Maternal copy of chromosome. Medical search. Frequent questions

some patients have maternal uniparental disomy of chromosome 7, with the possibility of imprinting (eg, inheriting two copies of maternal chromosome 7, with no paternal contribution). (medscape.com)
Maternal uniparental disomy of chromosome 14, paternal deletions and loss of methylation at the intergenic differentially methylated region (IG-DMR) result in a human phenotype of low birth weight, hypotonia, early puberty and markedly short adult stature. (bmj.com)
Temple syndrome (TS) is an imprinting disorder that was first described by Temple et al in 1991 in a report of a male aged 18 years with maternal uniparental disomy of chromosome 14. (bmj.com)
Overexpression of ZNF597 may contribute to some of the phenotypes associated with maternal uniparental disomy of chromosome 16 (UPD(16)mat), and some patients with UPD(16)mat presenting with Silver-Russell syndrome (SRS) phenotype have recently been reported. (bmj.com)

Another way to reduce false segments is to phase a child's DNA into the parental chromosomes. (thegeneticgenealogist.com)
There are a total of four parental chromosomes, and the allele transmission pattern is inferred, based on the pedigree structure, the CNV calls, as well as the signal intensity values for each of the six children. (openbioinformatics.org)
Strikingly, flipping imprinting on the parental chromosomes by crossing genotypes of complete and partial intergenic element deletions rescues the lethality of each deletion on its own. (nature.com)
The researchers coined the cell division leading to the segregation of parental chromosomes "heterogoneic," or of differential parental origin. (cshlpress.org)

Diploid organisms have two full sets of chromosomes, which exist in pairs known as homologous pairs. (actforlibraries.org)
The finding that normal fertilization can result in embryos containing cells with different parental sets of chromosomes is a new mechanism for chimerism, which was previously thought to occur only as the result of fertilization errors, for example, the fusion of multiple sperm or eggs to form an embryo. (cshlpress.org)

The following chromosomal conditions are associated with changes in the structure or number of copies of chromosome 14. (medlineplus.gov)
Ring chromosome 14 syndrome is caused by a chromosomal abnormality known as a ring chromosome 14 or r(14). (medlineplus.gov)
This disorder usually results from an extra chromosome 21, although in uncommon instances it is related to other chromosomal abnormalities such as translocation of the genetic material. (wikipedia.org)
Of the 60 SDHD tumours investigated, four tumours showing retention of chromosome 11 showed SLC22A18 and CDKN1C expression levels comparable to levels in tumours showing loss of chromosome 11, suggesting loss of protein expression despite chromosomal retention.Our data strongly suggest that SLC22A18 and/or CDKN1C are tumour modifier genes involved in the tumourigenesis of SDHD-linked paraganglioma. (nih.gov)
We also identify multiple cases of catastrophic chromosomal rearrangements known as chromoanagenesis, including somatic chromoanasynthesis, and extreme balanced germline chromothripsis events involving up to 65 breakpoints and 60.6 Mb across four chromosomes, further defining rare categories of extreme cxSV. (biomedcentral.com)
The number of possible chromosomal combinations is 2^n where n equals the haploid chromosome number. (actforlibraries.org)
The following chromosomal conditions are associated with such changes in chromosome 11. (blogspot.com)
About 1 percent of all people with Beckwith-Wiedemann syndrome have a chromosomal abnormality such as a rearrangement (translocation) involving 11p15.5 or abnormal copying (duplication) of genetic material in this region. (blogspot.com)
The parent carries a chromosomal rearrangement between chromosomes 11 and 22 called a balanced translocation. (blogspot.com)
PGS screens for a number of common embryonic chromosomal disorders, including a condition called aneuploidy - where embryos have too few or too many chromosomes. (sdfertility.com)
Techniques discussed include the use of ultrasound scanning and maternal serum alpha-fetoprotein estimation in screening for congenital malformations, the use of karyotyping to detect chromosomal abnormalities during pregnancy, and DNA methods for carrier diagnosis and prenatal diagnosis. (who.int)
Down Syndrome (DS) is the most common chromosomal aberration resulting from trisomy of the chromosome 21. (bvsalud.org)

It is primarily caused by trisomy of chromosome 21 (see the image below), which gives rise to multiple systemic complications as part of the syndrome. (medscape.com)

While nuclear DNA is made up of much longer strands of DNA that are tightly coiled into chromosomes, mitochondrial DNA is found as a small, circular chromosome. (easydna.co.uk)
As males are the heterogametic sex in mammals, such sex-specific patterns can be indirectly observed when Y chromosome polymorphism is combined with mitochondrial sequence information. (uzh.ch)
The mitochondrial haplogroup (L3e2b1a1) is indicative of maternal ancestors' arrival to the Indian subcontinent about 70 000 y ago, while the Y-chromosome haplogroup (J) is suggestive of the arrival of paternal ancestors less than 25 000 y ago. (ijpsonline.com)
Particularly, Y-chromosome and mitochondrial haplogroups have helped to develop a high resolution human migration map during the past 100 000 y. (ijpsonline.com)
and through the analysis of mitochondrial and Y-chromosome haplogroups decipher the migratory routes as well as the time for the ancestors of this individual to reach India. (ijpsonline.com)
Mitochondrial genes are typically inherited only from the maternal oocyte. (msdmanuals.com)

A deletion of genetic material from part of the long (q) arm of chromosome 14 can cause FOXG1 syndrome, which is a rare disorder characterized by impaired development and structural brain abnormalities. (medlineplus.gov)
PWS occurs due to abnormalities affecting certain genes in the proximal long arm of chromosome 15 when deleted from the father's chromosome 15 and hence referred to as a genomic imprinting disorder which depends on the sex of the parent donating the chromosome leading to the chromosome defect in the child. (rarediseases.org)
The technique can help identify abnormalities that can cause implantation failure during IVF, as well as uncover conditions like Down syndrome (which is caused by an extra chromosome). (sdfertility.com)
Our embryology team then screens the chromosomes to check for abnormalities, extra copies of chromosomes, or missing chromosomes. (sdfertility.com)
Surprisingly, 39% of all embryos contained cells with abnormalities of entire sets of maternal and/or paternal chromosomes. (cshlpress.org)

A rare condition known as terminal deletion 14 syndrome causes signs and symptoms similar to those of ring chromosome 14 syndrome (described above). (medlineplus.gov)
Terminal deletion 14 syndrome is caused by the loss of several genes at the end (terminus) of the long (q) arm of chromosome 14. (medlineplus.gov)
In hypermobility type of Ehlers-Danlos syndrome , haploinsufficiency (where one copy is unable to produce the protein in sufficient quantity) due to a 30-kb deletion of tenascin-X (TNXB) gene is responsible for the disease. (dorak.info)
In Cri-Du-Chat syndrome (5p deletion), the genetic basis of the phenotype is haploinsufficiency for the telomerase reverse transcriptase gene ( TERT ), which is included in the deleted part of chromosome 5. (dorak.info)
Angelman syndrome is caused by the mutation or complete deletion of a specific gene on a chromosome. (medicinenet.com)
A missing piece of genetic material (deletion) on one of the chromosomes (most common cause). (medicinenet.com)
AS is a classic example of genomic imprinting in that it is usually caused by deletion or inactivation of genes on the maternally inherited chromosome 15 while the paternal copy, which may be of normal sequence, is imprinted and therefore silenced. (medicalmarijuana.com)
In 1987, it was first noted that around half of the children with AS have a small piece of chromosome 15 missing (chromosome 15q partial deletion). (medicalmarijuana.com)
Angelman syndrome is caused by the loss of the normal maternal contribution to a region of chromosome 15, most commonly by deletion of a segment of that chromosome. (medicalmarijuana.com)
The above figure does not show deletion, but it is obvious that when there is a single-copy deletion, the two possible CNV-based SNP genotypes are A and B, respectively. (openbioinformatics.org)
Maternal deletion of the entire IG-DMR was shown to result in perinatal lethality, while paternal deletion was consistent with normal development 13 , 14 . (nature.com)
Surprisingly, an isolated paternally derived deletion of a CpG island (CGI) located at the 5′ portion of the IG-DMR was shown to result in the opposing paternal-to-maternal phenotype 15 . (nature.com)
This is a bit similar to how most people with Angelman syndrome have a deletion in their chromosome 15. (cureangelman.org)

In a diploid genome without CNVs, each SNP genotype call is composed of two allele calls from two homologous chromosomes. (openbioinformatics.org)
When family data is available, that is, when father, mother and child are all genotyped and when their CNV calls are generated by PennCNV, it is possible (but not always deterministic) to disambiguate the SNP allele composition in each of the two homologous chromosomes in parental genome. (openbioinformatics.org)
The different colors (cyan, yellow, orange, green) for the SNP alleles denote different homologous chromosomes. (openbioinformatics.org)
There are two major possibilities for the father: maybe the SNP allele composition is AA+B in two homologous chromosomes, or maybe it is A+AB in two homologous chromosomes. (openbioinformatics.org)
However, based one child (subject 4), who has a SNP allele composition of AAB, we can confidently tell that the father should have A in one homologous chromosome and AB in the other. (openbioinformatics.org)
Once the user has this information, it is relatively straitforward to infer SNP allele composition within each homologous chromosome for each marker within a CNV. (openbioinformatics.org)
Again note that the procedure of inferring SNP alleles in each homologous chromosome may not be deterministic. (openbioinformatics.org)
Using different colors to distinguish chromosomes of maternal and paternal origin, draw a metacentric set of homologous chromosomes at: b. (collepals.com)
Each homologous pair contains a paternal and a maternal copy of the chromosome. (actforlibraries.org)

People with ring chromosome 14 syndrome have one copy of this abnormal chromosome in some or all of their cells. (medlineplus.gov)
Abnormal levels of hCG and estriol lizing the serum triple test and other newly are indicators for chromosome abnormali- introduced investigations has become a ties. (who.int)
Beckwith-Wiedemann syndrome results from the abnormal regulation of genes on part of the short (p) arm of chromosome 11. (blogspot.com)
Image caption: Bovine embryos derived from in vitro fertilization are used to examine the prevalence of abnormal chromosome segregation during development. (cshlpress.org)
Two copies of an abnormal allele are needed to express an autosomal recessive trait. (msdmanuals.com)
Information is shown for the items: Risk factors in this pregnancy, Obstetric procedures, Characteristics of Objectives --This is the first report to present maternal and infant labor and delivery, Method of delivery, Abnormal conditions of the health information exclusive to the 2003 revision of the U.S. Standard newborn, and Congenital anomalies of the newborn. (cdc.gov)

An error in one of the genes on chromosome 15 causes Angelman syndrome. (medicinenet.com)
However, in the region of the chromosome that is critical for Angelman syndrome, the maternal and paternal contribution express certain genes very differently. (medicalmarijuana.com)
If the maternal contribution is lost or mutated, the result is Angelman syndrome. (medicalmarijuana.com)
The important chromosome for Angelman syndrome is number 15. (cureangelman.org)
This illustration of Chromosome 15 highlights in red the section that contains the UBE3a gene and is often deleted from the maternal chromosome in Angelman syndrome. (cureangelman.org)
A small number of individuals with Angelman have an imprinting centre (IC) defect on the maternal chromosome. (cureangelman.org)

A rearrangement (translocation) that moves genetic material from one of several other chromosomes to a region of chromosome 14 called 14q32 occurs in 20 to 60 percent of cases of multiple myeloma, which is a cancer arising from plasma cells, a type of white blood cell. (medlineplus.gov)
Among the many vital steps, genetic material packaged in chromosomes - half from mom and half from dad - must be faithfully copied and precisely parceled out to the new cells. (fredhutch.org)
These connections create tension that helps chromosomes properly pull apart as the cell divides, ensuring each new cell ends up with exactly the right set of genetic material. (fredhutch.org)
Chromosome 15q11-13 duplication occurs when there is an additional copy of genetic material on chromosome 15, which results in 15q duplication syndrome, a condition characterized by neurodevelopmental delay, hypotonia, epilepsy, and autism spectrum disorder. (ucla.edu)
Emanuel syndrome is caused by the presence of extra genetic material from chromosome 11 and chromosome 22 in each cell. (blogspot.com)
These individuals have two normal copies of chromosome 11, two normal copies of chromosome 22, and extra genetic material from the der(22) chromosome. (blogspot.com)

In addition to the usual 46 chromosomes, people with Emanuel syndrome have an extra (supernumerary) chromosome consisting of a piece of chromosome 22 attached to a piece of chromosome 11. (blogspot.com)

the protein coding genes DLK1, RTL1 and DIO3 are expressed from the paternal allele, while the imprinted genes expressed from the maternal allele are all non-coding RNAs ( GTL2/MEG3, MEG8, RTL1as, multiple additional miRNAs and snoRNAs). (bmj.com)
The unmethylated IG-DMR on the maternal allele is associated with expression of GTL2/MEG3 and RTL1as , one of whose functions is to repress expression of DLK1 and RTL1 in cis. (bmj.com)
The imprinted region on chromosome 14q32 and expression of imprinted genes on the maternal allele (upper) and paternal allele (lower) for six genes. (bmj.com)
Note that DLK, RTL1 and DIO3 are expressed from the paternal allele and non-coding RNAs, GTL2/MEG3 , MEG8 and RTL1as are expressed from the maternal allele. (bmj.com)
In a normal individual, the maternal allele is expressed and the paternal allele is silenced. (medicalmarijuana.com)
As we can see, when there is a 3-copy CNV, there are four possible SNP allele composition within the CNV, including AAA, AAB, ABB and BBB. (openbioinformatics.org)
This is a very confusing concept to use, because when people use this term, they were actually referring to the scenario such as '2 A allele, 1 B allele' for a particular marker within a particular duplication, as opposed to '2 copies in paternal chromosome, 1 copy in maternal chromosome' which should be the right way to use. (openbioinformatics.org)
The father (subject 2, with 3-copies) has a SNP allele composition of AAB, while the mother (subject 1, with normal 2-copy) has a SNP allele composition of AA. (openbioinformatics.org)
Dlk1 , Rtl1 , and Dio3 are exclusively expressed from the paternal allele, whereas multiple noncoding transcripts, including Gtl2 , and its associated transcripts Rian , and Mirg , are expressed from the maternally inherited chromosome (Fig. 1a ). (nature.com)
If expression of a trait requires only one copy of a gene (one allele), that trait is considered dominant. (msdmanuals.com)
Because males usually have no paired allele to offset the effects of most alleles on the X chromosome, the X chromosome allele is expressed in males even if the trait is recessive. (msdmanuals.com)

Seizures may occur because certain genes on the ring chromosome 14 are less active than those on the normal chromosome 14. (medlineplus.gov)
Only the healthy embryos showing normal chromosome pairs are transferred into the uterus. (sdfertility.com)

At USF, he will run the new clinic with Dr. Stephanie Romero, a USF Health obstetrician and gynecologist and an assistant professor of obstetrics and gynecology and maternal fetal medicine. (usf.edu)
Dr. Romero walked through the hushed and peaceful hallways of the maternal-fetal division on the fourth floor of the USF South Tampa Center, past examination and ultrasound rooms, stopping to greet and hug a staff member. (usf.edu)
The Down Syndrome Program works closely with the Maternal Fetal Care Center . (childrenshospital.org)
ACMG strongly recommends NIPS over traditional screening methods for all pregnant patients with singleton and twin gestations for fetal trisomies 21, 18, and 13 and strongly recommends NIPS be offered to patients to screen for fetal sex chromosome aneuploidy. (cdc.gov)

Individuals with Emanuel syndrome inherit an unbalanced translocation between chromosomes 11 and 22 in the form of a der(22) chromosome. (blogspot.com)
The remaining cases are due translocation, mosaicism and partial trisomy of the chromosome 21. (bvsalud.org)

The genes are located close together in a region designated 11p15.5 near one end of the chromosome. (blogspot.com)
Different genes are located in each chromosome the way that information might be organized in an encyclopedia. (cureangelman.org)

Chromosome 14 harbours an imprinted locus at 14q32. (bmj.com)
There is one known imprinted locus on human chromosome 14, at 14q32. (bmj.com)

Nearly 10 percent of the genome, including highly repetitive sequences at the ends (telomeres) and middles (centromeres) of chromosomes, remained inaccessible. (jax.org)

The 'Hensen' model postulates that a tumour modifier gene located on chromosome 11p15, a region known to harbour a cluster of imprinted genes, is essential to tumour formation. (nih.gov)

Humans normally have 46 chromosomes in each cell, divided into 23 pairs. (medlineplus.gov)
Two copies of chromosome 14, one copy inherited from each parent, form one of the pairs. (medlineplus.gov)
Chromosome 14 spans more than 107 million DNA building blocks (base pairs) and represents about 3.5 percent of the total DNA in cells. (medlineplus.gov)
Each of Drosophila's 4 pairs of chromosomes has undergone 10 rounds of DNA replication. (biology-pages.info)
Chromosome 9 is made up of about 140 million DNA building blocks (base pairs) and represents approximately 4.5 percent of the total DNA in cells. (news-medical.net)
Chromosome 11 spans about 135 million DNA building blocks (base pairs) and represents between 4 and 4.5 percent of the total DNA in cells. (blogspot.com)

Described by John Langdon Down in the 19th Century, Down syndrome is a birth defect caused by a random error in cell division during meiosis that results in an additional full or partial copy of chromosome 21. (cdc.gov)
Previous studies involving in vitro fertilized (IVF) human embryos have demonstrated large fractions of embryos contain at least one cell with either whole or partial gains or losses of chromosomes. (cshlpress.org)
Nearly three-fourths of embryos examined contained at least one cell with either partial or whole chromosome aberrations, similar to findings in human in vitro fertilized embryos. (cshlpress.org)

Scientists at Fred Hutchinson Cancer Research Center have worked out the molecular underpinnings of how chromosomes make the right number of crossovers - important links that make it possible for developing sex cells (eggs or sperm in humans) to sort those chromosomes properly. (fredhutch.org)
For example, in humans there are 23 chromosomes in our sex cells. (actforlibraries.org)

April 12, 2016 - Single-cell embryos contain a set of maternal and paternal chromosomes, and as the embryo grows, daughter cells receive a copy of each. (cshlpress.org)
In a study published online today in Genome Research , researchers have discovered errors during the earliest stages of embryonic development can lead to entire sets of maternal and paternal chromosomes segregating into different cells, resulting in chimeric embryos. (cshlpress.org)
Applying haplarithmisis, a method they previously developed, the researchers examined copy number and parental origin of chromosomes in single cells from 23 embryos. (cshlpress.org)

The lower prevalence in Brazil might be because of the difference in the maternal age profile ( 1 ). (cdc.gov)
This study describes the prevalence, associated malformations, and maternal characteristics among cases with sirenomelia. (cdc.gov)

Interestingly, cytoplasmic genetic elements have been shown to have very different inheritance patterns to classic Mendelian nuclear chromosomes. (nature.com)

The sister syndrome, Prader-Willi syndrome, is caused by a similar loss of paternally inherited genes and maternal imprinting. (medicalmarijuana.com)

These cells, at this point, are haploid in terms of chromosome number, but have twice the amount of DNA since each chromosome is still composed of sister chromatids. (actforlibraries.org)

Dominant negative mutations (where mutation on one copy renders the other copy inactive) are involved in osteogenesis imperfecta type I and autosomal dominant nephrogenic diabetes insidipus . (dorak.info)
Down syndrome is the most common dis- plore the risks for Down syndrome and order of the autosomal chromosomes, with neural tube defects estimated in the study an incidence of 1:800 live births [ 5 ]. (who.int)

A ring chromosome is a circular structure that occurs when a chromosome breaks in two places and its broken ends fuse together. (medlineplus.gov)
Mitochondria contain DNA in a single circular chromosome containing 37 genes that code for 13 proteins, various RNAs, and several regulating. (msdmanuals.com)

The extra chromosome affects the way the child's brain and body develop, leading to developmental delays , intellectual disability, and an increased risk for certain medical issues. (childrenshospital.org)

These transmit copies of themselves to the next generation via meiosis involving strict segregation. (nature.com)

Alternately, seizures might result from instability of the ring chromosome in some cells. (medlineplus.gov)

For some genes in the 11p15.5 region, however, only the copy inherited from a person's father (the paternal copy) is expressed. (blogspot.com)

BGI-Research and the Maternal and Child Health Hospital of Hubei Province (MCHH) published whole-genome sequencing research results in npj Genomic Medicine. (news-medical.net)
Array comparative genomic hybridization in patient one and patient two revealed copy-number variant (CNV) deletions, respectively, ~ 1.45 Mb in size involving FOXF1 and an ~ 0.7 Mb in size involving FOXF1 enhancer and leaving FOXF1 intact. (researchgate.net)

Imprinting occurs at the time of conception as part of the normal development of the fetus and each of us have regions on some of our chromosomes that are imprinted, meaning that only one parent's genetic information is available to our cells as instructions on how to grow and develop. (cureangelman.org)
This phenomenon occurs during spermatogenesis, resulting in three copies of the chromosome 21. (bvsalud.org)

Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. (medlineplus.gov)
Researchers believe that several critical genes near the end of the long (q) arm of chromosome 14 are lost when the ring chromosome forms. (medlineplus.gov)
If the researchers inserted into a chromosome a new DSB hotspot close to other hotspots, the frequency of DSBs at those other hotspots dropped. (fredhutch.org)

If expression of a trait requires 2 copies of a gene (2 alleles), that trait is considered recessive. (msdmanuals.com)

While your nuclear chromosomes are only found in 2 copies per cell, one from your mother and one from your father, mtDNA is found much more abundantly-anywhere between hundreds to thousands of copies per cell. (easydna.co.uk)
That may be due to the fact that while each cell contains exactly 2 copies of each nuclear chromosome, it contains numerous mitochondria and thus numerous copies of the MT chromosome (possibly 20-25 per cell, by one estimate). (massgenomics.org)

The extra chromosome is known as a derivative 22 or der(22) chromosome. (blogspot.com)

In addition, the DNA in our own cells undergoes an estimated 30 new mutations during our lifetime, either through mistakes during DNA copying or cell division or, more often, because of damage from the environment. (dorak.info)
Trisomy can occur if cells can't properly sort chromosomes during sex-cell formation. (fredhutch.org)
In work published today in the Proceedings of the National Academy of Sciences, Hutch molecular biologist Dr. Gerry Smith and his team outline just such a model in yeast that explains how chromosomes find their happy medium during sex-cell formation. (fredhutch.org)
Both the maternal and paternal duplication groups shared changes in genes related to synapses and cell homeostasis. (ucla.edu)
Megakaryocytes, from which platelets are made, may pass through as many as seven S phases producing a giant cell with a single nucleus containing 128n chromosomes. (biology-pages.info)
The photomicrograph (courtesy of B. P. Kaufmann) shows the polytene chromosomes in a salivary gland cell of a Drosophila melanogaster larva . (biology-pages.info)
Another mechanism resulting in variation is the random alignment of the maternal and paternal chromosomes along the midplane of the cell. (actforlibraries.org)
A typical person has 46 chromosomes inside every cell in their body. (cureangelman.org)
A screening centre, usually the maternal by MS/MS (API 3200TM, HVD/Perkin sickle-cell disease (SCD) screening and child health (MCH) centre of Elmer). (who.int)

Mosaic paternal UPD leads to an imbalance in active paternal and maternal genes on chromosome 11, which underlies the signs and symptoms of the disorder. (blogspot.com)

For individual D, indicate which parent contributed the extra chromosome. (collepals.com)
Imprinting means that some genes on the chromosome are "turned on" or "turned off" depending on which parent contributed the chromosome. (cureangelman.org)

This gene (UBE3A, part of the ubiquitin pathway) is present on both the maternal and paternal chromosomes, but differs in the pattern of methylation (imprinting). (medicalmarijuana.com)

Chromosome 14 likely contains 800 to 900 genes that provide instructions for making proteins. (medlineplus.gov)

The 15q Duplication can be inherited maternally or paternally, but is typically maternal. (ucla.edu)

To do this we collected and analyzed RNA sequencing data representing gene expression from the cerebral cortex of mice carrying either maternal or paternal 15q duplications. (ucla.edu)

People with Emanuel syndrome typically inherit the der(22) chromosome from an unaffected parent. (blogspot.com)

The region of chromosome 14 that is deleted includes the FOXG1 gene as well as several neighboring genes. (medlineplus.gov)
This chromosome has a region that is "imprinted. (cureangelman.org)

Maternal screening of pregnant women uti- drome. (who.int)

Inheritance, in this case, was strictly maternal: a seed derived from an ovule from a non-green stem gave rise to non-green progeny, irrespective of the source of pollen. (nature.com)

Anatomy64

Organisms7

Diseases26

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Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Psychiatry and Psychology1

Phenomena and Processes172

Disciplines and Occupations2

Technology, Industry, Agriculture1

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Health Care1

Uniparental disomy of chromosome4

Parental chromosomes4

Sets of chromosomes2

Chromosomal12

Trisomy of chromosome 211

Mitochondrial6

Abnormalities5

Deletion13

Homologous9

Abnormal6

Angelman6

Genetic material6

Piece of chromosome1

Allele11

Normal chromosome2

Fetal4

Translocation2

Genes are located2

14q322

Centromeres1

11p151

Pairs6

Partial3

Humans2

Embryos3

Prevalence2

Mendelian1

Syndrome is caused1

Haploid1

Autosomal2

Circular2

Child's1

Segregation1

Instability1

Paternal copy1

Genomic2

Occurs2

Researchers3

Alleles1

Nuclear2

Derivative1

Cell9

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Parent contributed2

Methylation1

Proteins1

Maternally1

Gene expression1

Typically1

Region2

Pregnant women1

Inheritance1