmu.edu.cn)
We commented on the limited real world data and empirical research-based evidence available to guide how such a mechanism could operate in practice. (digitalpolicy.ie)
reviewed current mechanisms for health research governance and discussed effective means of knowledge translation, dissemination and utilization for health policy-making in the Region. (who.int)
Research demonstrates that either of these approaches improves glucose regulation via weight loss, with additional metabolic benefits depending on mechanism of action. (medscape.com)

This Policy Brief assesses the extent to which the experience gained from the implementation of the ITC mechanism in the electricity sector could be relevant for an ITC mechanism for renewable and low-carbon gases. (eui.eu)
We conclude that the complexities encountered in the implementation of the electricity ITC mechanism were mostly due to the characteristics of electricity and the way in which it flows over the network, and therefore could not be expected to reoccur in the implementation of an ITC mechanism for renewable and low-carbon gases. (eui.eu)

The aspects associated with the maintenance of internal environment can be summed up as: Transport of ECF, Maintenance of pH of ECF (acid- base balance), Regulation of temperature, Maintenance of water and electrolyte balance, Supply of nutrients, oxygen, enzymes and hormones, Elimination of metabolic and other waste products, and Reproduction. (earthslab.com)

The experimental results show that the mechanism can provide 0.67±0.04 N and 0.57±0.02 N during its compression and return process. (sdu.dk)
Here, we reviewed the latest literatures on the mechanisms and treatments of SIC and hope to provide further insights to researchers and create a new road for the therapy of sepsis. (frontiersin.org)
however, here, we focus on the mechanisms of cardiomyocyte dysfunction and treatments of SIC and hope to provide further insights for the management of SIC . (frontiersin.org)

One cannot distinct the contingent capital mechanism in the framework of common regulatory capital rules by stating that it applies only if a bank's operation is going concern, whereas BRRD only applies when the bank's operation is gone concern. (ssrn.com)
These results indicate that USMB enhances both CME and fluid phase endocytosis through distinct signaling mechanisms, and suggest that strategies for potentiating the enhancement of endocytosis upon USMB treatment may improve targeted drug delivery. (plos.org)
Fekri F, Delos Santos RC, Karshafian R, Antonescu CN (2016) Ultrasound Microbubble Treatment Enhances Clathrin-Mediated Endocytosis and Fluid-Phase Uptake through Distinct Mechanisms. (plos.org)

The other framework where a contingent capital mechanism has been introduced, concerns the bail in mechanism of the BRRD. (ssrn.com)

Studies of these biochemically tractable factors have led to a series of new and well-defined hypotheses concerning their mechanisms of action. (grantome.com)

The structure of the negative-feedback mechanism enables it to work in precisely this way and is an excellent example of how anatomical structure matches function. (earthslab.com)
We also queried how such a mechanism will function alongside the role of the National Digital Services Coordinators provided for in the text of the EU Digital Services Act. (digitalpolicy.ie)

Committees, and ultimately to make technical recommendations to the Director-General regarding the functioning of the Regulations and the possible need for amendments. (who.int)

A Sweet Meet-New Mechanism on Nutrient and Hormone Regulation of Plant Growth[J]. Chinese Bulletin of Botany, 2021, 56(2): 138-141. (chinbullbotany.com)

Such a measure might call for the establishment of an Inter-TSO Compensation (ITC) mechanism enabling the TSOs hosting gas transits to be compensated for the revenues not collected through entry-exit fees. (eui.eu)

Third, we fitted the data to figure out the pre-regulatory mechanism of China's coal mining industry. (scirp.org)

Indeed, vacuolin-1 or desipramine treatment prevented the enhancement of CME but not of fluid phase endocytosis upon USMB, suggesting that lysosome exocytosis and acid sphingomyelinase, respectively, are required for the regulation of CME but not fluid phase endocytosis upon USMB treatment. (plos.org)
The first aim i s to dissect the nucleic acid-binding mechanisms of the Est3-TEN complex (comprised of two critical and conserved domains in the telomerase holoenzyme) and assess their contribution to telomerase activity and processivity in vitro and in vivo. (grantome.com)

This monitoring mechanism was reported to the WHO Global Nutrition Policy Review 2016-2017. (who.int)

mRNA transport in neurons: In neurons, thousands of mRNAs are transported into axons or dendrites by so far not identified transport mechanisms (6). (europa.eu)
Mutations affecting zipcodes, RBPs or motor-proteins required for neuronal mRNA localization were shown to lead to severe neurodegenerative diseases as ALS, FXTAS and FXS (7), underlining the need to understand the mechanisms that drive neuronal mRNA transport. (europa.eu)

The market correction mechanism will be automatically activated if the "market correction event" occurs: (1) the month-ahead price on the Title Transfer Facility (TTF) exceeds 180€/MWh for three working days and (2) the month-ahead TTF price is 35€ higher than a reference price for LNG on global markets for the same three working days. (regulationtomorrow.com)
Regulation tomorrow offers a convenient resource for those keeping track of the evolving and increasingly complex global financial services regulatory environment. (regulationtomorrow.com)
How have the Regulations contributed to the global response? (who.int)

Catecholaminergic polymorphic ventricular tachycardia: A paradigm to understand mechanisms of arrhythmias associated to impaired Ca(2+) regulation. (medlineplus.gov)

Under the current system of safety regulation in China, a lower level in the hierarchical system means more regulatory failure. (scirp.org)
Besides, compared with economic regulation, social regulation has received scarce attention in economics studies, and led to fewer results, particularly regarding safety regulation (See details in literature reviews). (scirp.org)
Therefore, preventing the consolidation of ownership and increasing supervision in the current local vertical regulatory system are essential for improving the effectiveness of safety regulations. (scirp.org)
Healthy employee sleep is important for occupational safety, but the mechanisms that explain the relationships among sleep and safety-related behaviors remain unknown. (cdc.gov)

Current paradigms span from instructive to noise-driven mechanisms. (lu.se)

In providing replies, we acknowledged the impacts of harmful content online and the efforts of many children's groups and advocates in Ireland who have called for individual complaints mechanisms. (digitalpolicy.ie)

Molecular mechanisms7

Regulatory mechanisms3

Epigenetic mechanisms1

Modulate2

Allosteric regulation2

Transcriptional4

Lifespan Regulation1

Regulate2

Proposal for a COUNCIL REGULATION1

20235

Inflammasome activation2

Pathways involved2

Oxidative2

Novel Mechanism1

Cellular6

Autonomic2

Physiologic2

Inflammatory1

Gene expression3

Cells6

Self-regulation1

Insulin1

Cytotoxicity1

Synaptic2

Reveals2

Receptor2

Investigate1

Understanding2

Processes3

20221

Autophagy1

Calcium regulation1

Draft3

Understood1

Protein4

Roles1

Research6

Implementation2

Enzymes1

Provide3

Distinct3

Framework1

Action1

Function2

Amendments1

Nutrient1

Establishment1

Figure1

Acid2

Review1

Transport2

Global3

Understand1

Safety4

Current1

Content1