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  • cortisol
  • In a recent study we showed that alterations in DNA methylation at genes important in regulating cortisol levels, tissue glucocorticoid action, blood pressure and fetal growth, are present in adulthood in association with both early life parameters and cardiometabolic risk factors. (biomedsearch.com)
  • Heightened concentration of maternal cortisol is a frequently proposed mechanism linking adverse maternal environments with poor birth outcomes, including birth weight. (bioportfolio.com)
  • abnormal
  • Working with lead author Tiziana Cotechini (PhD student, Biomedical and Molecular Sciences) and co-authors Maria Komisarenko, Arissa Sperou, Shannyn Macdonald-Goodfellow and Michael A. Adams, Dr. Graham's recent investigations have shown that anti-inflammatory drugs could be beneficial in the treatment of abnormal maternal inflammation during pregnancy, helping to stave-off the associated diseases like pre-eclampsia and fetal growth restriction. (chrcrm.org)
  • In our rat model, we established a causal relationship between abnormal inflammation and the development of fetal growth restriction and a pre-eclampsia-like state," explains Dr. Graham. (chrcrm.org)
  • restriction
  • Funded by the Canadian Institutes of Health Research and published in the Journal of Experimental Medicine , the promising research couldn't have come soon enough - there are currently no effective treatments to prevent fetal growth restriction or pre-eclampsia as doctors do not fully understand the factors that cause these diseases. (chrcrm.org)
  • immunology
  • While this is a critical aspect of reproductive immunology, it is also important to consider the function of the maternal immune system in the promotion of implantation and maintenance of pregnancy. (nih.gov)
  • outcomes
  • The effects of crystalloid warming on maternal body temperature and fetal outcomes: a randomized controlled trial. (bioportfolio.com)
  • Many reports have documented a considerable maternal risk of morbidity and mortality and high perinatal adverse outcomes [ 2 - 7 ]. (hindawi.com)
  • Research suggests that home visiting services can have a significant impact on pregnancy outcomes, child health and development, parenting and maternal life course. (dartmouth.edu)
  • diseases
  • Her team and others have found that maternal cells are normally present in a variety of organs and increased in some diseases. (fredhutch.org)
  • novel
  • We are investigating this further, using novel magnetic resonance imaging techniques to study the developing fetal brain in utero. (biomedsearch.com)
  • death
  • The study showed that the follow-up of patients was variable, but no maternal death was found. (hindawi.com)
  • They showed that women with SCD have an increased risk of preeclampsia and maternal death, stillbirths, preterm deliveries, and small-for-gestational-age newborns. (hindawi.com)
  • mainly
  • BACKGROUND: Observational studies have generated conflicting evidence on the effects of moderate maternal alcohol consumption during pregnancy on offspring cognition mainly reflecting problems of confounding. (le.ac.uk)