AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and Occupations
Tissue Inhibitor of MetalloproteinasesTissue Inhibitor of Metalloproteinase-1Matrix Metalloproteinase 2Matrix MetalloproteinasesTissue Inhibitor of Metalloproteinase-2Matrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsTissue Inhibitor of Metalloproteinase-3Matrix Metalloproteinase 3Matrix Metalloproteinase 1MetalloendopeptidasesMatrix Metalloproteinase 14Matrix Metalloproteinases, Membrane-AssociatedGelatinasesMatrix Metalloproteinase 7Matrix Metalloproteinase 13CollagenasesMatrix Metalloproteinase 8Extracellular MatrixMatrix Metalloproteinase 12MetalloproteasesMatrix Metalloproteinase 10Matrix Metalloproteinases, SecretedProtease InhibitorsMatrix Metalloproteinase 11Antigens, CD147CollagenMatrix Metalloproteinase 15Enzyme PrecursorsMatrix Metalloproteinase 16RNA, MessengerCells, CulturedExtracellular Matrix ProteinsADAM ProteinsGelatinGene Expression Regulation, EnzymologicNeoplasm InvasivenessFibroblastsPhenylmercuric AcetateCell MovementMicrobial CollagenaseReverse Transcriptase Polymerase Chain ReactionImmunohistochemistryMatrix Metalloproteinase 20Blotting, WesternEnzyme ActivationUp-RegulationCollagen Type I
MMPsTIMPsExtracellular matrixAngiogenesis inhibitorsTIMPEndogenousExogenousInhibitEndopeptidasesReceptorsIC50Regulate tissueTumorCancerMembraneInhibitsGelatinaseExpression of tissueSubstancesNeutrophilStem cellsInvasionGlycoproteinsAdiposeDiagnosticProteinsPlasmaHumanLiverActivityCellDestructionCellsInflammatoryFamilyPathologicalClinicalFoundPatientsDevelopmentRapid
MMPs26
  • Remodeling of atrial extracellular matrix (ECM) in atrial fibrillation (AF) involves changes in the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs). (unboundmedicine.com)
  • The expression and regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) in neuroectodermal precursor cells is undocumented. (uea.ac.uk)
  • Matrix metalloproteinases ( MMPs ) and tissue inhibitor of metalloproteinases (TIMPs) play a vital role in the pathogenesis of multiple myeloma (MM), especially for tumor invasion and osteolytic osteopathy. (bvsalud.org)
  • By breaking down extracellular matrix (ECM) components and releasing the proteins composing the ECM and growth factors , as well as their receptors, MMPs affect tissue integrity and promote cancer cell invasion and metastasis . (bvsalud.org)
  • The precursor of matrix metalloproteinase 9 (pro-MMP-9) forms a complex with the tissue inhibitor of metalloproteinases (TIMP)-1 through the C-terminal domain of each molecule, and the N-terminal domain of TIMP-1 in the complex interacts and inhibits active MMPs. (ox.ac.uk)
  • Matrix metalloproteinases (MMPs) are a family of endopeptidases playing a key role in tissue remodelling in both physiological and pathological conditions. (nih.gov)
  • Matrix metalloproteinases (MMPs) are a large family of mostly secreted, extracellularly acting proteolytic enzymes. (nature.com)
  • Matrix metalloproteinases (MMPs) are extracellularly acting enzymes that have long been known to have deleterious roles in brain injury and disease. (nature.com)
  • The balance of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) is crucial for the manifestation and progression of periodontal diseases and is one of the promising areas of scientific research in terms of developing methods for selective inhibition of MMPs. (spr-journal.ru)
  • Tissue inhibitor of metalloproteases (TIMPs) are inhibitors of matrix metalloproteinases (MMPs) that regulate tissue extracellular matrix (ECM) turnover. (nih.gov)
  • The underlying mechanisms of matrix destruction in TB remain poorly understood but consideration of the lung extracellular matrix predicts that matrix metalloproteinases (MMPs) will play a central role, owing to their unique ability to degrade fibrillar collagens and other matrix components. (ersjournals.com)
  • Since we proposed the concept of a matrix degrading phenotype in TB a decade ago, diverse data implicating MMPs as key mediators in TB pathology have accumulated. (ersjournals.com)
  • BACKGROUND: Changes in myocardial matrix metalloproteinases (MMPs) and the inhibitors of MMPs (TIMPs) have been demonstrated in congestive heart failure (CHF). (duke.edu)
  • The activities of matrix metalloproteinase (MMP)-2 and−9 were further inhibited and TIMP-1 and−2, and NM23-H1, the MMPs negative modulators, were further activated in the combined treatment. (frontiersin.org)
  • The metastasizing cells will proliferate in large numbers in situ and secrete proteolytic enzymes, such as the matrix metalloproteinases (MMPs), which degrade the extracellular matrix and blood vessel wall. (frontiersin.org)
  • Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. (biomedcentral.com)
  • It might have an important polymorphic association at the promoter regions of several MMPs such as MMP-1 (-1607 1G/2G), MMP-2 (-1306 C/T), MMP-3 (-1171 5A/6A), MMP-9 (-1562 C/T) and TIMP-2 (-418 G/C or C/C). Tissue inhibitors of metalloproteinases (TIMPs) are naturally occurring inhibitors of MMPs, which inhibit the activity of MMPs and control the breakdown of ECM. (biomedcentral.com)
  • Tissue inhibitors of matrix metallo-proteinases (TIMPs) are known to have the ability to inhibit the catalytic activity of MMPs. (biomedcentral.com)
  • Turpeenniemi-Hujanen et al suggested that the expressions of matrix expression of MMPs as well as their tissue inhibitors the TIMPs are associated with the clinical behaviour in head and neck malignancy [ 12 ]. (biomedcentral.com)
  • Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases. (molvis.org)
  • A reduction of MMPs in aqueous humor can alter the balance between MMPs and the tissue inhibitors of metalloproteinases (TIMPs). (molvis.org)
  • Batimastat (BB-94) is a potent and synthetic inhibitor of a broad spectrum of matrix metalloproteinases (MMPs), including interstitial collagenase (IC50 = 3 nM), stromelysin (IC50 = 20 nM), Mr 72,000 type IV collagenase (IC50 = 4 nM), Mr 92,000 type IV collagenase (IC50 = 4 nM), and matrilysin (IC50 = 6 nM). (adooq.com)
  • GM 6001 is a potent, reversible broad spectrum inhibitor of zinc-containing proteases, including matrix metalloproteinases (MMPs). (adooq.com)
  • TAPI-2 is an inhibitor of TACE, ADAMs, ACE secretase, and other MMPs (metalloproteinases). (adooq.com)
  • UK 356618 is a selective and potent inhibitor of MMP-3 that shows selectivity over a range of MMPs. (adooq.com)
  • Development of most solid tumors is characterized by an increase in secretion and activation of matrix metalloproteinases (MMPs) produced by either the tumor cells or tumor-associated fibroblasts. (bvsalud.org)
TIMPs3
  • The most notorious endogenous metalloproteinases are tissue inhibitors of metalloproteinases (TIMPs). (wikipedia.org)
  • The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). (embl.de)
  • It is suggested that the hemopexin domain facilitates binding to a variety of molecules and proteins, for example the HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs). (embl.de)
Extracellular matrix6
  • Lung extracellular matrix destruction is essential to TB transmission and consequently of critical importance to the global success of Mtb. (ersjournals.com)
  • The mechanism whereby Mtb targets the lung apices is unknown, but once it reaches the lung interstititum, breakdown of the extracellular matrix must occur for the pathogen to disseminate via the airways. (ersjournals.com)
  • According to a common concept of thrombosis and hemostasis, damage or injury of a vessel wall and ensuing exposure of extracellular matrix components to the blood stream triggers platelets from the circulation to become adherent and to assemble into a thrombus, thus limiting the extravasation of blood ( 1 , 2 ). (frontiersin.org)
  • The flow-dependent adhesion of platelets to those and other extracellular matrix components is stabilized by a panel of integrins, including integrin α 2 β 1 , α IIb β 3 , and α 6 β 1 (adhesive platelet population), while the initial activation of platelets is achieved by signaling via the collagen/laminin receptor, glycoprotein VI (GPVI). (frontiersin.org)
  • A critical step in this process is degradation of the basement membrane, which contains extracellular matrix (ECM) proteins and functions as a barrier to surrounding tissues. (aacrjournals.org)
  • During abruptions, decidual cell and neutrophil-derived proteases effectively degrade the decidual and fetal membrane extracellular matrix to promote preterm premature rupture of the membranes and preterm delivery (PTD). (scirp.org)
Angiogenesis inhibitors2
  • There are also cartilage-derived angiogenesis inhibitors. (wikipedia.org)
  • Batimastat is an anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. (adooq.com)
TIMP12
  • The inhibitory activities of glycosylated TIMP-1 and TIMP-3, but not TIMP-2, in AF tissues were markedly elevated and also localized in the atrial interstitium. (unboundmedicine.com)
  • TIMP-1 was found to be mostly colocalized with gelatinase activity over the AF tissues, implying the coexistence of gelatinase activity and TIMP-1, but TIMP-3 appeared only partially colocalized and discontinued the gelatinase activity surrounding the cardiomyocytes. (unboundmedicine.com)
  • pCellular activation of latent matrix metalloproteinase-2 (proMMP-2) requires formation of a cell membrane-associated activation complex that involves specific binding between the hemopexin domain of proMMP-2 (PEX) and the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (C-TIMP-2). (amrita.edu)
  • In this study, we tested the feasibility of inhibiting activation of proMMP-2 by exogenous inhibitors, which block the binding between PEX and TIMP-2. (amrita.edu)
  • The recombinant C-TIMP-2 and synthetic peptides from C-TIMP-2 were used as inhibitors for proMMP-2 activation. (amrita.edu)
  • These results suggest that neutrophil elastase may participate in the connective tissue destruction at the inflammatory sites not only by its direct action on matrix macromolecules but also by rendering pro-MMP-9 in the pro-MMP-9.TIMP-1 complex activable by MMP-3 as well as activating pro-MMP-3. (ox.ac.uk)
  • ΔMT1 isolated in a complex form with tissue inhibitor of metalloproteinases 2 (TIMP-2) from the stable transfectants demonstrated the NH 2 -terminal sequence of Ala 113 -Ile-Gln-Gly-Leu, indicating cleavage at one amino acid down-stream from the furin recognition sequence. (elsevierpure.com)
  • ΔMT1 isolated in a complex form with tissue inhibitor of metalloproteinases 2 (TIMP-2) from the stable transfectants demonstrated the NH2-terminal sequence of Ala113-Ile-Gln-Gly-Leu, indicating cleavage at one amino acid down-stream from the furin recognition sequence. (elsevierpure.com)
  • Duodenal biopsies from untreated, treated celiac patients and controls were used to quantify the expression of MMP-1, MMP-2, MMP-3, MMP-9, MMP-12, MMP-14, their inhibitor TIMP-1, IFN-gamma and TNF-alpha by using real-time reverse transcription-polymerase chain reaction and the gelatin/casein/elastin activities by gel zymography, and to isolate lamina propria mononuclear cells (LPMCs). (nih.gov)
  • Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2. (embl.de)
  • The binding properties of the newly described tissue inhibitor of metalloproteinases-4 (TIMP-4) to progelatinase A and to the COOH-terminal hemopexin-like domain (C domain) of the enzyme were examined. (embl.de)
  • To determine the expression of tissue inhibitors of metalloproteinases (TIMP-2) in oral squamous cell carcinoma (OSCC) and the difference in its expression level between positive and negative HPV-16 (human papilloma virus- 16) OSCC patients. (bvsalud.org)
Endogenous1
  • LTP-associated MMP proteolysis is probably then terminated by an increase in the activity of endogenous inhibitors called tissue inhibitors of metalloproteinases. (nature.com)
Exogenous1
Inhibit1
  • Matrix metalloproteinases and tissue inhibitors in multiple myeloma: promote or inhibit? (bvsalud.org)
Endopeptidases1
  • Matrix metalloproteinase are a family of zinc dependent endopeptidases that are capable of degrading most components of the extra cellular matrix (ECM) [ 7 - 9 ]. (biomedcentral.com)
Receptors1
  • TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. (adooq.com)
IC505
  • Compound 4 is also worth of note for its high potency as hBChE inhibitor (IC50 = 7 nM) and for the three order of magnitude selectivity versus hAChE. (ibecbarcelona.eu)
  • T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes. (adooq.com)
  • MMP3 inhibitor 1 is a potent and highly selective MMP-3 inhibitor with an IC50 of 1 nM. (adooq.com)
  • ARP 100 is a selective inhibitor of matrix metalloproteinases 2 (MMP-2) with IC50 value of 12 nM. (adooq.com)
  • ARP 101, selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1 (IC50 values are 0.81 and 486 nM respectively). (adooq.com)
Regulate tissue1
  • 2009) Progestin and thrombin regulate tissue factor expression in human term decidual cells. (scirp.org)
Tumor1
  • Tumor metastasis is characterized by cell detachment from primary tumors and invasion of recipient tissues ( 2 ). (aacrjournals.org)
Cancer4
  • During the metastasis, cancer cells in situ move to other tissues and organs from the blood circulation or the lymphatic system through proliferation, adhesion, invasion, and migration. (frontiersin.org)
  • It inhibited lung cancer cell invasion and down-regulated matrix metalloproteinase-7 (MMP-7), which promoted lung cancer cell invasion. (aacrjournals.org)
  • It was observed that miR‑130a was significantly upregulated in cervical cancer tissues compared with that in adjacent non‑tumorous tissues. (spandidos-publications.com)
  • These proteins play a master role in diverse physiological processes and diseases such as the homeostatic tissue remodeling and cancer 17 . (bvsalud.org)
Membrane1
  • The processing mechanism and gelatinolytic activity of the membrane-type matrix metalloproteinase 1 (MT-MMP-1) were examined by expressing in COS-1 cells a deletion mutant of MT-MMP-1 lacking the transmembrane domain (ΔMT1) and its site-directed mutant with a furin-resistant sequence in the propeptide domain (mutant ΔMT1). (elsevierpure.com)
Inhibits1
Gelatinase1
  • SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9. (adooq.com)
Expression of tissue1
  • De- cidual cells promote hemostasis through enhanced expression of tissue factor (TF), the primary initiator of hemostasis via thrombin generation, and plasminogen activator inhibitor-1, which inactivates tissue type plasminogen activator, the primary fibrinolytic agent. (scirp.org)
Substances1
  • Drug discovery and development of MMP inhibitors "The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances" (PDF). (wikipedia.org)
Neutrophil2
  • Preferential inactivation of tissue inhibitor of metalloproteinases-1 that is bound to the precursor of matrix metalloproteinase 9 (progelatinase B) by human neutrophil elastase. (ox.ac.uk)
  • Abruptions (decidual hemorrhage) produce excess thrombin which acts as autocrine/paracrine inducer of decidual cell expressed matrix metalloproteinases and of neutrophil chemoattractant and activator, interleukin-8. (scirp.org)
Stem cells1
  • Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
Invasion2
  • Degradation of matrix is a key event in progression, invasion and metastasis of potentially malignant and malignant lesions of the head and neck. (biomedcentral.com)
  • Degeneration of matrix is a key event in invasion and metastasis of malignant lesions of the head and neck. (biomedcentral.com)
Glycoproteins1
  • It constitutes fibrous proteins such as collagen and elastin, elongated glycoproteins such as fibronectin and laminin, which provide cell matrix adhesion. (biomedcentral.com)
Adipose2
  • TIMP4 is highly expressed in adipose tissue, its levels are further elevated following high-fat diet, but its role in obesity is unknown. (nih.gov)
  • Adipose tissue of Timp4 -/- -HFD mice showed reduced hypertrophy and fibrosis compared to WT-HFD mice. (nih.gov)
Diagnostic1
  • By integrating different datasets from the Gene Expression Omnibus (GEO) database, we analysed a merged expression matrix of pulpitis, aiming to identify biological pathways and diagnostic biomarkers of pulpitis. (researchsquare.com)
Proteins1
  • ECM consists of proteins and polysaccharides distributed in many different tissues of the body. (biomedcentral.com)
Plasma1
  • Scholars@Duke publication: Plasma matrix metalloproteinase and inhibitor profiles in patients with heart failure. (duke.edu)
Human3
  • Orthologous to human MMP9 (matrix metallopeptidase 9). (nih.gov)
  • CL-82198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), producing 89% inhibition at 10 mg/ml. (adooq.com)
  • Polymorphisms in the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 and the risk of human adenomyosis. (cdc.gov)
Liver1
  • CTS-1027 is a potent MMP inhibitor that protects Against TNFα- and α-Fas-Induced liver Injury. (adooq.com)
Activity3
  • Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. (embl.de)
  • Levels of PEX in these vascularized tissues suggest that it interacts with endothelial cell alphavbeta3 where it serves as a natural inhibitor of MMP-2 activity, thereby regulating the invasive behavior of new blood vessels. (embl.de)
  • In contrast, BH3 mimetics without BCL-XLi activity, conventional chemotherapy, and MEK inhibitors show no effect. (ibecbarcelona.eu)
Cell2
  • It is influenced by angiogenesis, cell-cell and cell-extra cellular matrix (ECM) interactions. (biomedcentral.com)
  • ECM environment provides appropriate conditions for cell growth, cell differentiation and survival of tissues. (biomedcentral.com)
Destruction5
  • The key consequences of such tissue destruction are morbidity and mortality in TB patients. (ersjournals.com)
  • Cavities are often several centimetres across, so there must be very extensive lung matrix destruction for such cavitation to occur. (ersjournals.com)
  • Lung matrix destruction is critical to the life cycle of Mycobacterium tuberculosis (Mtb). (ersjournals.com)
  • Once implanted at the apex, Mtb must engage the host immune response to drive matrix destruction, resulting in cavities within which it proliferates exponentially. (ersjournals.com)
  • Alpha-1 Antitrypsin Deficiency Alpha-1 antitrypsin deficiency is congenital lack of a primary lung antiprotease, alpha-1 antitrypsin, which leads to increased protease-mediated tissue destruction and emphysema in adults. (msdmanuals.com)
Cells4
  • If harmful stimuli cannot be removed in time, increasing numbers of immune cells are recruited to the pulp tissue[5] and the immune-inflammatory balance is disrupted. (researchsquare.com)
  • The metastasizing cells penetrate the blood vessel wall by invasiveness, and migrate in the circulation, extravasate out of the blood vessels, colonize in the distant tissue, initiate angiogenesis, and finally grow at the new site ( 2 , 3 ). (frontiersin.org)
  • We investigated the effect of HA on the expression of matrix metalloproteinases (MMP-2 and MMP-9) in cultured trabecular meshwork cells. (molvis.org)
  • Trabecular meshwork cells were cultured from trabecular tissues obtained from the POAG patients aged 23 to 45. (molvis.org)
Inflammatory1
  • Such inflammatory tissue damage is responsible for morbidity and mortality in patients. (ersjournals.com)
Family1
Pathological1
  • When the hard dental tissue is broken, various stimuli may induce pathological changes in dental pulp, which is difficult to heal due to the lack of collateral circulation[2]. (researchsquare.com)
Clinical1
  • Traditional methods of evaluating the status of dental pulp tissue in clinical practice have limitations. (researchsquare.com)
Found2
  • Examples include: Batimastat Cipemastat Ilomastat Marimastat MMI270 Prinomastat Rebimastat Ro 28-2653 Tanomastat Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algae, and bacteria. (wikipedia.org)
  • A total of 470 DEGs comprising 394 upregulated and 76 downregulated genes were found in pulpitis tissue. (researchsquare.com)
Patients1
  • The trabecular meshwork tissues used in this study were obtained from three POAG patients (2 males and 1 female) aged 23 to 45 years who underwent trabecular surgery. (molvis.org)
Development1
  • Currently, many MMP inhibitors (MMPIs) are under development for treating different malignancies. (biomedcentral.com)
Rapid1
  • TY - JOUR T1 - Upregulation of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases in rapid atrial pacing-induced atrial fibrillation. (unboundmedicine.com)