Maximal cell degranulation. Medical search. Frequent questions

Urticaria results from the release of histamine, bradykinin, leukotriene C4, prostaglandin D2, and other vasoactive substances from mast cells and basophils in the dermis. (medscape.com)
The type I allergic immunoglobulin E (IgE) response is initiated by antigen-mediated IgE immune complexes that bind and cross-link Fc receptors on the surface of mast cells and basophils, thus causing degranulation with histamine release. (medscape.com)
Anaphylaxis is an acute, potentially life-threatening, generalized, or systemic allergic reaction that is mediated by the degranulation of mast cells and basophils. (suratsamachar.net)

Valerian extracts may have direct inhibitory effects on the contractility of the human uterus and this justifies the traditional use of this plant in the treatment of uterine cramping associated with dysmenorrhoea….Valerian extract reduced the maximal contractile response induced by acetylcholine, phenylephrine and histamine…Read the full study here . (healinghistamine.com)
Histamine is the ligand for 2 membrane-bound receptors, the H1 and H2 receptors, which are present on many cell types. (medscape.com)
The activation of the H1 histamine receptors on endothelial and smooth muscle cells leads to increased capillary permeability. (medscape.com)
This inflammation of the nasal mucosal lining is a result of inhaled aeroallergens, which the patient has been previously sensitized to, binding to immunoglobulin E (IgE) on the surface of mast cells, leading to mast cell degranulation and release of preformed mediators, such as histamine and leuko-trienes. (uspharmacist.com)
It diminishes Histamine Release: Quercetin inhibits the synthesis of enzymes necessary for the release and degranulation of histamine. (purerxo.com)

As part of the inflammatory cells in the tumor microenvironment, neutrophils play both pro- and anticancer roles [ 9 ]. (biomedcentral.com)
At the same time, cancer cells shape the tumor microenvironment by secreting various cytokines and chemokines, providing the necessary environmental conditions for the reprogramming of neutrophils, which may explain the varied functions of neutrophils in cancer [ 12 ]. (biomedcentral.com)
In DLBCL, tumor-associated neutrophils contribute to the survival, growth, and drug resistance of malignant B cells [ 13 ]. (biomedcentral.com)
Neutrophils not only act through degranulation and phagocytosis but also create neutrophil extracellular traps (NETs), which destroy bacterial virulence factors and kill bacteria [ 14 ]. (biomedcentral.com)
In nasal cytologic studies, the presence of eosinophils and goblet cells is generally suggestive of allergy, whereas the presence of neutrophils and bacteria is characteristic of infection. (medscape.com)
In addition to potent and selective BTK enzyme and cellular activity, rilzabrutinib inhibited activation and inflammatory activities of B cells and innate cells such as macrophages, basophils, mast cells, and neutrophils, without cell death (in human and rodent assay systems). (aai.org)

Allergen-specific IgE molecules then bind to the surface of mast cells, sensitizing them. (medscape.com)

Examples are nasal polypectomy in the patients who have severe polyposis and various inferior turbinate reduction maneuvers in patients who have nasal obstruction caused by turbinate hypertrophy that persists despite maximal medical therapy. (medscape.com)
Patients with moderate to severe forms often suffer from recurrent infective exacerbations and disease recurrence/progression despite maximal baseline therapy and surgeries. (encyclopedia.pub)

MATERIALS AND METHODS: We investigated the anti-inflammatory effects of the U. cannabina water extract on lipopolysaccharide-stimulated RAW264.7 macrophages and paw edema in rats and analyzed its chemical components using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). RESULTS: U. cannabina water extract effectively inhibited the secretion of multiple inflammatory factors, and its corresponding mRNA expression in LPS-induced RAW264.7 cells (p (bvsalud.org)
After initial exposure to an antigen, antigen-processing cells (macrophages) present the processed peptides to T helper cells. (medscape.com)
IFN-gamma activates tissue macrophages and T cells. (medscape.com)
Toquet et al investigated the phenotype of the lesional inflammatory cell infiltrate in patients with eosinophilic fasciitis and demonstrated a predominance of macrophages, CD8 + lymphocytes, and few eosinophils. (medscape.com)

A sensitive marker for NK cell granule exocytosis is CD107a, also referred to as lysosomal-associated membrane protein-1 (LAMP-1), which is increased following NK cell activation. (rafsignaling.com)

Human adenovirus (HAdV) infection constitutes a major cause of morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). (biomedcentral.com)
Following allogeneic hematopoietic stem cell transplantation (HSCT), interferon (IFN)-γ levels in the recipient's body can strongly influence the clinical outcome. (uni-hannover.de)

Adenosine causes nonselective activation of four different receptors, including A2A-mediated vasodilation of the coronary microcirculation and 'off target' A2B receptor-mediated mast cell degranulation and bronchial constriction. (rcpe.ac.uk)
In addition to inflammatory cell infiltration in the bronchial wall 1 , histological analysis of endobronchial biopsy specimens and new methods of blood flow measurements have revealed prominent alterations of the tracheobronchial (airway) vasculature in patients with asthma. (ersjournals.com)

Viallard et al demonstrated that, when stimulated, peripheral blood mononuclear cells of eosinophilic fasciitis patients produce significantly higher amounts of five cytokines, including interleukin (IL)-5 and interferon (IFN)-gamma. (medscape.com)
Peptides were synthesized and tested for in vivo immunogenicity by screening peripheral blood mononuclear cells from healthy volunteers (n = 64) and HAdV-infected stem cell recipients (n = 26) for memory T cells recognizing the candidate epitopes in the context of most common HLA alleles. (biomedcentral.com)
The top layer of mononuclear cells was washed twice in cold HBSS and incubated in 2 cm polystyrene dishes at 37°C for 1 h. (osri.asia)

Human adenovirus (HAdV) infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). (biomedcentral.com)
Background: Mesenchymal stem cells (MSCs) are increasingly considered to be used as biological immunosuppressants in hematopoietic stem cell transplantation (HSCT). (uni-hannover.de)

The prognostic landscape of genes and infiltrating immune cells across human cancers. (bmj.com)
Together, our data indicate that SLAMF receptors are important modulators of the BCR signaling axis and may improve immune control in CLL by interference with NK cells. (nature.com)
Signaling Lymphocytic Activation Molecule Family (SLAMF) receptors are a group of nine type I transmembrane receptors that are mainly expressed on a variety of immune cells. (nature.com)
However, our understanding of how pathogens interact with cellular and humoral host factors in blood is limited, mainly due to technical issues: While it is relatively easy to study the interaction of pathogens with isolated blood cells, or their survival in serum or plasma, such approaches lack the complexity of interactions between different types of immune cells and additional factors, e.g., complement, present in blood. (frontiersin.org)
Therefore, we previously established an ex vivo human whole-blood infection model that allowed us to define which immune cells interact with the human fungal pathogen Candida albicans ( 4 ), to identify cross-talk between different components of the host response ( 5 ), and to detect substantial differences between related fungal pathogens ( 6 ). (frontiersin.org)
Efficient antiviral T-cell responses are necessary to clear infection, which is hampered by delayed immune reconstitution and medical immunosuppression after HSCT. (biomedcentral.com)
Identification of new immunodominant epitopes will facilitate and broaden immune assessment strategies to identify patients suitable for T-cell transfer. (biomedcentral.com)
Bruton tyrosine kinase (BTK) is expressed in B cells and innate immune cells, acting as an essential signaling element in multiple immune cell pathways. (aai.org)
Thus, the aim of this work is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, its mechanism of action, and to elucidate molecular mechanisms involved in endotoxin's recognition by the immune system and cell activation. (bvsalud.org)
Therefore, the objective of this study is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, as well as to elucidate molecular mechanisms involved in its recognition by the immune system and in cell activation. (bvsalud.org)

Background gdT-cells are innate-like lymphocytes described as potent killer of cancer cells whose infiltration into tumors is associated with a positive prognosis. (bmj.com)
1% TF extract with 0.1% HC inhibited skin inflammation through decrease in inflammatory cells infiltration as well as inhibition of Orai-1 expression in skin tissues. (hindawi.com)
Taken together, the findings of these studies suggest a mechanistic framework marked by a proinflammatory and fibrogenic cytokine response with resultant tissue inflammatory cell infiltration. (medscape.com)

Indeed, our experiments showed significantly decreased degranulation capacity of primary NK cells from CLL patients expressing low levels of SLAMF1 and SLAMF7. (nature.com)
Thus, in some experimental models of aseptic inflammation, such as peritoneal dextran sulfate-, lung asbestos-, cobalt-and bleomycin-induced inflammatory disorders, BN significantly suppressed the inflammatory response of granulocytes, including hemotaxis, and the release of hydroxyl radicals from inflamed cells. (osri.asia)

Since SLAMF receptors play a role in NK cell biology, we reasoned that these receptors may impact NK cell-mediated CLL immunity. (nature.com)
Protective immunity may be conferred by adoptive transfer of HAdV-specific T cells. (biomedcentral.com)
Monitoring HAdV-specific T-cell immunity may improve risk assessment in HSCT recipients and enhance treatment efficacy by determining the optimal time point for adoptive T-cell transfer. (biomedcentral.com)

ICT01-mediated killing activity of g9d2 T-cells was assessed using in vitro co-cultures with tumor and non-tumor cells. (bmj.com)
Immunocompromised mice bearing human tumors and adoptively transferred with human g9d2 T cells were used to assess ICT01 anti-tumor activity in vivo. (bmj.com)
In co-culture experiments, ~20% of target occupancy on tumor cells is sufficient for maximal g9d2 T-cell degranulation (e.g. (bmj.com)
ICT01-activated g9d2 T-cells continuously and serially kill a wide range of tumor cells in multi-day co-culture conditions. (bmj.com)
Conclusions The combined in vitro and in vivo pharmacology data provide evidence that ICT01 is an attractive and novel therapeutic approach for enhancing the innate anti-tumor potential of g9d2 T-cells by activating BTN3A. (bmj.com)
tumor iTreg cells, but not by control CD4 T cells, in terms of reduced expression of NKG2D and NKp44 from 3.8- to 1.8-fold and from 10.7- to 3.9-fold, respectively. (rafsignaling.com)
Upon delivery, an oncolytic virus (OV) will infect a relatively low percentage of cancer cells in the tumor tissue. (mdpi.com)
When an OV is armed with bi-specific T cell engager (BiTE), it also expresses and secretes a large quantity of BiTEs from infected cells, which can diffuse throughout the tumor tissue, activating T cells to recognize and kill cancer cells antigen-specifically. (mdpi.com)

AD has a complex etiology that involves activation of multiple immunological and inflammatory pathways along with disruption of epidermal barriers, elevated IgE levels, peripheral eosinophilia, and a predominance of Th2 cells expressing IL-4, IL-5, and IL-13 [ 2 ]. (hindawi.com)
In the early reconstitution phase following HSCT, natural killer (NK) cells represent the major lymphocyte population in peripheral blood and display graft-vs-leukemia (GvL) effects. (uni-hannover.de)

TF extract decreased β -hexosaminidase release in RBL-2H3 cells. (hindawi.com)
CGRP promotes mast cell degranulation, which results in the release of several inflammatory and proinflammatory substances. (medlink.com)
Further exposures result in the bridging of 2 adjacent IgE molecules, leading to the release of preformed mediators from mast cell granules. (medscape.com)
Maximal PGE2 release involved IL-1β priming of MSCs after close contact between the NK cells and UC-MSCs. (uni-hannover.de)
of NK cells resulted in a substantial release of IFN-γ after 36 h. (rafsignaling.com)
Cytotoxicity of NK cells is mediated by granule exocytosis and the release of perforin and granzymes to kill virally infected or neoplastic cells. (rafsignaling.com)

Overexpression of SLAMF1 or SLAMF7 in IGHV mutated CLL cell models resulted in reduced proliferation and impaired responses to BCR ligation, whereas the knockout of both receptors showed opposing effects and increased sensitivity toward inhibition of components of the BCR pathway. (nature.com)
In B cells, this class of receptors has been shown to be expressed in distinct patterns associated with development and activation [ 11 ]. (nature.com)
A previous study demonstrated that SLAMF1, SLAMF2, and SLAMF7 receptors are rather downregulated on CLL cells as compared to their normal B cell counterpart [ 12 ], suggesting that high expression of these molecules may have detrimental (e.g., antiproliferative) effects in the CLL context. (nature.com)
However, it is now clear that TP receptors exhibit a wide distribution in different cell types and among different organ systems. (wikipedia.org)
Staphylococcal enterotoxins are 23- to 29-kDa polypeptides in the bacterial superantigen protein family that act by cross-linking HLA-DR or DQ molecules and T-cell receptors. (cdc.gov)
Natural killer cells and cytotoxic T cells express both TIGIT and DNAM-1 receptors, and in certain cases their effector functions are dictated by TIGIT or DNAM-1 signaling. (cusabio.com)

The type II allergic response is mediated by cytotoxic T cells, causing deposits of immunoglobulins, complement, and fibrin around blood vessels. (medscape.com)
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. (cusabio.com)
However, multidrug-resistant (MDR) cancer cells may avoid the cytotoxic effects of chemotherapy by glycosylating ceramide. (sphingolipidclub.com)

The classic wheal-and-flare responses result from the interaction between the antigen and sensitized mast cells in the skin. (medscape.com)
Upon subsequent exposure to the same antigen, these cells are stimulated to differentiate into either more T helper cells or B cells. (medscape.com)
The B cells may further differentiate into plasma cells and produce immunoglobulin E (IgE) specific to that antigen. (medscape.com)
Antibodies (immunoglobulin (Ig) A, IgD, IgE, IgG, IgM) are secreted by B-cells that are activated to plasma cells after antigen presentation in regional lymph nodes or secondary lymphoid organs ( Figure 1 ) [ 9 ] . (encyclopedia.pub)
Monoclonal antibodies (mAbs) come from a single B-cell parent clone and recognize specifically a single epitope per antigen [ 10 ] . (encyclopedia.pub)

This paper describes successful treatment in three patients with Achilles tendonosis and interstitial tears using with non-manipulated autologous adipose derived stem/stromal cells and high-density platelet rich plasma concentrates (or bone marrow/platelet concentrate combination). (journalofprolotherapy.com)
Until date, MSC-NK cell interaction studies are largely focussed on bone marrow derived (BM)-MSCs. (uni-hannover.de)

BTN3A, which belongs to the B7-subfamily of Ig proteins, is required for the recognition of malignant or infected cells by human g9d2 T-cells by sensing intracellular accumulation of phosphoantigens. (bmj.com)
B cell receptor (BCR) signaling plays a critical role in driving proliferation and survival of the malignant clone in chronic lymphocytic leukemia (CLL), supported by the clinical activity of inhibitors targeted toward BCR-associated kinases [ 1 ]. (nature.com)

Natural product anticancer agents enhance intracellular levels of ceramide, a sphingolipid that promotes cell apoptosis. (sphingolipidclub.com)

Similarly, the expression of NKp44 on NK cells was inhibited by nTreg cells in all experiments but without reaching statistical significance (Fig. 2A and Tamoxifen nmr B). In agreement with previously published work, which showed a TGF-β-mediated modulation of NK cells by nTreg cells 11, 19, IL-2-activated NK cells cultured in the presence of 1 ng/mL TGF-β, showed no induction of NKG2D. (rafsignaling.com)

1 For practical purposes, maximal hyperaemia is typically induced using systemic administration of adenosine (rather than exercise). (rcpe.ac.uk)
They can be subdivided based on such as age of onset, presence of allergy (skin prick test or systemic allergen specific immunoglobulin E (IgE)), with or without nasal polyps and/or T helper (Th) cell 2 prominent inflammation. (encyclopedia.pub)

TF extract inhibited Orai-1 activity in Orai-1-STIM1 cooverexpressing HEK293T cells but increased TRPV3 activity in TRPV3-overexpressing HEK293T cells. (hindawi.com)
The present study demonstrates that the topical application of TF extract improves skin inflammation in AD mice, and the mechanism for this effect appears to be related to the modulation of calcium channels and mast cell activation. (hindawi.com)
In this study, we investigated the effects of TF extract on skin inflammation in an AD animal model and also investigated the mechanism responsible for the effects of TF extract in AD on the modulation of calcium channels and the activation of mast cells. (hindawi.com)

Effective immunotherapy of stromal-rich tumors requires simultaneous targeting of cancer cells and immunosuppressive elements of the microenvironment. (aacrjournals.org)
Many uninfected cancer or/and stromal cells can be killed by this mechanism, resulting in much improved therapeutic efficacy. (mdpi.com)

Thus, we studied the interaction of UC-MSCs with unstimulated allogeneic NK cells.Results: UC-MSCs could potently suppress NK cell cytotoxicity in overnight cultures via soluble factors. (uni-hannover.de)

Histology -Increased numbers of goblet cells in small airways as well as large airways. (slideserve.com)

In general, the pathophysiology underlying eosinophilic fasciitis is postulated to involve an inflammatory response resulting in an activated inflammatory cell infiltrate of affected tissues and subsequent dysregulation of extracellular matrix production by lesional fibroblasts. (medscape.com)
Organisms usually contain large numbers of sphingolipid subspecies (for a pathway based compilation, see www.sphingomap.org) and knowledge about the types and amounts is imperative because they influence membrane structure, interactions with the extracellular matrix and neighboring cells, vesicular traffic and the formation of specialized structures such as phagosomes and autophagosomes, as well as participate in intracellular and extracellular signaling. (sphingolipidclub.com)

When assayed in human and cynomolgus PBMCs in vitro, ICT01 promoted a robust and specific activation of g9d2 T-cells as shown by concentration dependent increase in cell surface CD69 and CD25 and cytokines secretion (IFNγ, TNFα). (bmj.com)
Both Treg subtypes and TGF-β, which served as a positive control in this assay (data not shown) 20, impaired IL-2-induced IFN-γ secretion from NK cells, with the effect of nTreg cells on NK cells being less prominent (Fig. 2C). (rafsignaling.com)

n\nMethods Twelve young male subjects performed a 30 min treadmill exercise at 80% of the maximal oxygen capacity. (pkcpathway.com)
We found that the BN effects on oxygen radical production by phagocytosing cells are much more complicated (3). (osri.asia)

Maximal instantaneous (peak) aortic ejection velocity was measured by means of continuous-wave Doppler echocardiography from a subcostal location. (avma.org)

3 ImCheck Therapeutics is developing ICT01, a humanized anti-BTN3A (IgG1, Fc-silenced), g9d2 T-cell-activating antibody for the treatment of patients with solid or hematologic tumors. (bmj.com)

Four wild-type (drug-sensitive) human breast cancer cell lines (MCF-7, T47D,MDA-MB-231, MDA-MB-435) were used to evaluate the influence of acute and chronic exposure to ceramide and ceramide metabolites on MDR1 mRNA,P-gp, and resistance to chemotherapeutic agents. (sphingolipidclub.com)
Acute exposure ofMCF-7 and MDA-MB-231 cells to C8-glucosylceramide (10 μg/ml culture medium), a cell-permeable analog of glucosylceramide, increased MDR1 mRNA levels by 2- and 4-fold, respectively. (sphingolipidclub.com)

In at least certain cell types, however, TPα also stimulates cells by activating the Gs family of G proteins while TPβ also stimulates cells by activating the Gi class of G proteins. (wikipedia.org)

These data are the first evidence that chronic exposure to ceramide and its metabolites enhances expression of the MDR phenotype in cancer cells. (sphingolipidclub.com)

In primates, ICT01 exposure and target engagement was dose-dependent, with all tested doses producing a specific g9d2 T cell activation and trafficking out of the circulation within 1 hour. (bmj.com)
We already know that physical activity can act as a pseudo-allergen for people who, like me, are diagnosed with Mast Cell Activation Syndrome (MCAS), as well as those who suffer from other types of Mast Cell Activation Disorders (MCAD). (weebly.com)
IL-1 receptor activation and subsequent downstream signalling events were found to require gamma-secretase activity.Conclusion: Although the role of PGE2 in NK cell-MSC has been reported, the requirement of cell-cell contact for PGE2 induced immunosuppression remained unexplained. (uni-hannover.de)
Activation of A 2A ARs results in an increase in cyclic AMP concentration in inflammatory cells which is increased further by concurrent type IV phosphodiesterase inhibitors. (biomedcentral.com)

Therefore, symptoms of mild exposure are anticipated to resemble T-cell-mediated recall responses, similar to a Mantoux skin test. (cdc.gov)
72 hours) to C8- ceramide (5 μg/ml culture medium), a cell-permeable analog of ceramide, enhanced MDR1 mRNA levels by 3- and 5-fold in T47D and inMDA-MB-435 cells, respectively, but did not affect MCF-7 cells.D-erythro-sphingosine exposure (5 μg/ml, 72 hr) increased MDR1 mRNA levels in MDA-MB-435 cells by 3.5-fold. (sphingolipidclub.com)
Exposure of cells to either octanoic acid (C8:0), a C8-ceramide hydrolysis product, or oleic acid (C18:1) did not affect MDR1 expression. (sphingolipidclub.com)

and (ii) the characteristic features of "healthy adipocytes" in WAT, which are relatively small fat cells endowed with a high capacity for mitochondrial oxidative phosphorylation, triacylglycerol/fatty acid (TAG/FA) cycling and de novo lipogenesis (DNL). (cas.cz)

They are known to be involved in the regulation of NK and T cell responses, mostly by homotypic interactions except for SLAMF2 (CD48) and SLAMF4 that interact with each other [ 10 ]. (nature.com)

The functional interactions between NK cells and MSCs have the potential to influence the leukemia relapse rate after HSCT. (uni-hannover.de)

Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy. (biomedcentral.com)
Diffuse large B-cell lymphoma (DLBCL) is a common aggressive form of non-Hodgkin's lymphoma. (biomedcentral.com)

Cytokine expression, inflammation, and therefore outcomes may differ during experimental sepsis depending upon the mouse strain and its T cell repertoire. (biomedcentral.com)

Antibodies are crucial to make leukocytes (such as T killer cells) to detect and destroy pathogens and infected host cells. (encyclopedia.pub)

In contrast, non-tumoral BTN3A-expressing B cells, HUVEC and fibroblasts were unaffected. (bmj.com)

Since the SLAMF low signature was strongly associated with an unmutated CLL immunoglobulin heavy chain (IGHV) status in large datasets, we investigated the impact of SLAMF1 and SLAMF7 on the B cell receptor (BCR) signaling axis. (nature.com)

The latter effect on adenyl cyclase may serve to suppress TPα's cell stimulating actions and thereby some of its potentially deleterious actions. (wikipedia.org)

Cell surface receptor for NECTIN2. (cusabio.com)

1-Increased pulmonary resistance 2- Limitation of maximal expiratory flow rates (reduced FEV1). (slideserve.com)
These cells not only demonstrated a 3-foldincrease in resistance to doxorubicin and a 9-fold increase in resistance to paclitaxel, but also showed increased efflux of rhodamine. (sphingolipidclub.com)

The expression of α and β isoforms is not equal within or across different cell types. (wikipedia.org)
For example, platelets express high concentrations of the α isoform (and possess residual RNA for the β isoform), while expression of the β isoform has not been documented in these cells. (wikipedia.org)
IL-2-activated NK cells showed 3.8- and 10.7-fold increased expression of NKG2D (Fig. 2A) and NKp44 (Fig. 2B) compared with basal expression of non-stimulated NK cells, respectively. (rafsignaling.com)
In the present study we examined the relationship between ceramide, ceramide metabolites and expression of the MDR1 gene in human breast cancer cell lines. (sphingolipidclub.com)

Galanin also plays a developmental cell survival role in the DRG. (biomedcentral.com)

The percutaneous use of a combination of autologous adipose tissue complex (inclusive of its heterogeneous cell populations and native bioactive scaffold) and either HD-PRP or HD-PRP/BMAC combination appear as promising options for non-surgical management of Achilles tendonosis and partial thickness interstitial tears. (journalofprolotherapy.com)

Mediators released by these cells prolong the earlier reactions and lead to chronic inflammation. (medscape.com)

This infection and viral spread lead to oncolysis limited to infected cancer cells, and thus suboptimal efficacy. (mdpi.com)

Importantly, ICT01 did not affect healthy BTN3A-expressing cells, and NHP studies confirmed ICT01 safety with a wide therapeutic index. (bmj.com)

Anatomy14

Organisms9

Diseases12

Chemicals and Drugs41

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes15

Mast cells and basophils3

Histamine5

Neutrophils6

Surface of mast cells1

Despite maximal2

Macrophages4

CD107a1

Allogeneic hematopoietic stem c2

Bronchial2

Mononuclear cells3

Hematopoietic stem cell trans2

Immune10

Infiltration3

Significantly2

Immunity3

Tumor8

Peripheral2

Release6

Receptors6

Cytotoxic3

Antigen5

Bone marrow2

Malignant2

Promotes1

Experiments1

Systemic2

Extract3

Stromal2

Cytotoxicity1

Goblet cells1

Extracellular matrix2

Secretion2

Oxygen2

Peak1

Tumors1

Acute2

Stimulates1

Phenotype1

Activation4

Exposure3

Capacity1

Responses1

HSCT1

Diffuse2

Cytokine1

Pathogens1

Fibroblasts1

Immunoglobulin1

Suppress1

Receptor1

Resistance2

Expression4

Survival1

Tissue1

Inflammation1

Cancer cells1

Studies1