Maturation of cells. Medical search. Frequent questions

In conclusion, in the oocytes obtained from bitches in diestrus and anestrus supplemented with FCS or BSA in SOF medium without oviductal cells, more positive effects were seen on canine oocyte maturation than with TCM-199 medium supplemented with same protein sources and oviductal cells. (tubitak.gov.tr)
Galvão A, Segers I, Smitz J, Tournaye H, De Vos M. In vitro maturation (IVM) of oocytes in patients with resistant ovary syndrome and in patients with repeated deficient oocyte maturation. (springer.com)
Single-cell transcriptome and translatome dual-omics reveals potential mechanisms of human oocyte maturation. (bvsalud.org)
Here, we developed a dual-omics methodology that includes both transcriptome and translatome sequencing (T&T-seq) of single- cell oocyte samples, and we used it to characterize the transcriptomes and translatomes during mouse and human oocyte maturation. (bvsalud.org)
T&T-seq analysis revealed distinct translational expression patterns between mouse and human oocytes and delineated a sequential gene expression regulation from the cytoplasm to the nucleus during human oocyte maturation. (bvsalud.org)

To elucidate the role of affinity in regulating these processes, a technique for measuring B cell receptor affinity maturation in GCs in situ was developed. (bham.ac.uk)
Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift. (cam.ac.uk)
Our findings thus suggest that the recycling of antigen variant-specific BEM cells and transport of antigen back to GC may support affinity maturation to antigenic drift. (cam.ac.uk)

In our lab, we found that hundreds of genes enriched in functional beta cells were not properly induced in the nonfunctional cells derived from embryonic stem cells, suggesting that manipulating critical regulators that can affect multiple beta cell genes simultaneously might be instrumental in directing beta cell differentiation and maturation in the culture dish. (ca.gov)
Therefore, this 3-year research proposal is intended to study the action of mechanisms of VPA in modulating DC differentiation and maturation, CD1 isoform molecules, adhesion molecules expression, possible signaling pathways, and the possible mechanisms underlied. (tmu.edu.tw)
Organic dust exposure alters monocyte-derived dendritic cell differentiation and maturation. (cdc.gov)

Despite some progress, it is at present still not possible to generate functional beta-cells in culture. (ca.gov)
However, when stem cell-derived beta-cell precursors are transplanted into mice, they acquire properties of functional beta-cells, indicating that the precursors have the potential to transition into a mature beta-cell state. (ca.gov)
This proposal explores strategies for maturing beta-cell precursors in the culture dish with the goal to produce fully functional insulin-producing beta-cells in vitro. (ca.gov)
The potential to generate functional pancreatic beta cells from human embryonic stem cells provides a promising avenue for beta cell replacement therapy for treatment of diabetes mellitus. (ca.gov)
Despite the rapid advancements in the field, current protocols still do not produce fully functional beta cells and the production of these cells takes at least six weeks. (ca.gov)
Understanding the molecular cues that regulate how a beta cell develops and matures would be critical in improving current approaches to generate functional beta cells. (ca.gov)
These novel regulators are highly expressed in insulin-producing islets and have very low expression in non-functional beta-like cells. (ca.gov)
This suggests that forcing expression of these regulators could accelerate the formation of functional mature beta cells. (ca.gov)
The morphological and functional maturation of Paneth cells occurred in the first 2 weeks and was accompanied by histone H3 lysine 27 (H3K27) trimethylation. (researchsquare.com)
Overall, our data show that post-transcriptional modification of histones, particularly H3K27 trimethylation, leads to the structural and functional maturation of Paneth cells during postnatal development. (researchsquare.com)
MyD88 and IFN-α/β are hierarchically required for functional maturation of dendritic cells and induction of CD4 T cells during infection. (gu.se)
Astrocytes have essential functions in brain homeostasis that are established late in differentiation, but the mechanisms underlying the functional maturation of astrocytes are not well understood. (nature.com)
The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state. (planteome.org)
Recent studies with adult-generated granule cells indicate that these cells are highly dynamic following denervation, surprisingly developing dendritic spines in the denervated zone in the absence of functional input. (frontiersin.org)
We found that efficient gene transfer into pDC can be achieved with VSVG-pseudotyped lentiviral vectors (LV) under the control of phoshoglycerate kinase (PGK) and elongation factor-1 (EF1α) promoters (28% to 90% of E-GFP + cells, respectively) in the absence of phenotypic and functional maturation. (biomedcentral.com)
Our findings reveal a novel type of activity-dependent plasticity acting on the timing of neuronal maturation and functional integration of newly generated neurons along the longitudinal axis of the adult hippocampus. (jneurosci.org)
The duration and the impact of those distinctive functional properties in the dentate gyrus network will depend on the speed of maturation of new DGCs. (jneurosci.org)
To determine the scope of the GATA-1/Foxo3 cooperativity, and to develop functional insights, we analyzed the GATA-1/Foxo3-dependent transcriptome in erythroid cells. (nih.gov)
Here we study the cellular phenotype of hPSC-CMs by comparing their single-cell gene expression and functional profiles in three engineered cardiac tissue configurations: human ventricular (hv) cardiac anisotropic sheet, cardiac tissue strip, and cardiac organoid chamber (hvCOC), with spontaneously aggregated 3D cardiac spheroids (CS) as control. (mssm.edu)
Towards the end of a HIV infection the number of functional CD4 + T cells falls, which leads to the symptomatic stage of infection known as the acquired immune deficiency syndrome ( AIDS ). (wikidoc.org)
This showed that helios is specifically found in immature outer hair cells, and is present at the point when they begin to mature into functional outer hair cells. (mrc.ac.uk)
Both of these genes code for proteins that are required for electromotility, reinforcing helios as an important factor regulating outer hair cell functional maturation. (mrc.ac.uk)
Therefore, a central goal of diabetes research is to generate large numbers of functional beta cells for transplantation into diabetic patients. (lu.se)

The effect of oviductal cells on in vitro maturation of canine oocytes" by SİNEM ÖZLEM ENGİNLER, ASİYE İZEM SANDAL et al. (tubitak.gov.tr)
The aims of this study were to investigate the effect of oviductal cells on in vitro maturation (IVM) of canine oocyte in Tissue Culture Medium 199 (TCM-199) or synthetic oviductal fluid (SOF) supplemented with bovine serum albumin (BSA) or fetal calf serum (FCS) and to compare the maturation rates of oocytes from the diestrus and anestrus stages. (tubitak.gov.tr)
We report the pregnancy and live birth achieved after in vitro maturation (IVM) of oocytes and PGT-A in a 23-year-old patient suffering from ovarian gonadotropin resistance. (springer.com)
Effect of granulosa cells source on in vitro maturation, fertilization and embryo development of prepubertal goat oocytes. (uab.cat)

Dendritic cells (DCs) are essential for the development of an immune response against pathogens such as Listeria monocytogenes and Salmonella typhimurium. (gu.se)
Differential expansion, activation and effector functions of conventional and plasmacytoid dendritic cells in mouse tissues transiently infected with Listeria monocytogenes. (gu.se)
Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
Dendritic cells (DC) play a critical role in initiating and directing adaptive immune responses against pathogens and tumours. (cmich.edu)
Gene modified dendritic cells (DC) are able to modulate DC functions and induce therapeutic immunity or tolerance in an antigen-specific manner. (biomedcentral.com)
Dendritic cells (DC) are the most efficient and crucial antigen presenting cells and the only cells capable of stimulating naïve T cells and initiating an effect immune response toward foreign antigens. (tmu.edu.tw)
Professional antigen presenting cells are primarily dendritic cells , macrophages and B cells , although dendritic cells are the only cell group that expresses MHC Class II constitutively (at all times). (wikidoc.org)
Some APCs also bind native (or unprocessed) antigens to their surface, such as follicular dendritic cells , but unprocessed antigens do not interact with T cells and are not involved in their activation. (wikidoc.org)
The constant region at the carboxyl-terminal end of the heavy chain, called the Fc region, binds to the Fc receptors of neutrophils, eosinophils, macrophages, dendritic cells, B cells, and the natural killer (NK) cells. (medscape.com)

Before DCs become potent antigen presenting cells, they undergo a maturation process that enables them to efficiently stimulate naïve T cells. (gu.se)
Function of T helper cells: Antigen presenting cells ( APCs ) present antigen on their Class II MHC molecules ( MHC2 ). (wikidoc.org)
Class II MHC proteins are generally only found on the surface of professional antigen-presenting cells (APCs). (wikidoc.org)
During an immune response, professional antigen-presenting cells (APCs) endocytose (absorb) foreign material (typically bacteria or viruses ), which undergoes processing , then travel from the infection site to the lymph nodes . (wikidoc.org)

B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene. (wikipedia.org)
TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF). (wikipedia.org)
Serum B-cell maturation antigen (sBCMA) is the cleaved form of BCMA, found at low levels in the serum of normal patients and generally elevated in patients with multiple myeloma (MM). The protein encoded by this gene is a member of the TNF-receptor superfamily. (wikipedia.org)
This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. (wikipedia.org)
This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. (wikipedia.org)
In addition, Paneth cells provide a niche for leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5)-expressing stem cells in crypts (Sato, et al. (researchsquare.com)
B-Cell Maturation Antigen, BCMA, human: BCMA, a member of the TNF receptor superfamily, binds to BAFF and APRIL. (nbsbio.co.uk)
Cytokines, including those that signal via receptors using the common cytokine receptor gamma-chain (gamma(c)), have been implicated at various stages of NK cell development. (pasteur.fr)
Here, we found that physiologically relevant concentrations of CORT, acting via the glucocorticoid receptor, functionally compromise DC maturation. (cmich.edu)
BCMA, B cell maturation antigen, is a member of the TNF receptor superfamily. (nexelis.com)
The research team also identified the role of the protein known as peroxisome proliferator activated receptor delta (PPARd) in inducing what is referred to as the metabolic switch in the lab-generated heart muscle cells. (azolifesciences.com)
While the signaling effects of the protein peroxisome proliferator activated receptor alpha (PPARa) are the most active in heart muscle cells, the researchers said PPARd signaling has a separate and important role in efficiently activating the gene regulatory networks, increasing the quantity and organization of the organelles involved in energy production, and augmenting the fatty acid oxidation process. (azolifesciences.com)
Helper T cells recognize these, with the help of their expression of CD4 co-receptor ( CD4+ ). (wikidoc.org)
Like all T cells, they express the T cell receptor / CD3 complex. (wikidoc.org)
The T cell receptor (TcR) consists of both constant and variable regions, the latter of which determines what antigen the T cell can respond to. (wikidoc.org)
In addition, an in vitro defect in CLL T-cell membrane receptor appearance is present. (elsevierpure.com)
PLA2G3 secreted from mast cells is coupled with fibroblastic lipocalin-type PGD 2 synthase (L-PGDS) to provide PGD 2 , which facilitates mast-cell maturation via PGD 2 receptor DP1. (elsevierpure.com)
Further, B cell antigen receptor (BCR) activation induced proteomic changes were studied in anti-IgM stimulated Ramos B cells in a long time series. (lu.se)

Preliminary studies so far show that forced expression of select candidates in immature precursor cells can induce the expression of several genes critical for beta cell maturation. (ca.gov)
In contrast, IL-15 plays a dominant role in early NK cell differentiation by maintaining normal numbers of immature and mature NK cells in the bone marrow and spleen. (pasteur.fr)
During a subsequent phase of maturation in the first few postnatal weeks, immature astrocytes exit the cell cycle and aquire a fully mature phenotype 1 . (nature.com)
In contrast, little is known of the mechanisms controlling the later step of maturation of immature postnatal astrocytes into fully mature adult astrocytes. (nature.com)
Immature DC are thought to act as sentinels in peripheral tissues where their main function is to capture antigen at sites of infection, whereas mature DC are highly efficient at priming T-cell-mediated immune responses against infectious pathogens. (cmich.edu)
To define the role of PKCζ signalling in the regulation of CBTC differentiation from a Th2 to a Th1cytokine phenotype we have developed a neonatal T cell maturation model which enables the cells to develop to CD45RA − /CD45RO + T cells while maintaining the Th2 immature cytokine bias, despite having normal levels of PKCζ. (edu.au)
The immature cells were treated with phytohaemagglutinin, but in addition with phorbol 12-myristate 13-acetate (PMA), an agonist which does not activate PKCζ. (edu.au)
The findings demonstrate that PKCζ signalling is essential for the immature neonatal T cells to transition from a Th2 to a Th1 cytokine production bias. (edu.au)
Our preliminary data show that treatment with VPA, enhanced cell aggregation of human monocyte-derived immature DC by increasing CD86 and down-regulation of CD1 molecule expression. (tmu.edu.tw)

Previous studies from our laboratory have resulted in a short list of candidate regulators of beta-cell maturation. (ca.gov)
Our studies have identified several novel regulators of gene expression, including transcription factors and small non-coding RNAs, which we predict will have critical roles in beta cell maturation. (ca.gov)
The objective of our research is to understand the molecular and cellular mechanisms that control beta cell maturation and function in the embryonic and adult pancreas. (lu.se)

We propose to manipulate these candidate regulators in vitro in order to force beta-cell precursors to adopt a mature phenotype. (ca.gov)
2007). It has been suggested that the intestinal transcription factor Blimp-1 is a critical driver of the postnatal epithelial phenotype, whose expression loss in the third postnatal week is a likely requirement for the maturation of the neonatal epithelium to adult epithelium (Harper, et al. (researchsquare.com)
Although IL-2, IL-4, and IL-7 have been reported to influence NK cell differentiation, we find that mice deficient in any or all of these cytokines have normal NK cell numbers, phenotype, and effector functions. (pasteur.fr)
We show that astrocyte maturation is promoted by extrinsic signals that induce multiple transcription factors that act largely independently to regulate distinct gene expression modules that together promote a mature astrocytic phenotype. (nature.com)
Microenvironment-based alterations in phenotypes of mast cells influence the susceptibility to anaphylaxis, yet the mechanisms underlying proper maturation of mast cells toward an anaphylaxis-sensitive phenotype are incompletely understood. (elsevierpure.com)
EE selectively increased cell differentiation into MSN phenotype and promoted host-to-graft connectivity. (lu.se)

Although the functions of astrocytes change profoundly during their maturation, the regulatory mechanisms underlying these changes have only begun to be examined. (nature.com)
To gain insights into the mechanisms driving astrocyte maturation, we have characterised acutely isolated murine astrocytes at both postnatal and adult stages, as well as in vitro differentiated astrocytes. (nature.com)

The septal dentate gyrus displayed higher levels of basal network activity and faster rates of newborn neuron maturation than the temporal region. (jneurosci.org)

These results highlight the central function of E-cadherin in the maintenance of two components of the intestinal epithelial defense: E-cadherin is required for the proper function of the intestinal epithelial lining by providing mechanical integrity and is a prerequisite for the proper maturation of Paneth and goblet cells. (uni-muenchen.de)

One of the most striking features of iNKT cells is usually their ability to rapidly produce multiple cytokines such as IL-4 IFN-γ GM-CSF IL-10 IL-13 and IL-17. (bioskinrevive.com)
These cytokines greatly impact innate immunity shape adaptive immune responses and donate to the defensive and detrimental assignments of iNKT cells in a variety of autoimmune allergic and inflammatory illnesses in protection against microbial an infection and in tumor surveillance (1-5). (bioskinrevive.com)
In this report, we have analyzed the roles for gamma(c)-dependent cytokines in the generation of bone marrow NKP and in their subsequent differentiation to mature NK cells in vivo. (pasteur.fr)
I). To investigate the effect of VPA, on human monocyte-derived DC functions, including surface markers expression, phagocytosis ability, cytokines production, and T cell proliferation/polarization. (tmu.edu.tw)
The activation of a resting helper T cell causes it to release cytokines and other stimulatory signals (green arrows) that stimulate the activity of macrophages , killer T cells and B cells , the latter producing antibodies . (wikidoc.org)

Afterwards, oocytes were fixed with acetic acid-ethyl alcohol and stained with aceto-orcein to determine nuclear maturation. (tubitak.gov.tr)
The combined use of transcriptome and translatome as indicators of gene expression profiles is usually more accurate than the use of transcriptomes alone, especially in cell types governed by translational regulation , such as mammalian oocytes . (bvsalud.org)
1998. Influence of organochlorine pesticides on maturation and post-fertilization development of bovine oocytes in vitro . (cdc.gov)

Although it is becoming apparent that TSC1/mTOR signaling is normally involved with many areas of T cell biology the need for TSC1/mTOR in iNKT cells is normally unclear. (bioskinrevive.com)
Postnatal maturation is associated with major changes in astrocyte biology. (nature.com)

A significant number of babies present transiently with low protein kinase C zeta (PKCζ) levels in cord blood T cells (CBTC), associated with reduced ability to transition from a neonatal Th2 to a mature Th1 cytokine bias, leading to a higher risk of developing allergic sensitisation, compared to neonates whose T cells have 'normal' PKCζ levels. (edu.au)
Mature T h cells are believed to always express the surface protein CD4 . (wikidoc.org)
After differentiating the mutant and corrected cells into lung organoids, we show expression of SFTPB mRNA during endodermal and organoid differentiation but the protein product only after organoid differentiation. (nature.com)
The ARID1A protein and other SWI/SNF subunits are thought to act as tumor suppressors, which keep cells from growing and dividing too rapidly or in an uncontrolled way. (medlineplus.gov)
B cell protein samples labeled with Cy3 and Cy5 and separated in nonlinear pH gradient 3-10. (lu.se)
Two-dimensional differential gel electrophoresis (2D-DIGE) and matrix-assisted laser desorption/ionization-time of flight-mass spectrometry (MALDI-TOF-MS) based proteomics was used to study differential protein abundance in various B cell types during B cell maturation (cell lines are listed in Supplementary Table 1 ). (lu.se)
A total of 2063 protein spots across eight human B cell lines were clustered on the basis of the relative protein abundance ( Supplementary Figure 1 and S2). (lu.se)
Antibodies can be found on the surface of lymphocytes as an integral part of the cell membrane protein or can be freely circulating in the blood or be part of one of the body's gland secretion. (medscape.com)

Evaluation of purified iNKT cells uncovered that TSC1 promotes T-bet which regulates iNKT maturation but downregulates ICOS appearance in iNKT cells by inhibiting mTOR complicated 1 (mTORC1). (bioskinrevive.com)
Here, we show that local network activity regulates the rate of maturation of adult-born neurons along the septotemporal axis of the hippocampus. (jneurosci.org)

Astrocytes are generated from neural stem cells (NSCs) during late embryonic and early postnatal stages. (nature.com)
Prenatal development can be divided into the embryonic phase (0-8 wk), characterized by organogenesis, and the fetal phase, characterized by organ maturation. (medscape.com)
Early in embryonic development, these cells begin to take different pathways in order to differentiate and mature into the two hair cell types. (mrc.ac.uk)
Cell replacement using human embryonic stem cells (hESCs) derivatives may offer new therapeutic opportunities to replace degenerated neurons and repair damaged circuits. (lu.se)

1997). Within 14 days of postnatal development, Paneth cells mature and express cryptdin proteins as a specific marker (Bry, et al. (researchsquare.com)
At each maturation stage, expression of proteins affects the commitment to move to the next stage. (lu.se)
Defects in genes and proteins important for B cell maturation block the maturation on certain stage and cause primary immunodeficiencies ( IDbase ). (lu.se)
These may be different molecules within the cells like proteins, polysaccharides, or nucleoproteins and may also be the whole cell, like a tumor cell or organisms like bacteria, viruses, fungi, parasites, or agents containing genetic material such as nucleic acids or lipids. (medscape.com)

Strikingly, downregulating Exosc8, or additional exosome complex components, in primary erythroid precursor cells induced erythroid cell maturation. (nih.gov)
For example, during the maturation of oxygen-transporting red blood cells called erythrocytes, a selective form of autophagy known as mitophagy eliminates most mitochondria from precursor cells called reticulocytes. (the-scientist.com)

Our data reveal that TSC1-reliant control of mTORC1 is essential Thy1 for terminal iNKT maturation and effector lineage decisions leading to the predominance of iNKT-1 cells. (bioskinrevive.com)
However, the pathway by which DCs mature can influence their capacity to induce effector functions in T cells. (gu.se)
T helper cells (also known as effector T cells or T h cells ) are a sub-group of lymphocytes (a type of white blood cell or leukocyte ) that plays an important role in establishing and maximizing the capabilities of the immune system . (wikidoc.org)

Asmani, M.N., J. Ai, G. Amoabediny, A. Noroozi, M. Azami, S. Ebrahimi-Barough, M. Navaei-Nigjeh, A. Ai, M. Jafarabadi (2013) Three-dimensional culture of differentiated endometrial stromal cells to oligodendrocyte progenitor cells (OPCs) in fibrin hydrogel. (karger.com)
Bakshi, A., C.A. Keck, V.S. Koshkin, D.G. LeBold, R. Siman, E.Y. Snyder, T.K. McIntosh (2005) Caspase-mediated cell death predominates following engraftment of neural progenitor cells into traumatically injured rat brain. (karger.com)
ISCs give rise to transient amplifying cells that become progenitor cells positioned at the bottom two-thirds of the crypts (Barker and Clevers, 2007). (researchsquare.com)
The activation of Notch signaling targets Hes-1 and Math-1 differentiates the early progenitor cells into absorptive cells and secretory cell lineages, respectively, in IECs (Fre, et al. (researchsquare.com)
Adult neurogenesis is a complex process whereby neural progenitor cells adopt a neuronal fate, migrate, and mature over several weeks. (jneurosci.org)

Crypts begin to form around day 7 of postnatal mice (P7), and Paneth cells usually appear within the first 2 weeks. (researchsquare.com)
Inhibition of H3K27 trimethylation suppressed crypt formation and Paneth cell maturation on organoids derived from ileum of early second postnatal mouse. (researchsquare.com)

they cannot kill infected host (also known as somatic ) cells or pathogens , and without other immune cells they would usually be considered useless against an infection. (wikidoc.org)
Xenophagy targets bacterial pathogens for destruction, while mitophagy aids red blood cell maturation. (the-scientist.com)

We have previously described committed NK cell precursors (NKPs), which have the capacity to generate NK cells, but not B, T, erythroid, or myeloid cells, after in vitro culture or transfer to a fetal thymic microenvironment. (pasteur.fr)

This protocol facilitates the use of human pluripotent stem cell-derived neurons for high content screening applications. (jove.com)
Human pluripotent stem cell-derived neurons are increasingly relevant in the areas of basic research, drug development, and degenerative medicine. (jove.com)
Cardiac in vitro models have become increasingly obtainable and affordable with the optimization of human pluripotent stem cell-derived cardiomyocyte (hPSC-CM) differentiation. (mssm.edu)
A Mount Sinai-led team has developed a reproducible and scalable method to advance maturation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs)-;cells that support heart muscle contraction, generated in the lab from human stem cell lines-;which researchers say will improve approaches for disease modeling, regenerative therapies, and drug testing. (azolifesciences.com)
2022) PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes. (azolifesciences.com)
Surfactant is produced by alveolar type II cells which can be differentiated in vitro from patient specific induced pluripotent stem cell (iPSC)-derived lung organoids. (nature.com)
They are 3-dimensional, complex, multicellular structures that can be derived from patient specific human induced pluripotent stem cells (hiPSCs). (nature.com)
Similarly, destruction of neonatally abundant pluripotent stem cells would likely have a more pervasive outcome than destruction of The value of incorporating immunologic appeared more severe and/or persistent when single lineages or differentiated cells that pre- data for the toxicologic assessment of drugs, the exposure occurred perinatally when com- dominate in adults. (cdc.gov)

Cells Tissues Organs (2016) 202 (1-2): 85-101. (karger.com)
From the SCS, BEM cells may exit the lymph node to enter distant tissues, while some BEM cells interact with and take up antigen from SCS macrophages, followed by CCL21-guided return towards the GC. (cam.ac.uk)
In humans, at least two subsets of DC are known in the blood, myeloid DC (also known as interstitial or dermal DC), and plasmacytoid DC (pDC) and Langerhans cells (LC) in the tissues [ 3 ]. (biomedcentral.com)
The cells that have the inherent property of innate and adaptive immunity within the body are present at different sites including the blood, lymphatic system (lymph, lymphoid nodules and lymphoid organs), epithelium, and connective tissues. (medscape.com)

Maturation and positioning of goblet cells and Paneth cells, the main cell lineage of the intestinal innate immune system, was severely disturbed. (uni-muenchen.de)
The earliest cell in B-lymphocyte lineage that produces Ig is the pre-B lymphocyte. (medscape.com)

A Phase 1b/2 study of JNJ-4528, a CAR-T cell therapy directed against BCMA in myeloma patients refractory to a proteasome inhibitor or immunomodulatory drug, and who had received an anti-CD38 antibody has been completed. (wikipedia.org)
ALLO-715 is a CAR-T therapy by Allogene Therapeutics that targets B-cell maturation antigen (BCMA). (wikipedia.org)
BCMA is expressed on mature B-cells and other B-cell lines and plays an important role in B cell development, function and regulation. (nbsbio.co.uk)
BCMA expression has been found in immune organs and mature B cell lines. (nexelis.com)
Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. (nexelis.com)
The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells, this is suggested that BCMA may play an important role in B cell development, function and regulation. (nexelis.com)
The BCMA assay is a solid-phase ELISA that may be used to measure BCMA in cell cuture supernates, serum, plasma, and urine. (nexelis.com)

This is mostly because of their unique capacity to stimulate naïve T cells. (gu.se)
Antigens are the molecules that are recognized and stimulate the cells of immune system. (medscape.com)

In earlier studies, the development of snoRNA expression vectors was one of the main approaches to study the influence of box C/D snoRNAs on target genes in mammalian cells. (hindawi.com)
Astrocytes are the most abundant glial cells in the mammalian central nervous system and they serve essential functions in brain development and homoeostasis. (nature.com)
We have investigated the maturation sites of avian and mammalian C-type retroviruses in polarized epithelial cells. (elsevierpure.com)

The most well characterized regulatory steps of adult hippocampal neurogenesis are the rate of progenitor cell proliferation and the survival rate of new DGCs. (jneurosci.org)
We examined the survival, maturation, self-organization and integration of the graft. (lu.se)
We examined the survival, maturation, self-organization and integration of the graft as well as its impact on lesion-dependent motor alterations up to 6 months post-graft. (lu.se)

Therefore, extrinsic signals orchestrate the expression of multiple intrinsic regulators, which in turn induce in a modular manner the transcriptional and chromatin changes underlying astrocyte maturation. (nature.com)
In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
The researchers found that this method can induce an independent mechanism of cardiac maturation, and when combined with PPARd, it enhances oxidative metabolism, allowing for efficient energy generation from both carbohydrates and fatty acids. (azolifesciences.com)

However, DCs that matured by direct contact with the bacteria, but in the absence of these two factors, were less competent at stimulating naïve T cells than their wild type counterpart due to a decreased capacity to process bacteria-derived antigens. (gu.se)

2008). Lgr5 deficiency leads to premature Paneth cell differentiation in the small intestine without detectable effects on the differentiation of other cell lineages, or on proliferation or migration (Garcia, et al. (researchsquare.com)

Deregulation of mTOR signaling because of TSC1 deficiency continues to be implicated in propensity to loss of life lack of quiescence and level of resistance to anergy of T cells aswell as unusual function of mast cells and macrophages (34-41). (bioskinrevive.com)
Mice lacking PLA2G3, L-PGDS or DP1, mast cell-deficient mice reconstituted with PLA2G3-null or DP1-null mast cells, or mast cells cultured with L-PGDS-ablated fibroblasts exhibited impaired maturation and anaphylaxis of mast cells. (elsevierpure.com)

mTOR is normally a serine/threonine kinase having the ability to integrate environmental stimuli to modify cell metabolism success development and proliferation. (bioskinrevive.com)

Launch The invariant NKT (iNKT) cells play essential jobs in both innate and adaptive immune system replies (1-4). (bioskinrevive.com)
T h cells are involved in activating and directing other immune cells, and are particularly important in the immune system . (wikidoc.org)
CD4 + T cells are generally treated as having a pre-defined role as helper T cells within the immune system , although there are known rare exceptions. (wikidoc.org)
The immune system is an inherent self-defense system consisting of cells that helps the body distinguish between self and non-self molecules. (medscape.com)
Different pathways regulate different immune cells to help the body differentiate the bodies own healthy cells from disease-causing agents including bacteria, viruses, fungi, parasites, cancerous cells, and many more. (medscape.com)

There was an increase of cell surface layers of the epithelium with the chronic use of alcohol. (bvsalud.org)
Over time, many studies have sought to evaluate the influence of extrinsic factors (tobacco and alcohol consumption) and intrinsic factors such as sex and age in the process of oral epithelium maturation 2,7 . (bvsalud.org)

2005). Furthermore, in secretory cell lineages, Gfi1 functions to select goblet/Paneth versus enteroendocrine progenitors (Shroyer, et al. (researchsquare.com)

Aizawa, Y., N.D. Leipzig, T. Zahira, M.S. Shoichet (2008) The effect of immobilized platelet derived growth factor AA on neural stem/progenitor cell differentiation on cell-adhesive hydrogels. (karger.com)

Here we identify extensive transcriptional changes that occur during murine astrocyte maturation in vivo that are accompanied by chromatin remodelling at enhancer elements. (nature.com)

Inasmuch as artificial box C/D RNAs decreased viability of transfected human cells, we propose that natural snoRNAs as well as their artificial analogues can influence the maturation of complementary pre-mRNA and can be effective regulators of vital cellular processes. (hindawi.com)
Loss of E-cadherin led cells migrate faster along the crypt-villus axis and perturbed cellular differentiation. (uni-muenchen.de)
The cellular response is mainly a lymphocyte-mediated reaction, whereas the humoral response includes production of antibodies against the antigen by the plasma cells. (medscape.com)

However, whether the timing of maturation of newborn DGCs can be regulated by changes that occur within a physiological range of neuronal activity remains unknown. (jneurosci.org)

A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation. (uni-muenchen.de)
Paneth cells are antimicrobial peptide-secreting epithelial cells located at the bottom of the intestinal crypts of Lieberkühn. (researchsquare.com)
Paneth cell dysfunction has been reported to correlate with Crohn's disease-like inflammation, showing narrow crypts or loss of crypt architecture in mice. (researchsquare.com)
The morphology of dysfunctional Paneth cells is similar to that of a Paneth/goblet intermediate cell. (researchsquare.com)
However, it remains unclear whether the formation of the crypt is related to the maturation of Paneth cells. (researchsquare.com)
2005). Mucus-secreting goblet cells migrate toward the villi tip, whereas antimicrobial peptide-secreting Paneth cells move to the base of the crypts. (researchsquare.com)
2009). However, the relation between the localization of Paneth cells at the bottom of the crypt and their maturation remains to be elucidated. (researchsquare.com)

We found that transfection of artificial box C/D snoRNA analogues directed to HSPA8 pre-mRNAs into human cells induced suppression of the target mRNA expression in a time- and dose-dependent manner. (hindawi.com)
This protocol describes a detailed procedure for resuspending and culturing human stem cell derived neurons that were previously differentiated from neural progenitors in vitro for multiple weeks. (jove.com)
In addition to human iPSCs, it can be used to replate culture of primary neurons or to resuspend them for fact sorting or single cell sequencing. (jove.com)
We are moving a step closer to understanding how to leverage our knowledge of human development to improved access to mature human cell types. (azolifesciences.com)
Here we show the differentiation of patient specific iPSCs derived from a patient with SFTPB deficiency into lung organoids with mesenchymal and epithelial cell populations from both the proximal and distal portions of the human lung. (nature.com)
Gene therapy has been utilized successfully to repair or inactivate mutations in animal models of monogenic human diseases 19 as well as human in vitro cells 12 . (nature.com)
Conclusions: The data support the long-term therapeutic potential of ESC-derived human striatal progenitor grafts for the replacement of degenerated striatal neurons in HD and suggest that EE can effectively accelerate the maturation and promote the integration of human striatal cells. (lu.se)

Our versatile team of scientists, working with state of the art technology platforms, were instrumental in the development, qualification, validation, and large-scale sample testing of assays that supported the FDA filing of almost 350 new molecular entities, including blockbuster vaccines and biologics, anti-viral drugs, immunotherapy, gene and cell therapy products. (nexelis.com)
According to our (Global Info Research) latest study, due to COVID-19 pandemic, the global B Cell Maturation Antigen Targeted Therapy market size is estimated to be worth US$ million in 2021 and is forecast to a readjusted size of USD million by 2028 with a CAGR of % during forecast period 2022-2028. (market.biz)
Hospitals accounting for % of the B Cell Maturation Antigen Targeted Therapy global market in 2021, is projected to value USD million by 2028, growing at a % CAGR in next six years. (market.biz)
Market segmentation B Cell Maturation Antigen Targeted Therapy market is split by Treatment Method and by Application. (market.biz)
Chapter 2, to profile the top players of B Cell Maturation Antigen Targeted Therapy, with revenue, gross margin and global market share of B Cell Maturation Antigen Targeted Therapy from 2019 to 2022. (market.biz)
Chapter 3, the B Cell Maturation Antigen Targeted Therapy competitive situation, revenue and global market share of top players are analyzed emphatically by landscape contrast. (market.biz)
Chapter 11 and 12, to describe B Cell Maturation Antigen Targeted Therapy research findings and conclusion, appendix and data source. (market.biz)
Because of this, potential therapies to restore hearing have been focused on understanding the genetic roadmap that dictates how these hair cells develop and mature, as this could help initiate their replacement using stem cell therapy. (mrc.ac.uk)

Here you can view 2D-DIGE images representing B cell proteomes at different maturation stages. (lu.se)

2000. A metabolite of methoxychlor, 2,2-bis( p hydroxyphenyl)-1,1,1-trichloroethane, reduces testosterone biosynthesis in rat leydig cells through suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme. (cdc.gov)

Infection or vaccination leads to the development of germinal centers (GC) where B cells evolve high affinity antigen receptors, eventually producing antibody-forming plasma cells or memory B cells. (cam.ac.uk)
Here we follow the migratory pathways of B cells emerging from germinal centers (BEM) and find that many BEM cells migrate into the lymph node subcapsular sinus (SCS) guided by sphingosine-1-phosphate (S1P). (cam.ac.uk)

Immunoglobulins (Igs), the term is sometimes used interchangeably with "antibodies," are glycoprotein molecules produced by B lymphocytes and plasma cells in response to an immunogen or after recognition of specific epitopes on the antigen. (medscape.com)

however, stem cell injection alone has been unsuccessful in many areas of neural regeneration. (karger.com)
Aboody, K., A. Capela, N. Niazi, J.H. Stern, S. Temple (2011) Translating stem cell studies to the clinic for CNS repair: current state of the art and the need for a Rosetta stone. (karger.com)
Complex genetic networks control hematopoietic stem cell differentiation into progenitors that give rise to billions of erythrocytes daily. (nih.gov)
A study reporting this new protocol was published in the April 7 print edition of the journal Cell Stem Cell . (azolifesciences.com)
Cell Stem Cell. (azolifesciences.com)
These new insights into hair cell maturation bring us a crucial step closer in the goal towards developing stem cell therapeutic approaches to treat hearing loss. (mrc.ac.uk)

All intestinal epithelial cells (IECs) originate from intestinal stem cells (ISCs) that reside in niches of the lower crypt. (researchsquare.com)
Similar results were obtained with a continuous line of mouse mammary epithelial cells infected with Fried, Moloney, Rauscher, or Kirsten murine leukemia viruses, or Friend virus-related or Moloney virus-related mink cell focus-forming viruses. (elsevierpure.com)
Alveolar type II (ATII) epithelial cells synthesize, secrete and recycle all components of surfactant and dysfunction in surfactant metabolism can result in a variety of pediatric lung diseases including respiratory distress syndrome and interstitial lung disease 3 . (nature.com)

Conditional roles of MyD88 and IFN-α/β in homeostatic regulation of dendritic cell maturation but not for development of protective CD8 T cell memory response against Listeria. (gu.se)
Alternatively, abnormal SWI/SNF complexes may disrupt the regulation of genes that help control the growth and division of cells, which leads to cancer. (medlineplus.gov)

Furthermore mice missing T-bet exhibited both a terminal maturation defect of iNKT cells and a predominance of iNKT-17 cells and elevated ICOS appearance was necessary for the predominance of iNKT-17 cells in the populace of TSC1-lacking iNKT cells. (bioskinrevive.com)

Following T cell development , matured, naïve (meaning they have never been exposed to the antigen to which they can respond) T cells leave the thymus and begin to spread throughout the body, including the lymph nodes . (wikidoc.org)
CD4 + T cells have TcRs with an affinity for Class II MHC, and it is believed that CD4 is involved in determining MHC affinity during maturation in the thymus . (wikidoc.org)

Applying MPTR to dermal fibroblasts from middle-aged donors, we found that cells temporarily lose and then reacquire their fibroblast identity, possibly as a result of epigenetic memory at enhancers and/or persistent expression of some fibroblast genes. (elifesciences.org)

Our previous study showed that the absorptive cells of the jejunum and ileum change rapidly and dramatically from suckling to adult type during the weaning period (Fujita, et al. (researchsquare.com)
NK cells differentiate in adult mice from bone marrow hemopoietic progenitors. (pasteur.fr)
Early studies revealed that in response to deafferentation, axons of remaining fiber systems and dendrites of mature granule cells undergo lamina-specific changes, providing one of the first examples of structural plasticity in the adult brain. (frontiersin.org)
Given the increasing role of adult-generated new neurons in the function of the dentate gyrus, we also compare the response of newborn and mature granule cells following lesioning of the perforant path. (frontiersin.org)
This classic lesion provided some of the first evidence for structural plasticity following injury in the CNS, and also provides an opportunity to examine the injury response of some of the most highly plastic neurons in the brain, adult-generated newborn granule cells. (frontiersin.org)

Therefore, researchers have begun exploring combined therapies with biomaterials that promote cell growth and differentiation while localizing cells in the injured area. (karger.com)

This volume is concerned with the individual steps in the pathway of retrovirus morphogenesis and maturation starting at the point where the components of the virion have been synthesized within the infected cell and ending once the infectious virion has been released from this cell. (powells.com)
The individual chapters of the book deal with specific steps in the pathway of retroviral morphogenesis and maturation, starting at the time when the components of the virus have been synthesized within the infected cell and ending once the infectious virion has been released from the cell. (powells.com)

Surprisingly, the few residual NK cells generated in absence of IL-15 appear relatively mature, expressing a variety of Ly49 receptors and demonstrating lytic and cytokine production capacity. (pasteur.fr)

Once at the lymph nodes, the APC begins to present antigen peptides that are bound to Class II MHC, allowing CD4 + T cells that express specific TcR's against the peptide/MHC complex to activate. (wikidoc.org)

These effects were biologically significant, as CORT treatment resulted in a marked reduction in the ability of DC to prime naive CD8 + T cells in vivo. (cmich.edu)

These variants are somatic, which means they are acquired during a person's lifetime and are present only in tumor cells. (medlineplus.gov)

Anatomy56

Organisms20

Chemicals and Drugs66

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes75

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Named Groups1

Health Care1

Oocyte maturation5

Affinity maturation3

Differentiation and maturation3

Functional23

Vitro maturation4

Dendritic cells9

Antigen prese4

Receptor18

Immature9

Beta cell maturation3

Phenotype6

Mechanisms2

Neuron maturation1

Proper maturation1

Cytokines5

Oocytes3

Biology2

Protein8

Regulates2

Embryonic4

Proteins4

Precursor cells2

Effector3

Progenitor cells5

Postnatal2

Pathogens2

Erythroid1

Pluripotent8

Tissues4

Lineage2

BCMA7

Stimulate2

Mammalian3

Survival3

Induce3

Antigens1

Migration1

Mast cells2

Proliferation1

Immune5

Epithelium2

Lineages1

Platelet1

Transcriptional1

Cellular3

Neuronal1

Paneth7

Human7

Therapy8

Stages1

20001

Germinal2

Molecules1

Stem cell6

Epithelial cells3

Regulation2

Defect1

Thymus2

Fibroblasts1

Adult5

Therapies1

Morphogenesis2

Surprisingly1

Peptide1

Vivo1

Tumor1