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  • outcomes
  • We analyzed these outcomes in a large cohort of AML patients (n=1134), age ≥50 years, who were alive and leukemia-free 2 years after SCT from matched siblings (n=848) or MUD (n=286), with a median follow up 8.9 years. (nih.gov)
  • The current study aimed to compare the outcomes of allo-SCT from matched sibling donors (MSD) (n=660) vs UDs (n=381), for patients with PRF AML. (linkos.cz)
  • In addition to potentially changing the outcomes, these factors can complicate the experimental setup and cause inefficiencies or bias in the generation of blood cell precursors. (prolife.ie)
  • patient's
  • In the USA , the only way to effectively, safely and legally perform an Orthopedic Stem Cell treatment is to use the patient's' own stem cells, anything else is either illegal, consumer fraud (or both). (medindia.net)
  • A dominant polyclonal CD4 T cell response against patient's mismatched HLA-DRB3 molecule was found in addition to an immune response against patient's mismatched HLA-DPB1 molecule. (ovid.com)
  • registry
  • He's lucky that Mr Jiang gave a saliva sample in order to sign up for the stem cell registry, since relatively few in China have signed up for the scheme. (bbc.co.uk)
  • Chinese people make up approximately 20% of the world's population, but only 4% of people on the global stem cell registry are of Chinese origin, explains the OtherHalf Chinese Stem Cell Initiative. (bbc.co.uk)
  • Within the NMDP registry, the probability of identifying at least one antigen level-matched (HLA-A and -B) and potential allele level-matched (HLA-DRB1) donor depends upon race/ethnicity. (psychiatryadvisor.com)
  • Most donors in the registry are partially matched at HLA A and B. The HapLogic algorithm in the NMDP utilizes extended HLA typing for haplotype analysis to predict the donor's DRB1 type and narrow the list of potential unrelated donors. (psychiatryadvisor.com)
  • That's why I'm letting people know they have the power to save a life by joining the Be The Match Registry. (stemcellumbilicalcordblood.com)
  • 70% of these patients don't have a matching donor in their families, so they depend on the Be The Match Registry, the world's largest and most diverse listing of potential marrow donors, to find that life-saving match. (stemcellumbilicalcordblood.com)
  • Shaq is an American icon who's respected for his talents, on and off the court," said Jeffrey W. Chell, M.D., chief executive officer of the National Marrow Donor Program, which operates the Be The Match Registry. (stemcellumbilicalcordblood.com)
  • Global search for full match donor through Indian registry named 'Datri' located one donor from Israel registered with Ezir Mizion, on 07th May'17. (change.org)
  • patients
  • Overall a 9-10/10 matched HSC donor can now be identified for 60-80% of patients of European descent. (hindawi.com)
  • Black patients were 2.83 times, Asian patients 2.05 times, and Hispanic patients 1.73 times more likely to have a less-matched HCT donor than Caucasian patients. (psychiatryadvisor.com)
  • Patients may not have an HLA-matched sibling donor. (mskcc.org)
  • Patients must have a partially HLA-matched donor. (mskcc.org)
  • We're honored that he is championing our mission and advocating for patients who are searching for a marrow match. (stemcellumbilicalcordblood.com)
  • It remains a lengthy procedure to identify and procure HSC from an acceptably matched unrelated donor, which may lead to disease progression in some patients. (nus.edu.sg)
  • 660 patients received a MSD, 296 patients a matched UD (10/10) and 85 a mismatched UD (9/10), respectively. (linkos.cz)
  • For patients with PRF AML, that do not have a matched sibling donor, allo-HST from UD is a suitable option and thus initiation of an early search and allocating of a suitable donor is therefore indicated. (linkos.cz)
  • We're pleased to partner with Be The Match BioTherapies to progress our clinical investigation of ATIR101 and to expedite its availability to patients," said Andrew Sandler, chief medical officer of Kiadis Pharma. (globenewswire.com)
  • We believe this therapeutic approach could allow family members to serve as stem cell donors for those patients who would otherwise not find a matching donor in time, ultimately saving lives. (globenewswire.com)
  • This allows scientists to study the factors that affect early stages of blood cell development, and provides a mechanism for clinician-researchers to develop therapies for patients. (prolife.ie)
  • donate stem cells
  • In the past, if recipients met donors directly, they sometimes pressured them to donate stem cells again if their illness resurfaced. (bbc.co.uk)
  • Learn about how to donate stem cells, donor eligibility, important registration information, registration forms (available in multiple languages), knowledge testing and more. (blood.ca)
  • cancer
  • Have cancer stem cells MET their match? (sciencemag.org)
  • Matthews' sister Debbie was found to be a perfect match, and she happily donated stem cells to help her sibling battle cancer. (mdanderson.org)
  • At the same time, ATIR101 contains potential cancer-killing T-cells from the donor that could eliminate residual cancer cells and help prevent relapse of the disease. (globenewswire.com)
  • Successful virotherapy of cancer is critically dependent on the ability of oncolytic viruses like vaccinia to overcome multiple defense barriers including the complement/antibody-mediated neutralization [ 1 ], the interferon-induced anti-viral state [ 2 - 5 ], as well as the innate and adaptive anti-viral immune mechanisms mediated by NK and T cells, respectively. (biomedcentral.com)
  • and the investigation of "immune checkpoint" blocking antibodies that unleash a sustained immune response against cancer cells. (onclive.com)
  • acute and chronic
  • iOBX, one of the national leaders in orthopedic stem cells for treating acute and chronic injuries, has announced an expansion of their stem cell facility. (medindia.net)
  • 2016 and they are now one of the national leaders in orthopedic stem cells for treating acute and chronic injuries such as arthritis, joint, ligament and tendon injuries. (medindia.net)
  • cord
  • MEDS ) announced today peer-reviewed publication of its data on what is believed to be the first "combination therapy" adult stem cell protocol for spinal cord injury. (marketwired.com)
  • Learn about stem cell and cord blood donor eligibility, how to register, who can register, the stem cells knowledge test, registration events, accessing registration forms in other languages, donating cord blood for research and more. (blood.ca)
  • dose
  • The first treatment cohort will be 0.5 X 106 cells/kg dose cohort. (clinicaltrials.gov)
  • Conclusion: Further increases in the size and diversity of CB inventories may realise the potential of every patient having access to at least a 5/6 matched CB unit of adequate cell dose (70-fold relative value for each CB unit banked versus each BM donor recruited). (nus.edu.sg)
  • The UCB median cell dose was 3.43 x 10 7 NC/kg (0.9 -10.8) and 1.62 x 10 5 CD34/kg (0.3 -6.9). (aacrjournals.org)
  • diseases
  • Medistem Inc. is a biotechnology company developing technologies related to adult stem cell extraction, manipulation, and use for treating inflammatory and degenerative diseases. (marketwired.com)
  • The cells we derive can be used to study factors for their effects on hPSC differentiation, paving the way for studies of drug efficacy and toxicity, and to model diseases. (prolife.ie)
  • tumor cells
  • The T-cells in ATIR101 will help fight infections and remaining tumor cells, until the immune system has fully re-grown from stem cells in the transplanted graft. (globenewswire.com)
  • Here, we demonstrate that adipose-derived stem cells (ADSCs) have the potential to eradicate resistant tumor cells through a combination of potent virus amplification and sensitization of the tumor cells to virus infection. (biomedcentral.com)
  • immune
  • In reality, that means the matched pair must have the same ethnic background so the immune cells of the donor and recipient work in tandem. (bbc.co.uk)
  • HLA protein is made up of six antigens, molecules that stimulate an immune response and help your body identify which cells belong to your body and which do not. (wdxcyber.com)
  • With headquarters in Amsterdam, the Netherlands, Kiadis Pharma is reimagining medicine by leveraging the natural strengths of humanity and our collective immune system to source the best cells for life. (globenewswire.com)
  • Comparative analysis was performed to establish statistically significant correlations and to evaluate the effect of stem cells on the activity of key immune cell populations. (biomedcentral.com)
  • lymphoma
  • The B-Cell Lymphoma Moon Shot is revolutionizing the conventional medical research approach to rapidly translate findings into patient treatment options and develop personalized therapeutic strategies. (mdanderson.org)
  • Extranodal natural killer (NK)/T cell lymphoma, nasal type, is a recently recognized distinct entity and the most common type of non-B cell extranodal lymphoma in Asia. (nih.gov)
  • differentiation
  • These factors include co-culturing the hPSC with non-human animal cells that secrete an un-measurable amount of substances into the media, which is used to promote differentiation. (prolife.ie)
  • We demonstrated that the unique approach we developed efficiently promotes differentiation of hPSC to blood cell precursors, while eliminating many complications," she continues. (prolife.ie)
  • investigational
  • iOBX is fully FDA compliant, but Orthopedic stem cell treatments are considered investigational by the FDA. (medindia.net)
  • The company has filed an Investigational New Drug Application (IND) with the FDA for use of its universal donor endometrial regenerative cells (ERC) for treatment of critical limb ischemia, an advanced form of peripheral artery disease. (marketwired.com)
  • siblings
  • Since there is a higher chance of matching HLA antigens within families, it may be recommended that family members, and particularly siblings, be tested as potential donors. (wdxcyber.com)
  • transfusion
  • However, Mr Jiang was able to use a different method that extracts cells using a lengthy blood transfusion. (bbc.co.uk)
  • He was then hooked up to a transfusion machine for three hours, while the healthy stem cells were extracted from his blood system. (bbc.co.uk)
  • clinical
  • The collaboration will leverage Be The Match BioTherapies' industry-leading expertise in cell delivery logistics and supply chain case management, including the company's MatchSource ® end-to-end supply chain management software, to manage the transport and processing of cellular products for use at Kiadis' clinical trial sites in the U.S. and Canada. (globenewswire.com)
  • probability
  • This paper summarizes our experience with a search algorithm that includes at the start of the search a probability estimate (high/intermediate/low) to identify a HLA-A, B, C, DRB1, DQB1-compatible donor (a 10/10 match). (hindawi.com)
  • The probability of finding an unrelated HLA-matched donor depends on many factors including the ethnic homogeneity of the people in the nation and the size of the country's stem cell donor pool. (bloodresearch.or.kr)
  • patient
  • Alloreactive CD4 T cells were isolated from peripheral blood after CD4 donor lymphocyte infusion and recognition of donor-derived target cells transduced with the mismatched patient variant HLA-DRB3 and HLA-DPB1 molecule was tested. (ovid.com)
  • We envision, for example, the ability to take blood cells from a patient, correct the genetic defects in the lab, and then re-introduce them into the patient. (prolife.ie)
  • potential
  • We have found only 320 matches using the Shanghai database, out of 13,700 potential donors. (bbc.co.uk)
  • This makes it more likely for a sibling to be a potential stem cell donor, with a 25% chance of inheriting the same antigens from the parents. (wdxcyber.com)
  • This type of stem cell has the potential to develop into many different kinds of cells in the body, and is capable of participating in organ repair and function. (prolife.ie)