• For example, arterial hypertension is modeled increasing the arterial resistances of the model. (wikipedia.org)
  • This study describes a multidimensional 3D/lumped parameter (LP) model which contains appropriate inflow/outflow boundary conditions in order to model the entire human arterial trees. (sharif.edu)
  • A new extensive LP model of the entire arterial network (48 arteries) was developed including the effect of vessel diameter tapering and the parameterization of resistance, conductor and inductor variables. (sharif.edu)
  • 2) The role of pulsatile arterial load (vascular stiffness in particular) in cardiovascular function. (pitt.edu)
  • Computational models of human physiology offer the potential, with clinical data, to create patient-specific models that capture a patient's physiological status. (springeropen.com)
  • Mathematical Biology is the application of mathematical modelling to solve problems in biology and physiology. (gla.ac.uk)
  • 5) Development of novel, physiology-based cardiovascular monitoring technologies. (pitt.edu)
  • A lumped parameter cardiovascular model is a zero-dimensional mathematical model used to describe the hemodynamics of the cardiovascular system. (wikipedia.org)
  • The lumped parameter model is used to study the hemodynamics of a three-dimensional space (the cardiovascular system) by means of a zero-dimensional space that exploits the analogy between pipes and electrical circuits. (wikipedia.org)
  • Dr. Shroff has been serving as the Principal Investigator on a NIH-NHLBI pre-doctoral training grant (Cardiovascular Bioengineering Training Program) since 2005 and the Coulter Translational Research Partnership II Program since 2013, and Co-Director on a NIH-NHLBI post-doctoral training grant (Training Program in Imaging Sciences in Translational Cardiovascular Research) since 2016. (pitt.edu)
  • Department faculty members have teaching and research expertise in areas related to cardiovascular and fluid biomechanics, musculoskeletal biomechanics, biomaterials and tissue engineering, bioinstrumentation, biosystems, biomedical imaging, biological signal analysis, bioinformatics and computational biology, respiratory and pulmonary engineering, and other allied fields. (uiowa.edu)
  • The Biomechanics and Biomaterials Laboratory is equipped to perform experiments relating to the cardiovascular and human musculoskeletal systems as well as the various properties of biomaterials. (uiowa.edu)
  • The lab is used for the course BME:2500 Biomaterials and Biomechanics , elective courses in cardiovascular and musculoskeletal biomechanics, and senior design projects. (uiowa.edu)
  • Mascheroni, P., Penta, R., Merodio, J. (2023) The impact of vascular volume fraction and compressibility of the interstitial matrix on vascularised poroelastic tissues Biomechanics and Modeling in Mechanobiology, 22, pp. 1901-1917. (gla.ac.uk)
  • Miller, L., Penta, R. (2023) Investigating the effects of microstructural changes induced by myocardial infarction on the elastic parameters of the heart Biomechanics and Modeling in Mechanobiology, 22, pp. 1019-1033. (gla.ac.uk)
  • Sensitivity analysis has been performed with a Jacobian matrix, representing the proportional change in a group of output indexes (y,-) in response to isolated changes in input parameters (x j ), [(oy i /y j -VCo-4/x i )], demonstrating the complementary nature of mitral and pulmonary venous A-wave velocity for predicting ventricular stiffness and atrial systolic function. (northwestern.edu)
  • Sensitivity analysis has been performed with a Jacobian matrix, representing the proportional change in a group of output indexes (y,-) in response to isolated changes in input parameters (xj), [(oyi/yj-VCo-4/xi)], demonstrating the complementary nature of mitral and pulmonary venous A-wave velocity for predicting ventricular stiffness and atrial systolic function. (northwestern.edu)
  • The splitting of the pulmonary and systemic circulation is not fixed, for example, if the interest of the study is in systemic capillaries, the compartment accounting for the systemic capillaries can be added to the lumped parameter model. (wikipedia.org)
  • Methods: Using a mouse model of bleomycin (BLM)-induced lung fibrosis, in the current work we asked whether treatment with pro-resolution molecules, such as pro-resolving lipid mediators (SPMs) could ameliorate pulmonary fibrosis. (bvsalud.org)
  • To study the physical and physiological determinants of transmitral and pulmonary venous flow, a lumped-parameter model of the cardiovascular system has been created, modeling the instantaneous pressure, volume, and influx/efflux of the pulmonary veins, left atrium and ventricle, systemic arteries and veins, right atrium and ventricle, and pulmonary arteries. (northwestern.edu)
  • One of the hypotheses being investigated is that aberrant vascular stiffness changes are involved in the genesis of certain cardiovascular pathologies (e.g., preeclampsia, isolated systolic hypertension in elderly). (pitt.edu)
  • 3) Cardiovascular actions of relaxin and its therapeutic potential in the context of three pathologies: (i) relaxin-induced maternal vascular remodeling and associated functional benefits in preeclampsia, (ii) relaxin-induced left atrial remodeling and suppression of atrial fibrillation, and (iii) relaxin-induced left ventricular remodeling and associated functional benefits in the setting of diastolic dysfunction. (pitt.edu)
  • Ramírez-Torres, A., Penta, R., Grillo, A. (2023) Effective properties of fractional viscoelastic composites via two-scale asymptotic homogenization Mathematical Methods in the Applied Sciences, 46, pp. 16500-16520. (gla.ac.uk)
  • Acute kidney injury (AKI) is a life-threatening disease with high mortality characterized by an abrupt decrease of the kidney glomerular filtration rate, extra-kidney consequences (cardiovascular diseases, lung injury, neurological impairment) and high risk of secondary chronic kidney disease (CKD). (hrb.ie)
  • Human exposure to H2S results in dose-related human exposure to low levels of H2S is widespread due to its neurological, respiratory, and cardiovascular effects. (cdc.gov)
  • A 2021 analysis of cardiovascular risk related to systolic blood pressure shows what happens if data for two sexes are pooled rather than analysed appropriately. (whyevolutionistrue.com)
  • In this review, we introduce the concept of computational fluid dynamics (CFD) modeling with a clinical perspective and we review the CFD models used to study RE from the fluid mechanics point of view. (unav.edu)
  • In this study, Computational Fluid Dynamics (CFD) techniques are used to model and simulate the gas flow in the melt nozzle area for a convergent-divergent, close-coupled gas atomiser in the absence of the melt stream. (unav.edu)
  • In this study, anatomically ac- curate computational fluid dynamics (CFD) models were used to and respiratory systems (ATSDR, 1999). (cdc.gov)
  • To test this hypothesis, computational fluid dynamics (CFD) models have been de- veloped to describe the uptake of inhaled H2S in rat nasal passages (Moulin et al. (cdc.gov)
  • Given a set of parameters that have a physical meaning (e.g. resistances to blood flow), it allows to study the changes in blood pressures or flow rates throughout the cardiovascular system. (wikipedia.org)
  • The parameter of the model are the resistances, the capacitances, the inductances and the elastances. (wikipedia.org)
  • A focus of this paper is that the model-based methods discussed here can provide patient-specific care that is robust to these intra- and inter-patient variabilities. (springeropen.com)
  • His idea is to use mathematical and statistical methods to develop a computer program that will propose the best cancer treatment. (sciencenorway.no)
  • Motivated by studies showing that BLM-induced lung fibrosis is linked to angiogenesis, we asked whether ATRvD1 could blunt BLM-induced angiogenesis in the hamster cheek pouch model (HCP). (bvsalud.org)
  • SPECIAL NOTE OMB Supporting Statement OMB SUPPORTING STATEMENT This statement is submitted by the National Heart, Lung, and Blood Institute (NHLBI), in support of a Cardiovascular Risk Factor Supplement to be added to the Current Population Survey (CPS). (cdc.gov)
  • The National Heart, Lung, and Blood Institute (NHLBI) under the Department of Health and Human Services is requesting that a Cardiovascular Disease Risk Factor Supplement be added to the September 1989 and 1990 Current Population Survey. (cdc.gov)
  • This collection is authorized under 42 of the United States Code 285b-2 and 3, Sections 420 and 421 of the Public Health Service Act, as amended by the Health Research Extension Act (Attachment B). This requires the NHLBI to collect and disseminate information on the prevention and treatment of lung and cardiovascular disease to the public and various agencies, and other groups. (cdc.gov)
  • The present study tested whether quantitative parameters that describe the spatial 3D coronary geometry is associated with the extension and composition of the underlying coronary artery disease (CAD). (bvsalud.org)
  • Systems biology combines mechanistic modelling with quantitative experimentation in studies of networks and better understanding of the interaction of multiple components in disease processes. (biomedcentral.com)
  • Arnoldo Frigessi is an expert in describing biological processes with mathematical models. (sciencenorway.no)
  • The proposed method of parameter estimation for hydraulic electric analogy model is recursive least squares algorithm. (sharif.edu)
  • The reduction from three to zero dimensions is performed by splitting the cardiovascular system into different compartments, each of them representing a specific component of the system, e.g. right atrium or systemic arteries. (wikipedia.org)
  • The lumped parameter model consists in a system of ordinary differential equations that describes the evolution in time of the volumes of the heart chambers, and the blood pressures and fluxes through the blood vessels. (wikipedia.org)
  • The lumped parameter model consists in a system of ordinary differential equations that adhere to the principles of conservation of mass and momentum. (wikipedia.org)
  • It is well known that the modern understanding of the cardiovascular system undoubtedly starts with the work of William Harvey (1578-1657) who published his discovery of the circulation of blood in 1628. (scirp.org)
  • A model of blood buffer system. (physiome.cz)
  • A quasidynamic model of the blood buffer system. (physiome.cz)
  • Conventional models of cardiovascular system frequently lack required detail and focus primarily on the overall relationship between pressure, flow and volume. (sharif.edu)
  • This study proposes a localized and regional model of the cardiovascular system. (sharif.edu)
  • The stable download Windows для профессионалов (программирование в Win32 API position simulation electromagnetic was in its active modern set in 1998 maintained for choosing the possible and cardiovascular diesel of sonar multimedia from system trees, mock as after an metric in a new length page. (taido-hannover.de)
  • The simulation results show how similarly these two parameters modify gas mass flow rates, gas velocity fields, aspiration pressures in the melt delivery tube or the size of the recirculation zones below the melt nozzle. (unav.edu)
  • In addition to basic and translational research, Dr. Shroff and colleagues have developed and continue to develop novel, simulation-based material (i.e., mathematical models of biological systems and associated "virtual experiments") for education and engineering design. (pitt.edu)
  • GREAT IDEA: Arnoldo Frigessi is the main person behind the new idea of making tens of thousands of virtual copies of the individual cancer patient and then testing all the treatments in a simulation model to find the most optimal treatment. (sciencenorway.no)
  • This unified numericalexperimental programming environment should facilitate model refinement and physiological data exploration, in particular guiding more accurate interpretations of Doppler echocardiographic data. (northwestern.edu)
  • Physiological modeling, tight glycemic control, and the ICU clinician: what are models and how can they affect practice? (springeropen.com)
  • Such models can provide new insights into patient condition by turning a series of sometimes confusing clinical data into a clear physiological picture. (springeropen.com)
  • Geometric features remained significantly associated with all IVUS-VH parameters even after multivariate adjustment for clinical characteristics. (bvsalud.org)
  • This article presents the concept of model-based therapeutics, the use of computational models in clinical medicine and critical care in specific, as well as its potential clinical advantages, in a format designed for the clinical perspective. (springeropen.com)
  • The overall review clearly shows the concept and significant clinical potential of using computational models in critical care medicine. (springeropen.com)
  • In the Fall 2019 Quarter, he taught a special study course (BioE 297: Physics-Based Modeling and In Silico Clinical Trials). (ucsf.edu)
  • 50%), better clinical models and pipelines for targeted therapies are urgently required. (hrb.ie)
  • PoliticsBeyond Labourism and g: How the 32 Labor Party sent the Model of' New Labour'This JavaScript found the market the groups and country of the Asymptotic Labour Party( 1983-1996) kept a basic Daedric objective latterly widely 9auploaded at that history in optional clinical year and leitfaden findings. (macgregor.net)
  • Modifying the parameters, it is possible to study the effects of a specific disease. (wikipedia.org)
  • The proposed questions comprise the Cardiovascular Disease Risk Factor Supplement (Attachment A). This supplement will collect data on the prevalence of cigarette smoking and awareness and treatment of the two other major cardiovascular disease risk factors (high blood cholesterol and high blood pressure). (cdc.gov)
  • For disease models in living animals, DISEASE MODELS, ANIMAL is available. (lookformedical.com)
  • If other studies solidify these findings, the result would be a sea change in risk calculation for cardiovascular disease. (whyevolutionistrue.com)
  • Coronary Artery Disease: When plaque accumulates in the arteries that provide blood to the heart, it can cause upper body discomfort, cardiovascular disease, and also other heart-related problems. (silverstreamdesign.com)
  • Smoking Cigarettes Cessation: Stopping smoking can have numerous wellness advantages, consisting of improving HDL cholesterol levels and decreasing the danger of cardiovascular disease. (silverstreamdesign.com)
  • Wildhirt, S.M. (2015) A closed loop 0D-3D model of patient specific cardiac mechanics for cardiac assist device engineering , 4th Int. Conf. (tum.de)
  • Wall, W.A. (2015) Pericardial Boundary Conditions for Cardiac Mechanics Simulations , 4th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2015, P. Nithiarasu and E. Budyn (Eds. (tum.de)
  • Regular Workout: Participating in physical activities, such as brisk strolling, jogging, cycling, or swimming, can enhance HDL cholesterol degrees as well as advertise total cardiovascular health and wellness. (silverstreamdesign.com)
  • Each heart chamber is modeled by means of the elastances that describe the contractility of the cardiac muscle and the unloaded volume, that is the blood volume contained in the chamber at zero-pressure. (wikipedia.org)
  • In fact, although in the introduction to the problem (paragraphs 1-8), Euler focuses on the discussion on blood flow through arteries, to such a degree to even proposing adhoc models for the behavior of their elastic cross-sections, surprisingly, and also somehow disappointing, is that the main body of the manuscript (paragraphs 9-34) is devoted to the modeling of flows through rigid tubes, driven by a piston pump. (scirp.org)
  • frictional, elastic and hydraulic were considered for the prosthetic joints of the amputee and their design parameters were optimized to achieve the closest. (sharif.edu)
  • Large animal models and computer simulations indicate that adding non-contractile material to the damaged left ventricular wall can potentially reduce myofiber stress. (ucsf.edu)
  • Then, the influence of both the inlet gas pressure and this design parameter are investigated, comparing the numerical results provided by simulations varying the inlet pressure from 5 to 80 bar and modelling different convergent-divergent gas nozzles with throat widths of 0.29¿Lo, 0.5¿Lo, 0.77¿Lo and 2¿Lo respectively. (unav.edu)
  • That includes using model organisms such as mice, which may show related sex differences. (whyevolutionistrue.com)
  • In what follows the focus will be on a specific lumped parameter model. (wikipedia.org)
  • These aspects directly address questions concerning what makes a model, how it is made patient-specific, what it can be used for, its limitations and, importantly, what constitutes sufficient validation. (springeropen.com)
  • of rats to 80 ppm resulted in full thickness necrosis of the Scaled kinetic parameters were incorporated into a human CFD model to predict H olfactory mucosa on the dorsal meatus (Brenneman et al. (cdc.gov)
  • A two-dimensional, seven link, nine degrees of freedom biped model was developed to investigate the dynamic characteristics of normal and transfemoral amputee locomotion during the entire gait cycle. (sharif.edu)
  • A computer aided-design (CAD) algorithm was proposed to efficiently handle the coupling of two or more 3D models with the LP model, and substantially lessen the coupling processing time. (sharif.edu)
  • From the 23 geometric indexes, 18 parameters were significantly (p (bvsalud.org)
  • Over the past decade or so, a growing list of funders and publishers, including the US National Institutes of Health (NIH) and the European Union, have been asking researchers to include two sexes in their work with cells and animal models. (whyevolutionistrue.com)
  • The download Windows brings developed for a vast potassium, and the order is damped emitted out until method modeling 40000. (taido-hannover.de)
  • download the anthology of Subject Classification - the MR Citation Database covers findings by boundary or many world + usually uncovered pictures by offender or page + applications of editors by their Mathematical Citation Quotient. (quietisolation.de)
  • All three main geometric categories provided parameters significantly related with atherosclerosis variables. (bvsalud.org)
  • Working with a faculty steering committee, Dr. Hay led the redesign of the entire university budget away for historical budgeting to an RCM model. (arizona.edu)