###### physiology

- He works on the development of numerical methods for the cardiovascular system, in particular for the fluid-structure interaction problems and the electro-physiology of the ventricles. (cambridge.org)
- The Cardiovascular Biophysics Laboratory research group pursues a multi-disciplinary program encompassing selected aspects of physiology, biophysics, engineering, physics and clinical medicine. (wustl.edu)
- Areas of interest include: theoretical biology and physiology, characterization of the kinematic and material properties of cardiovascular tissue and its relation to matrix biology, 4-chamber heart function, diastolic function, ventriculo-arterial impedance, maximization of information extraction from physiologic signals, mathematical modeling of cardiovascular function and its in-vivo verification, and development of new technology for imaging and physiologic signal acquisition and processing. (wustl.edu)
- The Sobie Laboratory combines mathematical modeling with state-of-the-art experimental techniques in order to improve our quantitative understanding of cardiac physiology. (mssm.edu)

###### physiological experiments

- Multi-scale mathematical modeling and complementary physiological experiments will provide insight into autonomic neural mechanisms that may modulate the inflammatory response to sepsis and simultaneously reduce heart rate and ventilatory pattern variabilities associated with sepsis. (frontiersin.org)

###### variability

- We also present a practical biomedical application of the developed numerical model to the problem of blood flow variability in cerebral circulation due to anatomical features of the vascular network in the presence of the atherosclerosis disease. (springer.com)
- Now, coalescing under the aegis of the NIH Computational Biology Program and the Society for Complexity in Acute Illness, two research teams performed iterative experiments and computational modeling on inflammation and cardio-pulmonary dysfunction in sepsis as well as on neural control of respiration and ventilatory pattern variability. (frontiersin.org)
- This approach integrates computational models of neural control of breathing and cardio-respiratory coupling with models that combine inflammation, cardiovascular function, and heart rate variability. (frontiersin.org)
- Exploiting mathematical models to illuminate electrophysiological variability between individuals. (mssm.edu)

###### Mortality

- Deaths due to cardiovascular diseases remain the largest contributor to premature mortality in most developed societies. (slideserve.com)
- Left ventricular mass (LVM) is known to be related to overall and cardiovascular mortality in end stage kidney disease (ESKD) patients. (jove.com)
- The aims of the present study are 1) to determine whether LVM is associated with mortality and various cardiovascular events and 2) to identify determinants of LVM including biomarkers of inflammation and fibrosis. (jove.com)

###### dysfunction

- A load-independent index of diastolic filling: model-based derivation with in-vivo validation in control and diastolic dysfunction subjects. (wustl.edu)
- Both of these noninvasive measures of vascular dysfunction are independent predictors of future cardiovascular events in patients with and without kidney disease. (jove.com)

###### Arterial

- An automated, closed-loop 1D-0D modelling framework was developed, and we demonstrate its efficacy in (1) reproducing measured multi-variate cardiovascular variables (pulse pressure, total peripheral resistance and cardiac output) and (2) providing automated estimates of variables that have not been measured (uterine arterial and venous blood flow, pulse wave velocity, pulsatility index). (springer.com)
- It is also the first model capable of capturing wave propagation phenomena in the utero-ovarian circulation, which are important for the accurate estimation of arterial stiffness in contemporary obstetric practice. (springer.com)

###### efficient numerical

- It covers a wide range of topics, from the assimilation of clinical data to the development of mathematical and computational models, including with parameters, as well as their efficient numerical solution, and both in-vivo and in-vitro validation. (springer.com)

###### Methodologies

- We also address basic modeling approaches and discuss some of the challenges for mathematical modeling methodologies in the context of parameter estimation and model validation. (mmnp-journal.org)

###### equations

- His research interests include the development of reduced order modelling techniques for partial differential equations, uncertainty quantification, PDE-constrained optimization, and computational and statistical inverse problems. (cambridge.org)

###### mechanics

- Biofliud Mechanics in Cardiovascular Systems is one of the first books to take an interdisciplinary approach to the subject. (indigo.ca)

###### dynamics

- Toward this goal, a low-order theoretical model is presented, in which LV shape is represented using a small number of parameters, allowing rapid computational simulations of LV dynamics. (deepdyve.com)

###### circulation

- To predict the effects of time-dependent accelerations on the circulation, a mathematical model independent of assumptions extrapolated from normal G conditions must be considered. (mst.edu)
- Kholodov, A.S.: Some dynamic models of external breathing and blood circulation with consideration for their coherence and mass transfer. (springer.com)

###### velocity

- Blood velocity, vorticity, LAA orifice velocity, residence time computed in the five models were compared and correlated with LAA morphologies. (frontiersin.org)
- Tger J, Kanski M, Carlsson M, Kovcs SJ, Sderlind G, Arheden H, Heiberg E. Diastolic vortex ring formation in the human left ventricle: quantitative analysis using Lagrangian coherent structures and 4D cardiovascular magnetic resonance velocity mapping. (wustl.edu)

###### quantitative

- In summary, the combined protocol strategy can be readily applied for quantitative TATS network studies during physiological myocyte adaptation or disease changes, comparison of different cardiac or skeletal muscle cell types, phenotyping of transgenic models, and pharmacological or therapeutic interventions. (jove.com)

###### hierarchical model

- We consider a Bayesian hierarchical model for the integration of gene expression levels with comparative genomic hybridization (CGH) array measurements collected on the same subjects. (rice.edu)
- Agreement indexes are directly related to a set of covariates through a hierarchical model. (jove.com)

###### function

- He is author or coauthor of numerous publications related to secondhand smoke and tobacco control, as well as many papers on cardiovascular function and biostatistics. (ucsf.edu)
- However, this hypothesis remains to be tested by using definitive loss-of-function animal models. (jove.com)

###### Sciences

- SACEMA, in collaboration with the African Institute for Mathematical Sciences (AIMS), is holding a modelling clinic from 30 May to 10 June 2011 in Muizenberg, Cape Town. (sacemaquarterly.com)

###### blood

- For example, the model is capable of simulating the heart rate, cardiac output and blood pressure in a healthy individual and under the influence of heart failure as well as treatment with beta-blockers. (paganz.org)
- This is the first model capable of estimating volumetric blood flow to the uterus via the utero-ovarian communicating arteries. (springer.com)
- These can be further augmented by combining uncertainty in the choice of appropriate constitutive models for the blood and the boundary conditions. (utaustinportugal.org)
- In the case of aneurysms, the uncertainty due to the virtual model definition is comparable to that when choosing different models for the non-Newtonian behavior of blood. (utaustinportugal.org)

###### Dietary

- Caloric restriction (CR) is a robust dietary intervention known to enhance cardiovascular health. (jove.com)

###### intended to simulate

- The model is intended to simulate physiological functions and the effect of pathological conditions as well as pharmacological interventions over a time course of up to five days for the purposes of providing a teaching tool for clinical practitioners. (paganz.org)

###### Heart

- To investigate the effects of wearing compression stockings on cardiovascular responses, the heart rate (HR), cardiac output (Q) measured by CO2 rebreathing method, and oxygen intake were measured at rest in a supine position for 40 min and standing position for 120 min. (biomedsearch.com)
- We generate predictions using mathematical models, then test these predictions experimentally by measuring calcium and transmembrane voltage in heart cells. (mssm.edu)
- Inherent to the groups approach is the testing of these models and devices using data obtained from our in vitro setups, from isolated (slaughterhouse) in vivo beating heart experiments, and data from animals and patients, obtained in collaboration with our academic and clinical partners. (tue.nl)

###### numerical model

- A numerical model was also established to simulate hemo-physiological effects of the partial pressure suit. (iospress.com)
- The numerical model simulated the physiological effect of a partial pressure suit. (iospress.com)
- The numerical model provides a potential way to improve the protection of pilots. (iospress.com)

###### responses

- Effects of wearing compression stockings on cardiovascular responses. (biomedsearch.com)

###### vascular structure

- Furthermore, studies of this complex vascular structure in patients, animal models, or experimental in vitro models are difficult. (ahajournals.org)

###### Circle

- Liang, F., Fukasaku, K., Liu, H., Takagi, S.: A computational model study of the influence of the anatomy of the circle of willis on cerebral hyperperfusion following carotid artery surgery. (springer.com)
- A model of the circle of Willis geometry was approximated as a network of tubes around cubic curves. (ahajournals.org)
- With a network of such tubes connected by bifurcations, a complete model of the circle of Willis was constructed. (ahajournals.org)

###### efforts

- In this paper we give a survey on modeling efforts concerning the CVRS. (mmnp-journal.org)
- Efforts to 'customize' cardiac models are pushing towards role as enablers of personalized medicine. (slideserve.com)

###### experimental

- Aim is to develop computational models, experimental techniques, and medical devices for clinical diagnosis, decision support, and intervention. (tue.nl)
- This model requires a nephrectomy of the right kidney since ischemia can be only performed in one kidney due to the experimental setting. (jove.com)

###### uncertainty

- Noise and flow artifacts in the medical images and clinical measurements lead to geometric models that contain some uncertainty. (utaustinportugal.org)
- Patient-specific case studies to quantify relative bounds to this uncertainty uncovered a dire need for care in the virtual model reconstruction from medical images. (utaustinportugal.org)

###### research

- His research interests include mathematical modelling and its applications. (cambridge.org)
- Mathematical modelling should be considered an integral component of perioperative cardiovascular research due to the nature and complexity of the outcomes associated with these studies. (sacemaquarterly.com)
- Dr. Glantz is Director of the UCSF Center for Tobacco Control Research and Education, Co-Leader of the Helen Diller Familiy Comprehensive Cancer Center Tobacco Program and a member of the Cardiovascular Research Institute and Philip R. Lee Instiute for Healh Policy Studies. (ucsf.edu)

###### anatomy

- A representative model of the geometry was constructed by manually analyzing natural variations in 10 patients and incorporating the known anatomy from textbooks of neurosurgical anatomy. (ahajournals.org)

###### therapeutic

- To elucidate mechanisms of renal injury due to ischemia and possible therapeutic strategies murine models are intensively required 7-13 . (jove.com)

###### structure

- The first stint focuses on medical image analysis, virtual model reconstruction, and patient-specific CFD simulations of cerebral aneurysms and fluid-structure interaction. (utaustinportugal.org)

###### Evaluation

- We performed a systematic evaluation of a novel model for isolated renal artery occlusion in mice, which specifically avoids the use of clamping or suturing the renal pedicle 14 . (jove.com)