PlacentaTissuesPlacentalPregnancyCoronavirus diseaseLipidCongenital rubellaTissueRatiosSerumImmunosorbent assaysAdverse effectsImmunologicalGestationalRatioSystemicInfectionLymphocytesGrowth1999SignificantlyExpressionAbsorptionSevereMembranePatientsBrainVesselsDoseDemonstrateHumanCellsGenesLevelsRolePlasmaGroupStudiesInfantsSurfaceWomenImportantDrugProcess
Placenta4
- TRPV6 protein bears a 40-a.a-long N-terminal extension in placenta and in some physiological settings in comparison to the annotated version of the protein used in biological studies. (wikipedia.org)
- Furthermore, SARS-CoV-2 spike (S) protein expression was investigated in cells of the placenta, amnion, and umbilical cord. (news-medical.net)
- Finally, in situ hybridization of rabbit placenta sections with a syncytin-Ory1 probe revealed specific expression at the level of the junctional zone between the placental lobe and the maternal decidua, where the invading syncytial fetal tissue contacts the maternal decidua to form the labyrinth, consistent with a role in the formation of the syncytiotrophoblast. (biomedcentral.com)
- Thrombophilia is claimed in many adverse pregnancy outcomes such as recurrent pregnancy loss, intrauterine growth retardation, abruptio placenta, intrauterine fetal death, and pre-eclampsia with onset before 34 wk. (contemporaryobgyn.net)
Tissues8
- However, it is still to be determined whether the long version of the TRPV6 protein is the dominant form in different tissues. (wikipedia.org)
- In the present study, researchers assessed the effects of coronavirus disease 2019 (COVID-19) on fetal brain tissues. (news-medical.net)
- The study was conducted between July 2020 and mid-April 2022 in the United Kingdom (UK), wherein human fetal tissues aged 9.0 to 21.0 pcw (post-conception weeks) were obtained from the HDBR (human development biology resource). (news-medical.net)
- In addition, SARS-CoV-2 was present sparsely in the placental, umbilical cord and amniotic tissues, indicating SARS-CoV-2 presence in maternal and fetal tissues. (news-medical.net)
- Fetal brain regions and peripheral tissues were examined for nAChR subtypes, other neurotransmitter receptors, and indices of cell signaling and cell damage. (nature.com)
- To investigate whether immune-mediated mechanisms are involved in the pathogenesis of autism, we used immunocytochemistry, cytokine protein arrays, and enzyme-linked immunosorbent assays to study brain tissues and cerebrospinal fluid (CSF) from autistic patients and determined the magnitude of neuroglial and inflammatory reactions and their cytokine expression profiles. (blogspot.com)
- Fresh-frozen tissues available from seven patients and CSF from six living autistic patients were used for cytokine protein profiling. (blogspot.com)
- Immunocytochemical studies showed marked activation of microglia and astroglia, and cytokine profiling indicated that macrophage chemoattractant protein (MCP)-1 and tumor growth factor-beta1, derived from neuroglia, were the most prevalent cytokines in brain tissues. (blogspot.com)
Placental3
- Fetal/maternal ratios of local anesthetics appear to be inversely related to the degree of plasma protein binding, because only the free, unbound drug is available for placental transfer. (nih.gov)
- Cannabis consumption by pregnant women continues to increase worldwide, raising concerns about adverse effects on fetal growth and deleterious impacts on the newborn, in connection with evidence of placental transfer of cannabis compound. (biomedcentral.com)
- Recent data suggest that thrombophilia associated placental vasculopathy in the form of villous infarcts, multiple infarcts, fibrinoid necrosis of decidual vessels, fetal stem vessel thrombosis, placental hypoplasia and spiral artery thrombosis lead to inadequate fetomaternal circulation and decreased placental perfusion. (contemporaryobgyn.net)
Pregnancy6
- Both heterogeneity and tissue specialization of immune cells may hold the key to understanding the pathophysiology of some important pregnancy complications, such as miscarriage and fetal growth restriction (FGR), which is defined as the failure of the fetus to achieve its genetically determined growth potential. (elifesciences.org)
- Intrahepatic cholestasis of pregnancy (ICP) is a condition specific to pregnancy, leading to increased fetal morbidity and mortality. (medscimonit.com)
- In the USA, while fetal exposure to tobacco decreases, cannabis use during pregnancy rises along with the enhanced perception that there are no risks with cannabis consumption during pregnancy [ 2 ]. (biomedcentral.com)
- When the body mass index (BMI) or the ratio of weight to height squared before pregnancy is low, 4,000 calories are provided, while with excess weight or obesity, 3,000 calories per day. (youaremom.com)
- Protein accounts for 20 percent of all calories in a twin pregnancy diet . (youaremom.com)
- During normal pregnancy, the fetus grows and develops in an immunologically privileged environment, part of this privilege is associated with the intrinsic capacity of the maternal-fetal interface to respond promptly and efficiently to any immunological challenge [ 1 ]. (biomedcentral.com)
Coronavirus disease1
- There is a low prevalence of novel coronavirus disease in neonates, infants, and children. (thieme-connect.com)
Lipid1
- The rate and degree of diffusion is governed by (1) the degree of plasma protein binding, (2) the degree of ionization, and (3) the degree of lipid solubility. (nih.gov)
Congenital rubella3
- The fetal defects observed in congenital rubella syndrome are likely secondary to vasculitis resulting in tissue necrosis without inflammation. (medscape.com)
- For instance, in 1969, a total of 57,686 cases of rubella and 31 cases of congenital rubella syndrome were recorded. (medscape.com)
- Since 2001, the annual number of rubella cases ranged from a record low of 7 in 2003 to 23 in 2001, and congenital rubella syndrome cases between 0-3 per year (see the images below). (medscape.com)
Tissue2
- Second, the larger amounts of tissue available from fetal monkey brain enables determinations to be carried out more readily in specified regions and subregions. (nature.com)
- A metabolic increase for maternal and infant tissue formation. (youaremom.com)
Ratios1
- Similarly, indices of cell loss (reduced DNA), cell size and neuritic outgrowth (protein/DNA and membrane/total protein ratios) were distinct for each region and did not necessarily follow the rank order of nAChR upregulation, suggesting the involvement of additional mechanisms such as oxidative stress. (nature.com)
Serum3
- A multivariate linear regression model was used to identify the independent factors of serum total biliary acids (TAB) in ICP. (medscimonit.com)
- Fetal bovine serum is a component in the culture medium used to culture the thymus slices and RETHYMIC is formulated in media that is supplemented with fetal bovine serum. (rxlist.com)
- The measurement of serum testosterone in women is difficult with most automated immunoassays because of poor sensitivity, accuracy and precision at low concentrations. (endocrine-abstracts.org)
Immunosorbent assays1
- Enzyme-linked immunosorbent assays were used to investigate maternal plasma iNOS levels. (medscimonit.com)
Adverse effects1
- Our results indicate that nicotine elicits neurodevelopmental damage that is highly selective for different brain regions, and that dietary supplements ordinarily thought to be neuroprotectant may actually worsen some of the adverse effects of nicotine on the fetal brain. (nature.com)
Immunological2
- Previous studies have reported that maternal SARS-CoV-2 infections and immunological responses elevate the risk of altered fetal brain development, fetal death, growth restrictions and severe pathologies such as intraventricular hemorrhages and pneumonia. (news-medical.net)
- Cortical hemorrhages were associated with reduced integrity of blood vasculature and increased immunological cell infiltration in the fetal brain. (news-medical.net)
Gestational1
- We administered nicotine to pregnant Rhesus monkeys from gestational day 30 through 160 by continuous infusion, achieving maternal plasma levels comparable to those in smokers (30 ng/ml). (nature.com)
Ratio1
- Bupivacaine with a high protein binding capacity (95%) has a low fetal/maternal ratio (0.2 to 0.4). (nih.gov)
Systemic2
- The rate of systemic absorption of local anesthetics is dependent upon the total dose and concentration of drug administered, the route of administration, the vascularity of the administration site, and the presence or absence of epinephrine in the anesthetic solution. (nih.gov)
- Indeed, maternal ILC2s promote fetal growth and protect against fetal mortality upon systemic endotoxin challenge. (elifesciences.org)
Infection3
- Image in a 4-year-old girl with a 4-day history of low-grade fever, symptoms of an upper respiratory tract infection, and rash. (medscape.com)
- Fetal infection occurs transplacentally during the maternal viremic phase, but the mechanisms by which rubella virus causes fetal damage are poorly understood. (medscape.com)
- The low severity of SARS-CoV-2 infection in this population is associated with a high incidence of asymptomatic or mildly symptomatic infection making them efficient carriers. (thieme-connect.com)
Lymphocytes1
- For a long time before, the responses of lymphocytes and platelets in obese women can cause a low-grade inflammation. (mdpi.com)
Growth1
- This decidual vasculopathy is characterized by acute atherosis, intimal thickening, fibrinoid necrosis, and an absence of the normal physiologic changes in the spiral arteries and also has been associated with pre-eclampsia and fetal growth retardation. (contemporaryobgyn.net)
19991
- Peng et al identified TRPV6 in 1999 from rat duodenum in an effort to search for Ca2+ transporting proteins involved in Ca2+absorption. (wikipedia.org)
Significantly1
- In the cortical regions of the hemorrhagic specimens, blood vessels situated proximal to erythrocyte clusters showed significantly lower claudin-5 expression compared to away from vessels located far from the erythrocyte clusters. (news-medical.net)
Expression3
- Placentas exhibit signs of adaptation to stress, including larger maternal blood spaces and increased expression of nutrient transporter genes. (elifesciences.org)
- SARS-CoV-2 spike (S) expression was sparse in cortical microtubule-associated protein 2 (MAP2)-positive and HuC/D-positive neurons and the nestin-positive and Hopx (homeodomain-only protein)-positive radial glial, and Sox2 (sex-determining region Y-box 2)-positive ventricular zone and subventricular zone progenitor cells. (news-medical.net)
- We determined the expression of components of the ECS in the human fetal testis from 6 to 17 developmental weeks and assessed the direct effects of phytocannabinoids Δ9-trans-tetrahydrocannabinol (THC) and cannabidiol (CBD) on the testis morphology and cell functions ex vivo. (biomedcentral.com)
Absorption3
- A dilute concentration of epinephrine (1:200,000 or 5 mcg/mL) usually reduces the rate of absorption and peak plasma concentration of bupivacaine, permitting the use of moderately larger total doses and sometimes prolonging the duration of action. (nih.gov)
- TRPV6 is a membrane calcium (Ca2+) channel protein which is particularly involved in the first step in Ca2+absorption in the intestine. (wikipedia.org)
- In addition, low glycemic index (GI) carbohydrates are recommended, that is, those of slow absorption. (youaremom.com)
Severe4
- In a recent study published in BRAIN , researchers evaluated the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on fetal brain health. (news-medical.net)
- COVID-19 in Newborns and Infants-Low Risk of Severe Disease: Silver Lining or Dark Cloud? (thieme-connect.com)
- Data from China and the United States suggest a low prevalence of neonates, infants, and children, with those affected not suffering from severe disease. (thieme-connect.com)
- More severe lower respiratory infections (LRIs) were associated with the recent zoonotic crossovers of the severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) identified in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) identified in 2012. (thieme-connect.com)
Membrane2
- In the intestine, the protein is expressed on the brush-border membrane of enterocyte. (wikipedia.org)
- These 2 envelope proteins comprise the spiked 5-nm to 6-nm surface projections that are observed on the outer membrane of rubella virus and are important for the virulence of the virus. (medscape.com)
Patients1
- Patients with evidence of maternal engraftment or an elevated response to phytohemagglutinin (PHA) should receive RETHYMIC with immunosuppressive medications (Table 2). (rxlist.com)
Brain3
- Cortical hemorrhage was observed among 26 specimens out of 661 fetal brain specimens. (news-medical.net)
- SARS-CoV-2 presence was detected in the initial- and subsequent-trimester fetal brain associated with hemorrhage in the cortex. (news-medical.net)
- Essentially, by providing excessive cholinergic stimulation throughout fetal life, nicotine discoordinates the numerous events in cell replication, differentiation and synaptic development that are necessary to the proper assembly of the mammalian brain. (nature.com)
Vessels1
- A spiral arterial vasculopathy in decidual vessels also has been linked to aPL-related fetal loss. (contemporaryobgyn.net)
Dose1
- The total dose, based on the number of slices administered to the patient, is 5,000 to 22,000 mm² of RETHYMIC/m² recipient BSA. (rxlist.com)
Demonstrate1
- We demonstrate the presence in the human fetal testis of two key endocannabinoids, 2-arachidonylglycerol (2-AG) and to a lower level anandamide (AEA), as well as a range of enzymes and receptors for the ECS. (biomedcentral.com)
Human2
- In this context, we aimed to determine whether cannabis exposure has the potential to directly impact the human fetal testis. (biomedcentral.com)
- Our study is the first to evidence the presence of the ECS in the human fetal testis and to highlight the potential adverse effect of cannabis consumption by pregnant women onto the development of the male gonad. (biomedcentral.com)
Cells1
- Studies have demonstrated that cells infected with rubella in the early fetal period have reduced mitotic activity. (medscape.com)
Genes1
- Transcriptomic analysis on 72 h-exposed fetal testis explants revealed 187 differentially expressed genes (DEGs), including genes involved in steroid synthesis and toxic substance response. (biomedcentral.com)
Levels1
- Homocysteine levels greater than 9 to 11 µmol/L conferred a 4- to 5-fold increased risk of pre-eclampsia compared with lower levels. (contemporaryobgyn.net)
Role1
- The fetal hemoglobin may play a protective role against coronavirus in neonates. (thieme-connect.com)
Plasma2
Group1
- The TRP family is a group of channel proteins critical for ionic homeostasis and the perception of various physical and chemical stimuli. (wikipedia.org)
Studies1
- TRPV6 was also called calcium transport protein 1 (CaT1) initially although the names epithelial calcium channel 2 (ECaC2) and CaT1-like (CaT-L) were also used in early studies to describe the channel. (wikipedia.org)
Infants1
- This study will compare the effectiveness of two surgical procedures -laparotomy versus drainage - commonly used to treat necrotizing enterocolitis (NEC) or isolated intestinal perforations (IP) in extremely low birth weight infants (≤1,000 g). (stanford.edu)
Surface1
- The dosage is determined by the total surface area of the RETHYMIC slices and recipient body surface area (BSA). (rxlist.com)
Women1
- Women with pre-eclampsia/eclampsia were more likely to have heterozygous factor V Leiden mutation, heterozygous G20210A prothrombin gene mutation, homozygous MTHFR C677T mutation, protein C deficiency, protein S deficiency or activated protein C resistance compared with controls. (contemporaryobgyn.net)
Important1
- 1990. Identification of ammonia as an important sediment-associated toxicant in the lower Fox River and Green Bay, Wisconsin. (cdc.gov)
Drug1
- Three to 11 drug product containers, with a total of 10 to 42 RETHYMIC slices, are provided for each patient. (rxlist.com)
Process1
- APAS are thought to cause these thrombotic events either by (1) binding and decreasing the function of antithrombin III (38,39) (2) enhancing thromboxane release, which leads to platelet aggregation, or (3) decreasing the activation of protein C, which is needed to inactivate the clotting process. (contemporaryobgyn.net)