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  • collagenases
  • Conditioned culture medium from HAC cultures incubated with and without 20 μM histamine was assayed by enzymne linked immunosorbent assay (ELISA) for MMP-1, MMP-8, MMP-13 (collagenases 1, 2, and 3, respectively) and MMP-3 (stromelysin). (bmj.com)
  • Chondrocytes have been shown to produce three different collagenases (MMP-1, MMP-8, and MMP-13) and stromelysin 1 (MMP-3) in situ, enzymes considered crucial for collagen and aggrecan degradation. (bmj.com)
  • We investigated cells and conditioned media of the three human keratinocyte cell lines HaCaT (non-tumorigenic), A5 (benign, tumorigenic) and II-4RT (malignant, tumorigenic) with regard to production and secretion of the collagenases-1 to -3 (MMP-1, MMP-8 and MMP-13) and TIMP-1 using semi-nested RT-PCR, Western blots, ELISA, immunocytochemistry and casein zymography. (uni-bielefeld.de)
  • MMP-13 is distinguished from the other human collagenases by its effecient degradation of type II collagen. (rndsystems.com)
  • suggest that MMP-13
  • The results of the present study suggest that MMP-13 may serve as an early indicator for bone remodeling which may lead to vertebral compression, and that there is a relationship between the development of vertebral compression and increased remodeling activities in farmed Atlantic salmon. (bibsys.no)
  • MMP13
  • During embryonic development, MMP13 is expressed in the skeleton as required for restructuring the collagen matrix for bone mineralization. (wikipedia.org)
  • zinc
  • One is a chelating moiety that interacts with the zinc ion and the other is a hydrophobic extension from the catalytic site that project into S1' pocket (P1' group) of the metalloproteinase. (wikipedia.org)
  • proteins
  • Transcripts of MMP-1, -8, -13 and TIMP-1 were detected in all cell lines by RT-PCR and the corresponding proteins were found in the cytoplasm of all three cell lines by Western blot analysis and/or immunocytochemistry. (uni-bielefeld.de)
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. (wikipedia.org)
  • The most basic description of the plant extracellular matrix (ECM) is the cell wall, but it is actually the cell surface continuum that includes a variety of proteins with major roles in plant growth, development, and response. (wikipedia.org)
  • Epithelial
  • Using a MMP9 deficient mouse model, it was seen that MMP9 coordinated epithelial wound repair and deficient mice were unable to remove the fibrinogen matrix during wound healing. (wikipedia.org)
  • molecular
  • Thus, rather than a lymphoid cytokine, IL-13 acts more prominently as a molecular bridge linking allergic inflammatory cell to the non-immune cells in contact with them, thereby altering physiological function. (wikipedia.org)
  • human
  • In this study, Boyden chamber analysis, Western blotting and gelatin zymography assays indicated that flaccidoxide-13-acetate exerted inhibitory effects on the migration and invasion of RT4 and T24 human bladder cancer cells. (mdpi.com)
  • Neoh C-A, Wu W-T, Dai G-F, Su J-H, Liu C-I, Su T-R, Wu Y-J. Flaccidoxide-13-Acetate Extracted from the Soft Coral Cladiella kashmani Reduces Human Bladder Cancer Cell Migration and Invasion through Reducing Activation of the FAK/PI3K/AKT/mTOR Signaling Pathway. (mdpi.com)
  • Detects human MMP-13 in Western blots. (rndsystems.com)
  • MMP‑13 in Human Ovarian Cancer Tissue. (rndsystems.com)
  • MMP‑13 in Human Breast. (rndsystems.com)
  • 1996). "Cellular mechanisms for human procollagenase-3 (MMP-13) activation. (wikipedia.org)
  • Furthermore, IL-13 can induce immunoglobulin E (IgE) secretion from activated human B cells. (wikipedia.org)
  • Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. (wikipedia.org)