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  • CTLs
  • Clinical evidence confirmed the importance of CTLs in patients suffering from melanoma and other cancers, as infiltrating CD8 + T cells found in tumor biopsies were strongly associated with improved life expectancy ( 18 - 20 ). (frontiersin.org)
  • vitro
  • The aim of this study was to investigate the effect of different concentrations of royal jelly (RJ) on in vitro maturation (IVM), fertilization, cleavage, blastocyst rates, glutathione (GSH) content in ovine oocyte, mRNA abundance of antioxidant enzymes in both oocyte and cumulus, and glucose metabolism-related genes in cumulus cells. (blogspot.com)
  • In vitro maturation of oocyte was performed in the presence of control (RJ0), 2.5 (RJ2.5), 5 (RJ5), and 10 (RJ10) mg/mL of RJ. (blogspot.com)
  • In some respects, dendritic cells cultured in vitro do not show the same behaviour or capability as dendritic cells isolated ex vivo . (wikidoc.org)
  • tumors
  • In these studies, DCs have been shown both to inhibit the growth of nascent tumors and to provide a memory response to previously encountered antigen. (frontiersin.org)
  • All these functions make DCs key elements in the immunological response against pathogens, viruses and tumors. (units.it)
  • immunological
  • We have previously shown that in DCs engaged in antigen specific immunological synapses (IS), IL-12 is found enriched in the proximity of the contact site between DC and T cells, and several evidences suggest that its secretion is polarized towards the T cell. (units.it)
  • Upon such interaction, a so called "immunological synapse" is formed and signals are transmitted to the T cells ( Huppa and Davis, 2003 ). (frontiersin.org)
  • viral
  • Preliminary experiments suggest that in podocytes SRA antagonizes APOL1 induction by viral stimulus and subsequent cell death, opening new perspectives to treat kidney disease. (europa.eu)
  • Induction triggers the host immune system to recognize the presence of viral infection or tumor and subsequently eliminates the presenting lesion. (jddonline.com)
  • myeloid
  • APOL1 belongs to a family of proteins induced under inflammatory conditions in myeloid and endothelial cells. (europa.eu)
  • Therefore, we propose that the pathology of APOL variants is due to their deregulated activity on the control of the cellular lifespan in myeloid/endothelial cells activated by pathogen detection. (europa.eu)
  • look like plasma cells , but have certain characteristics similar to myeloid dendritic cells. (wikidoc.org)
  • migration
  • Transwell and wound healing assays demonstrated that CAPE treatment suppressed the migration and invasion of PC-3 and DU-145 PCa cells. (blogspot.com)
  • Overexpression or knockdown of ROR2 suppressed or enhanced cell migration of PC-3 cells, respectively. (blogspot.com)
  • Lipocalin-2-loaded amphiphilic polyanhydride microparticles accelerate cell migration. (naver.com)
  • complexes
  • They have the unique ability of recognizing antigens, internalizing and processing them for presentation on MHC complexes. (units.it)
  • Circulating immune complexes and cell-bound immunoglobulins present in normal human sera represent a potential stimulus for inadvertent DC activation in the steady state and during autoimmunity. (pnas.org)
  • activation
  • Intracellular NOD2 in DCs could be activated by MDP and this activation could promote maturation and the ability to prime Th0 cells to Th2 cells of DCs exposed to P. gingivalis -LPS. (alliedacademies.org)
  • It seems that the improvement of oocyte maturation and its subsequent development in RJ10 group may be associated with amelioration of redox status in the oocytes and activation of glucose metabolic pathways in their surrounding cumulus cells. (blogspot.com)
  • My aim is to develop an understanding of the cellular mechanisms that underlie critical B cell activation steps. (europa.eu)
  • These cells are characterized by high endocytic activity and low T-cell activation potential. (wikidoc.org)
  • rapid
  • Some of these activated CTLs then travel to the infected tissue to form part of the adaptive immune response, while others become memory cells that are ready to mount a rapid response in case of a rechallenge by the pathogen. (frontiersin.org)
  • interactions
  • Summary This project focuses on two questions about host/parasite interactions: how do biotrophic plant pathogens suppress host defence? (europa.eu)
  • infections
  • Summary The production of antibodies against pathogens is an effective mechanism of protection against a wide range of infections. (europa.eu)
  • therefore
  • we've discovered that almost each constitution of the attention harbors those cells, but they fluctuate of their actions and therefore within the ways that they shield opposed to - or perform - illnesses of the attention. (waal.co.nz)
  • Melanoma
  • Normally TGF- suppresses growth of human Filagra and sports but this response is lost in melanoma cells 82-84. (ideiseo.ru)
  • production
  • Ligation of AhR by a candidate endogenous ligand (FICZ) which is a UV metabolite of tryptophan causes expansion of Th17 cells and the induction of IL-22 production. (europa.eu)