• Cultured bovine retinal endothelial cells (BREC) and bovine retinal pericytes (BRP) were incubated with Ang II (100 nmol/l) or Ang II+candesartan (1 μmol/l). (diabetesjournals.org)
  • The modern cancer model has developed into a cancer-niche complex that includes cancer cells, cancer-associated fibroblasts (CAFs), endothelial cells, immune inflammatory cells, pericytes, and cancer stem cells [ 2 ]. (biomedcentral.com)
  • Here, we report the development and applicability of a functional neurovascular unit on a microfluidic chip as a microphysiological model of ischaemic stroke that recapitulates the function of the blood-brain barrier as well as interactions between therapeutic stem cells and host cells (human brain microvascular endothelial cells, pericytes, astrocytes, microglia and neurons). (stanford.edu)
  • This might be particularly damaging in insulin independent tissues that are more exposed to hyperglycaemia because they cannot regulate glucose inflow, such as retinal capillary endothelium and pericytes, the neuroretina, renal podocytes and mesangium. (unito.it)
  • Lined by vascular endothelium and pericytes, these histologic benign lesions manifest at birth or within the first 3 months of life, enlarge rapidly, and begin to commence contracting around age 1 year. (medscape.com)
  • Nile grass rats ( Arvicanthis niloticus ) were fed standard rodent chow, which was associated with hyperinsulinemia at 2 month, followed by hyperglycemia by 6 month, and retinal pericyte drop by 18 month. (mitoeagle.org)
  • The accuracy and precision of brain signaling are primarily based on interactions involving neurons, astrocytes, oligodendrocytes, microglia, pericytes, and dendritic cells within the CNS. (cdc.gov)
  • The half maximal inhibitory concentration of 5-fluorouracil and levels of cell apoptosis were examined using cell viability assay and flow cytometry, respectively. (biomedcentral.com)
  • The half maximal inhibitory concentration for 5-fluorouracil in BGC-823 cells was elevated after treatment with conditioned medium, and early apoptosis was inhibited. (biomedcentral.com)
  • Inhibition was half-maximal at 250-300 micrograms cholesterol/ml and nearly complete at 350-400 micrograms/ml. (rupress.org)
  • Using loss-of-function pericyte-deficient mice, here we show that pericyte degeneration diminishes global and individual capillary CBF responses to neuronal stimuli, resulting in neurovascular uncoupling, reduced oxygen supply to the brain and metabolic stress. (nature.com)
  • Figure 1: Delayed capillary dilation and reduced capillary red blood cell flow in response to a hindlimb stimulus in 1- to 2-month-old pericyte-deficient Pdgfrb +/− mice. (nature.com)
  • PCNs significantly inhibited hypoxia and increased pericyte coverage, leading to the inhibition of tumor growth and metastasis, while increasing survival in LLC allograft and MMTV-PyMT spontaneous breast cancer models. (biomedcentral.com)
  • Leukotriene C 4 also induced these responses, but the maximal responses to leukotriene C 4 were less than the maximal responses to U-46619 or histamine. (aspetjournals.org)
  • Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). (thermofisher.com)
  • Thus, pericyte degeneration as seen in neurological disorders such as Alzheimer's disease may contribute to neurovascular dysfunction and neurodegeneration associated with human disease. (nature.com)
  • To attempt to block TRAP6 mediated Ca2+ mobilization in human pericytes. (tocris.com)
  • The role of pericytes in the regulation of cerebral blood flow (CBF) and neurovascular coupling remains, however, under debate. (nature.com)
  • Figure 4: Diminished brain tissue oxygen levels and oxygen delivery in young pericyte-deficient Pdgfrb +/− mice. (nature.com)
  • 16. Phosphatidylcholine hydrolysis and DNA synthesis in cultured retinal capillary pericytes. (nih.gov)
  • Arteriolar and capillary pericytes attracted and interacted with myeloid leukocytes after extravasating from postcapillary venules, 'instructing' them with pattern-recognition and motility programs. (bioxcell.com)
  • 13. Phospholipase d signaling and extracellular signal-regulated kinase-1 and -2 phosphorylation (activation) are required for maximal phorbol ester-induced transglutaminase activity, a marker of keratinocyte differentiation. (nih.gov)
  • At 1¨C5 min of incubation with one mM CCh, a maximal improve in HSP27 phosphorylation was observed. (pdgf-receptor.com)
  • E10030 is an aptamer directed against PDGF subunit B, which regulates neovascular pericytes (cells associated with the walls of newly formed small blood vessels). (medscape.com)
  • Mural cells (vascular smooth muscle cells and pericytes) play an essential role in the development of the vasculature, promoting vascular quiescence and long-term vessel stabilization through their interactions with endothelial cells. (nih.gov)
  • The accuracy and precision of brain signaling are primarily based on interactions involving neurons, astrocytes, oligodendrocytes, microglia, pericytes, and dendritic cells within the CNS. (cdc.gov)
  • In response to inflammatory mediators, pericytes upregulated expression of the adhesion molecule ICAM-1 and released the chemoattractant MIF. (bioxcell.com)