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Matrix Metalloproteinase 2Matrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsMatrix Metalloproteinase 14Matrix Metalloproteinase 1Matrix Metalloproteinase 3Matrix MetalloproteinasesMetalloendopeptidasesMatrix Metalloproteinase 13Matrix Metalloproteinase 7Matrix Metalloproteinases, Membrane-AssociatedExtracellular MatrixTissue Inhibitor of Metalloproteinase-2Matrix Metalloproteinase 8Matrix Metalloproteinase 12Tissue Inhibitor of Metalloproteinase-1CollagenasesGelatinasesMatrix Metalloproteinase 10Matrix Metalloproteinase 11Tissue Inhibitor of MetalloproteinasesAntigens, CD147MetalloproteasesProtease InhibitorsMatrix Metalloproteinase 15Matrix Metalloproteinases, SecretedMatrix Metalloproteinase 16CollagenExtracellular Matrix ProteinsTissue Inhibitor of Metalloproteinase-3Matrix Metalloproteinase 20Enzyme PrecursorsCells, CulturedNeoplasm InvasivenessRNA, MessengerGene Expression Regulation, EnzymologicCell MovementADAM ProteinsMatrix Metalloproteinase 17GelatinFibroblastsReverse Transcriptase Polymerase Chain ReactionBlotting, WesternPhenylmercuric AcetateEnzyme ActivationCollagen Type IImmunohistochemistryCell Line, TumorChondrocytesDipeptidesUp-RegulationCartilage, ArticularHemopexinThiophenesMolecular Sequence DataSynovial MembraneNuclear MatrixProteoglycansOsteoarthritisHydroxamic AcidsDisease Models, AnimalAmino Acid SequenceFibronectinsSignal TransductionDoxycyclineProcollagen N-EndopeptidaseTumor Cells, CulturedAggrecansEnzyme InhibitorsCartilageMice, Inbred C57BLLamininBone MatrixGene ExpressionMice, KnockoutCulture Media, ConditionedRecombinant ProteinsEnzyme InductionElastinPhenylalanineCell LineCell ProliferationTransfectionFurinTime FactorsCollagen Type IIIFibrosisVentricular RemodelingNeovascularization, PathologicMicrobial CollagenaseGene Expression RegulationUrokinase-Type Plasminogen ActivatorBase SequenceInterleukin-1Enzyme-Linked Immunosorbent AssayCollagen Type IIDown-RegulationWound HealingTumor Necrosis Factor-alphaDose-Response Relationship, Drug
MMPsInhibitorsTissueExtracellular matrix pCollagenStromelysinEnzymesCytokinesGeneInhibitionMetabolism2002MyocardialDisintegrinMMP3DegradeSynovialTuberculosisCleavageCathepsin2000ProteinsVascularDetectionArthritis ResearchBacteriaPathwaysPlasmaLaminin2001RecombinantMetallopeptidaseMorpheaBreakdownActivity of matrixGenesLevelsHumanPathologyBoneLungPrognosis
MMPs17
  • MMPs were described initially by Jerome Gross and Charles Lapiere (1962), who observed enzymatic activity (collagen triple helix degradation) during tadpole tail metamorphosis (by placing a tadpole tail in a collagen matrix plate). (wikipedia.org)
  • Diabetes mellitus in rats is characterized by excessive activity of several matrix metalloproteinases (MMPs), notably collagenase(s) and gelatinase(s), in skin, gingiva, and other tissues. (nih.gov)
  • The underlying mechanisms of matrix destruction in TB remain poorly understood but consideration of the lung extracellular matrix predicts that matrix metalloproteinases (MMPs) will play a central role, owing to their unique ability to degrade fibrillar collagens and other matrix components. (ersjournals.com)
  • Since we proposed the concept of a matrix degrading phenotype in TB a decade ago, diverse data implicating MMPs as key mediators in TB pathology have accumulated. (ersjournals.com)
  • Matrix metalloproteinases (MMPs) are enzymes capable of breaking down various connective tissue elements. (scite.ai)
  • This study aims to explore the association between the single-nucleotide polymorphisms (SNPs) of genes encoding ECM processing enzymes (a disintegrin and metalloproteinase with thrombospondin motifs [ADAMTSs]), ECM degrading enzymes (matrix metalloproteinases [MMPs]) and their tissue inhibitors of metalloproteinase (TIMPs), and POP. (scite.ai)
  • The degradation of type IX collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (MMPs) purified from the culture medium of rheumatoid synovial cells. (elsevierpure.com)
  • The pathology of ankylosing spondylitis (AS) suggests that certain cytokines and matrix metalloproteinases (MMPs) might provide useful markers of disease activity. (bath.ac.uk)
  • Measurement of 30 cytokines, five MMPs and four tissue inhibitors of metalloproteinases was carried out using Luminex® technology on a well-characterised population of AS patients (n = 157). (bath.ac.uk)
  • BACKGROUND: Changes in myocardial matrix metalloproteinases (MMPs) and the inhibitors of MMPs (TIMPs) have been demonstrated in congestive heart failure (CHF). (duke.edu)
  • Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components. (anaspec.com)
  • Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. (anaspec.com)
  • Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. (anaspec.com)
  • These groups include: serine proteinases, cysteine (thiol) proteinases, aspartic proteinases, and matrix metalloproteinases (MMPs). (stratech.co.uk)
  • One of the main difficulties in studying the mechanism of action of these matrix metalloproteinases (MMPs) derives from the physicochemical properties of the natural triple-helical collagen, which makes ii difficult to handle. (uni-bielefeld.de)
  • Some molecules are involved in several stages of the process of alveolar repair, for example matrix metalloproteinases (MMPs) 2 , among others. (bvsalud.org)
  • MMPs are an important family of metal-dependent endopeptidases and represent the major class of enzymes responsible for the degradation or resorption of all components of the extra-cellular matrix (ECM) 38 . (bvsalud.org)
Inhibitors2
Tissue6
Extracellular matrix p1
Collagen11
  • The present study evaluated cell viability, expression levels of collagen II (Col II) and matrix metalloproteinase‑13 (MMP‑13), and activity of the Wnt/β‑catenin and NF‑κB signaling pathways in treated SW1353 cells. (spandidos-publications.com)
  • Neither MMP-1 (collagenase) nor MMP-2 (so-called 'gelatinase') could digest type IX collagen, but MMP-3 (stromelysin) readily degraded it into smaller fragments. (elsevierpure.com)
  • This suggests that MMP-3 may be responsible for the pathological degradation and/or normal turnover of type IX collagen. (elsevierpure.com)
  • The ultimate result of the endothelial injury and inflammatory cascade is increased collagen and extracellular matrix deposition. (medscape.com)
  • Matrix Metalloproteinase-9 (MMP-9) may play a vital role in remodeling the basal lamina via its ability to degrade type IV collagen, one of the most abundant proteins comprising the basal lamina. (wku.edu)
  • This gene provides instructions for making an enzyme called matrix metallopeptidase 2, whose primary function is to cut (cleave) a protein called type IV collagen. (medlineplus.gov)
  • The MMP2 gene mutations that cause MONA completely eliminate the activity of the matrix metallopeptidase 2 enzyme, preventing the normal cleavage of type IV collagen. (medlineplus.gov)
  • MMP-3 enzyme is also known as Stromelysin-1or as Transin-1 which hydrolyzes natural collagen at physiological pH and temperature. (prospecbio.com)
  • MMP-3 hydrolyzes components of the extracellular matrix like proteoglycan, laminin, fibronectin, gelatin and collagen types III, IV and IX. (prospecbio.com)
  • Conclusions: The results confirm the usefulness of synthetic heterotrimeric collagenous peptides in the folded and unfolded state as mimics of the natural substrates collagen and gelatin, respectively, to gain a better a insight into the proteolytic mechanisms of matrix metalloproteinases. (uni-bielefeld.de)
  • Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases", CHEMISTRY & BIOLOGY , vol. 7, 2000, pp. 119-132. (uni-bielefeld.de)
Stromelysin2
  • MMP-3 (stromelysin-1, transin-1) is proposed as a potential therapeutic target. (anaspec.com)
  • Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3). (anaspec.com)
Enzymes1
  • Mouse gingival explants were cultured overnight in DMEM and the expression of secreted enzymes was analyzed by gelatin zymography in buffers containing 5 mM CaCl 2 (Tris-CaCl 2 ) in 50 mM Tris-HCl buffer with the addition of TEGDMA at different concentrations (0.62%, 1.25%, 2.5%, or 5.0% (v/v)). The gelatinolytic proteinase present in the conditioned media was characterized as matrix metalloproteinase by means of specific chemical inhibition. (springer.com)
Cytokines4
  • Still, activation of SF by LN1 may serve as a model for activation of fibroblasts by extracellular matrix compounds in the presence of growth factors or cytokines, and both pathways contribute to the aggressive invasive growth of SF in the course of RA. (biomedcentral.com)
  • The first profile was a surge of proinflammatory cytokines in semen (IL-6, IFN-γ, CCL-3, CCL-4) and plasma (CCL-3, CXCL-10, VEGF-A) at early stages of infection. (cdc.gov)
  • Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells. (bvsalud.org)
  • The detection of periodontopathic bacteria , host matrix metalloproteinases and cytokines in periodontitis patients with lesions undergoing episodic attachment loss could partially explain the mechanisms associated with the destruction of the supporting tissues of the tooth . (bvsalud.org)
Gene5
  • Liacini A, Sylvester J, Li WQ, Huang W, Dehnade F, Ahmad M and Zafarullah M: Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes. (spandidos-publications.com)
  • Diesel exhaust particles activate the matrix-metalloproteinase-1 gene in human bronchial epithelia in a beta-arrestin-dependent manner via activation of RAS. (duke.edu)
  • and (3) developing methods for delivery of extracutaneous gene therapy in epidermolysis bullosa. (stanford.edu)
  • Comparing HESC controls with HESCs deficient in SRC-3, gene enrichment analysis of the differentially expressed gene set revealed an overrepresentation of genes involved in chromatin remodeling, cell proliferation/motility, and programmed cell death. (frontiersin.org)
  • Pamidronate does not improve peripheral osteolysis in multicentric osteolysis and nodular arthropathy caused by a mutation in the matrix metalloproteinase 2 gene. (medscape.com)
Inhibition1
  • The aim of this study was to evaluate the effect of different concentrations of triethylene glycol dimethacrylate (TEGDMA) on the inhibition of matrix metalloproteinase 2 (MMP-2). (springer.com)
Metabolism2
  • Introduction and hypothesis Extracellular matrix (ECM) synthesis and metabolism abnormalities may influence the pelvic supporting system and lead to the occurrence and development of pelvic organ prolapse (POP). (scite.ai)
  • Identification of a novel heart/liver axis: Matrix metalloproteinases-2 negatively regulates cardiac secreted phospholipase a2 to modulate lipid metabolism and inflammation in the liver. (ualberta.ca)
20021
  • Gusman H, Santana RB, Zehnder M (2002) Matrix metalloproteinase levels and gelatinolytic activity in clinically healthy and inflamed human dental pulps. (springer.com)
Myocardial1
  • 3.DeCoux A, Lindsey ML, Villarreal F, Garcia RA, Schulz R. Myocardial matrix metalloproteinase-2: inside out and upside down. (bvsalud.org)
Disintegrin1
  • Matrix metalloproteinase-7 and adam-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy. (ualberta.ca)
MMP31
  • Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Dog Matrix Metalloproteinase 3 (MMP3) in serum, plasma and other biological fluids. (stemcellcharter.org)
Degrade2
Synovial1
  • However, an autocrine stimulation of MMP-3 expression by SF via TGF-β and LN1 seems rather unlikely, as LN1 is not expressed in high amounts in the adult synovial membrane. (biomedcentral.com)
Tuberculosis3
  • Approximately one-third of the world's population is thought to be infected with the causative organism, Mycobacterium tuberculosis (Mtb) [ 3 ]. (ersjournals.com)
  • Lung matrix destruction is critical to the life cycle of Mycobacterium tuberculosis (Mtb). (ersjournals.com)
  • Matrix metalloproteinase-1 (MMP-1) has been implied as an (etio)pathogenic factor in human lung and airway diseases such as emphysema, chronic obstructive pulmonary disease, chronic asthma, tuberculosis, and bronchial carcinoma and has been reported to be regulated by DEPs. (duke.edu)
Cleavage2
  • Upon the cleavage of the FRET peptide by MMP-3, the fluorescence of 5-FAM is recovered, and can be continuously monitored at excitation/emission = 490 nm/520 nm. (anaspec.com)
  • Component A: MMP-3 substrate 5-FAM/QXL™520 FRET peptide Ex/Em=490 nm/520 nm upon cleavage: 60 µL Component B: 5-FAM-Pro-Leu-OH, fluorescence reference standard Ex/Em=490 nm/520 nm: 1 mM, 10 µL Component C: APMA, 4-aminophenylmercuric acetate (Caution: Organic mercury. (anaspec.com)
Cathepsin1
  • MMP-3 is secreted as a latent proenzyme and is activated by a variety of proteinases, e.g. plasmin, trypsin, chymotrypsin, cathepsin G or human neutrophil elastase. (prospecbio.com)
20001
Proteins1
Vascular1
  • Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor. (ualberta.ca)
Detection2
  • Description: A sandwich ELISA kit for detection of Matrix Metalloproteinase 3 from Dog in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (stemcellcharter.org)
  • Furthermore, detection of replicative virus in semen and sexual transmission of the infection resulted in a paradigm shift in Zika virus virology ( 2 , 3 ). (cdc.gov)
Arthritis Research1
  • Arthritis Research & Therapy , 14 (3), [R127]. (bath.ac.uk)
Bacteria1
  • At 3, 10, and 20 days post-infection 4 infected animals, 3 animals inoculated with heat-inactivated bacteria and 1 control were sacrificed. (bmj.com)
Pathways2
  • which are all enrolled in extracellular matrix (ECM) pathways. (scite.ai)
  • To identify genes, signaling pathways and networks that are controlled by SRC-3 and potentially important for hormone-dependent decidualization, we performed RNA-sequencing on HESCs in which SRC-3 levels were significantly reduced at the time of administering the deciduogenic stimulus. (frontiersin.org)
Plasma3
  • The third profile involved sustained altered levels of factors in semen (IL-18, sICAM-1, G-CSF, MMP-2) and plasma (CCL-3, CXCL-1, sICAM-1, MMP-2, MMP-9), even after complete viral RNA clearance in plasma. (cdc.gov)
  • Scholars@Duke publication: Plasma matrix metalloproteinase and inhibitor profiles in patients with heart failure. (duke.edu)
  • Matrix metalloproteinase content and activity in low-platelet, low-leukocyte and high-platelet, high-leukocyte platelet rich plasma (PRP) and the biologic response to PRP by human ligament fibroblasts. (anaspec.com)
Laminin1
  • Attachment to LN1-laminin in the presence of TGF-β induces elevated MMP-3 expression in SF. (biomedcentral.com)
20011
Recombinant1
  • MMP 3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 401 amino acids (100-477a.a) and having a molecular mass of 45.2kDa. (prospecbio.com)
Metallopeptidase2
  • The activity of matrix metallopeptidase 2 appears to be important for a variety of body functions, including bone remodeling, which is a normal process in which old bone is broken down and new bone is created to replace it. (medlineplus.gov)
  • How a shortage of matrix metallopeptidase 2 leads to the other features of MONA, such as subcutaneous nodules and skin abnormalities, is unknown. (medlineplus.gov)
Morphea1
  • Women are affected approximately 3 times as often as men for all forms of morphea except the linear subtype, which only has a slight female predominance. (medscape.com)
Breakdown1
  • The mechanism whereby Mtb targets the lung apices is unknown, but once it reaches the lung interstititum, breakdown of the extracellular matrix must occur for the pathogen to disseminate via the airways. (ersjournals.com)
Activity of matrix1
  • The aim of this study was to evaluate comparatively the effect of fluoride (F) on the activity of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) involved in process of alveolar bone repair. (bvsalud.org)
Genes1
  • Klatt AR, Klinger G, Paul-Klausch B, Kühn G, Renno JH, Wagener R, Paulsson M, Schmidt J, Malchau G and Wielckens K: Matrilin-3 activates the expression of osteoarthritis-associated genes in primary human chondrocytes. (spandidos-publications.com)
Levels3
  • Since EMPD is a skin adenocarcinoma of apocrine gland origin that expresses high levels of RANKL and matrix metalloproteinase (MMP) 7, and EMPD is associated with the presence of RANK + M2 macrophages, we hypothesized that tumor-associated macrophages (TAMs) in adenocarcinomas such as PCAC might also express RANKL and MMP7. (iiarjournals.org)
  • These molecular findings are supported at the cellular level by the inability of HESCs to morphologically transform from a stromal fibroblastoid cell to an epithelioid decidual cell when endogenous SRC-3 levels are markedly reduced. (frontiersin.org)
  • Since perturbation of normal homeostatic levels of SRC-3 is linked with common gynecological disorders diagnosed in reproductive age women, this endometrial coregulator-along with its new molecular targets described here-may open novel clinical avenues in the diagnosis and/or treatment of a non-receptive endometrium, particularly in patients presenting non-aneuploid early pregnancy loss. (frontiersin.org)
Human2
  • Molecular changes in human osteoarthritic cartilage after 3 weeks of oral administration of BAY 12-9566, a matrix metalloproteinase inhibitor. (jrheum.org)
  • We show here that, like SRC-2, SRC-3 is expressed in the epithelial and stromal cellular compartments of the human endometrium during the proliferative and secretory phase of the menstrual cycle as well as in cultured HESCs. (frontiersin.org)
Pathology1
  • Our studies show that failure of the laminae is preceded by local elevated expression of the neutrophil chemoattractant IL-8, followed by recruitment of blood neutrophils which release matrix metalloproteinase 9 and oxygen radicals possibly causing laminar pathology. (umass.edu)
Bone2
  • The digital laminae are composed of extracellular matrix and link the coffin bone of the foot to the hoof wall, thus suspending the horse's weight within the hoof. (umass.edu)
  • or =3 mm and radiographic bone loss. (bvsalud.org)
Lung3
  • Lung extracellular matrix destruction is essential to TB transmission and consequently of critical importance to the global success of Mtb. (ersjournals.com)
  • Cavities are often several centimetres across, so there must be very extensive lung matrix destruction for such cavitation to occur. (ersjournals.com)
  • It inhibited lung cancer cell invasion and down-regulated matrix metalloproteinase-7 (MMP-7), which promoted lung cancer cell invasion. (aacrjournals.org)
Prognosis1
  • Despite advances in surgical techniques and multimodal treatment regimens with radio-, chemo-, and immunotherapy [ 3 - 5 ], the prognosis for malignant glioma patients is very poor with a median survival time of approximately 15 months after diagnosis [ 6 , 7 ]. (hindawi.com)