AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
HydroxyprolineCollagenProlineHydroxylysineProcollagen-Proline DioxygenasePulmonary FibrosisBleomycinOsteitis DeformansUronic AcidsLiver Cirrhosis, ExperimentalReproducibility of ResultsPlant Somatic Embryogenesis TechniquesMicrobial CollagenaseAscorbic Acid DeficiencyAmino AcidsTime FactorsLungOxalatesBone and BonesProcollagenDesmosineWound HealingCollagen Type IIIPeplomycinCollagen Type IHydroxylationGlycolatesGalactansCarbon TetrachlorideAlkaline PhosphataseFibrosisBone ResorptionDisease Models, AnimalAnastomosis, SurgicalReference ValuesLiver CirrhosisPhosphorusRats, WistarAmino Acid Metabolism, Inborn ErrorsGlycosaminoglycansSkinOrgan SizeArabinoseProline OxidaseMusaCalcitoninCalciumMethodsCreatinineCattleHyperoxaluriaPeptidesChromatography, High Pressure LiquidKineticsCarbon Tetrachloride PoisoningSensitivity and SpecificityFibroblasts
CollagenSerum hydroxyprolineUrinary hydroxyprolineAssayELISAIncreasesIntakeAssessmentContentProteinChemicalCommonLevelsConvertWaterResultsAbilityNormalSkinTestModelUnitBloodUrinarySerumProlineUrinePeptidesCollagen breakdownTissueBoneMarkersDeterminationLungExtracellularUnsaturated fattTemperatureSensitivityDifferentialTotalMethodMarkerStabilityDiagnosisResultsParametersSpecificAnalysisFunctionConditionNormalPotentialValues
Collagen14
  • A component of bone collagen, hydroxyproline is released into the serum during degradation of bone, reaching the urine in free and bound forms. (medscape.com)
  • As a major part of collagen, hydroxyproline has an essential role in collagen stability. (medscape.com)
  • Two isomeric forms of hydroxyproline have been identified in collagenTrans-4-hydroxy-L-proline is found in type I and type III collagen, whereas higher amounts of trans-3-hydroxy-L-proline are found in type IV collagen. (medscape.com)
  • Therefore, without hydroxyproline, no functional collagen fibers appear in the extracellular space. (medscape.com)
  • The ratio of hydroxyproline/creatinine in a fresh specimen of early morning urine, considered the total urinary hydroxyproline, is the best index of collagen breakdown in metastatic bone disease. (medscape.com)
  • Spot urine testing is measurement of choice in screening for bony involvement by malignancy because collagen intake does not influence hydroxyproline/creatinine. (medscape.com)
  • Afterward, the efficacy of decellularization procedure was evaluated using multiple approaches including assessment of DNA, hydroxyproline, and GAG content as well as Masson's trichrome and orcein staining used for collagen and elastin determination. (biomedcentral.com)
  • a study of collagen metabolism in cell cultures by fluorometric determination of proline and hydroxyproline. (liverpool.ac.uk)
  • a technique of derivatization of proline (pro) and 4-hydroxyproline (hyp) by 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole permitted the measurement of pro and hyp radioactivities, concentrations, and specific activities in the main fractions separated from cultures of fibroblast cells (extracellular collagen and non-collagen proteins, intracellular free pro and hyp, pro- and hyp-containing peptides, procollagen, and non-collagen proteins). (liverpool.ac.uk)
  • Background/Purpose: Many studies have been undertaken to prevent anastomosis leakage of the colon, and several methods have been used to assess anastomosis healing, such as measurement of bursting pressure or hydroxyproline (a marker of collagen) content at the anastomosis site. (korea.ac.kr)
  • On the 7th postoperative day, SD-PS-OCT images were acquired, a histopathologic exam was performed, and hydroxyproline levels as well as mRNA expressions of collagen-1 and collagen-3 were measured at the anastomosis site. (korea.ac.kr)
  • The measurement of collagen content by SD-PS-OCT was found to provide a good means of assessing anastomosis healing, because it allows in situ assessment of collagen contents at baseline and during the postoperative period. (korea.ac.kr)
  • 8 h following single oral doses of the compounds was associated with significant losses of radiolabelled proline and 4-hydroxyproline from collagen during this period. (embl.de)
  • Glycine, proline, alanine and hydroxyproline are the main constituents of collagen and prevent skin ageing. (absolutecollagen.com)
Serum hydroxyproline3
Urinary hydroxyproline4
Assay1
  • To determine this, scientists ran several experimental procedures, including a hydroxyproline assay, impedance measurements, water loss from the epidermis and scanning electron microscopy to analyze the rigidity and dryness of the skin. (wikipedia.org)
ELISA1
  • A sandwich ELISA for quantitative measurement of Canine Interferon alpha in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (gentaur.pl)
Increases1
Intake1
  • the reported rates depend on age, sex, iodine intake, sensitivity of measurements, and definition used (Biondi et al. (nationalacademies.org)
Assessment1
  • [ 9 ] Moreover, hydroxyproline level measurements may permit illness monitoring and assessment of treatment response in such settings. (medscape.com)
Content2
Protein1
  • directly, shop between data from the Joint measurements is referred by following advances of transverse, pristine, protein. (scoutconnection.com)
Chemical1
  • Chemical measurements tested the ability of the recirculating system to increase the clearance of selected solutes. (stanford.edu)
Common2
Levels1
  • Organ coefficients, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), hexadecenoic acid (HA), laminin (LN), procollagen type III (PCIII), hydroxyproline (Hyp), glutathione (GSH‑Px), malondialdehyde (MDA), superoxide dismutase (SOD) and transforming growth factor β1 (TGF‑β1) levels were measured in rats with hepatic fibrosis. (spandidos-publications.com)
Convert2
  • sl/tsp to gr/in³ conversion table , sl/tsp to gr/in³ unit converter or convert between all units of density measurement. (aqua-calc.com)
  • The resulting data, in the form of a calibration curve , is now used to convert a given measurement of radiocarbon in a sample into an estimate of the sample's calendar age. (wikizero.com)
Water1
  • results for inanimate objects agree within 1 percent with comparable measurements by water displacement. (liverpool.ac.uk)
Results1
  • The results were then measured - skin hydration measurements were taken with a Corneometer ® CM 825 device. (absolutecollagen.com)
Ability1
  • For online der eisenbau grundlagen der konstruktion feste, they are the trait2 ability of repeated measurements over expression and independent textbook may comply Furthermore site-specific in multidimensional proteins. (naturheilpraxis-gisbert-fussek.de)
Normal1
  • All measurements are in micromoles per liter (µmol/L). Normal values may vary between different laboratories. (medlineplus.gov)
Skin1
  • To measure the anti-ageing effects, polymer silicone skin prints were taken from the studied area before and at each time of measurement then studied using the Skin Image Analyser® or 3D roughness analyser. (absolutecollagen.com)
Test2
  • There was significant reduction in the wound area measurement of the test group as compared to that of controls. (manipal.edu)
  • Some laboratories use different measurements or may test different specimens. (medlineplus.gov)
Model2
  • We performed centronucleation, Evans blue dye, hydroxyproline, and treadmill assays on the disease model mice versus NRG controls to evaluate muscle histology and function. (plos.org)
  • Both iterations show quick online der eisenbau grundlagen der konstruktion to be the measurements by contacting the model of beads in the colony enzyme but proves scFv-Fc of asymmetric algorithms. (naturheilpraxis-gisbert-fussek.de)
Unit1
  • A square meter per hour (m²/h) is a derived metric SI (System International) measurement unit of kinematic viscosity . (aqua-calc.com)
Blood1
  • Health Care settings: The female abnormalities of pumping Branches extruded to the disorder of growth blood, concerning the atoms of PVD, disorders, and measurements. (ajw-service.de)
Urinary8
Serum9
  • Testing hydroxyproline in the serum and in the urine is common. (medscape.com)
  • Hydroxyproline can be tested in the serum and in the urine. (medscape.com)
  • This measurement is preferable to free serum hydroxyproline measurement in this setting. (medscape.com)
  • Measurement of serum alkaline phosphatase-in some cases, bone-specific alkaline phosphatase (BSAP)-can be useful in the diagnosis of Paget disease. (medscape.com)
  • 8. Derivatization-based magnetic dummy molecularly imprinted polymers integrated with 4-plex stable isotope labeling derivatization strategy for specific and rapid determination of L-hydroxyproline in human serum. (nih.gov)
  • A component of bone collagen, hydroxyproline is released into the serum during degradation of bone, reaching the urine in free and bound forms. (medscape.com)
  • However, because it is derived from the degradation of newly synthesized collagens, from collagens of nonbone tissues, and from diet, serum hydroxyproline is now considered to be a nonspecific marker of bone turnover. (medscape.com)
  • In addition, Triangulum Biopharma also conducts comprehensive clinical chemistry for the plasma/serum bio-markers, hematocrit, plasma erythropoietin, ferritin measurements, cytokine analysis, biochemical and ELISA assays, gene expression analysis by qPCR, renal hydroxyproline assays and comprehensive histopathology evaluation. (triangulumbiopharma.com)
  • Ahmann F. R., Schifman R. B. Prospective comparison between serum monoclonal prostate specific antigen and acid phosphatase measurements in metastatic prostatic cancer//J. Urol. (medchitalka.ru)
Proline1
  • Collagen model peptides (CMPs), composed of proline-(2S,4R)-hydroxyproline-glycine (POG) repeat units, have been extensively used to study the structure and stability of triple-helical collagen─the dominant structural protein in mammals─at the molecular level. (nih.gov)
Urine3
  • Spot urine testing is measurement of choice in screening for bony involvement by malignancy because collagen intake does not influence hydroxyproline/creatinine. (medscape.com)
  • Unhydrolyzed prolyl hydroxyproline (Pro-Hyp) and total 4-hydroxyproline (Hyp) in urine have been suggested as disease biomarkers for bone turnover and osteoporosis. (wichita.edu)
  • The measurement of the 3-OH pyridinium compounds, pyridinoline (Pyr) and deoxypyridinoline (Dpyr), in urine by high performance liquid chromatography is potentially useful in clinical studies, since they are specific biochemical markers of bone resorption. (ox.ac.uk)
Peptides2
  • A study of vertebrate and invertebrate species by Taga et al indicated that 4-hydroxyproline in the Yaa position of collagen peptides is the dominant contributor to collagen's thermal stability, particularly in vertebrates. (medscape.com)
  • 93 Alkaloid work 93 Kallikrein-kallidinogen-kallidin system 93 Informal collaborative research 93 Laboratory of clinical biochemistry 94 Am ine biogenesis and metabolism 94 Collagen and hydroxyproline 95 Proteins and peptides 95 Amino acid uptake by animal tissues 96 Biosynthesis of phospholipids and other lipids- 97 Vitamin B 12 97 Development of analytical procedures 98 Section on biochemical genetics 98 RNA and genetic code 98 Cell-free assay for messenger RNA. (nih.gov)
Collagen breakdown1
Tissue3
  • This analysis included bronchoalveolar lavage (BAL) for cell and fluid analysis, and tissue for pathology, immunohistology, mRNA, and hydroxyproline. (nih.gov)
  • exposed KKAy lungs was confirmed with immunohistochemistry, tissue hydroxyproline content, and tissue mRNA expression of fibrosis-associated genes ( Ccl11 , Il13 , and Mmp12 ). (nih.gov)
  • We classify the Raman spectral measurements of the tissue samples with an unsupervised clustering method, k-means and compare their chemical properties. (nature.com)
Bone2
Markers1
  • thus, these measurements are potential markers of skeletal metastatic disease and may be recommended in settings where advanced imaging modalities are not readily available. (medscape.com)
Determination1
  • 1. Enzyme-free impedimetric biosensor-based molecularly imprinted polymer for selective determination of L-hydroxyproline. (nih.gov)
Lung3
  • Lung coefficient and the levels of hydroxyproline (HYP) in lung tissues were measured at the same time. (biomedcentral.com)
  • Lung function decrements were determined by intubation of anesthetized rats and measurements of pulmonary function parameters such as flow, volume, transpulmonary pressures, and ventilatory performance. (cdc.gov)
  • The Minusil group had significantly greater average lung weight and hydroxyproline content than the slag treated groups. (cdc.gov)
Extracellular1
Unsaturated fatt2
  • Even though we were able to highlight some metabolites, e.g. , hydroxyproline, galactinol, and unsaturated fatty acid, explaining specific differential physiological (MI) responses in peanut seedlings, overall our data suggested general stress responses rather than adaptive mechanisms to heat. (peanutscience.com)
  • The genotype SPT 06-07 exhibited lower MI, increased galactinol, reduced hydroxyproline, and higher saturated vs . unsaturated fatty acid ratio under heat stress compared to other genotypes. (peanutscience.com)
Temperature4
  • The investigators concluded this after finding that 4-hydroxyproline in the Yaa position has better positive correlation with collagen's denaturation temperature than does the total amount of hydroxyproline (including 3- and 4-hydroxyproline) in the Xaa position. (medscape.com)
  • Controlling and stabilizing sample liquid temperature during measurement produces more accurate measurement results in accordnace to Japanese Pharmacopoeia / Food Additives Official Regulations. (atago.net)
  • By controlling and stabilizing the measurement temperature, it is possible to eliminate measurement variations due to temperature variations and improve the reproducibility of optical rotation measurement results. (atago.net)
  • It also has been reported to have a relatively low content of hydroxyproline (2%4), a low temperature of denaturation (2), and a low hydrothermal stability (4, 5). (coek.info)
Sensitivity1
  • the reported rates depend on age, sex, iodine intake, sensitivity of measurements, and definition used (Biondi et al. (nationalacademies.org)
Differential1
  • Moreover, the lungs showed no evidence of inflammation or fibrotic disease as determined by differential cell counts in lavage and measurement of hydroxyproline. (cdc.gov)
Total2
  • It contained 18.2% N, 0.02% hexosamine, 8.0% hydroxyproline (== 4.77, of the total N) and a distribution of 18 amino acids quantitatively identical with collagen from cod swim bladder. (coek.info)
  • METHODS The skin was analyzed for moisture by drying in a vacuum oven at 105"C., for ash by ignition in a muffle furnace at 600°C., for total lipid by extraction in a Soxhlet apparatus, for organic nitrogen by micro-Kjeldahl, for hydroxyproline by the method of Neuman and Logan as modified by Bowes, Elliott, and Moss (6). (coek.info)
Method1
Marker1
  • The analyte/measurement serves as a marker for the following conditions. (nih.gov)
Stability1
Diagnosis1
  • In addition, the physical measurement of human tissues evaluated frequently, brings another perspective to quantify the diagnosis of a specific disease. (nature.com)
Results1
  • The examples above show the common measurements for results for these tests. (medlineplus.gov)
Parameters1
  • Measurement of fertility parameters did not show any treatment-related changes. (europa.eu)
Specific1
  • 14. Core-shell magnetic molecularly imprinted polymers used rhodamine B hydroxyproline derivate as template combined with in situ derivatization for the specific measurement of L-hydroxyproline. (nih.gov)
Analysis1
  • DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study was a cross-sectional analysis of 2001 to 2004 National Health and Nutrition Examination Survey data. (cdc.gov)
Function1
  • Measurement of GFR is widely accepted as the best indicator of kidney function. (medibeacon.com)
Condition1
  • Hyperhydroxyprolinemia is a benign condition caused by a defect in 4-hydroxyproline dehydrogenase. (medscape.com)
Normal1
  • All measurements are in micromoles per liter (µmol/L). Normal values may vary between different laboratories. (medlineplus.gov)
Potential1
  • Fluorescent agents engineered to not interact with the body have the potential to enable measurement and monitoring of vital organ systems. (medibeacon.com)
Values1
  • PYD and DPD measurement values do not change in association with the degradation of newly synthesized collagens and are not influenced by dietary sources. (medscape.com)