Mechanical properties pericardium. Medical search. Frequent questions

The effect of monomeric glutaraldehyde fixation and amino acid detoxification on biocompatibility and tissue-guided regenerative potential of decellularized bovine pericardium was evaluated. (bvsalud.org)
RESILIA tissue is bovine pericardium that has been transformed by stable capping and glycerolisation. (edwardseducation.com)
Basement membrane proteins modulate cell migration on bovine pericardium extracellular matrix scaffold. (mayo.edu)
Li C, Shklover J, Parvizi M, Sherlock BE, Alfonso Garcia A, Haudenschild AK, Griffiths LG , Marcu L. Label-Free Assessment of Collagenase Digestion on Bovine Pericardium Properties by Fluorescence Lifetime Imaging. (mayo.edu)
For the tissue in the valves, porcine (pig) pericardium was selected due to its lower profile (compared with bovine (cow) pericardium) and its durability. (wikidoc.org)
in the second generation they are made of bovine (cow) pericardium with improvements made in the frame suture and an increase in the skirt length to decrease the risk of aortic regurgitation . (wikidoc.org)
The valve orifice is made by suturing three valve leaflets, each made from a single layer of bovine pericardium, into a tri-leaflet configuration on the stent frame. (wikidoc.org)
Efficient decellularization for bovine pericardium with extracellular matrix preservation and good biocompatibility. (isbweb.org)

Surprisingly, notwithstanding the large number of valves in the world every year, a standard protocol for the mechanical characterization of the pericardial tissue adopted for valve leaflets fabrication is still lacking. (polito.it)
In detail, an experimental protocol was identified for a through-scales mechanical characterization of pericardial tissue samples, including the macroscopic mechanical response of the tissue as well as its mechanical behavior at the microscale. (polito.it)
As the uniaxial tests for ultimate strength characterization are destructive by nature and cannot be adopted for selecting tissue samples to be used for manufacturing bio-prostheses, the use of nanoindentation was explored to unveil the micromechanical properties of the tissue providing measurements of elastic modulus and indentation stress, similarly to the macroscopic tensile test. (polito.it)
The identification of the link between the mechanical properties measured at different scales will make possible the introduction of nanoindentation as non-destructive test to obtain information about the mechanical behavior of the pericardial tissue without damaging it, minimizing the manufacturing waste and making the tissue selection process more standardizable. (polito.it)
Coloplast offers Pericardium Allograft - preserved donated human tissue that has been sterilized through the Tutoplast ® Tissue Sterilization Process. (coloplast.us)
Tutoplast Processed Pericardium is dehydrated, Tutoplast processed pericardium from donated human tissue. (coloplast.us)
The implant is preserved by the Tutoplast tissue sterilization process which retains the three-dimensional collagen structure responsible for the multidirectional, mechanical properties of the original pericardium tissue. (coloplast.us)
Tutoplast Processed Pericardium is regulated as a 361 human cell and tissue product (HCT/P) as defined in USFDA 21 CFR 1271 and is restricted to homologous use for the repair, replacement, reconstruction or augmentation of soft tissue by a qualified healthcare professional (e.g., physician). (coloplast.us)
Tissue was subcutaneously implanted for eight weeks in male juvenile Sprague-Dawley rats, and mechanical properties, host cell infiltration, and calcification were evaluated. (bvsalud.org)
The fixation and detoxification process adequately removes free aldehyde groups and reduces toxicity, preventing enzymatic degradation and allowing for host cell infiltration while mitigating calcification and retaining the mechanical properties of the tissue. (bvsalud.org)
Explanted leaflet and wall tissue evaluated histologically, on electron microscopical appearance, mechanical properties and calcium content. (bvsalud.org)
An acellular xenograft made from porcine pericardium was used as the tissue-scaffold. (desktopmetal.com)
they may also originate in valve tissue, cardiac connective tissue, or the pericardium. (msdmanuals.com)
Bioprosthetic heart valves may have addressed some of the limitations of mechanical valves but still carry their own: gradual degeneration such as pannus growth, leaflet fibrosis and calcification, delamination of the connective tissue, and emergence of ruptures and perforations all eventually lead to valve failure (Kostyunin et al, 2020). (vascudyne.com)
Understanding how these changes impact the mechanical properties of skin requires three-dimensional (3D) quantification of the tissue microstructure and its kinematics. (frontiersin.org)
The development of these computational models has outpaced experimental measurements of the collagen microstructure under mechanical loading, and many assumptions regarding the fiber and tissue kinematics at the microscale remain untested, which limits our understanding of tissue structure-function relationships ( Fang and Lake, 2016 ). (frontiersin.org)
However, this assessment of microstructure is inherently destructive due to the sample preparation process and cannot be used to track tissue or fiber kinematics during mechanical loading. (frontiersin.org)
The viscoelastic properties of kidney tissue during incubation with collagenase was precisely measured using the ElastoSens™ Bio . (rheolution.com)
In this study, the degradation of kidney tissue due to the exposure to collagenase was evaluated through its viscoelastic properties non-destructively measured (during the whole experiment) using the ElastoSens™ Bio . (rheolution.com)
Although mechanical valves offer extended durability, 1 patients are increasingly turning towards tissue valves. (edwardseducation.com)
Mechanical valves are seen to have increased durability with reduced reoperation rates compared to tissue valves. (edwardseducation.com)
Tissue valves do not require lifelong anticoagulation therapy 3-5 but have decreased durability compared to mechanical valves. (edwardseducation.com)
Similar survival rates were observed for mechanical and tissue valves, in a retrospective analysis study by Chiang et al. (edwardseducation.com)
While this method of mitigating calcification is suitable for certain applications, not all polymers impart an elastomeric property to the tissue. (justia.com)
EAT is located between the myocardium and the visceral pericardium and is considered the heart's visceral adipose tissue [3-6]. (researchsquare.com)
The heart is supported by connective tissue called the pericardium. (benfuchsarchives.com)
Decellularized cryopreserved human pericardium: a validation study towards tissue bank practice / Montagner, G. (polito.it)

In this project, porcine pericardium samples were collected from the local abattoir. (ntu.edu.sg)
The trileaflet valve is made of six individual pieces of porcine pericardium, with three pieces used to make a skirt at the inflow section of the valve thus preventing aortic regurgitation and three leaflet elements that are constructed with long commissures to distribute the aortic pressure load to the valve leaflets and the commissural posts. (wikidoc.org)
The valve cuff is made from porcine pericardium that is sutured to the stent frame. (wikidoc.org)

After the decellularization procedure, results were characterized by 1) tensile properties, 2) histology analysis and 3) Deoxyribonucleic acid (DNA) quantification. (ntu.edu.sg)
The tensile properties of the decellularized pericardium in SDS decrease significantly while for TX, the tensile properties do not defer much when compared to the control. (ntu.edu.sg)
The goal of this study was to quantify these structure-function relationships via second harmonic generation (SHG) microscopy of mouse skin under tensile mechanical loading. (frontiersin.org)

Broadly, they can be classified into three categories: mechanical heart valves, bioprosthetic valves, and homograft. (medscape.com)
Bioprosthetic valves (see the image below) generally offer functional properties (eg, hemodynamics, resistance to thrombosis) similar to that of native valves, but longevity is limited relative to mechanical valves. (medscape.com)
2-4 This trend might reflect the patients' unwillingness to accept the compromises of lifelong anticoagulation as required by mechanical valves. (edwardseducation.com)
Structural valve deterioration (SVD) is rare in mechanical valves though other factors such as valve thrombosis, bleeding, pannus growth and endocarditis may lead to reoperation. (edwardseducation.com)
and (c) avoid the undesirable use of anticoagulants required to prevent thromboembolism associated with the use of non-bioprosthetic (mechanical) heart valves especially in children. (justia.com)
Moreover, it was initially contemplated that children and adolescents would be among those deriving the greatest benefit from the glutaraldehyde-preserved bioprosthetic heart valves since the anticoagulants required with mechanical prostheses could be eliminated. (justia.com)
Bioprosthetic valves (see the image below) used in heart valve replacement generally offer functional properties (eg, hemodynamics, resistance to thrombosis) that are more similar to those of native valves. (medscape.com)
In a retrospective cohort analysis of 4253 patients who underwent primary isolated aortic-valve replacement, 15-year survival and stroke rates were equivalent with bioprosthetic and mechanical valves. (medscape.com)

CNTs can also impart conductivity to other insulating materials, improve mechanical stability, guide neuronal cell behavior, and trigger axon regeneration. (bvsalud.org)

Practical differences between methodologies for the characterization of tissues and organs degradation (weight loss and mechanical measurements with the ElastoSens™ Bio) during the exposure to enzymes. (rheolution.com)
Development of a multiscale testing method for the reduction of soft biological tissues waste during mechanical characterization / Lugas, Andrea T. (polito.it)

All ECM samples originate from mammalian tissues, such as dermis, pericardium, and small intestinal submucosa (SIS). (wikipedia.org)
Such an elastomeric property may be desirable in tissues which will be subjected to stretching or flexing once implanted. (justia.com)

The results showed that at higher SDS concentrations, the pericardium can reach complete decellularization, however the major ECM structure was disrupted. (ntu.edu.sg)
On the other hand, the ECM was preserved well for pericardium treated with higher concentrations of TX nevertheless still not able to achieve full decellularization. (ntu.edu.sg)
Increasing SDS concentration enhances the decellularization process however it has negative effects on the ECM structure and mechanical properties of the pericardium. (ntu.edu.sg)
TX is less destructive than SDS as it retains the ECM structure over time and conserves the mechanical properties however it should be at an optimal range to achieve complete decellularization. (ntu.edu.sg)

Press Release, 02/2020: AdjuCor enters BMBF supported research collaboration for developing 3D printable biomimetic polymers that mimic properties of the pericardium. (adjucor.com)

Their physical and chemical properties and biocompatibility were evaluated. (bvsalud.org)

Through histology study, scanning electron microscopy and DNA quantification, lower concentrations of SDS and TX were not able to decellularize the pericardium completely. (ntu.edu.sg)

The allograft particulate, pericardium membrane and the dbm putty are currently available for order in the US and Canada only. (nobelbiocare.com)

Non-calcific, non-immunogenic, 100% biological without any synthetic raw materials, and with tunable mechanical properties that mimic native valve performance, TRUE™ Heart Valve has been shown to support somatic growth in animal models as published in peer-reviewed publications. (vascudyne.com)

Although they are similarly composed of fibril collagen, the microstructure, specific composition (including presence of non-collagenous protein and glycosaminoglycans and ratio of different types of collagen), physical dimensions and mechanical properties can differ. (wikipedia.org)
Among them, collagen membranes have attracted great interest due to their excellent biological properties and desired bone regeneration results to non-absorbable membranes even without a second surgery for removal. (encyclopedia.pub)

In all, the small variances from origin, time of harvest, and processing method can direct the final properties of the ECM biomaterial. (wikipedia.org)

We performed a global sensitivity analysis to identify the different modes responsible for different simulated electrical and mechanical measures of cardiac function. (plos.org)
Simulations of cardiac electrical activation and mechanical pump function in hearts with shapes described by different combinations of shape components were performed. (plos.org)
The myocardium defines the middle layer of the cardiac wall between the endocardium and the pericardium and forms the muscular part of the heart . (radiopaedia.org)
It is located between the endocardium and the epicardial layer of the pericardium within the walls of the cardiac chambers arranged in different sheets wrapped around in different orientations. (radiopaedia.org)

In propensity-matched comparisons, actuarial 15-year mortality rates were 60.6% with the bioprosthetic aortic valve and 62.1% with the mechanical valve. (medscape.com)

The reoperation rate was 12.1% in the bioprosthetic valve group at 15 years and 6.9% in the mechanical valve group, while major bleeding occurred in 6.6% of bioprosthesis patients and in 13.0% of the mechanical-valve group. (medscape.com)

We are always on the lookout for specialists in the medical, biotechnology, mechanical engineering, electrical engineering and IT fields to join our team. (adjucor.com)

This result, along with the other outcomes, highlights the importance of accurate, scale-matched 3D experimental measurements when developing multi-scale models of skin mechanical function. (frontiersin.org)
Nonetheless, a recent review has highlighted the disconnect between Doppler echo measurements and true diastolic properties of the left ventricle, and has questioned the prevailing assumption that HF with preserved systolic function is always caused by diastolic dysfunction. (bmj.com)

Lecture Notes in Mechanical Engineering). (elsevierpure.com)

The measurement of the substrate's weight loss and mechanical properties are two common methods to assess the performance of enzymes and to characterize degradation. (rheolution.com)

Mechanical Support reBEAT contains air cushions that gently squeeze the heart, in sync with its natural rhythm. (adjucor.com)
This Das perfekte Fotobuch gestalten: Ihre Bilder, gute Ideen, schöne Seiten, is the most mechanical heart production for transporters over 65 hydrates of heart. (augenta.net)

Due to its elastic property, superficial fascia can stretch to accommodate the deposition of adipose that accompanies both ordinary and prenatal weight gain. (wikidoc.org)

[6] It is a balloon-expendable valve made of a stainless steel frame covered by a Dacron skirt where three leaflets of pericardium are sutured. (wikidoc.org)

Table 1 summarizes the differences in some practical aspects between the weight loss technique and the mechanical testing using the ElastoSens™ Bio . (rheolution.com)
Shamloo, A. Mechanical differences between atp and adp actin states: a molecular dynamics study. (isbweb.org)

BIOSKY photonic crystal - red significantly improves water properties: it structures, eliminates negative information, decreases the redox potential (RP) of the water. (biomedis.life)

This allowed us to show that some shape components that explain a large amount of electrical and mechanical function variance only explain a small amount of anatomical variance. (plos.org)
The interventricular septum (IVS) accommodates the ventricular portion of the conduction system and contributes to the mechanical function of both ventricles. (encyclopedia.pub)

This creates a mechanical advantage for turning hard-to- torque assemblies. (globalspec.com)

Titanium is resistant to corrosion, has good mechanical properties, is very strong, and is stiff enough to enable support for a bone graft to maintain its volume during healing. (cdeworld.com)

The creos allografts portfolio offers you a wide range of particulate grafts, a 100% demineralized bone matrix (dbm) putty and a pericardium barrier membrane. (nobelbiocare.com)

Subsequently, the properties and specific application scenarios of microcarriers with different materials and functions were introduced according to the materials and functions of microcarriers used in cartilage repair. (bvsalud.org)

Although the first step in processing reduced the immunological response, photooxidation is still necessary to retain the structure and mechanical integrity of the cartilage, which would allow for immediate joint resurfacing. (biomedcentral.com)

Myocardial conduction happens from cardiomyocyte to cardiomyocyte via the intercalated disks, which form the mechanical and electrical contacts between the myocardial cells 10 . (radiopaedia.org)

The mechanical response of skin has been extensively studied in the past. (frontiersin.org)

Products acquire properties that promote the elimination of toxins, free radicals, heavy metals from the body. (biomedis.life)

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