• Most patients in the United States in need of a bone marrow transplant will find a suitable donor, but finding a perfect match is less likely and varies by race/ethnicity, according to a study published online July 24 in the New England Journal of Medicine . (medscape.com)
  • Our research shows that almost all patients who need an unrelated marrow transplant will have a suitably matched, available adult donor or cord blood unit on the Be The Match registry," said investigator Dennis Confer, MD, chief medical office of the National Marrow Donor Program (NMDP) in Minneapolis, Minnesota. (medscape.com)
  • Even without a fully matched donor, transplant is often the best or only option for patients with blood cancers and other deadly diseases where nontransplant therapy offers little chance of cure. (medscape.com)
  • There is a huge need for unrelated donors because only about 30% of patients in need of HSCT will have a human leukocyte antigen (HLA)-matched sibling, the preferred donor, the investigators explain. (medscape.com)
  • They used HLA matching, adult-donor availability, and cord blood dose to predict the likelihood of finding a suitable donor. (medscape.com)
  • The results suggest that from 66% to 97% of patients will have a suitably matched donor. (medscape.com)
  • Although the chances of "finding an available unrelated donor or cord blood unit are very high, we cannot find a suitably matched and available donor for every patient," Dr. Confer emphasized. (medscape.com)
  • The Collaborative Corneal Transplantation Studies (CCTS) suggested instead that matching patient and donor blood types (ABOcompatibility), a test that is not currently standard practice in corneal transplantation, might be effective in improving patient outcome. (nih.gov)
  • Previous studies had suggested that closely matching the donor's HLA with those of the recipient may increase the likelihood that a person's immune system would accept, rather than reject, the donor tissue. (nih.gov)
  • Moreover, since there is already a national shortage of donor corneas, high-risk patients would likely have to wait even longer for a suitably matched donor cornea. (nih.gov)
  • For patients lacking a HLA-matched related donor, it is routine to initiate an unrelated donor search. (nih.gov)
  • However some patients, particularly ethnic minorities, experience disease progression while awaiting identification of a suitably HLA-matched donor. (nih.gov)
  • Patients less than 71 years of age with acute leukemia or lymphoma and lacking a suitable HLA-matched related donor were eligible to participate. (nih.gov)
  • A first degree relative is likely to be the best candidate for donation if the human leukocyte antigen (HLA) markers are a sufficient match. (nih.gov)
  • Initially, these transplants were restricted to patients who had a relative with a good match, but in recent years there has been a big increase in transplants from unrelated donors, spurred both by medical advances and the use of umbilical cord blood as a new source of hematopoietic stem cells. (medscape.com)
  • After three years of patient follow-up, CCTS researchers found that people who received corneal transplants with well-matched antigens did not fare significantly better than those with a poor match. (nih.gov)
  • Regardless of race/ethnicity, suitable cord blood matches with high enough cell doses are available for almost all patients younger than 20 years and for more than 80% of patients older than 20. (medscape.com)
  • For each case-patient, all eligible controls were listed, and one suitably matched control was identified at random. (cdc.gov)
  • You can use this independent agent matching tool to find the best insurance solution in your area. (trustedchoice.com)
  • Research has indicated that patients transplanted earlier in their disease have better outcomes than patients with advanced disease, regardless of the degree of match. (medscape.com)
  • The researchers also noted that CCTS patients who matched the donor's blood type had a better outcome than unmatched patients. (nih.gov)
  • All CCTS patients received more intensive postoperative topical steroid therapy than did patients in two recent investigations that showed HLA matching positively influence transplant survival. (nih.gov)
  • Dr. Walter Stark, chairman of the study and professor of ophthalmology at The Johns Hopkins University Medical Institutions, said that although the CCTS found HLA matching had no effect on graft survival, high-dose topical steroid therapy proved so effective in the study that it could have actually masked any beneficial effect of antigen matching. (nih.gov)
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  • The control was matched with the case-patient according to unit, age at the time of hospitalization (±3 years), date of hospitalization (±3 months), and date of transfer to the present unit (±3 months). (cdc.gov)
  • Finding an optimally matched cord blood unit could prove more difficult, and varies by race/ethnicity. (medscape.com)
  • To address bony protuberance on normal bone surface, is a this, we have proposed the use of partial shape matching characteristic feature of degenerative joint disease of the (PSM) methods for spinal X-ray image retrieval. (nih.gov)
  • It is critical that those who join the registry remain committed to donate when called, and that we continue to add people to the Be The Match registry for the racial and ethnic groups of highest need. (medscape.com)