AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation Science
Transcription FactorsGene Expression Regulation, BacterialBacterial ProteinsSignal TransductionPromoter Regions, GeneticTrans-ActivatorsTranscription, GeneticRepressor ProteinsMolecular Sequence DataGene Expression RegulationDNA-Binding ProteinsCell DifferentiationProtein BindingRegulonGenes, RegulatorBase SequenceMutationGene Expression Regulation, DevelopmentalModels, BiologicalGene Expression ProfilingNuclear ProteinsCell LineChromatin ImmunoprecipitationMice, KnockoutAmino Acid SequenceRNA, MessengerCells, CulturedHomeodomain ProteinsReverse Transcriptase Polymerase Chain ReactionGene Knockdown TechniquesBasic Helix-Loop-Helix Transcription FactorsBinding SitesFlagellaMice, Inbred C57BLCystic Fibrosis Transmembrane Conductance RegulatorArtificial Gene FusionTranscriptional ActivationCell Line, TumorRNA InterferenceHypoxia-Inducible Factor 1, alpha SubunitGene Regulatory NetworksOligonucleotide Array Sequence AnalysisQuorum SensingCaulobacter crescentusCaulobacterMicroRNAsRNA, Small InterferingElectrophoretic Mobility Shift AssayPhosphorylationPhenotypeNF-E2-Related Factor 2Gene DeletionHypoxia-Inducible Factor 1Blotting, WesternProtein Structure, TertiaryCell ProliferationFeedback, PhysiologicalHEK293 CellsDown-RegulationAdipogenesisCell LineageMicrophthalmia-Associated Transcription FactorArabidopsis ProteinsCampomelic DysplasiaGATA3 Transcription FactorOperonHomeostasisGene Expression Regulation, FungalGenes, ReporterCell CycleGene ExpressionCell Cycle ProteinsMultiprotein ComplexesArabidopsisBacillus subtilisEscherichia coli ProteinsUp-RegulationMembrane ProteinsGene Expression Regulation, PlantEmbryonic Stem CellsSigma FactorGenes, SwitchGene Expression Regulation, NeoplasticMice, TransgenicDNA PrimersDrosophila ProteinsPPAR gammaGenes, BacterialReal-Time Polymerase Chain ReactionProtein-Serine-Threonine KinasesBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsGene SilencingTwist Transcription FactorSequence AlignmentIntracellular Signaling Peptides and ProteinsProtein KinasesApoptosisCarrier ProteinsSOX9 Transcription FactorForkhead Transcription Factors
Major regulatorDifferentiationTranscriptionalOncogenicGenesCressiTumorPathway2023OctopusErgonomicTranscription factorsGeneProteinsInspectTwistPropaneGaugeParticipantsTargets2021TypesRegulatoryPressureProductProductsResponseCellApproachCriticalBrainAnalysisSwitchPerformanceFederalMainExamplesRangeSeriesInstallationActivity
Major regulator2
  • We conclude that ADR-1 acts as a major regulator of editing by binding ADR-2 substrates in vivo. (genengnews.com)
  • Cyclic nucleotide signalling is a major regulator of malaria parasite differentiation. (crick.ac.uk)
Differentiation3
  • In genetics, a master regulator gene is a regulator gene at the top of a gene regulation hierarchy, particularly in regulatory pathways related to cell fate and differentiation. (wikipedia.org)
  • Conclusions Our results demonstrate that FOXO1 is a master regulator of CAR T cell memory programming and that overexpression of FOXO1 triggers both transcriptional and epigenetic changes in CAR T cells that enhance memory differentiation, persistence, and potency. (bmj.com)
  • GATA-3 acts as a master regulator of Th2 differentiation 12-13 . (bvsalud.org)
Transcriptional3
  • A network-based integrative genomic analysis of 20 The Cancer Genome Atlas cohorts characterizes conserved master regulator blocks underlying cancer hallmarks across different tumor types, providing insights into the connection between genetic alterations and tumor transcriptional identity. (biu.ac.il)
  • We subsequently use the inferred transcriptional network to perform master regulator analyses nominating transcription factors predicted to control oncogenic transcription in specific PPGL molecular subtypes. (elsevierpure.com)
  • The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. (nature.com)
Oncogenic1
  • The oncoprotein c-Myc belongs to the IDP group of proteins and is an oncogenic master regulator overexpressed in more than half of human cancers, but characterizing its interactions are inherently difficult due to their short-lived nature. (lu.se)
Genes8
  • Most genes considered master regulators code for transcription factor proteins, which in turn alter the expression of downstream genes in the pathway. (wikipedia.org)
  • Other genes reported as master regulators code for SR proteins, which function as splicing factors, and some noncoding RNAs. (wikipedia.org)
  • Identification of master regulator (MR) genes offers a relatively rapid and efficient way to characterize disease-specific molecular programs. (aging-us.com)
  • Thus, the study team used computational systems biology approaches to discern a disease-relevant core pathway in schizophrenia and to discover a master regulator in that pathway that affects hundreds of downstream genes. (newmindjournal.com)
  • Researchers believe that the RUNX2 protein acts as a "master switch," regulating a number of other genes involved in the development of cells that build bones (osteoblasts) and in the development of teeth. (medlineplus.gov)
  • Dynamical models based upon known interactions between these master genes, such as mutual antagonism and autoregulation, fail to make the system bistable, a desired feature for robust lineage determination. (lu.se)
  • We therefore suggest a new mechanism involving a cofactor that is regulated as well as recruited by one of the master genes to bind to the antagonistic partner that is necessary for bistability and hence switch-like behavior. (lu.se)
  • The latter pair inherits the state of its upstream master genes and further reinforces the decision due to several feedback loops, thereby leading to irreversible commitment. (lu.se)
Cressi6
  • The Cressi Master Ellipse T10-SC Regulator Set is simply one of the world's top-performing technical and recreational diving reg sets. (divegearaustralia.com.au)
  • The Cressi T10 SC Master Regulator is Performance, ergonomic reliability, and ease of maintenance make this Cressi Master Ellipse T10-SC Regulator Set a product for true diving professionals. (divegearaustralia.com.au)
  • The SC designation on this model of the Cressi T10 SC Master series regulators stands for "Sealed Chamber" , signifying the environmentally sealed diaphragm first stage is rated for cold water. (divegearaustralia.com.au)
  • The first stage stands out from the range of Cressi balanced diaphragm regulators because the mechanism is arranged on an axis perpendicular to the axis of air entry, creating a "T" shape. (divegearaustralia.com.au)
  • The Master Ellipse second stage has installed the exceptional and proven Cressi balanced valve to ensure minimum inhalation effort. (divegearaustralia.com.au)
  • Cressi Octopus MG Balanced, regulator 2nd. (dive-connection.com)
Tumor2
  • Correspondingly, most cancer signaling pathways seem to converge on one or more TFs, termed "master regulators" (MRs) [ 4 ], which direct tumor development, progression, and metastasis through hierarchical control of gene expression patterns. (aging-us.com)
  • Integrative genomic analysis, using a network-based approach, identified 407 master regulator (MR) proteins responsible for canalizing the genetics of individual samples from 20 cohorts in The Cancer Genome Atlas (TCGA) into 112 transcriptionally distinct tumor subtypes. (biu.ac.il)
Pathway1
  • Collectively, our results reveal the molecular mechanism that controls the stability of D-type cyclins during cell-cycle progression, in development and in human cancer, and implicate AMBRA1 as a critical regulator of the RB pathway. (uniroma3.it)
20231
  • The Environmental Protection Agency on Nov. 2, 2023, granted a petition submitted by Native American tribes in California and Washington state asking federal regulators to prohibit the use of the chemical 6PPD in tires due to its lethal effect on salmon, steelhead trout, and other wildlife. (koin.com)
Octopus1
Ergonomic2
  • Performance, ergonomic reliability, and ease of maintenance make this regulator a product for true diving professionals. (dive-connection.com)
  • Thanks to its light weight and ergonomic design, this regulator is very handy and easy to use. (dive-connection.com)
Transcription factors3
Gene2
  • Using computational tools to investigate gene transcription networks in large collections of brain tissues, a scientific team has identified a gene that acts as a master regulator of schizophrenia during early human brain development. (newmindjournal.com)
  • First, we looked at LIN28B, a gene recognized as the master regulator of fetal blood cell formation. (lu.se)
Proteins1
  • MR proteins could be further organized into 24 pan-cancer, master regulator block modules (MRBs), each regulating key cancer hallmarks and predictive of patient outcome in multiple cohorts. (biu.ac.il)
Inspect2
  • It is no different than safety regulators who failed to inspect carnival rides and 100s of children died. (ritholtz.com)
  • Once this is off you can inspect the regulator and unbolt the glass & motor from the regulator. (carwindowregs.co.uk)
Twist3
  • Master regulators involved in development and morphogenesis can also appear as oncogenes relevant to tumorigenesis and metastasis, as with the Twist transcription factor. (wikipedia.org)
  • The Hox Transcription Factor Ubx Ensures Somatic Myogenesis by Suppressing the Mesodermal Master Regulator Twist. (bvsalud.org)
  • Using the Drosophila mesoderm as a model and a comparative genomic approach, we identify the Hox transcription factor Ultrabithorax (Ubx) to be critical for the repression of the master regulator Twist. (bvsalud.org)
Propane1
  • This propane regulator will fit 20 LB and 30 LB propane tanks similar to what is used on an outdoor gas grill. (glasstorchtech.com)
Gauge2
  • This regulator features a gauge to show the tank pressure and a gauge to show the working pressure that is set with the adjustment handle. (glasstorchtech.com)
  • The Gun comes with a high-flow air pressure regulator with a gauge. (airpaintspray.com)
Participants2
  • Russell Penn IV, Allied Forces South Battalion, ensure participants during Regulator Week in Naples, Italy are ready to deploy. (army.mil)
  • Summit participants also noted that regulators must come to a consensus regarding requirements for clinical trial data, become more familiar with technology platforms through review of data across various pathogens over time, and provide guidance on the feasibility of alternative pathways to emergency use approval, especially in the context of the 100 Days Mission ( 10 ). (cdc.gov)
Targets2
  • D-type cyclins are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer(1), but the mechanisms that regulate their turnover are still being debated(2,3). (uniroma3.it)
  • Perturbing the feedback between the master regulators and downstream targets suggests potential reprogramming strategies. (lu.se)
20211
  • 2021). CRL4AMBRA1 is a master regulator of D-type cyclins. (uniroma3.it)
Types3
  • There are a number of different types of window regulator, but most either use wire cables or a gear system to lift or lower the window. (carwindowregs.co.uk)
  • We then perform a similar master regulator analysis in SDH-loss mouse embryonic fibroblasts (MEFs) to infer aspects of SDH loss master regulator response conserved across species and tissue types. (elsevierpure.com)
  • Early lineage-specific master regulators are essential for the specification of cell types. (bvsalud.org)
Regulatory2
  • While I have been frustrated by the poor policy and personnel choices Obama has made - and continues to make - the Bush administration was uniquely incompetent when it came to filling regulatory positions with anti-regulators. (ritholtz.com)
  • The Role of MB0, MBI and MBII in Interaction and Dynamics of the Master Regulatory Transcription Factor c-Myc. (lu.se)
Pressure2
  • High-pressure regulator (0-250 bar) suitable for most applications. (weldingandwelder.com)
  • Master HP Pro 33 Series High-Performance HVLP Spray Gun with 1.8mm Tip, Air Pressure Regulator, MPS Cup Adapter. (airpaintspray.com)
Product2
  • and product master file. (who.int)
  • A manufacturer submitting an IVD to WHO for evaluation for prequalification must compile a product dossier from its existing technical documentation to provide evidence that the product conforms to the internationally recognized set of safety and performance principles described in the International Medical Device Regulators Forum document Essential Principles of Safety and Performance of Medical Devices and IVD Medical Devices . (who.int)
Products1
  • The regulators that GTT carries are high quality products made in the USA. (glasstorchtech.com)
Response4
  • As such, they are the master regulators of the immune response and serve this function by linking the microbial sensing features of the innate immune system to the exquisite specificity of the adaptive response. (aacrjournals.org)
  • Finally, a whole-genome, CRISPR-Cas9 screen identified AMBRA1 as a regulator of the response to CDK4/6 inhibition. (uniroma3.it)
  • Analysis of conserved SDH-loss master regulators in human tumors and MEFs implicated ZNF423, a known modulator of retinoic acid response in neuroblastoma. (elsevierpure.com)
  • Nrf2 is a master-regulator of host antioxidant response and exposures to toxicants is known to reduce Nrf2 activity. (cdc.gov)
Cell3
  • The master regulator concept has been criticized for being a "simplified paradigm" that fails to account for the multifactorial influences on some cell fates. (wikipedia.org)
  • Adaptor Protein LNK Is a Negative Regulator of Brain Neural Stem Cell Proliferation after Stroke. (lu.se)
  • These cell lines reported on the levels of ARX, an alpha-cell master regulator that appears to be inhibited when Pax4 activity increases. (medscape.com)
Approach2
  • Sets out our supervision and enforcement approach for master trusts once they are authorised. (thepensionsregulator.gov.uk)
  • Gathering such data and experience will build confidence in the approach and inform regulators as they make decisions about the emergency authorization of vaccines against related pathogens. (cdc.gov)
Critical1
  • Uncovering the critical regulators of the ubiquitin-proteasomal system in leukemia. (lu.se)
Brain2
  • Downstream effects of master regulators in two brain diseases. (lu.se)
  • HSUEH, Y. T-Brain-1-A Potential Master Regulator in Autism Spectrum Disorders. (bvsalud.org)
Analysis1
  • Focusing on computational and statistical aspects of MR discovery, the ARACNe-MRA (Algorithm for the Reconstruction of Accurate Cellular Networks-Master Regulator Analysis) method has shown competent performance in this regard [ 4 ]. (aging-us.com)
Switch3
  • On the other hand, a switching regulator uses a switch to regulate energy levels. (calpoly.edu)
  • They can be either manual, where a handle will be used to move the glass or electric window regulators are driven by a motor controlled by a switch inside the vehicle. (carwindowregs.co.uk)
  • A slower up or down window action, no movement at all or a grinding noise when the window switch button is pressed will indicate there is problem with the car window regulator. (carwindowregs.co.uk)
Performance1
  • Master HP Pro Series HVLP Spray Gun: Master HP Pro 33 Series High Performance HVLP Spray Gun with 1.8mm Fluid Tip and a 1-liter Aluminum Cup. (airpaintspray.com)
Federal1
  • Federal regulators have been warning lenders for months about [home mortgage underwriting standards but little has changed [American Banker]](http://www.americanbanker.com/article.html?id=200511141X0CX0ZL&from=home) According to a survey by the Federal Reserve, only 5 in 60 banks have made changes. (millersamuel.com)
Main1
  • DC-DC converters can be separated into two main groups: switching converters and linear regulators. (calpoly.edu)
Examples1
  • The reader is invited to add categories or examples of regulators to this list. (masterresource.org)
Range3
  • Jourdain Smithson, Multinational Division - Southeast G2, at the M17 pistol qualification range during Regulator Week in Naples, Italy. (army.mil)
  • 4 / 7 Show Caption + Hide Caption - Lt. Col. Jaime Birmingham, NATO Rapid Deployable Corps - Greece G5, fires an M17 at the qualification range during Regulator Week in Naples, Italy. (army.mil)
  • In order to select the correct window regulator for your vehicle, you must match the vehicle make (VW, Audi, BMW etc), the Model and check that the year of your car fits into the year range we have stated. (carwindowregs.co.uk)
Series1
  • Master HP Pro Series spray guns are designed with the professional painter in mind. (airpaintspray.com)
Installation1
  • Note whether the model of window regulator is intended for installation in a 3-door, 5-door, Estate, Coupe or Convertible version. (carwindowregs.co.uk)
Activity1
  • Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila" (PDF). (wikipedia.org)