Measurements magnetic resonance spectroscopy. Medical search. Frequent questions

Fluorine-19 nuclear magnetic resonance spectroscopy (fluorine NMR or 19F NMR) is an analytical technique used to detect and identify fluorine-containing compounds. (wikipedia.org)
19F is an important nucleus for NMR spectroscopy because of its receptivity and large chemical shift dispersion, which is greater than that for proton nuclear magnetic resonance spectroscopy. (wikipedia.org)
The Ad Bax Group makes available downloadable software for nuclear magnetic resonance (NMR) research. (nih.gov)
Recent improvements have made nuclear magnetic resonance (NMR) spectroscopy a prime method for studying organic matter chemistry. (usda.gov)
Spin counting on solid-state **13C cross-polarization (CP) nuclear magnetic resonance (NMR) spectra of two humic fractions isolated from tropical lowland soils showed that only 32-81% of potential **13C NMR signal was detected. (usda.gov)
Analytical chemists often make use of nuclear magnetic resonance (NMR) spectroscopy to identify molecules and measure their concentrations. (spectroscopyeurope.com)
Nuclear magnetic resonance (NMR) spectroscopy is particularly suited for large-scale untargeted metabolomics studies due to its high reproducibility and cost effectiveness. (nih.gov)
The modification of surface passivation is evidenced by both Fourier transform infrared spectroscopy and nuclear magnetic resonance measurements. (fzu.cz)
Further structural characterization of the ARP was accomplished by using nuclear magnetic resonance (NMR) spectroscopy, including 1D 1 H NMR and 13 C NMR, the distortionless enhancement by polarization transfer (DEPT-135) and 2D 1 H- 1 H and 13 C- 1 H correlation spectroscopy (COSY) and 2D nuclear overhauser enhancement spectroscopy (NOESY). (hindawi.com)
Modern analytical techniques have been applied in structural characterization of ARPs, such as circular dichroism, infrared spectroscopy, fluorescence spectroscopy, mass spectrometry, and nuclear magnetic resonance (NMR) spectroscopy [ 12 ]. (hindawi.com)
To confirm the connection between the amino acid and glucose, 2D nuclear overhauser enhancement spectroscopy (NOESY) experiments were performed. (hindawi.com)
To date, nuclear magnetic resonance spectroscopies are being used for these analyses. (optics.org)
With the development and optimization of non-invasive techniques, such as nuclear magnetic resonance spectroscopy (MRS), several groups have worked on assessing cerebral metabolism in vivo . (frontiersin.org)
Dr. Grame F. Mason develops experimental models and methods for studies of brain metabolism using 1H and 13C Nuclear Magnetic Resonance (NMR) and Mass Spectrometry in conjunction with 13C isotopic labeling in vivo, in cell preparations, and other systems. (yale.edu)
In dynamic nuclear polarization nuclear magnetic resonance (DNP-NMR) experiments, the large Boltzmann polarization of unpaired electrons is transferred to surrounding nuclei, leading to a significant increase in the sensitivity of the NMR signal. (weizmann.ac.il)
To achieve its goals, the CRC is focusing on the miniaturisation of all components involved in magnetic resonance technology: superconducting magnets, cooling systems, high-speed electronics, magnetic resonance sensors, devices for ultra-fast data transfer and devices for the nuclear spin hyperpolarisation of materials and biological samples. (spectroscopyeurope.com)
Advanced Characterisation: Scanning Electron Microscopy (SEM), Nuclear Magnetic Resonance (NMR) spectroscopy, X-Ray Photoelectron Spectroscopy (XPS), Raman and FTIR Spectroscopy, Differential Scanning Calorimetry, Thermogravimetric Analysis, mechanical properties, water contact angle measurements. (itsligo.ie)
They combined "in-cell" nuclear magnetic resonance (NMR) spectroscopy, a bioreactor system and cutting-edge computational algorithms to determine protein structures in crowded intracellular environments for the first time. (analytica-world.com)
To tackle this challenge, a team from Tokyo Metropolitan University led by Assistant Professor Teppei Ikeya and Professor Yutaka Ito applied nuclear magnetic resonance (NMR) spectroscopy measurements to specific proteins expressed inside sf9 cultured insect cells, a strain of cells originally derived from a type of moth larva widely used for protein production. (analytica-world.com)
The problem with simply applying the same techniques to proteins in sf9 cells was the significantly lower concentration of target proteins and short lifetime of cells, making it difficult to collect high quality multi-dimensional NMR spectra for nuclear Overhauser effect spectroscopy (NOESY) which would give precise information about how different atoms are spaced inside individual molecules. (analytica-world.com)
Our nuclear magnetic resonance (NMR) methods are changing this situation. (utmb.edu)
This dissertation demonstrates the superior ability of solid-state nuclear magnetic resonance (SSNMR) spectroscopy to both detect and quantitate physical forms of APIs within formulations, relative to other solid-state characterization techniques. (ku.edu)
Moreover, we systematically investigate changes of dynamical behavior by varying the molecular weight of the polymers and investigate the interpretation of experimental results, in particular of nuclear magnetic resonance data. (tu-darmstadt.de)
Recent studies have developed new approaches to study diffusion coefficients and structural relaxation times by way of nuclear magnetic resonance spectroscopy for wide time ranges and long times. (tu-darmstadt.de)
Hence, the key aspects in the interpretation of spin-lattice relaxation times from nuclear magnetic resonance experiments are evaluated from a molecular dynamics simulation perspective. (tu-darmstadt.de)
Nuclear magnetic resonance (NMR) titration and isothermal titration calorimetry can be combined to provide an assessment of how multivalent intrinsically disordered protein (IDP) interactions can involve enthalpy-entropy balance. (elsevierpure.com)
Molecular mobility in keratin-rich materials monitored by nuclear magnetic resonance: A tool for the evaluation of structure-giving properties. (lu.se)
Molecular dynamics simulations and solid-state nuclear magnetic resonance spectroscopy measurements of C-H bond order parameters and effective correlation times in a POPC-GM3 bilayer. (lu.se)
Global and targeted urine metabolomics data, generated using mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR), were utilized to investigate biochemical differences between persons exposed and unexposed to Mn. (cdc.gov)

Liver fat was measured with proton magnetic resonance spectroscopy. (nature.com)
To assess brain biochemistry changes, the researchers used localized high-resolution proton magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) on the hippocampi of the rats. (prohealth.com)
While various methods have investigated these deviations, only proton magnetic resonance spectroscopy (1H MRS) enables noninvasive measurement of small-molecule metabolites in the living human. (lu.se)
Proton magnetic resonance spectroscopy ( 1 H MRS) consistently detects significant differences in choline phospholipid metabolites of malignant versus benign breast lesions. (aacrjournals.org)

NMR results, supported by X-ray photoelectron spectroscopy and electron microscopy, reveal that the actual composition of the deposited layer is an amorphous Al-O-F phase. (weizmann.ac.il)

To examine the respective roles of Cai, Pi, pH, and vascular pressure in regulating contractility during mild flow reductions, Indo-1 calcium fluorescence and 31P magnetic resonance spectroscopy measurements were performed on Langendorff-perfused rat hearts. (jci.org)
To assess for cutaneous porphyria, the plasma porphyrin level should be measured, using fluorescence emission spectroscopy. (medscape.com)

My personal expertise is in imaging the human gastrointestinal (GI) tract using magnetic resonance imaging (MRI). (nottingham.ac.uk)
Magnetic Resonance Imaging Quantification of Fasted State Colonic Liquid Pockets in Healthy Humans. (nottingham.ac.uk)
This discovery formed the basis of a powerful technique used nowadays to study brain activity: blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI). (frontiersin.org)
He then joined as a senior scientist in Biological Imaging Center at the Beckman Institute of California Institute of Technology, California where he worked on high field Magnetic Resonance Microscopy (1999-2003). (selectbiosciences.com)
In June 2009 he joined the laboratory of molecular imaging, Singapore Bioimaging Consortium as the Head of Magnetic Resonance Spectroscopy and Metabolic Imaging group. (selectbiosciences.com)
He has developed several magnetic resonance techniques for Magnetic Resonance imaging, EPR Imaging, self-diffusion measurements, high resolution MRS, and localized MRS suitable for pre-clinical and clinical applications. (selectbiosciences.com)
Apart from chemical and material synthesis, Usaid has hands-on experience in different characterisation instruments such as metallurgical microscopes and SEM for the surface imaging of materials, FTIR spectroscopy (identify molecular composition), fatigue testing machine (FTS) and universal testing machine (UTM) to determine the mechanical properties of materials. (itsligo.ie)
The wide range of related subjects covered, including basic Magnetic Resonance Imaging theory, practical applications and hands on experience, gives you a broad understanding of Magnetic Resonance Imaging. (abdn.ac.uk)
You will be in the advantageous position of learning in an environment that was pivotal in the early development of Magnetic Resonance Imaging and continues to contribute to its development. (abdn.ac.uk)
Clinical magnetic resonance spectroscopy (MRS), particularly 1 H MRS imaging, is attracting a high level of interest as a method to detect the extent of invasion of brain tumors (1) , as well as prostate (2) and breast cancer (3) , and to differentiate between recurrence or necrosis after treatment (2, 4) . (aacrjournals.org)
My interdisciplianry research team is focused on the development of innovative magnetic resonance imaging (MRI) and spectroscopy methods to characterise the structure, function and physiology of human tissues and organs through non-invasive and repeatable scans. (ncl.ac.uk)
Our 7Li-MRI scans allow MR imaging of this pharmaceutical agent in its target organ, allowing direct but non-invasive measurement of how the concentration of lithium varies across the brain and over time. (ncl.ac.uk)
Using the same exposure model, the relationship between modeled air Mn and Mn at the target organ (as determined by magnetic resonance imaging) was investigated. (cdc.gov)
However, tumor recurrence may occur in the setting of normal CA 125 levels, and serum measurements do not replace imaging and physical examination of the patient. (medscape.com)
Optimal experimental design for filter exchange imaging: Apparent exchange rate measurements in the healthy brain and in intracranial tumors. (lu.se)
For instance, functional magnetic resonance imaging monitors the blood oxygen level dependent (BOLD) contrast but is sensitive only to deoxygenated hemoglobin and the MRI machine is bulky. (lu.se)

Phosphorus ( 31 P) magnetic resonance spectroscopy (MRS) is known to be a powerful tool in the assessment of cell energy metabolism [ 1 - 3 ]. (frontiersin.org)
In this context, 1 H MRS has allowed the measurements of energy metabolism-related compounds, whose concentrations can vary under different brain activation states. (frontiersin.org)
In this study, differences in choline membrane metabolism were characterized in breast cancer cells and normal human mammary epithelial cells (HMECs) labeled with [1,2- 13 C]choline, using 1 H and 13 C magnetic resonance spectroscopy. (aacrjournals.org)

In addition, single-nanocrystal spectroscopy reveals the occurrence of a systematic fine structure in the emission single spectra, which is connected with an intrinsic property of small nanocrystals since a very similar structure has recently been observed in specially passivated semiconductor CdZnSe nanoparticles. (fzu.cz)
1D 1 H NMR and 13 C NMR, the distortionless enhancement by polarization transfer (DEPT-135) spectrum, and 2D 1 H- 1 H and 13 C- 1 H correlation spectroscopy (COSY) were used to assign correlations between the signals in the 1 H and 13 C NMR spectra. (hindawi.com)
Thus, they combined a sparse sampling -based rapid NMR measurement scheme with state-of-the-art computational methods employing statistical techniques like Bayesian inference , methods tailored to elucidate protein structures efficiently based on a limited amount of structural information from in-cell NMR spectra with inherently low-sensitivity. (analytica-world.com)

Over the past decade, one common feature consistently revealed by magnetic resonance (MR) spectroscopic studies is the elevation of phosphocholine (PC) and total choline-containing metabolites [tCho, glycerophosphocholine (GPC)+PC+free choline (Cho)] in cancer cells and solid tumors. (aacrjournals.org)
Several magnetic resonance spectroscopic studies have shown that lactate accumulates in areas of the brain that are damaged in methylmalonic acidemia. (medscape.com)

Here, one-dimensional (1D) 1 H NMR experiments offer good sensitivity at reasonable measurement times. (nih.gov)

Currently, the improvement of detection modalities (i.e., direct detection of 13 C isotopomers), the progress in building adequate mathematical models along with the increase in magnetic field strength now available render possible detailed compartmentalized metabolic flux characterization. (frontiersin.org)

This was verified by phantom measurements, where an SNR increase of 46% could be observed for localized 31 P spectroscopy in a voxel positioned comparable to an in vivo cardiac measurement scenario. (frontiersin.org)
A flexible 31 P/ 1 H RF coil array with improved SNR is presented, enabling localized in vivo cardiac 31 P spectroscopy at 7 T. (frontiersin.org)
In vivo NMR spectroscopy. (abdn.ac.uk)
The system was validated in vivo against complementary techniques, including white light and diffuse reflectance spectroscopy. (lu.se)

This is because both resolution and sensitivity scale up with a magnetic field used in an NMR spectrometer. (spectroscopyeurope.com)
Its goal is to improve the sensitivity, resilience and usability of magnetic resonance in equal measure. (spectroscopyeurope.com)

Co-authors outside our institution contributed by applying single-nanocrystal spectroscopy and performing NMR, FTIR, STM and dynamic light-scattering measurements. (fzu.cz)

To reach nanomolar limits of detection one has to use high magnetic fields and cryogenically cooled probes that are beyond the reach of most analytical laboratories. (spectroscopyeurope.com)

Our projects span the intersection of magnetic resonance physics, bioscience and clinical research, and aim to develop reliable and valuable quantitative measurements for implementation in clinical research and development into robust tools used in clinical practice. (ncl.ac.uk)
We use a wide range of conventional MRI scan methods to make quantitative measurements of anatomy, microstructure and tissue physiology, and have expertise in developing multinuclear MR methods for clinical research that can bring novel measurements to the study of disease processes and the effects of therapies. (ncl.ac.uk)
The lung function measurement in current clinical use have limited or no information on how lung function varies across the lungs, and so early detection of disease processes or progression of disease can be difficult to detect. (ncl.ac.uk)

Additionally, in order to perform quantitative measurements pure standards are needed and calibration curves must be generated for most of these characterization techniques. (ku.edu)

Crystallography and NMR spectroscopy indicate that these internal ions can be located between the G-quartet planes as well as in the thymine loops, but the precise ion coordination has been firmly established in only a few cases. (lu.se)
More detailed information of completely dehydrated alkali ions (usually K+ or Na+) about the internal ions can be obtained by measuring the coordinated to the buried carbonyl oxygens of the nucleotide spin relaxation rate(s) over a wide range of resonance bases. (lu.se)

Magnetic resonance is both the most chemically specific and the most versatile measurement method for acquiring detailed information on the structure and function of molecular matter. (spectroscopyeurope.com)
Tracking solvents in the skin through atomically resolved measurements of molecular mobility in intact stratum corneum. (lu.se)

Experimental measurements of the diffusion and structural relaxation is a fundamental prerequisite for the study of the glass transition. (tu-darmstadt.de)
Our research group, the MR physics research group at Lund university, is situated in the expanding Öresund region in southern Sweden, is active in the field of medical magnetic resonance, and has its primary focus on development of new techniques for assessment of functional information related to perfusion, diffusion, cortical activation/fMRI and flow. (lu.se)

The partners in the CRC expect the results of their research to make the use of magnetic resonance for fast and high-resolution characterisation of materials affordable for facilities with smaller budgets, and to advance research in chemistry and materials science in general. (spectroscopyeurope.com)

Here, we examine the bimolecular diagonal-looped foldback quadruplexes [d(G3T4G3)]2 (Q3) and [d(G4T4G4)]2 (Q4) by 2H, 17O, and 23Na magnetic relaxation dispersion (MRD). (lu.se)
Such magnetic relaxation dispersion (MRD1) structural polymorphism of quadruplexes ( 2, 5, 6 ), but little measurements have been used to study ion binding (via 23Na is known about the energetics and kinetics of ion binding. (lu.se)
first MRD studies of quadruplex DNA, using the 2H/17O (for A variety of NMR spectroscopy and relaxation techniques hydration) and 23Na (for ion binding) nuclides. (lu.se)

Dive into the research topics of 'Non-invasive measurement of lactate concentration in whole human breast tumours using advanced magnetic resonance spectroscopy (MRS)'. Together they form a unique fingerprint. (elsevierpure.com)
Non-invasive measurement of lactate concentration in whole human breast tumours using advanced magnetic resonance spectroscopy (MRS) . European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) Annual Scientific Meeting, Rotterdam, Netherlands. (elsevierpure.com)
Additional techniques include MR spectroscopy (MRS), which allows clinicians to characterize the chemical composition of the mass by determining the presence and/or alteration of components such as lactate, N -acetylaspartate (NAA), choline (Cho), and myo-inositol (Ins). (medscape.com)

In cardiovascular disease and diabetes the measurement of abnormalities of the microcirculation can monitor the progression of the disease. (lu.se)

Dr. Velan received his Ph.D. in Chemical Physics - Biophysics (Interdisciplinary) with a research focus in Magnetic Resonance from University of Madras, India (1997), and his Post-doctoral fellowship in MR methodologies at the NIH (1997-98). (selectbiosciences.com)

This feature allows for the user-determination of the orientation of droplets relative to the main axes of the shim stack, permitting improved shimming and a more homogeneous magnetic field inside the droplet below the microcoil, which leads to improved spectral lineshape. (rsc.org)
This volume corresponds with the most homogeneous region of the magnetic field, although the magnetic field spans a much larger region and can still adequately polarise the sample outside of the active volume. (spectroscopyeurope.com)

However, DEPT-135 and 2D NMR techniques provided more structural information to assign the 1 H and 13 C resonances of ARP. (hindawi.com)

An investigation of the factors influencing the chemical shift in fluorine NMR spectroscopy revealed the solvent to have the largest effect (Δδ = ±2 ppm or more). (wikipedia.org)

However, newer NMR techniques suggest inaccuracies in previous measurements. (usda.gov)

The magnetic resonance spectroscopy data indicated that elevated phosphocholine in breast cancer cells was primarily attributable to increased choline kinase activity and increased catabolism mediated by increased phospholipase C activity. (aacrjournals.org)

Here we present an in-depth investigation of a nominal AlF3 coating on LiNi0.5Mn1.5O4 based on solid state NMR spectroscopy to determine the composition and function of the Al/F coating layer. (weizmann.ac.il)

Neutron Spin-Echo spectroscopy (NSE) on the other hand, offers the highest energy resolution in the field of neutron spectroscopy and allows the study of slow collective motions in proteins up to several hundred nanoseconds and in the nanometer length-scale. (lu.se)
Volumetric velocity measurements in restricted geometries using spiral sampling: a phantom study. (lu.se)

Magnetic Resonance in Medicine. (lu.se)

The "active volume" (red square) represents a small portion of the sample, but many similar portions are still strongly polarised by the magnetic field. (spectroscopyeurope.com)
B) Profile of magnetic field magnitude along the axis of the spectrometer. (spectroscopyeurope.com)
NMR spectroscopy or X-ray crystallography, but important width measurements at a single resonance frequency (or questions remain concerning the energetics, stability, and magnetic field strength), making it difficult to separate dynamics of this structurally diverse nucleic acid class. (lu.se)

The method used is non-contact, suitable for measurement on conveyor ore streams or slurries, and has high resolution and low detection limits for selected minerals. (edu.au)

In QSPEC, which is funded by the German Federal Ministry of Education and Research (BMBF), the focus is on quantum-based spectroscopy. (optics.org)
In the Collaborative Research Center for High Performance Compact Magnetic Resonance (HyPERiON) coordinated by the Karlsruhe Institute of Technology (KIT), researchers from KIT and the universities of Kaiserslautern, Konstanz and Stuttgart are jointly developing technology for compact high-performance magnetic resonance units. (spectroscopyeurope.com)

Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. (nature.com)

The method is highly specific, as each target has a response unaffected by other mineral resonances. (edu.au)

NMR spectroscopy makes it possible to clearly identify almost any organic substance in a given sample. (optics.org)

Although the reference compound for 19F NMR spectroscopy, neat CFCl3 (0 ppm), has been used since the 1950s, clear instructions on how to measure and deploy it in routine measurements were not present until recently. (wikipedia.org)

The Total Absolute Measurement System (TAMS) unit allows you to choose the right detector for angular-dependent measurements of optical properties of thin and thick samples. (azooptics.com)
In order to rationalize the origin of the difference in the efficiency of DNP in amorphous and crystalline inorganic matrices, we performed a detailed comparison in terms of their magnetic resonance properties. (weizmann.ac.il)

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