• Inasmuch as glucose absorption from the shell of the striatum into the ventral tegmental area infusion of mecamylamine was opposite to that of liver biopsy in diagnosing cirrhosis. (haverford.edu)
  • We show that drugs which desensitize and do not activate the receptor ion channel can still be effective at treating inflammatory diseases. (grantome.com)
  • We will use mammalian cells transfected with a7 alone, or in combination with pro-inflammatory cytokine receptors to test the hypothesis that drugs which induce stable desensitization of the a7 ion channel may still be effective at mediating ion channel independent signal transduction through the intracellular JAK/STAT pathway. (grantome.com)
  • Previous reports have identified interactions between childhood trauma and sequence variation in the CRH receptor 1 gene (CRHR1) that increase risk for affective disorders. (virginia.edu)
  • The results indicate that the greatest deficits in long-term retention (1 week) of contextual fear are produced by central infusion of MLA minutes to hours post-conditioning or mecamylamine within minutes of conditioning. (virginia.edu)
  • Table 8.1 presents the increase in DMTS task performance efficiency by macaques obtained from the best dose for eight nicotinic compounds of differing chemical structure and nicotinic receptor selectivity. (alpfmedical.info)
  • The desensitization is due to prolonged binding to the receptor, and the desensitizing properties of specific agents are likely to impact their therapeutic utility for specific indications. (grantome.com)
  • We will investigate the potential importance of hydrogen bonding and hydrophobic interactions on the binding, gating, and desensitizing properties of the specific receptor/ligand combinations. (grantome.com)
  • Pre-treatment with mecamylamine inhibited the rate-inhibiting properties of ethanol in the VTA, but not in the nAc. (gu.se)