• The selectivity of mecamylamine for neuronal nAChR was manifested primarily in terms of slow recovery rates from mecamylamine-induced inhibition. (aspetjournals.org)
  • Neuronal receptors showed a prolonged inhibition after exposure to low micromolar concentrations of mecamylamine. (aspetjournals.org)
  • Mecamylamine inhibition of neuronal nAChR was noncompetitive and voltage dependent. (aspetjournals.org)
  • Together, these findings suggest that in chronic (i.e., therapeutic) application, S- (+)-mecamylamine might be preferable to R- (−)-mecamylamine in terms of equilibrium inactivation of neuronal receptors with decreased side effects associated with muscle-type receptors. (aspetjournals.org)
  • Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic acetylcholine (ACh) receptors (nAChRs) and, despite its common usage, questions still exist as to its precise specificity and mechanisms of action. (aspetjournals.org)
  • When Mecamylamine HCl is withdrawn, this should be done gradually and other antihypertensive therapy usually must be substituted. (nih.gov)
  • These have occurred most often when large doses of Mecamylamine HCl were used, especially in patients with cerebral or renal insufficiency. (nih.gov)
  • During therapy with Mecamylamine HCl, sodium intake should not be restricted but, if necessary, the dosage of the ganglion blocker must be adjusted. (drugs.com)
  • Mecamylamine HCl is a potent, oral antihypertension agent and ganglion blocker, and is a secondary amine. (nih.gov)
  • Mecamylamine, a secondary amine, readily penetrates into the brain and thus may produce central nervous system effects. (nih.gov)
  • You may not be able to take mecamylamine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above. (cigna.com)
  • the average dose of mecamylamine for those patients who did respond to the drug alone during prolonged treatment was 34 mg. daily. (jamanetwork.com)
  • Mecamylamine HCl is excreted slowly in the urine in the unchanged form. (nih.gov)
  • S)-(+)-Mecamylamine dissociates more slowly from α4β2 and α3β4 receptors than does the (R)-(−)-enantiomer. (wikipedia.org)
  • Specifically, S -(+)-mecamylamine appeared to dissociate more slowly from α4β2 and α3β4 receptors than did R- (−)-mecamylamine. (aspetjournals.org)
  • S )-(+)-Mecamylamine dissociates more slowly from alpha-4 beta-2 and alpha-3 beta-4 receptors than does the ( R )-(-)- enantiomer . (curecrowd.com)
  • The use of Mecamylamine HCl in patients with marked cerebral and coronary arteriosclerosis or after a recent cerebral accident requires caution. (nih.gov)
  • A large SAR study of mecamylamine and its analogs was reported by a group from Merck in 1962. (wikipedia.org)
  • Mecamylamine HCl reduces blood pressure in both normotensive and hypertensive individuals. (nih.gov)
  • Alkalinization of the urine reduces, and acidification promotes, renal excretion of mecamylamine. (nih.gov)
  • Alcohol may increase drowsiness and dizziness while you are taking mecamylamine. (cigna.com)
  • The data include the average of all blood pressure levels and pulse rates obtained weekly or biweekly for a period of three months approximately one year after beginning therapy with mecamylamine. (jamanetwork.com)
  • Take mecamylamine every day at the same time, usually after meals. (cigna.com)
  • Although there was little difference between S -(+)-mecamylamine and R -(−)-mecamylamine in terms of 50% inhibition concentration values for a given receptor subtype, there appeared to be significant differences in the off-rates for the mecamylamine isomers from the receptors. (aspetjournals.org)
  • A comparison was made between one group of 17 patients receiving mecamylamine alone and another group of 58 receiving mecamylamine with reserpine. (jamanetwork.com)
  • If these are present, Mecamylamine HCl should be discontinued immediately and remedial steps taken. (drugs.com)
  • Store mecamylamine at room temperature away from moisture and heat. (cigna.com)