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  • mastocytosis
  • 10%. The common phenotypic features of pathologic mast cells encountered in most forms of mastocytosis are unreliable in MCL. (bloodjournal.org)
  • In non mastocytosis patients there is no evidence of mast cell activation in Food intolerance which has a wide definition: from lactose intolerance which does not involve mast cell activation and is the result of lactase deficiency to gluten enteropathy which is an IgG mediated immune reaction. (worldallergy.org)
  • This study will determine what growth factors are involved in promoting and inhibiting mastocytosis-an abnormal increase of mast cells in one or more organ systems. (clinicaltrials.gov)
  • This protocol is designed to examine those growth potentiating and inhibiting factors which regulate mast cell number in patients with mastocytosis, and to explore the molecular basis of the disease process in hopes of improving therapy. (clinicaltrials.gov)
  • pathogens
  • An important feature of mast cells is their ability to release the content of their cytoplasmic granules extracellularly upon activation by stimuli such as IgE , complement components, as well as viral and bacterial pathogens. (abcam.com)
  • Marshall JS (2004) Mast-cell responses to pathogens. (springer.com)
  • Biology
  • Despite their growing significance in physiological and pathological conditions, much still remains to be learned about mast cell biology. (hindawi.com)
  • Kalesnikoff J, Galli SJ (2008) New developments in mast cell biology. (springer.com)
  • A survey of mast cell biology offers insight into its history and the implications for adaptive immunity. (springer.com)
  • dog's
  • Grade II can also be treated by surgical excision only, but the veterinarian will likely run tests to ensure the cells haven't spread to other locations in your dog's body. (petfinder.com)
  • If your dog's mast cell tumors have not yet spread to other parts of his body, then surgical removal of the tumors could be the only treatment he'll need. (vetinfo.com)
  • Mast cell tumors appear in a wide variety of shapes, sizes and textures and can from on any area of a dog's skin. (vetinfo.com)
  • MCAS
  • Kaufman first learned about MCAS about 5 years ago from a patient who introduced him to the published work of mast cell expert Lawrence Afrin, MD. "I spoke to him and then I started looking for it, and the more I looked, the more I found it," Kaufman said, estimating that he has identified MCAS in roughly half his patients who meet ME/CFS criteria. (medscape.com)
  • Vivo
  • However, there are no drugs currently available that can specifically down-regulate mast cell function in vivo when chronically administered. (eurekalert.org)
  • atherosclerosis
  • An increase in the number of mast cells in atherosclerotic lesions with variable focal accumulations was later proposed with the progression of human atherosclerosis . (abcam.com)
  • tissues
  • They occur when mast cells, a type of cell responsible for regulating inflammation and the repair of damaged tissues, mutate and grow out of control. (vetinfo.com)
  • Mast cells are present in nearly all vascularized tissues, but not the blood. (springer.com)
  • They reside within many tissues of the body, and dogs have a great deal of these cells located within their skin. (petmd.com)
  • 1997
  • In addition, activated mast cells nonspecifically bind to low-density lipoproteins (LDL) , which can be phagocytosed by macrophages to form foam cells, a major cellular component of advanced human atherosclerotic lesions (Metzler and Xu, 1997). (abcam.com)
  • Interactions
  • The two types of cells hang out in the same locations in the body, and researchers have found evidence of indirect interactions between them ( 2 , 3 ). (rupress.org)
  • immunoregulatory cells
  • Recently, they have gained new importance as immunoregulatory cells with the recognition that they are a major source of cytokines and chemokines and play roles in both innate and adaptive immunities [ 7 , 9 , 10 ]. (hindawi.com)
  • Dogs
  • Mast cell tumors can occur in dogs of any age, breed or gender, but they're most common in dogs older than eight years of age. (vetinfo.com)
  • In some dogs with mast cell tumors, mast cells can be found circulating in the blood. (vetinfo.com)
  • Chemotherapy can be of benefit to dogs whose mast cell tumors have already spread throughout the body. (vetinfo.com)
  • SK- In a review of mast cell tumors from 1988 (Vet Med, Paul Dean, 2/88), 44% of dogs with Grade II mast cell tumors survived more than 1500 days after surgical removal of the tumors, without additional treatment. (vetinfo.com)
  • A paper from the Animal Medical Center in Manhattan (Saraff, et al, 1996), of radiation therapy for the treatment of grade 2 mast cell tumors in 32 dogs with Grade 2 tumors of the skin, had a better prognosis, with 86% of dogs treated with surgery and radiation making it to five years post treatment. (vetinfo.com)
  • researchers
  • Comprehensive and highly practical, Mast Cells: Methods and Protocols provides mast cell researchers with reproducible accounts of basic and advanced molecular and cellular techniques used in studying this fascinating, multifunctional cell. (springer.com)
  • The researchers utilized a technique known as exon skipping, a form of RNA splicing, to eliminate the portion of one of the IgE receptor gene's mRNA that is essential to making a protein which places the IgE receptor on the mast cell surface. (eurekalert.org)
  • For example, the researchers found that the cells released different amounts of certain cytokines after contact. (rupress.org)
  • lymph
  • Aspiration of the lymph glands in the groin area indicated mast cells-- not cancerous but described as "tweener" by the pathologist. (vetinfo.com)