Loading...
  • fetal
  • We conducted a case-referent study of the effect of exposure to bisphenol-A on fetal growth in utero in full-term, live-born singletons in Alberta, Canada. (mdpi.com)
  • Using in situ hybridization to measure HES-1 and HES-5 mRNA (direct markers of Notch activity), our laboratory has found that both maternal thyroid status and maternal exposure to PCBs influences Notch signaling in the fetal rat brain. (epa.gov)
  • ¹⁴C]-DBC (GD 17) dosing revealed transplacental distribution to fetal tissues at 10-fold lower concentrations than in paired maternal tissue and residual [¹⁴C] 3 weeks post dose. (oregonstate.edu)
  • Endocrine disruptors (EDs) are compounds known to promote transgenerational inheritance of adult-onset disease in subsequent generations after maternal exposure during fetal gonadal development. (ovid.com)
  • Increasing evidence has shown that exposure to ambient fine particles (PM 2.5 ) is associated with abnormal fetal development. (biomedcentral.com)
  • Prostaglandins, masculinization and its disorders: effects of fetal exposure of the rat to the cyclooxygenase inhibitor- indomethacin. (nih.gov)
  • nicotine and chlorpyrifos
  • The objective of this research project was to test the hypothesis that combined exposure to nicotine and chlorpyrifos (CPF) during the critical periods of development of cholinergic pathways in the central nervous system disrupts the structural organization of the cholinergic system and interferes with the cholinergic transmission, resulting in neurologic deficits such as impairments in learning and memory performance. (epa.gov)
  • Maternal exposure to nicotine and chlorpyrifos, alone and in combination leads to persistently elevated expression of glial fibrilary acidic protein in the cerebellum of the offspring at late puberty. (epa.gov)
  • trimester
  • Research from the Canadian province of Alberta in 2005 on pooled sera of 26-30 year old pregnant women (in the first trimester) suggested that mean exposures were between 0.07 and 0.6 ng/g, with standard deviation of means of pools of 0.231 ng/g [ 3 ]. (mdpi.com)
  • Can breastfeeding help decrease or alleviate a newborn's symptom severity from withdrawals associated w/ 3rd trimester, high-dose RX Xanax (alprazolam) exposure? (healthtap.com)
  • concentrations
  • Maternal xenobiotic treatment appeared to modify specific Leydig cell gene expression in male offspring, particularly during the dynamic phase of mid-puberty, with serum INSL3 concentrations showing that these compounds led to a faster attainment of peak values, and a modest acceleration of the pubertal trajectory. (nottingham.ac.uk)
  • Hair samples were prepared and measured by inductively coupled plasma mass spectrometry (ICP-MS). The correlation between CHDs and maternal aluminum concentrations was estimated by a 1:1 conditional logistic regression. (nih.gov)
  • Neonatal
  • Our data indicate that environmental contaminants such as dioxins have a long-lasting capability to modify neonatal thyroid function after the initial exposure. (plos.org)
  • Abdel-Rahman A, Dechkovskaia A, Mehta-Simmons H, Guan X, Khan W, Abou-Donia M. Increased expression of glial fibrillary acidic protein in cerebellum and hippocampus: differential effects on neonatal brain regional acetylcholinesterase following maternal exposure to combined chlorpyrifos and nicotine. (epa.gov)
  • doses
  • Altogether, these data show that early exposure to post-accidental doses of 137 Cs induces the alteration of vitamin D metabolism, associated with a dysregulation of mineral homeostasis. (springer.com)
  • DEHP's adverse effects were observed at doses relevant for human exposure. (ovid.com)
  • pollutants
  • Our aim is to investigate how maternal exposure to a mixture of 29 different persistent organic pollutants, formulated to mimic the relative POP levels in the food basket of the Scandinavian population, could alter reproductive endpoints. (ovid.com)
  • significantly
  • Exposures to PM 2.5 and SO 2 during the 1st and 2nd trimesters were also associated with significantly increased ORs, which were 1.09 (95% CI 1.02-1.17) and 1.07 (95% CI 1.01-1.14) for PM 2.5 , and 1.37 (95% CI 1.30-1.45) and 1.38 (95% CI 1.31-1.46) for SO 2 . (mdpi.com)
  • A high maternal aluminum concentration may significantly increase the risk of delivering a child with a CHD, such as a septal defect, conotruncal heart defect and right-side obstruction. (nih.gov)
  • The growth trajectory of offspring revealed that maternal exposure to CAP significantly decreased offspring birth weight but increased body weight of adult male but not female offspring, and the latter was expressed as increased adiposity. (biomedcentral.com)
  • In contrast, maternal exposure did not significantly change any of these indexes in adult female offspring. (biomedcentral.com)
  • investigate
  • The purpose of this study was to investigate whether the maternal exposure to different sources of electromagnetic fields affect on the rate and severity of speech problems in their offspring. (stopumts.nl)
  • testicular
  • Maternal exposure to estrogenic xenobiotics or phthalates has been implicated in the distortion of early male reproductive development, referred to in humans as the testicular dysgenesis syndrome. (nottingham.ac.uk)
  • study
  • Although a major limitation in our study is the relatively small sample size, this study indicates that the maternal exposure to common sources of electromagnetic fields such as mobile phones can affect the occurrence of speech problems in the offspring. (stopumts.nl)
  • This study was supported, in part, by the Agency for Toxic Substances and Disease Registry and the Centers for Disease Control and Prevention through a cooperative agreement grant to NYSDOH titled "Program to Conduct and Coordinate Site-Specific Activities" (U50/ATU200002) and by New York State's Maternal and Child Health Services (MCH) block grant through the NYSDOH Maternal and Child Health Graduate Assistant Program. (nih.gov)
  • A multi-center, hospital-based case-control study was performed at four maternal and child tertiary hospitals in China. (nih.gov)
  • However, estimated exposure to other oxygenated solvents such as aliphatic alcohols, ketones, esters and aldehydes, in our study population is unknown. (cdc.gov)
  • indicate
  • Our data indicate that maternal exposure to ambient PM 2.5 programs obesity in male offspring probably through alterations in the methylation of the promoter region of the leptin gene. (biomedcentral.com)
  • development
  • The result suggested a positive effect of maternal PYR exposure on infant development, the reason for which is not clear, but an unknown confounding factor is suspected. (mdpi.com)
  • Taken together, these results support the notion that maternal exposure to certain xenobiotics can also influence the development of the adult-type Leydig cell population, possibly through an effect on the Leydig stem cell population. (nottingham.ac.uk)
  • clefts
  • As noted in their comment, our exposure assessment did not include oxygenated solvents such as glycol ethers, which have been previously linked with an increased prevalence of some birth defects, including both oral clefts and neural tube defects. (cdc.gov)
  • deficits
  • In addition, deficits associated with PCBs are inversely associated with maternal thyroid hormone (TH) levels. (epa.gov)
  • pregnant
  • The discrepancy between self-reported emvironmental tobacco smoke exposure and cotinine levels in pregnant non-smokers in France was examined. (ovid.com)
  • mothers
  • These mothers were asked whether they had exposure to different sources of electromagnetic fields such as mobile phones, mobile base stations, Wi-Fi, cordless phones, laptops and power lines. (stopumts.nl)
  • birth
  • These codes are for use when the listed maternal conditions are specified as the cause of confirmed morbidity or potential morbidity which have their origin in the perinatal period (before birth through the first 28 days after birth). (icd10data.com)
  • We encourage further dialogue and research aimed at elucidating the true underlying relation between exposure to distinct classes of organic solvents and birth defects. (cdc.gov)
  • type
  • We agree with Garlant zec and colleagues that differences in the definition of exposure (characterised by solvent type, formulation or mixture, frequency and intensity, etc, as noted in our Discussion section) may explain apparent 'inconsistencies' in reported results across studies. (cdc.gov)
  • There were no statistically significant differences for ASD or ADHD in subgroup analyses according to type of exposure (i.e., preeclampsia or other HDP). (drugs.com)