AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth Care
LungLung Volume MeasurementsImaging, Three-DimensionalMagnetic Resonance ImagingOrgan SizeLung DiseasesImage Processing, Computer-AssistedLung NeoplasmsReproducibility of ResultsBrainTomography, X-Ray ComputedLung InjuryBlood VolumeAtrophyPulmonary Diffusing CapacityAdipose TissueSubcutaneous FatCarcinoma, Non-Small-Cell LungSubcutaneous Fat, AbdominalAcute Lung InjuryIntra-Abdominal FatLung TransplantationTime FactorsAlgorithmsReference ValuesSensitivity and SpecificityPhantoms, ImagingBronchoalveolar Lavage FluidPneumonectomyImage Interpretation, Computer-AssistedModels, BiologicalAntipyrineDogsPulmonary AlveoliPancreatitis, ChronicDisease Models, AnimalPulmonary FibrosisBone and BonesPericardiumCerebrovascular CirculationFemurAnalysis of VarianceMicrocirculationAgingTissue DistributionBone DensityRats, Sprague-DawleyPneumoniaStroke VolumePlasma VolumeBiomechanical PhenomenaBreastLung Diseases, InterstitialRegional Blood FlowForced Expiratory VolumeInfant, NewbornInfant, PrematurePulmonary EmphysemaCell CountExtravascular Lung WaterRespiratory Function TestsRespiratory MechanicsPulmonary EdemaMice, Inbred C57BLBlood Volume DeterminationCerebral CortexVentilator-Induced Lung InjuryMacrophages, AlveolarRespiratory Distress Syndrome, AdultPulmonary CirculationErythrocyte VolumeBronchiOvariectomyObserver VariationRNA, MessengerProspective StudiesImmunohistochemistryTotal Lung CapacityBody Mass IndexAdenocarcinomaRespiratory MucosaPulmonary SurfactantsSmokingOxygenAsthmaMice, Inbred BALB CEmphysemaRespiration, ArtificialLung ComplianceAsbestosAdministration, InhalationTreatment OutcomePressureAerosolsLung Diseases, ObstructiveSmall Cell Lung CarcinomaIdiopathic Pulmonary FibrosisRespirationEquipment DesignPredictive Value of Tests
FibrosisInterstitial Lung DiComputed tomographyImpaired lung functionLiverExtravascular lung waterVentilator-induced lungAirwaysAirwayFunction and diagnose respiratoryVentilationNormal tissuesTumorsAdipose tissueConnective Tissue DAlveoliDiseasesChronic ObstrucOrgansParametersCancerEmphysemaPatients with lungHysteresisAlveolar volumeUnderwentInflammationPatient'sEvaluateTumor VolumeEuropean Respiratory SocietyDensitySevereMethodsTomographicTherapeuticConclusionsAutoimmuneCOPDTidal volumesChestTotal lung capPerfusionAttenuationParenchymaSoft tissueOxygenExpiratoryNodulesSignificantlyObstructiveTransplantationAirflow limitationPulmonary complianceSeverityDisordersOscillometryRadiotherapyIndividual lungClinical practiceDiagnosis of lungDiffusion capacity
Fibrosis8
  • Low compliance indicates a stiff lung (one with high elastic recoil) and can be thought of as a thick balloon - this is the case often seen in fibrosis. (wikipedia.org)
  • These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)
  • The anti-cancer agent bleomycin as well as radiation therapy for lung cancer are known to lead to the development of pulmonary fibrosis in most patients. (oncodesign-services.com)
  • We also modeled the normal pressure-volume relationship as well as curves representative of fibrosis and emphysema. (dal.ca)
  • COPD can also be complicated by the destruction of the parenchymal tissue (i.e., emphysema) or by a fibrotic tissue transformation (i.e., peribronchial fibrosis), which are evidenced by modifications of lung compliance. (biomedcentral.com)
  • Some of the damage to the human body is to lymph tissue, kidneys, developing fetuses, neurological system, the bones, lung fibrosis, and an increase in the risk of many types of cancer and malignancies. (whatreallyhappened.com)
  • The effects of asbestos include severe lung fibrosis or scarring, lung cancer, including cancer of the lining of the lungs or pleura called mesothelioma. (cdc.gov)
  • 4 (Fibrosis and granuloma reduce gas-exchange area in the lung, thus making breathing difficult. (cdc.gov)
Interstitial Lung Di4
  • Interstitial Lung Disease refers to a large group of lung disorders that cause inflammation or scarring in the lung tissue. (stanford.edu)
  • This usually takes the form of Interstitial Lung Disease (ILD), but Obstructive Lung Disease (OLD) and Pulmonary Artery Hypertension (PAH) can also occur. (biomedcentral.com)
  • The main clinical presentation is Interstitial Lung Disease (ILD), characterized by an involvement of the lung interstitium with inflammatory cells and/or exaggerated deposition of extracellular matrix by myofibroblasts. (biomedcentral.com)
  • Precapillary PH was found in 64 patients (5%), of whom 42 had pulmonary arterial hypertension (PAH) and 22 had PH secondary to interstitial lung disease (ILD). (jrheum.org)
Computed tomography4
  • Lung volumes derived from computed tomography (CT) scans can include estimates of abnormal lung tissue volumes, in addition to normal lung tissue volumes and the volume of gas within the lungs. (ersjournals.com)
  • 2007) Assessing Respiration-Induced Tumor Motion and Internal Target Volume Using Four-Dimensional Computed Tomography for Radiotherapy of Lung Cancer. (scirp.org)
  • Objective: To evaluate the use of inflation-fixed lung tissue for emphysema quantification with computed tomography (CT) and 3He magnetic resonance (MR) diffusion imaging. (monash.edu)
  • The study aimed to evaluate the diaphragm morphology (height and thickness) in single-lung transplantation (SLTx), using computed tomography (CT), by assessing the evolution of the hemidiaphragm of the transplanted and the native side. (frontiersin.org)
Impaired lung function2
  • Several SNPs in the SUMF1 gene are shown to be associated with COPD and impaired lung function. (lu.se)
  • Patients experienced frequent exacerbations (annualized exacerbation rate [AER]: 4.10, severe AER: 0.98), with impaired lung function and poor asthma control (median ACT score: 14) despite 25.3% reported oral corticosteroid (OCS) use. (biomedcentral.com)
Liver7
  • Reduction in normal tissue dose was evaluated in the new plan by using the parameters V5, V10, and V20 in the cumulative dose-volume histogram for the following structures: total lung minus GTV (gross target volume), heart, esophagus, spinal cord, liver, parotids, and brainstem. (tmc.edu)
  • An interventional radiologist may perform a pressure measurement study to evaluate the level of pressure in the hepatic (liver) vein. (hopkinsmedicine.org)
  • This is often because the liver tissue is scarred and blood cannot flow through normally. (hopkinsmedicine.org)
  • These have proved extremely useful in improving diagnostic outcomes, delivering reliable performance in everyday clinical routine - increasing reader confidence and shortening evaluation time.1-3 However, these automated tools do not cover the evaluation of lymph nodes and liver nodules, for example, which together with the evaluation of lung lesions are the bread and butter imaging of clinical routine. (diagnosticimaging.com)
  • syngo® CT Oncology* is a new software, which offers automated workflows for the 3D evaluation and follow-up of tumors in the liver and in the lung, incorporating lung CAD. (diagnosticimaging.com)
  • Liver, lung and kidney tissues from trapped small mammals were sampled in accordance with the recommended conditions of biosafety and bioethics. (who.int)
  • of the liver, the kidney, and the lung (8). (lu.se)
Extravascular lung water2
Ventilator-induced lung2
  • The authors elaborate on the fact that rapid changes of ventilatory variables in time, meaning a high strain rate, lower the threshold for stress injury and ventilator-induced lung damage, especially in heterogeneous lungs. (ventinovamedical.com)
  • Providing alveolar stabilization with HFOV while avoiding harmful distending pressures and pulmonary overdistension might be a key in the context of ventilator-induced lung injury. (biomedcentral.com)
Airways8
  • The tissue resembles a sponge, he noted, with the smallest airways merely the width of two layers of cells. (asme.org)
  • It involves inserting a thin, flexible tube into the airways to examine the lungs and collect tissue samples for analysis. (marham.pk)
  • Inflating mouse lungs to a given pressure followed by connection of animal's airways to a negative pressure reservoir allows to trigger a forced expiratory maneuver and thus to measure FEV0.1 (forced expiratory volume in the first 0.1 s), FVC (forced vital capacity), and the surrogate of the human FEV1/FVC ratio, so-called FEV0.1/FVC ratio [ 6 ]. (biomedcentral.com)
  • Single frequency Forced Oscillation Technique (FOT) measurements fitted to single compartment model allow to only measure resistance (Rrs) and compliance (Crs) of the respiratory system, whereas broadband FOT measurements fitted to constant phase model distinguish airway and tissue mechanics by quantifying tissue damping (G), tissue elastance (H) and the resistance of the central airways (Rn) [ 7 ]. (biomedcentral.com)
  • The toxins present in cigarette smoke can cause inflammation and damage to the airways and lung tissue. (dollarsforhomework.com)
  • As a result, the airways become obstructed, making it harder for air to flow in and out of the lungs. (dollarsforhomework.com)
  • The voice box (larynx), windpipe (trachea), or airways of the lungs can be affected, resulting in hoarseness, a nonproductive cough, shortness of breath, and tenderness over the Adam's apple. (msdmanuals.com)
  • Multi-walled carbon nanotubes in conducting airways of the mouse lung after inhalation exposure. (cdc.gov)
Airway3
  • The continuous distending pressure (CDP) during HFOV con was set at mean airway pressure plus 5 cmH 2 O. For HFOV P Lmean it was set at mean P L plus 5 cmH 2 O. Baseline measurements were obtained before and after induction of ARDS under volume controlled ventilation with PEEP 5. (biomedcentral.com)
  • However, it also can arise from tissue viscoelasticity, upper airway shunt, and recently a novel mechanism due to time-variation in mechanical properties, but potential sources of this time variation such as from the nonlinear mechanical properties have not been investigated. (dal.ca)
  • Pulmonary Artery Hypertension (PAH, a potentially lethal condition characterized by high blood pressure in lung arteries) and Obstructive Lung Diseases (OLDs, an airway obstruction with airflow limitation) can also occur. (biomedcentral.com)
Function and diagnose respiratory2
  • There are several diagnostic methods that a pulmonologist may use to evaluate a patient's lung function and diagnose respiratory problems. (marham.pk)
  • Spirometry is a common diagnostic test used to assess lung function and diagnose respiratory conditions. (dollarsforhomework.com)
Ventilation7
  • In the end, EIT-based monitoring of respiratory ventilation and lung perfusion could reveal local ventilation and perfusion matching which may be useful in the treatment of patients suffering from acute respiratory distress syndrome (ARDS). (answerdiaries.co.uk)
  • Electric impedance tomography (EIT) is one of the radiation-free functional imaging modality that permits non-invasive monitoring at bedside of both regional lung ventilation , and possibly perfusion. (answerdiaries.co.uk)
  • Consequently, gradual increases of tidal volumes that may be applied during individualization of FCV are directly related to individual dynamic compliance and reflect ventilation of the available aerated lung tissue, and simultaneously decrease the risk of atelectasis and/or overdistension. (ventinovamedical.com)
  • High frequency oscillatory ventilation (HFOV) is another approach to lung-protective ventilation, since it employs very low tidal volumes and very small changes in delta pressure [ 3 ] applied with higher continuous distending pressure (CDP). (biomedcentral.com)
  • We also investigated if time-varying properties from ventilation or oscillometry due to the nonlinear pressure-volume relationship can also predict () and if it is increased in patients with lung transplants including patients with chronic lung allograft dysfunction. (dal.ca)
  • CONCLUSIONS: Nonlinearity in lung tissue or the pressure-volume curve during stretch or ventilation respectively, leads to time variations in mechanical properties that cause increases in low-frequency resistance and thus () larger than observed from tissue viscoelastic properties alone. (dal.ca)
  • While pressure-volume nonlinearity can strongly affect () determined during mechanical ventilation, measurements by oscillometry are likely not susceptible, although we did not model other sources of time variation such as flow limitation. (dal.ca)
Normal tissues2
  • Nanoparticle s scatter light with high efficiency while normal tissues do not. (cdc.gov)
  • The enzyme is widely distributed in normal tissues with the exception of the skin and lungs, both targets of bleomycin toxicity. (nih.gov)
Tumors3
  • The Air-Bag System is expected to be provided an effective reduction in the motion of lung tumors. (scirp.org)
  • 1999) Deep Inspiration Breath-Hold Technique for Lung Tumors: The Potential Value of Target Immobilization and Reduced Lung Density in Dose Escalation. (scirp.org)
  • Breast metastatic tumors in lung can be substituted by lung-derived malignant cells transformed by alternative splicing H19 lncRNA. (medscape.com)
Adipose tissue2
  • Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
  • But also because adipose tissue (AT) is, by far, the most varying compartment-between individuals, but also within an individual over time. (highwire.org)
Connective Tissue D3
  • Connective Tissue Diseases (CTDs) are systemic autoimmune conditions characterized by frequent lung involvement. (biomedcentral.com)
  • Connective Tissue Diseases (CTDs) are often characterized by pulmonary involvement. (biomedcentral.com)
  • Pulmonary venoocclusive disease is also a recognized cause of PH, which is thought to be more common in connective tissue diseases 9 . (jrheum.org)
Alveoli3
  • The term "interstitial" refers to the area that surrounds the airsacs (alveoli) of the lung. (stanford.edu)
  • The interstitial space around the alveoli can become inflamed, thickened or scarred because of a variety of insults or reactions in the lungs. (stanford.edu)
  • The interstitium refers to the tissue area in and around the wall of the airsacs (alveoli) of the lung area where oxygen moves from the alveoli into the capillary network (small blood vessels) that covers the lung like a thin sheet of blood. (stanford.edu)
Diseases7
  • It provokes cell of the angiotensinogen and hospital of the 2+ measurement diseases. (siriuspixels.com)
  • A pulmonologist is a medical doctor specializing in diagnosing and treating respiratory diseases and conditions affecting the lungs and respiratory system. (marham.pk)
  • However, monitoring lung function in mice, as above described, requires a tracheostomy, a procedure that has hampered longitudinal studies in animal models of chronic respiratory diseases. (biomedcentral.com)
  • By measuring how much air you exhale, and how quickly you exhale, spirometry can evaluate a broad range of lung diseases. (medlineplus.gov)
  • Some lung diseases (such as emphysema, asthma, chronic bronchitis, and infections) can make the lungs contain too much air and take longer to empty. (medlineplus.gov)
  • These lung diseases are called obstructive lung disorders. (medlineplus.gov)
  • Other lung diseases make the lungs scarred and smaller so that they contain too little air and are poor at transferring oxygen into the blood. (medlineplus.gov)
Chronic Obstruc2
  • Chronic obstructive lung disease (COPD) is a common and disabling lung disease for which there are few therapeutic options. (nih.gov)
  • Forty-eight human lung samples were obtained from tissue resected from five nonsmokers, 21 GOLD (Global Initiative for Chronic Obstructive Lung Disease) stage 0, 9 GOLD stage 1, 10 GOLD stage 2, and 3 GOLD stage 3 patients. (nih.gov)
Organs6
  • EDM has the potential to identify the critical target sites for nanoparticle deposition and injury in the lungs and other organs. (cdc.gov)
  • Replacement with a healthy lung can promote the recovery of the diaphragm to its anatomical morphology, reinforcing the close relationship between these two organs. (frontiersin.org)
  • However, the effects of radiation on the tumor and on organs at risk (OARs) are also influenced by the applied dose and volume of irradiated tissues. (maastrichtuniversity.nl)
  • Many autoimmune disorders affect connective tissue and a variety of organs. (msdmanuals.com)
  • characterized by episodes of painful, destructive inflammation of the cartilage and other connective tissues in many organs. (msdmanuals.com)
  • Also, they can clump together or agglomerate, which can affect their potential for settling in the lungs if inhaled, their ability to penetrate the body's membranes and consequently move from the lungs to other organs, and their interaction with cells and tissue. (cdc.gov)
Parameters8
  • The variation in normal tissue dose reduction was not predictable, and we found no clear parameters that indicated which patients would benefit most from jaw tracking. (tmc.edu)
  • severe AER: − 96.9%), improved respiratory parameters (median increase in pre-bronchodilator forced expiratory volume [pre-BD FEV1]: + 400 mL) and asthma control (median ACT score: 23) while eliminating OCS in 60% patients. (biomedcentral.com)
  • This subset of lung function parameters in orotracheally intubated mice is reliable, thereby allowing relevant longitudinal studies. (biomedcentral.com)
  • For instance, parameters derived from the forced expiratory maneuvers, such as the forced expiratory volume in the first second (FEV1) to the forced vital capacity (FVC) ratio are widely used to characterize functional obstruction [ 1 ]. (biomedcentral.com)
  • PiCCO allows for minimally invasive measurement of hemodynamic parameters like cardiac output, and its determinants: Preload, Afterload, and Contractility. (getinge.com)
  • When performing spirometry, several parameters are measured, including forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and the ratio of FEV1 to FVC. (dollarsforhomework.com)
  • The software facilitates 3D lesion segmentation and delivers standard lesion parameters: RECIST, WHO and volume (Fig. 1). (diagnosticimaging.com)
  • measurements available to infer the value of the parameters available. (lu.se)
Cancer14
  • Lung Cancer, 56, 56-67. (scirp.org)
  • The aim of this study was to evaluate the accuracy of 3-dimensional PET/ CT image coregistration of pulmonary lesions in patients with non-small cell lung cancer (NSCLC). (snmjournals.org)
  • shop molecular biology of the lung volume ii asthma and cancer: including to make with count or muscle abdominal to the failure. (siriuspixels.com)
  • shop molecular biology of the lung volume ii asthma and cancer species: therapeutic stores, not libraries, which produce physiological in the tags, course, or head of the Multivariate patient anatomy. (siriuspixels.com)
  • Translational Lung Cancer Research , 6 (6), 661-669. (maastrichtuniversity.nl)
  • Studying the association between longitudinal mammographic density measurements and breast cancer risk: a joint modelling approach. (medscape.com)
  • Correction: Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy. (medscape.com)
  • The AATS recommends annual screening with LDCT from age 55 to 79 years in persons with a 30 pack-year history of smoking, with the option of starting screening at age 50 years in persons with a 20 pack-year history who have an additional cumulative risk of developing lung cancer of 5% or greater over the following 5 years. (medscape.com)
  • Additionally, the AATS recommends annual screening to detect second primary lung cancer in long-term cancer survivors aged 55 to 79 years. (medscape.com)
  • The NCCN advises that patients are not eligible for lung cancer screening if they have symptoms of lung cancer, a past history of lung cancer, or functional status and/or comorbidity that would prohibit curative intent treatment. (medscape.com)
  • None of the guidelines recommend using chest radiography or sputum cytology to screen asymptomatic patients for lung cancer. (medscape.com)
  • CHEST updated its comprehensive set of lung cancer guidelines in 2013. (medscape.com)
  • The guideline set of more than 275 recommendations includes an executive summary of current recommendations for diagnosis and treatment, along with additional recommendations for screening, chemoprevention and treatment of tobacco use in patients with lung cancer. (medscape.com)
  • We previously reported a positive association between serum perfluorooctanoate (PFOA) concentrations and risk of renal cell carcinoma (RCC) within the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, comprising predominantly White individuals enrolled in 1993-2001. (cdc.gov)
Emphysema1
  • Conclusions: Concordance of CTand 3He MR imaging measurements in unfixed and inflation-fixed lungs supports the use of inflation-fixed lungs for quantitative imaging studies in emphysema. (monash.edu)
Patients with lung1
  • The purpose of this study was to evaluate the accuracy of image coregistration of PET and CT (PET/CT) images in patients with lung lesions and the influence of the breathing protocol during CT. (snmjournals.org)
Hysteresis1
Alveolar volume1
  • Other SNPs (rs4685744, rs2819562, rs2819561 and rs11915920) were instead associated with impaired lung volumes and exhibited a lower FVC, total lung capacity and alveolar volume, in individuals having the variance allele. (lu.se)
Underwent2
  • Methods: Fourteen subjects representing a range of chronic obstructive pulmonary disease severity who underwent complete or lobar lung resection were studied. (monash.edu)
  • Patients who underwent single lung transplantation in our center (Marseille, France) between January 2009 and January 2022 were retrospectively included. (frontiersin.org)
Inflammation5
  • Lung injury, inflammation, and cytokine alteration were determined. (bvsalud.org)
  • In vivo lung damage, inflammation and alteration in cytokines were observed 1 day post exposure and this response resolved by day 7. (bvsalud.org)
  • This inflammation and scarring also makes the lung a bit stiffer which can increase the 'work' of breathing and make you feel more breathless than normal, especially with exertion such as walking up stairs. (stanford.edu)
  • The decreased lung function observed in smokers can be attributed to both the chronic inflammation caused by smoking and the development of conditions like COPD. (dollarsforhomework.com)
  • Sepsis is a clinical syndrome that complicates severe infection and is characterized by systemic inflammation and widespread tissue injury. (medscape.com)
Patient's2
  • That could change soon with the development of a computational lung model that can map a patient's unique tissue, identify damaged areas, and calculate strains placed on the lung microlevel tissues by different ventilator settings. (asme.org)
  • Using artificial intelligence and a CT scan of a patient's lungs, the model is a digital tool that can map an individual's lungs. (asme.org)
Evaluate6
  • Lung transplantation (LTx), by replacing a diseased lung with a healthy one, is an interesting model to evaluate the evolution of the diaphragmatic morphology before and after transplantation in the context of lung disease. (frontiersin.org)
  • To evaluate normal tissue dose reduction in step-and-shoot intensity-modulated radiation therapy (IMRT) on the Varian 2100 platform by tracking the multileaf collimator (MLC) apertures with the accelerator jaws. (tmc.edu)
  • The use of a contrast agent, such as saline, could be necessary to evaluate the regional perfusion of the lungs. (answerdiaries.co.uk)
  • These tests evaluate lung function and measure how much air a person can inhale and exhale. (marham.pk)
  • Chest X-rays, CT scans, and MRI scans to diagnose lung conditions and evaluate the severity of respiratory problems. (marham.pk)
  • These tests measure the blood's oxygen and carbon dioxide levels, which can help evaluate how well the lungs work. (marham.pk)
Tumor Volume1
  • Gross tumor volume (GTV) was 8.1 ± 11.0 cc (range 0.3 - 77.5 cc). (scirp.org)
European Respiratory Society1
  • The present document integrates and consolidates the recommendations of the current American Thoracic Society (ATS)/European Respiratory Society Task Force on pulmonary function standards, and the recommendations from an earlier National Heart, Lung, and Blood Institute (NHLBI) workshop convened by the ATS. (ersjournals.com)
Density2
  • EDM determined nanoparticle volume density was directly proportional to total lung burden of exposed animals. (cdc.gov)
  • Lung density, total lung volume, and normally and poorly aerated lung areas were significantly greater during HFOV con , while there was less over-aerated lung tissue in HFOV P Lmean . (biomedcentral.com)
Severe3
  • Mortality rates for patients with Acute Respiratory Distress Syndrome placed on ventilators for a week or more can reach 40 percent to 50 percent because the pressure causes severe damage to the lungs. (asme.org)
  • Besides, beyond a certain point, severe lung function loss can no longer be compensated. (oncodesign-services.com)
  • Lung involvement is often severe, representing the first cause of death in CTD. (biomedcentral.com)
Methods2
  • Methods HRCT, echocardiography and lung function assessments were made in 35 adults, 20 of whom had previously been assessed a median of 6.6 years prior to this study. (bmj.com)
  • and (2) various measurement methods, with or without RHC, considered the "gold standard" in the diagnostic confirmation of precapillary PH. (jrheum.org)
Tomographic1
  • Computed tomographic measurements of lung attenuation and MR measurements of the hyperpolarized 3He apparent diffusion coefficient (ADC) in resected specimens fixed in inflation with heated formalin vapor were compared with measurements obtained before fixation. (monash.edu)
Therapeutic2
  • The results provide evidence that genes involved in tissue remodeling and repair are differentially regulated in the lungs of obstructed smokers and suggest that they are potential therapeutic targets. (nih.gov)
  • Unclear volume status and therapeutic conflicts, makes it harder to implement an appropriate therapy strategy: Volume expansion? (getinge.com)
Conclusions1
  • Conclusions Abnormalities in pulmonary vascular volumes may explain some of the lung function abnormalities and the decline in lung function seen in adults with SCD. (bmj.com)
Autoimmune2
  • Currently, Pulmonary Function Tests (PFTs) in clinical practice appear to be confined to the follow up of autoimmune patients in which an established lung involvement is known. (biomedcentral.com)
  • Overview of Autoimmune Disorders of Connective Tissue In an autoimmune disorder, antibodies or cells produced by the body attack the body's own tissues. (msdmanuals.com)
COPD3
  • We reasoned that gene expression profiling of COPD lungs could reveal previously unidentified disease pathways. (nih.gov)
  • Sulfatase modifying factor (SUMF1) is a key modifier in connective tissue remodelling, and we have shown previously that several SNPs in SUMF1 are associated with COPD. (lu.se)
  • These genetic variants of SUMF1 may cause a deficient sulfation balance in the extracellular matrix of the lung tissue, thereby contributing to the development of COPD. (lu.se)
Tidal volumes1
  • The animals were initially ventilated in volume-controlled mode with low tidal volumes (6 ml kg − 1 ) at three positive end-expiratory pressure (PEEP) levels (5, 10, 20 cmH 2 O) followed by HFOV con and then HFOV P Lmean each at PEEP 10 and 20. (biomedcentral.com)
Chest3
  • In contrast, lung volumes derived from conventional chest radiographs are usually based on the volumes within the outlines of the thoracic cage, and include the volume of tissue (normal and abnormal), as well as the lung gas volume. (ersjournals.com)
  • However, patients can remain asymptomatic for lung time despite evidence of lung involvement already being present ("Velcro" crackles in auscultation, impaired PFTs or evidence of lung involvement in chest imaging ) [ 2 , 3 ]. (biomedcentral.com)
  • Abnormal results usually mean that you may have chest or lung disease. (medlineplus.gov)
Total lung cap3
Perfusion4
  • Electrical Impedance Tomography (EIT) is an instrument used to monitor the bed that can be used to visualize the local airflow and , possibly, lung perfusion distribution. (answerdiaries.co.uk)
  • Recent studies assessed EIT as a means to measure regional lung perfusion. (answerdiaries.co.uk)
  • Sufficient organ perfusion and optimal tissue oxygenation are of great importance. (getinge.com)
  • Extended-wavelength diffuse reflectance spectroscopy for a comprehensive view of blood perfusion and tissue response in human forearm skin. (lu.se)
Attenuation1
  • The CT-measured amount of soft tissue of the nodules was calculated as follows: soft tissue amount = volume x (1 + mean attenuation value / 1,000). (nih.gov)
Parenchyma1
  • This can result in narrowing of the bronchioles, increased mucus production, and the destruction of lung parenchyma. (dollarsforhomework.com)
Soft tissue5
  • To devise a new method to measure the amount of soft tissue in pulmonary ground-glass opacity nodules, and to compare the use of this method with a previous volumetric measurement method by use of a phantom study. (nih.gov)
  • The reference-standard amount of soft tissue in the nodules was obtained by dividing the weight by the specific gravity. (nih.gov)
  • The relative percentage error (RPE) between the CT-measured amount of the soft tissue and the reference-standard amount of the soft tissue was also measured. (nih.gov)
  • The amount of soft tissue measured by the use of CT reflects the reference-standard amount of soft tissue in the ground-glass opacity nodules much more accurately than does the use of the CT-measured volume. (nih.gov)
  • A great time saver is the ability to switch between lung and soft tissue windows, for example, which means that lung nodules (Figs. 1 and 2) can be easily evaluated at the same time, without loading a new data set. (diagnosticimaging.com)
Oxygen2
  • This involves evaluating lung function and oxygen levels during physical activity, which can help diagnose exercise-induced asthma or other respiratory conditions. (marham.pk)
  • This test allows the health care provider to estimate how well the lungs move oxygen from the air into the bloodstream. (medlineplus.gov)
Expiratory4
  • The expiratory reserve volume (ERV) is the volume of gas that can be maximally exhaled from the end-expiratory level during tidal breathing ( i.e. from the FRC). (ersjournals.com)
  • Gene expression was related to forced expiratory flow between 25 and 75% of forced expiratory volume (FEF(25-75%) % predicted) revealing a signature gene set of 203 transcripts. (nih.gov)
  • Research is currently focused on its clinical applications to measure lung collapse TIDAL recruitment, as well as lung overdistension, in order to determine positive end-expiratory pressure (PEEP) and the volume of tidal. (answerdiaries.co.uk)
  • In mice, it is usually performed using forced oscillation technique (FOT), negative pressure-driven forced expiratory (NPFE) and pressure-volume (PV) curve maneuvers. (biomedcentral.com)
Nodules1
  • Phantom nodules were prepared with material from fixed normal swine lung. (nih.gov)
Significantly4
  • After a SLTx, diaphragmatic morphology significantly changed on the transplanted lung, while remaining altered on the native lung. (frontiersin.org)
  • Our TPS model of MLC transmission agreed with measurements with absolute transmission differences of less than 0.1 % and thus uncertainties in the model did not contribute significantly to the uncertainty in the dose determination. (tmc.edu)
  • Cardiac output, stroke volume, mean arterial pressure and intrathoracic blood volume index were significantly higher during HFOV P Lmean than during HFOV con at PEEP 20. (biomedcentral.com)
  • In summary, smoking can significantly impact spirometry test results by causing airflow limitation, reduced lung function, and increased bronchial hyperresponsiveness. (dollarsforhomework.com)
Obstructive1
  • Obstructive proliferative vasculopathy of the small and medium-size pulmonary arterial circulation and chronic hypoxemia due to advanced lung disease are major causes of precapillary PH in SSc 7 , 8 . (jrheum.org)
Transplantation2
Airflow limitation1
Pulmonary compliance1
  • Lung compliance, or pulmonary compliance, is a measure of the lung's ability to stretch and expand (distensibility of elastic tissue). (wikipedia.org)
Severity2
  • Inspired and expired lung volumes measured by spirometry are useful for detecting, characterising and quantifying the severity of lung disease. (ersjournals.com)
  • The role of lung volume measurements in the assessment of disease severity, functional disability, course of disease and response to treatment remains to be determined in infants, as well as in children and adults. (ersjournals.com)
Disorders1
Oscillometry1
  • LCO) measurement and impulse oscillometry. (lu.se)
Radiotherapy1
  • 2001) The Effectiveness of an Immobilization Device in Conformal Radiotherapy for Lung Tumor: Reduction of Respiratory Tumor Movement and Evaluation of the Daily Setup Accuracy. (scirp.org)
Individual lung2
  • The eventual goal is to provide an individual lung model for each patient on a ventilator and optimize its use, he said. (asme.org)
  • Furthermore, the authors note that the direct intratracheal pressure measurements allow a much more precise analysis of individual lung mechanics than conventional strategies. (ventinovamedical.com)
Clinical practice1
  • In clinical practice it is separated into two different measurements, static compliance and dynamic compliance. (wikipedia.org)
Diagnosis of lung1
  • In view of this, PFTs can also represent a useful, inexpensive and safe tool for the diagnosis of lung disease in CTDs and its management in the early stages, in which the disease could be more responsive to treatment. (biomedcentral.com)
Diffusion capacity1