• 5 Hematopoietic disruptions in the myeloid lineage can lead to 3 major disease categories: acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), and myelodysplastic syndrome (MDS). (oncomine.com)
  • 1,2 The 4 primary disorders of MPNs are chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). (oncomine.com)
  • 12,13 They also have a high propensity to progress to acute myeloid leukemia (AML). (oncomine.com)
  • Characterized by excessive, abnormal white blood cell (granulocyte) production and the presence of the Philadelphia chromosome/BCR-ABL mutation, chronic myeloid leukemia (CML) is a slow-growing cancer of the blood-forming tissue (bone marrow). (oncomine.com)
  • Epigenetic modifying enzymes such as histone deacetylases (HDACs), p300, and PRMT1 are recruited by AML1/ETO, the pathogenic protein for t(8;21) acute myeloid leukemia (AML), providing a strong molecular rationale for targeting these enzymes to treat this disease. (ashpublications.org)
  • Cytogenetic studies performed on bone marrow provide important prognostic information and can guide treatment by confirming a diagnosis of acute promyelocytic leukemia (APL). (medscape.com)
  • Acute promyelocytic leukemia (APL), also known as M3, is the most common subtype of AML associated with DIC. (medscape.com)
  • Patients with acute monocytic leukemia also have a high incidence of clinically significant DIC. (medscape.com)
  • Immunophenotyping by flow cytometry of bone marrow or peripheral blood samples can be used to help distinguish AML from acute lymphocytic leukemia (ALL) and further classify the subtype of AML. (medscape.com)
  • Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases are myeloid in origin. (wikipedia.org)
  • See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)
  • Although the incidence of acute nonlymphocytic leukemia is increased in PV, the incidence of acute leukemia in patients not exposed to chemotherapy or radiation therapy is low. (basicmedicalkey.com)
  • Also, see the Childhood Acute Lymphoblastic Leukemia: Diagnosis, Management, and Complications slideshow to help recognize and treat this disease and its associated complications. (medscape.com)
  • citation needed] Historically, hematological malignancies have been most commonly divided by whether the malignancy is mainly located in the blood (leukemia) or in lymph nodes (lymphomas). (wikipedia.org)
  • Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children, representing more than a quarter of all pediatric cancers. (medscape.com)
  • Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
  • This group of heterogeneous bone marrow disorders is characterized by defective hematopoiesis, growth, and maturation of blood-forming cells, resulting in an abnormal reduction of 1 or more types of blood cells in the bone marrow.11 MDS present with bone marrow failure and associated abnormal cell morphology. (oncomine.com)
  • The image below depicts bone marrow aspirate from a child with T-cell acute lymphoblastic leukemia. (medscape.com)
  • Children with acute lymphoblastic leukemia (ALL) often present with signs and symptoms that reflect bone marrow infiltration and/or extramedullary disease. (medscape.com)
  • BL is characterized by monomorphic medium-sized B cells with basophilic cytoplasm and numerous mitotic figures [ 3 , 4 ]. (longdom.org)
  • Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases are myeloid in origin. (wikipedia.org)
  • Provides a list of recurrent somatic mutations and associated pathways in small B-cell lymphoma/leukemia. (paramedicalinfo.com)
  • In contrast, acute anemia develops suddenly, in a matter of hours or days. (medscape.com)
  • Acute anemia is usually due to acute blood loss or acute hemolysis. (medscape.com)
  • An exception is acute anemia that occurs in patients with existing chronic anemia. (medscape.com)
  • For example, patients with sickle cell anemia who already have chronic anemia may develop additional acute anemia due to bone marrow failure (aplastic crisis). (medscape.com)
  • For unexplained acute anemia after exclusion of other causes, performing bone marrow biopsy is imperative to diagnose PRCA and rule out involvement of bone marrow by primary tumor. (amjcaserep.com)
  • With anemia due to acute blood loss, a reduction in oxygen-carrying capacity occurs along with a decrease in intravascular volume, with resultant hypoxia and hypovolemia. (medscape.com)
  • There are no life-threatening causes of pancytopenia that require acute treatment within 24 hours. (wikidoc.org)
  • Leukemia-mediated pancytopenia is typically due to marrow replacement of normal hematopoietic precursors, a process known as myelopthisis. (wikidoc.org)