Means to assess assays. Medical search. Frequent questions

Treatment with EDG-5506 led to a significant decrease in key biomarkers of muscle damage when assessed by laboratory assays. (businesswire.com)
The aim of this study was to assess the biomarkers of eosinophilic airways inflammation in patients with severe asthma in a single secondary care center. (ersjournals.com)
The development of assays to validate candidate biomarkers is costly and time-consuming. (lu.se)
We used a previously validated multiplexed 10-min, targeted proteomic assay to assess 54 candidate cerebrospinal fluid (CSF) biomarkers in two independent cohorts comprising individuals with neurodegenerative dementias and healthy controls. (lu.se)
This targeted proteomic multiple reaction monitoring (MRM)-based assay can simultaneously and rapidly measure multiple candidate CSF biomarkers. (lu.se)
Thirty plasma biomarkers of diet were assayed in the Oregon Brain Aging Study cohort (n = 104). (neurology.org)
We concluded that DBS-assessed biomarkers represent a valid alternative to venipuncture assessments. (cdc.gov)

These are widely used in clinics and include ferritin, serum iron, serum transferrin, total iron binding capacity (TIBC) and mean cell volume (MCV). (bmj.com)
Blood eosinophils (Eos) were measured by automatic haemoanalyser and serum total IgE levels were assessed by immunofluorescence assay. (ersjournals.com)
Concurrent venipuncture serum and DBS samples (n = 150 adults) were assayed in Clinical Laboratory Improvement Amendments-certified and DBS laboratories, respectively. (cdc.gov)
ABSTRACT To assess the serum folate and vitamin B12 status in healthy Iranian adults, we designed a population-based cross-sectional study of 1200 individuals aged 20-80 years. (who.int)
The mean serum folate was 4.61 (SD 2.40) ng/mL and the mean serum vitamin B12 level was 265.6 (SD 170.9) pg/mL. (who.int)
The mean serum folate and vitamin B12 levels were significantly lower in men. (who.int)
Objectives: To assess any additional benefits of the estimation of serum TGF Beta1 over serum PSA for differentiating localized from metastatic prostatic carcinoma. (bvsalud.org)
while the mean serum TGF Beta1 in the metastatic disease group only was significantly higher than in the control: group (p0.01). (bvsalud.org)

Maintain the quality of folate measurements and document continued laboratory proficiency in performing the folate microbiologic assay through an annual performance report. (cdc.gov)
The performance verification program follows the CLSI EP9-A2 guideline (Clinical Laboratory Standards Institute, 2002) and provides 40 samples per matrix to allow a comprehensive method comparison to the CDC CLIA-approved microbiologic assay. (cdc.gov)
There are currently several laboratory assays available for assessing the iron status in children. (bmj.com)
C) Correlations of cytokine/chemokine levels with arthritic hindlimb scores and laboratory assays are shown. (ipa2014.org)

In conclusion, we provide useful experimental approaches and bioinformatics to identify informative and predictive genes at the single-cell level, which opens up new means to describe and understand cell proliferation and subpopulation dynamics. (frontiersin.org)
The collagen content of the BTC and cellular proliferation of fibroblasts were assessed using colorimetric assays. (researchgate.net)
Cell proliferation and viability were assessed by means of BrdU assay and MTT assay, respectively. (aaem.pl)
At 7, 14, and 21 days, proliferation activity was assessed using MTT assay, while alkaline phosphatase (ALP) activity was assessed by the BCIP/NBT method. (techscience.com)
This proliferation is proportional to the dose applied (and to the potency of the allergen) and provides a simple means of obtaining an objective, quantitative measurement of sensitisation. (cdc.gov)
The LLNA assesses this proliferation as a dose- response in which the proliferation in test groups is compared to that in vehicle treated controls. (cdc.gov)

Organotypic fibroblast-endothelial cell cocultures and matrigel assays were employed to assess angiogenesis. (whiterose.ac.uk)
VEGF-induced angiogenesis was assessed in vitro using an aortic sprouting assay and a Matrigel lung endothelial cell tubulogenesis assay. (bmj.com)

Skin sensitising potential of the test substance was assessed on the source substance DL-Citronellol by an activation of keratinocytes study and an LLNA study. (europa.eu)
Skin sensitisation was assessed in an LLNA (OECD 429) where approximately 25µl of a 2.5, 5, 10, 25 or 50% w/v preparation of the test substance in 1:3 Et0H:DEP was applied to the dorsal surface of each ear for 3 consecutive days. (europa.eu)
Toward that end, a new assay for the determination of skin sensitisation in the mouse, the Local Lymph Node Assay (LLNA) has been sufficiently validated and accepted to justify its adoption as a new Test Guideline (1)(2)(3). (cdc.gov)
This does not necessarily imply that in all instances the LLNA should be used in place of guinea pig tests, but rather that the assay is of equal merit and may be employed as an alternative in which positive and negative results generally no longer require further confirmation. (cdc.gov)

It shows the extent of variability in relation to the mean of the population. (wikipedia.org)
Full validation of the above assays, including intra-assay/inter-assay variability, spike recovery, dilution linearity, and limit of detection, is not usually reported. (jneurosci.org)

Their often excellent antioxidant properties are determined by in vitro assays. (teknoscienze.com)
In this paper, the antioxidant activity of individual coffee fractions (roasted and unroasted) is compared by means of in vitro antioxidant assays, and the influence of the formulation on skin penetration of the antioxidant active is examined by in vivo Raman spectroscopy. (teknoscienze.com)
The KeratinoSens assay was accepted when the positive control (cinnamic aldehyde) caused an in vitro score that fell within two standard deviations of the historical mean. (europa.eu)

This is the second Guideline to be promulgated for assessing skin sensitisation potential of chemicals in animals. (cdc.gov)

We performed ELISAs on all dried blood spot eluates to assess the quantity of circulating cholera toxin B (CtxB) or V. cholerae -specific LPS antibodies. (cdc.gov)
2 SD above the mean, we performed vibriocidal assays to assess presence of functional antibodies ( Appendix ). (cdc.gov)
Box-and-whisker plots of WBC counts in 146 lactating Holstein cows from a herd (farm 16) with high seroprevalence for anti-BLV antibodies classified by stage of lactation (A) and parity (B). The mean ± SD stage of lactation and number of lactations for the 146 cows were 2.603 ± 0.581 and 2.849 ± 1.122, respectively. (avma.org)
In contrast, serological assays are blood tests that detect circulating antibodies to SARS-CoV-2 and as you mentioned, antibodies are formed following viral infection. (aacc.org)
So, the presence of these antibodies indicates previous exposure to the virus, but one of the most important differences between molecular and antibody tests is that professional societies including the CDC and the FDA, the WHO, and the Infectious Diseases Society Of America do not advocate for the use of serological assay for an acute diagnosis of COVID-19. (aacc.org)

Evaluation was done at term (30 days' gestation) assessing fetal survival, fetal membrane integrity and histology of the membranes. (researchgate.net)

We sought to develop a robust assay to quantify oligomers from CSF. (jneurosci.org)
High-throughput nuclear magnetic resonance metabolomics and biochemical assays were used to quantify 87 circulating metabolic measures in seven cohorts from Finland and the UK, comprising altogether 18 288 individuals (mean age 26 years, range 15-75). (nih.gov)

This study assessed 80 cardiovascular and inflammatory proteins for biomarker discovery and prediction of MACE in type 2 diabetes. (springer.com)
Targeted proteomics is an attractive means of quantifying novel proteins in cerebrospinal and other fluids, and has potential to help overcome this bottleneck in biomarker development. (lu.se)
Principal component analysis constructed nutrient biomarker patterns (NBPs) and regression models assessed the relationship of these with cognitive and MRI outcomes. (neurology.org)
scientists with a deep insight into genetics, biomarker discovery, development of novel imaging assays for assessing progression of complications, novel animal models for chronic diabetic complications, in silico models to predict development of complications and response to novel treatments. (lu.se)

The assay is designed to provide full automation, which means no reagent preparation or hands-on testing is required. (genomeweb.com)
A membrane receptor reagent and assay is disclosed in which liposomes are bound to an evanescent wave emitting surface. (google.com)

We combined data from six prospective epidemiological studies of 30-77-year-old individuals with type 2 diabetes in whom 80 circulating proteins were measured by proximity extension assay. (springer.com)
Of 1211 adults with type 2 diabetes (32% women), 211 experienced a MACE over a mean (±SD) of 6.4 ± 2.3 years. (springer.com)

Assess the effectiveness of exhaled nitric oxide (eNO) for detecting acute cross-shift bronchial responsiveness changes. (cdc.gov)

The performance verification program for the folate microbiologic assay assesses the performance and continued proficiency of regional resource laboratories engaged in public health work. (cdc.gov)
Laboratories engaged in public health work assessing folate status in populations. (cdc.gov)
The folate microbiologic assay used in the folate performance verification program was selected based on a WHO recommendation (WHO, 2015). (cdc.gov)
La prévalence de la déficience en vitamine B12 était considérablement plus élevée que celle de la déficience en folate. (who.int)

While CK reductions were sustained and in line with observations made at 2 months, mean fast skeletal muscle troponin I levels decreased with continued exposure to EDG-5506. (businesswire.com)

The program uses objective quality goals based on biologic variation to assess the acceptability of method performance (Fraser et al. (cdc.gov)

So, these are usually done on nasal swabs and sometimes saliva and this assay can tell if viral particles are present in your respiratory tract, but it cannot differentiate if the detected viral particles are infectious or not. (aacc.org)
Biodistribution and viral shedding assays are two critical means by which such safety can be assessed. (absorption.com)
Biodistribution (BD) assays determine the amount of viral DNA/RNA in different cells and organs in an organism. (absorption.com)

We used gradient-boosted machine learning and lasso regularised Cox regression in a random 75% training subsample to assess whether adding proteins to risk factors included in the Swedish National Diabetes Register risk model would improve the prediction of MACE in the separate 25% test subsample. (springer.com)
Metabolic associations with birthweight were assessed by linear regression models adjusted for sex, gestational age and age at blood sampling. (nih.gov)

A paper appearing in the August 2020 issue of Clinical Chemistry examined two such assays in an attempt to characterize assay performance and validate the manufacturers' claims. (aacc.org)

La selecci n y el cuidado del donador antes de la procuraci n de los rganos juegan un papel primordial en los resultados en el receptor. (medigraphic.com)
En este art culo revisamos aspectos hist ricos y avances recientes en el manejo de estos pacientes incluyendo indicaciones y contraindicaciones, evaluaci n y cuidado del donador y del receptor, t cnica quir rgica y manejo peri- y posoperatorio. (medigraphic.com)

There are currently several methods you can use to assess the potential future effectiveness of your child's cord blood collection including the collection's volume (in milliliters), the number of total cells (TNC count), the number of stem cells (CD34+ count), and a measurement of the stem cell functionality and potency (such as a colony-forming unit [CFU] count). (cryo-cell.com)
One study found that the number of colony-forming units (CFUs) was found to be a stronger independent predictor of engraftment and a potential better option in assessing the potency of a cord blood unit for transplantation. (cryo-cell.com)

OBJECTIVE -The A1C assay, expressed as the percent of hemoglobin that is glycated, measures chronic glycemia and is widely used to judge the adequacy of diabetes treatment and adjust therapy. (diabetesjournals.org)

Biodistribution assays are performed to determine the in vivo distribution or localization of a drug product in selected species to support early biotherapeutic drug development. (absorption.com)

Eosinophilic cationic protein: is it useful in assessing control of childhood asthma? (who.int)

The program assesses the mean difference between the test and the CDC method, as well as the relationship between the two (2) methods across the concentration range. (cdc.gov)
Methods to detect picric acid and picramic acid in rabbit urine using calorimetric assays have been reported (Zambrano and Mandovano 1956). (cdc.gov)

Results: Inhalable dust concentrations ranged between 0.09.4.95 mg/m3 with a geometric mean of 0.59 mg/m3. (cdc.gov)
Additionally, the results of the three definitive trials for each plate were assessed, but not necessarily deemed valid, using similar criteria outlined in the validation ring trial. (europa.eu)

Median urinary iodine concentrations can be used to assess the iodine status of populations, but single spot or 24-hour urine iodine concentrations are not a valid marker for the iodine nutritional status of individual patients. (medscape.com)

The A1C assay is widely accepted and used as the most reliable means of assessing chronic glycemia ( 1 - 3 ). (diabetesjournals.org)

The CV or RSD is widely used in analytical chemistry to express the precision and repeatability of an assay. (wikipedia.org)

Mean cell haemoglobin concentration (MCHC), using a cut-off of 32.1 g/dl, had a sensitivity of 67% and specificity of 64% for detecting iron stores deficiency. (bmj.com)
In lieu of measuring free T4, total T4 measurement (with a pregnancy-adjusted reference range) is a highly reliable means of estimating hormone concentration during the last part of pregnancy. (medscape.com)

We examined 73 outpatients (32% male, aged 18-82 yr, mean age 55 yrs) with severe asthma (ERS/ATS 2014), among them 14% had orally streroid-dependent asthma. (ersjournals.com)
We aimed to assess whether timapiprant attenuated or prevented asthma exacerbations induced by experimental rhinovirus (RV) infection. (imperial.ac.uk)

mean caliper measurement. (ipa2014.org)

This is why it is important to more directly assess the number of stem cells in a collection to ensure its effectiveness in transplantation. (cryo-cell.com)

agreement and bias were assessed via Bland-Altman plots. (cdc.gov)

Paroxetine was treated as a drug substance and validated as a purity assay in phase II of development. (chromatographyonline.com)
These cumulative advantages reduce assay development time and risk, easing the submission process for approval of CGT products. (absorption.com)
This diagram shows where BD/shedding assays sit in the development pipeline of a typical VGT product. (absorption.com)

Namely, in the past two weeks the US Food and Drug Administration has granted 510(k) clearances to PCT assays from Roche and BioMérieux to test for the risk of severe sepsis or septic shock. (genomeweb.com)
The Roche procalcitonin assay assesses risk when somebody presents with sepsis-related symptoms. (genomeweb.com)
BioMérieux, in the week following Roche's clearance, announced on Friday that it has received FDA 510(k) clearance for the expanded use of its Vidas BRAHMS PCT assay for managing sepsis patients with elevated risk of mortality. (genomeweb.com)
Addition of the 80-protein assay to established risk factors improved discrimination in the separate test sample from 0.686 (95% CI 0.682, 0.689) to 0.748 (95% CI 0.746, 0.751). (springer.com)

precision worsened at higher mean values of CRP. (cdc.gov)

Knowledge about species infectivity, tissue tropism, and cellular infectivity of different vectors is very important for assessing the BD of a cell and gene therapy product. (absorption.com)

Inhalable endotoxin concentrations ranged between 4.1968 EU/m3 with a geometric mean of 117 EU/m3. (cdc.gov)

Time controls of DBS standard samples were assayed single-blind along with test samples. (cdc.gov)
Means were compared using the Student's t -test. (techscience.com)

So, we began planning our study prior to the FDA requiring emergency use authorization for serological assays for SARS coronavirus. (aacc.org)
At the time we were planning our study, there was also nothing in the published literature that compared various commercially available serological assays for accuracy. (aacc.org)
At the start of the study, animals should be between 8-12 weeks old, and the weight variation of the animals should be minimal and not exceed 20% of the mean weight. (cdc.gov)
To assess if exposure to influenza A(H5N1) viruses among PMWs has changed over this period, we conducted a seroprevalence study among PMWs in three provinces of northern Viet Nam in 2011. (who.int)

The lower limit of reliable quantification of the assay was 0.18 pg/ml and the antibody pairs recognized Aβ multimers comprised of either synthetic standards, or endogenous oligomers isolated from confirmed human AD and healthy control brain. (jneurosci.org)
There was no significant difference between the mean maximum loads to failure of the bone-tendon interface in the control group (0.33 N (± 0.24)) and the AMA group (0.23 N (± 0.10)) (p = 0.371). (researchgate.net)
There was no sig- nificant difference in the mean quantity of hydroxyproline per milligram of tissue in the control group (31.7 lg/mg) and the treat- ment group (35.8 lg/mg) (p = 0.72). (researchgate.net)
It also provides eight (8) quality control samples to assess multi-day method imprecision. (cdc.gov)

We describe and assess the relative importance of information sources about familial breast cancer at the individual, family, and healthcare provider levels influencing women's reporting they had enough information to speak with daughters about breast cancer. (cdc.gov)

Its activation can be monitored in real-time by following the formation of fluorescent ASC specks and measuring pyroptotic cell death with the LDH assay. (invivogen.com)

0.1) difference in mean WBC count among stage of lactation or parity. (avma.org)

The coefficient of variation may not have any meaning for data on an interval scale. (wikipedia.org)
Data symbolize Mean? (ipa2014.org)
lactonase activity Data represent Mean? (ipa2014.org)

Participation can either be on a one-time basis to assess method performance (e.g., upcoming survey) or on a continuous basis, where the 40 samples are analyzed over the course of one year (e.g., 10 samples per quarter). (cdc.gov)
The pattern of metabolic deviations associated with lower birthweight resembled the metabolic signature of higher adult BMI (R 2 = 0.77) assessed at the same time as the metabolic profiling. (nih.gov)

Using the assay, a significant 3- to 5-fold increase in Aβ oligomers in human AD CSF compared with comparably aged controls was demonstrated. (jneurosci.org)

While they occur in plant materials such as tea, cocoa, coffee, herbs and phytochemicals, coffee as beverage has been shown by an LDL oxidation assay to have among the highest contents (1). (teknoscienze.com)

In probability theory and statistics, the coefficient of variation (CV), also known as Normalized Root-Mean-Square Deviation (NRMSD), Percent RMS, and relative standard deviation (RSD), is a standardized measure of dispersion of a probability distribution or frequency distribution. (wikipedia.org)
with many assays only reporting relative relationships. (jneurosci.org)

limb perfusion was assessed 21 days later using laser Doppler and gastrocnemius muscle capillary density defined histologically. (bmj.com)

Of notice, IL-4, IL-5, IL-10, TNF-, IP-10, MIG, MIP-1, and VEGF were assessed in the Luminex panel but values were too low in majority of specimens to allow reliable analysis. (ipa2014.org)

Au total, 38 enfants souffrant d'asthme (contrôlé pour 16 d'entre eux et partiellement contrôlé pour 22 autres) ont été comparés à 16 enfants en bonne santé de même sexe et de même âge. (who.int)

Biomarkers7

Serum8

Laboratory4

Proliferation6

Matrigel2

LLNA4

Variability2

Vitro3

Sensitisation1

Antibodies5

Fetal1

Quantify2

Biomarker4

Reagent2

Type 2 diabet2

Detecting acute1

Folate4

Continued exposure1

Biologic1

Viral3

Regression2

Validate1

Receptor2

Potency2

Objective1

Vivo1

Eosinophilic1

Methods2

Results2

Populations1

Chronic1

Widely1

Concentration2

Asthma2

Measurement1

Effectiveness1

Bias1

Development3

Risk4

Precision1

Cellular1

Concentrations1

Test2

Study4

Control4

Describe1

Cell1

Difference1

Data3

Time2

Significant1

Shown1

Relative2

Days1

Values1

Total1