• Polygalacturonase inhibitor proteins (PGIPs), also known as polygalacturonase-inhibiting proteins, are plant proteins capable of inhibiting the action of polygalacturonase (PG) enzymes produced by bacterial and fungal pathogens. (wikipedia.org)
  • against fungal pathogens. (informationalwebs.com)
  • Activation of autophagy in addition has been shown Rabbit Polyclonal to RAD21 to become an important level of resistance response utilized by vegetation against necrotrophic fungal pathogens. (informationalwebs.com)
  • New studies are revealing that many fungal pathogens that were previously believed to lead strictly necrotrophic lifestyles do in fact have brief biotrophic phases. (informationalwebs.com)
  • MALDI-TOF MS's ability to differentiate between species and strains at a remarkable pace has streamlined the identification of bacterial, fungal, and viral pathogens. (aurorabiomed.com)
  • The genetically engineered FcMBL protein, coupled to magnetic beads, can capture more than 100 different microbial species with high efficiency, including all of the bacterial and fungal pathogens causing sepsis. (rapidmicromethods.com)
  • Mixed infections of fungal trunk pathogens and induced systemic phenolic compound production in grapevines. (usda.gov)
  • Colletotrichum species are major fungal pathogens that cause devastating anthracnose diseases in many economically important crops. (inra.fr)
  • Untargeted mass spectrometry (MS)-based proteomics reveals that some proteins also expressed in saliva were detected with greater expression differences in blood plasma when comparing mpox patients and healthy subjects, suggesting a promising alternative to be applied in screening or diagnostic platforms for mpox salivary diagnostics coupled to OMICs. (bvsalud.org)
  • Recent developments in purification strategies, together with mass spectrometry (MS)-based proteomics, have identified numerous in vivo protein complexes and suggest the existence of many others. (ox.ac.uk)
  • In a recent paper in the journal Molecular & Cellular Proteomics , Tirsa L.E. van Westering and researchers at the University of Oxford used mass spectrometry to identify differential protein expression in muscles at three different ages (representing the different stages of DMD pathology) from two strains of mice with genetically altered DMD and one strain of unaltered mice (control). (asbmb.org)
  • Enzymatic digestion of protein into shorter peptides by sequence-specific proteases is a key step in mass spectrometry-based shotgun proteomics experiments. (asbmb.org)
  • Proteomics approaches using two-dimensional gel electrophoresis (2-DE) were adopted to identify proteins from oil palm that were differentially expressed in response to the fungus. (mpob.gov.my)
  • Markus Kalkum, Ph.D., is a professor in the Department of Immunology & Theranostics and co-director of the Mass Spectrometry and Proteomics Core. (cityofhope.org)
  • Here we report the first application of a matrix-assisted laser desorption/ionization (MALDI) triplequadrupole mass spectrometer for targeted proteomics. (canada.ca)
  • The technique was then applied to validate an important virulence biomarker of the fungal pathogen Candida albicans, which was not accurately quantified using global proteomics experiment employing two-dimensional liquid chromatography/electrospray ionization tandem mass spectrometry (2D-LC/ESI)-MS/MS. Using LC/MALDI-MRM analysis of five tryptic peptides, the protein PHR1 was found to be upregulated in the hyphal (pathogenic) form of C. albicans by a factor of 7.7W0.8. (canada.ca)
  • Diana Samodova and a team at the University of Copenhagen characterized another protease, ProAlanase, isolated from the fungus Aspergillus niger , that cleaves primarily on the C-terminal side of proline and alanine amino acid residues of proteins. (asbmb.org)
  • Peptide and protein samples containing varying concentrations of synthetic melanin or fungal pigments extracted from Aspergillus niger were analyzed by MALDI-TOF and MALDI-qTOF (quadrupole TOF) MS. Signal suppression was observed in samples containing greater than 250ng/µl pigment. (cdc.gov)
  • a , Maximum-likelihood tree using concatenated protein sequences of 100 genes randomly selected from 4,694 Fusarium orthologous genes that have clear 1:1:1:1 correlation among the Fusarium genomes and have unique matches in Magnaporthe grisea , Neurospora crassa and Aspergillus nidulans . (nature.com)
  • functional characterization of nat/ncs2 proteins of aspergillus brasiliensis reveals a genuine xanthine-uric acid transporter and an intrinsically misfolded polypeptide. (liverpool.ac.uk)
  • construction of a shuttle vector for heterologous expression of a novel fungal α-amylase gene in aspergillus oryzae. (liverpool.ac.uk)
  • the filamentous fungus aspergillus oryzae is a well-known expression host used to express homologous and heterologous proteins in a number of industrial applications. (liverpool.ac.uk)
  • Proteome Profiling and Functional Classification of Intracellular Proteins from Conidia of the Human-Pathogenic Mold Aspergillus fumigatus. (hki-jena.de)
  • Nonetheless, according to our results, this fungal species also exhibits a complete set of genes coding for plant cell wall degrading Carbohydrate-Active enZymes (CAZymes), enabling a full endophytic stage and, consequently, its dual ability to both parasitize insects and live inside plant tissue. (bvsalud.org)
  • Some of these weapons, which take the form of natural products that are toxic to unrelated fungal species, have serendipitously been identified as life-saving drugs for humans: penicillin, statins, and cyclosporine to name a few. (drugdiscoverynews.com)
  • To do this, scientists developed heterologous expression systems to isolate potentially interesting BGCs from diverse fungal species that may be otherwise difficult or impossible to grow in the lab. (drugdiscoverynews.com)
  • Because fungi have so many BGCs, and many of them are conserved across fungal species, it's important for drug discovery efforts to identify the ones that code for new compounds. (drugdiscoverynews.com)
  • To prevent BSIs from progressing to full-blown sepsis, the infection-causing bacterial or fungal species must be identified as fast as possible. (rapidmicromethods.com)
  • The findings, published in the Proceedings of the National Academy of Sciences , represent a major shift from the conventional scientific understanding of fungal evolution, which is based on the idea that genetic diversity is relatively random within fungi species, with evolution occurring slowly and throughout an entire species. (eurekalert.org)
  • The findings , published in the Journal of Agricultural and Food Chemistry , stated that on fermenting different fungal species with various foods, the meat aromas were only observed from foods in the Allium family, for instance, onions and leeks. (foodingredientsfirst.com)
  • Liquid chromatography-mass spectrometry analysis identified PnMas1 and PnMas2 but not PnMas3 in flagellar extracts. (springer.com)
  • Moreover, we examined the decomposition of cell-wall materials from the fungal surface after reaction with PepEST, which led to the identification of 1,2-dithiane-4,5-diol (DTD) by gas chromatography mass spectrometry analysis. (inra.fr)
  • The analysis of the onions by gas chromatography-mass spectrometry revealed the presence of flavor and odor chemicals that are responsible for different flavors in meats, such as bis(2-methyl-3-furyl) disulfide, a potent odorant in meaty and savory foods. (foodingredientsfirst.com)
  • In the current study, genes encoding two related proteins, PnMas1 and PnMas3, were identified in the genome of P. parasitica . (springer.com)
  • The MPXV uses the host cell's rough endoplasmic reticulum, ribosomes, and cytoplasmic proteins to replicate its genome and synthesize virions for cellular exit. (bvsalud.org)
  • The main objective of our study was the sequencing and full characterization of the genome of the fungal strain of O. australis (CCMB661) and its predicted secretome. (bvsalud.org)
  • Most fungal natural products are encoded in regions of the genome called biosynthetic gene clusters (BGCs). (drugdiscoverynews.com)
  • Keller's team uses fungal artificial chromosomes (FACs) to express BGC-sized regions of the fungal genome in an A. nidulans model to find new BGCs and their associated natural products. (drugdiscoverynews.com)
  • Previously, the genome of the cereal pathogen Fg was sequenced and shown to encode a larger number of proteins in pathogenicity related protein families compared to non-pathogenic fungi, including predicted transcription factors, hydrolytic enzymes, and transmembrane transporters 5 . (nature.com)
  • The present study aimed to investigate the capability of the filamentous fungus Penicillium parvum 4-14 to enzymatically saccharify CBAX and reveal the fungal carbohydrate-active enzyme (CAZyme) repertoire by genome sequencing and secretome analysis. (biomedcentral.com)
  • Fungal pigments inhibit the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis of darkly pigmented fungi. (cdc.gov)
  • Among the various diagnostic techniques available, Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) has revolutionized clinical diagnostics. (aurorabiomed.com)
  • Cells exposed to gliotoxin and control cells were then labeled with ICAT reagents and analysed by offline reversed phase liquid chromatography followed by matrix-assisted laser desorption/ionization tandem mass spectrometry. (wgtn.ac.nz)
  • Wadsworth Center, the New York State public health laboratory, conducted testing to confirm presumptive C. auris isolates from various health care facilities in New York during August 2016-June 2019 by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, using both the manufacturer's and in-house validated library databases. (cdc.gov)
  • The specificity of the PGIPs for certain pathogenic PGs may significantly contribute to different crops being susceptible or resistant to different bacterial and fungal infections. (wikipedia.org)
  • AllPrep Bacterial/Fungal. (qiagen.com)
  • Easy-to-use AllPrep Bacterial/Fungal DNA/RNA/Protein Kits isolate total nucleic acids and cellular proteins from Gram (+/-) bacterial cultures and fungal cell cultures. (qiagen.com)
  • Cultured bacterial and fungal cells are first lysed using glass bead tubes, and nucleic acids and proteins are solubilized and mixed with a binding solution. (qiagen.com)
  • Faculty conduct research on bacterial, viral and fungal infectious diseases, including detection and vaccine development, supported by state-of-the-art facilities in mass spectrometry and NMR. (cityofhope.org)
  • Here, using the same approaches, we show that physiological concentrations of hemin in the bacterial growth medium result in the repression of the expression of the proteins of the PVD- and PCH-dependent iron uptake pathways, leading to less production of these two siderophores. (cnrs.fr)
  • 2021. "Resin Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation. (pnnl.gov)
  • An indirect benefit of the isotopic labelling technique is a significant enhancement of the a1 ion in tandem mass (MS/MS) spectra of all peptides studied. (canada.ca)
  • Serum Vitamin D was measured using a standardized liquid chromatography-tandem mass spectrometry method and was categorized using data driven tertiles. (cdc.gov)
  • To determine the cellular basis for the growth inhibition, we observed the localization of PepEST on the fungus and found the attachment of the protein on surfaces of conidia and germination tubes. (inra.fr)
  • Development of liquid extraction surface analysis mass spectrometry for protein analysis in microbial colonies. (bham.ac.uk)
  • This advanced technology can rapidly analyze biomolecules based on their mass-to-charge ratios, leading to diverse applications that span microbial identification, disease diagnosis, and personalized medicine. (aurorabiomed.com)
  • This technique enables rapid and accurate identification of microorganisms by creating a unique "fingerprint" for microbial cells or components through ionization and mass analysis. (aurorabiomed.com)
  • however, numerous proteins were differentially expressed between DMD mice and unaltered mice at each of three stages of DMD pathology. (asbmb.org)
  • Differentially expressed protein spots between the infected and uninfected palms were determined using PD-Quest Software. (mpob.gov.my)
  • Seven protein spots were differentially expressed in the infected root at Day 3 post-infection. (mpob.gov.my)
  • At Day 7, the number of differentially expressed protein spots increased to 25, with a molecular weight less than 50 kDa. (mpob.gov.my)
  • Twelve candidate proteins were identified by a comparison of differentially expressed proteins at Day 7 with the database. (mpob.gov.my)
  • This new approach has been shown to preserve mobility and enzymatic activity of transmembrane proteins in the resulting nSLB. (lu.se)
  • however, darkly pigmented fungi yield poor fingerprint mass spectra that contain few peaks of low relative abundance. (cdc.gov)
  • The addition of tricyclazole to the fungal growth media blocks fungal melanin synthesis and results in less melanized fungi that may be analyzed by MALDI-TOF MS. (cdc.gov)
  • The key to drug discovery with fungi is to find the BGCs [and] to be able to express them, whether it's in the endogenous fungus or in a model organism," said Nancy Keller, a fungal microbiologist at the University of Wisconsin-Madison. (drugdiscoverynews.com)
  • Likewise, for doctors treating fungal diseases, knowing which strain of fungi is afflicting a patient - and what that strain's metabolomic profile looks like - could be key to finding the correct cure. (eurekalert.org)
  • Ergosterol was detected by high-pressure liquid chromatography with a UV detector (HPLC-UV) and corroborated by mass spectrometry analysis. (napier.ac.uk)
  • Then, the amplified microbes are grown on solid media as isolated colonies whose constituent cells eventually can be identified with a highly sensitive, yet fast and relatively inexpensive analytical method know as MALDI-TOF mass spectrometry (MS). "Indeed, isolating the infectious microbes directly from grown liquid blood cultures using FcMBL makes them available for MALDI-TOF MS analysis much earlier," added Super. (rapidmicromethods.com)
  • In an effort to identify PD 0332991 HCl pontent inhibitor proteins required for BAG6 cleavage, a pull-down assay followed by mass spectrometry was performed to detect BAG6 binding partners and infection as the mutant line. (informationalwebs.com)
  • The researchers created a publicly available data set that reports the quantification of 4,974 proteins across the DMD mice and control mice at various disease time points - the highest number of quantified proteins in dystrophic muscle described to date. (asbmb.org)
  • The SARS-CoV-2 entry into host cells is mainly mediated by the interactions between the viral spike protein (S) and the ACE-2 cell receptor, which are highly glycosylated. (bvsalud.org)
  • A total of 376 CAZymes including plentiful lignocellulolytic enzymes were predicted in P. parvum based on the fungal genomic sequence (25.8 Mb). (biomedcentral.com)
  • This investigation disclosed the CAZyme repertoire of P. parvum at the genomic and proteomic levels, and elaborated on the promising potential of fungal lignocellulolytic enzymes upon saccharification of corn bran biomass after AHP pretreatment. (biomedcentral.com)
  • In some occupational environments, workers are at an increased risk of exposure to fungal enzymes used in industrial production. (cdc.gov)
  • Fungal enzymes have been associated with adverse health effects in the work place, in particular in baking occupations. (cdc.gov)
  • Exposure-response relationships have been demonstrated, and atopic workers directly handling fungal enzymes are at an increased risk for IgE-mediated disease and occupational asthma. (cdc.gov)
  • The utilization of new and emerging fungal enzymes in industrial production will present new occupational exposures. (cdc.gov)
  • Allergen avoidance strategies including personal protective equipment, engineering controls, protein encapsulation, and reduction of airborne enzyme concentrations are required to mitigate occupational exposure to fungal enzymes. (cdc.gov)
  • 6]. Some of the best examples of high-molecular-weight sectors, workers are at increased risk of becoming sensitized occupational allergens are the fungal enzymes. (cdc.gov)
  • Table 1: Fungal enzymes utilized in different industries and associations with occupational sensitization. (cdc.gov)
  • Principal component and biomarker analyses of mass spectra showed clustering, and mass peaks correlated with capsule type-specific genetic lineages. (cdc.gov)
  • Mounting evidence suggests that the genetic disorders/mutation and diseases change not only the protein expression patterns but also membranes themselves. (lu.se)
  • First, a procedure to extract ergosterol, a molecule used to estimate living fungal biomass, from various environmental matrices was developed. (napier.ac.uk)
  • All protein spots were analysed by MALDI TOF/TOF mass spectrometry. (mpob.gov.my)
  • In this study, the effect of dark fungal pigments on the observed MALDI mass spectra was investigated. (cdc.gov)
  • Acquisition of MALDI mass spectra from these darkly pigmented regions of the sample deposit yielded poor or no [M+H](+) ion signal. (cdc.gov)
  • fastidiosa using MALDI-TOF-TOF-MS and MS/MS. International Journal of Mass Spectrometry. (usda.gov)
  • Scientists are developing computational approaches to identify lowly expressed or silent fungal natural products to discover new potential therapeutic molecules for maladies as diverse as infectious diseases and cancer. (drugdiscoverynews.com)
  • 2010. The twin arginine protein transport pathway exports multiple virulence proteins in the plant pathogen Streptomyces scabies . (hutton.ac.uk)
  • Some applications, including 2D SDS-PAGE and solution phase proteolytic digestion for mass spectrometry, may require an additional detergent removal step following protein elution. (qiagen.com)
  • Due to the lack of detergent solubilization and reconstitution steps, the nSLBs created using this approach contain essentially all of the native lipids, as well as the membrane-associated proteins and carbohydrates from the donor membrane. (lu.se)
  • No yeast two-hybrid interactions found for this protein. (yeastrc.org)
  • Moreover, as proteases with different cleavage sites will generate different sets of peptides for the same proteome, combination digestion will yield improved results for various applications, such as identification of proteins, protein-protein interactions and post-translational modifications in various biological systems. (asbmb.org)
  • Seasonal variations in fungal biomass and fungal production, the latter measured by the incorporation of [1_14C] acetate into ergosterol, associated with SCilPUS stems, both above and below water, were determined. (napier.ac.uk)
  • Changes in fungal biomass and productivities on freshly cut green Scirpus stems decaying in the water under either natural solar radiation (UV +) or protected from ultraviolet (UV -) radiation, were followed over the summer. (napier.ac.uk)
  • Several experiments measuring the impact of temperature on fungal biomass and production on Scirpus decaying in pond water were conducted in the laboratory. (napier.ac.uk)
  • With respect to Scirpus decaying under UV+ or UV- in pond water, there was no significant difference in either fungal biomass (P = 0.76) or production (P = 0.96) between the two treatments. (napier.ac.uk)
  • The aim of this study was to use HL-60 cells treated with gliotoxin, a fungal metabolite with a reactive disulfide bridge, as a system to evaluate the performance of ICAT for identification of cysteine modification in a whole cell proteome. (wgtn.ac.nz)
  • Fungal decomposition began and was the greatest in the spring despite low water temperatures. (napier.ac.uk)
  • Wei-Jun Qian is a bioanalytical chemist whose research centers primarily on the development and applications of mass spectrometry-based approaches to better quantify the dynamic changes in protein abundances and protein post-translational modifications in biological and clinical applications. (pnnl.gov)
  • Furthermore, the successful accommodation of the fungus in the root cells is preceded by protein modifications in the endoplasmatic reticulum as well as at the plasma membrane of the host. (ufz.de)
  • In cells, membrane fusion is mediated by SNARE proteins, whose activities are calcium-dependent. (rsc.org)
  • While many studies have been focused on the membrane structure, the dynamics of such systems are crucial for the function of the membrane including membrane bound proteins. (lu.se)
  • Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)
  • 2021. "Mass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress. (pnnl.gov)
  • They are foliar applied compounds that control many fungal diseases including early and late blights, leaf spots, rust mildew and scabs in various field crops such as fruits, nuts, cucurbits, vegetables, grapes, and ornamentals. (cdc.gov)
  • Using bioinformatics and machine learning, scientists probe the depths of fungal genomes to find new compounds for undruggable cancers and infections. (drugdiscoverynews.com)
  • Candida albicans uses human complement regulators such as factor H and factor H-like protein 1 (FHL-1) for immune evasion. (leibniz-hki.de)
  • The 3 human complement regulators, when attached to candida Gpd2, became functionally active, and the attached host proteins assist in inactivation of the complement cascade or cleave fibrinogen in the extracellular matrix component fibrinogen. (leibniz-hki.de)
  • Nancy Keller and her colleagues at the new biotech company Terra Bioworks develop approaches to identify fungal natural products for human health. (drugdiscoverynews.com)
  • The work started at UW-Madison, where Nancy Keller leads a research program on fungal pathogenesis in the UW School of Medicine and Public Health. (eurekalert.org)
  • These findings put the evolution of fungal pathogenicity into a new perspective. (nature.com)
  • These motifs contain 2 hydrophobic alpha-helical segments connected by an extensive hydrophilic sequence, resulting in 6 transmembrane portions of the protein. (medscape.com)
  • We optimized our protocol with two protein assemblies from Saccharomyces cerevisiae (scavenger decapping and nuclear cap-binding complexes), establishing subunit stoichiometry and identifying substoichiometric binding. (ox.ac.uk)
  • When a defined protein/peptide (or combinations thereof) control and define the synthesis of an inorganic nanoparticle, the result is a cloneable NanoParticle (cNP). (rsc.org)
  • Sulfonylurea herbicides are a group of non-selective herbicides that act by disrupting plant protein synthesis. (cdc.gov)
  • The protein blends E_CBAX1, E_CBAX2, and E_CBR were produced by the fungus grown on CBAX1, CBAX2, or CBR, respectively. (biomedcentral.com)
  • DNA and RNA are ready for qPCR, RT-PCR and next-generation sequencing, while protein is ready for 1D SDS-PAGE and mass spectrometry following in-gel trypsin digestion. (qiagen.com)
  • Alternatives to trypsin will be beneficial in cases where digestion by trypsin is not ideal, such as when the content of arginine and lysine in the protein is low. (asbmb.org)
  • The 1.6 Å X-ray structure of the homodimeric A. fumigatus protein reveals unique properties including N-linked glycosylation and a Ca 2+ -binding site whose occupancy regulates activity. (nature.com)
  • 2013. Two major ruminant acute phase proteins, haptoglobin and serum amyloid A, as serum biomarkers during active sheep scab infestation . (hutton.ac.uk)
  • Top-down proteomic identification of protein biomarkers of Xylella fastidiosa subsp. (usda.gov)
  • The D-amino acid oxidase (DAAO) protein metabolizes D-amino acids and maintains motoneuron function by regulating D-serine levels and N-methyl-D-aspartate-receptor activation in the brain and spinal cord. (d-aminoacids.com)
  • As with other mitochondrial carrier family proteins, the ornithine carrier is composed of 300 amino acids that constitute 3 repeated motifs of approximately 100 amino acids each. (medscape.com)
  • Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. (creativebiomart.net)
  • The transporter was identified by probing a mammalian-expressed sequence tag database with 2 fungal mitochondrial ornithine carrier protein sequences. (medscape.com)
  • Moreover, the presence of both hemin and a xenosiderophore resulted in (i) the strong induction of the expression of the proteins of the added xenosiderophore uptake pathway, (ii) repression of the PVD- and PCH-dependent iron uptake pathways, and (iii) no effect on the expression levels of the Has, Phu, or Hxu systems, indicating that bacteria use both xenosiderophores and heme to access iron. (cnrs.fr)
  • Anti-PnMas1 and anti-PnMas2 antibodies co-labelled two high-molecular-weight (~400 kDa) protein complexes in native gels but anti-PnMas3 antibodies labelled a 65 kDa protein complex. (springer.com)
  • First identified in Drosophila, the conserved Polycomb group (Pc-G) protein complexes were shown to be both writers (Polycomb Repressive Complex 2, PRC2) and readers (Polycomb Repressive Complex 1, PRC1) of H3K27me3 [ 19 , 20 , 21 ]. (biomedcentral.com)
  • In the present study, we show that benzoic acid derivatives isolated from Bjerkandera adusta promote the activity of the two main protein degradation systems, namely the ubiquitin-proteasome (UPP) and especially the autophagy-lysosome pathway (ALP) in human foreskin fibroblasts. (mdpi.com)
  • Figure 2 Open in a separate window FIGURE 2: The implication of the Arabidopsis BAG-family proteins in various cellular processes linked to abiotic and biotic stress responses, and cell death regulation.The function of the nuclear BAG1-3, and mitochondrial localized BAG5 is currently unknown. (informationalwebs.com)
  • It is reasonable to speculate that the early and timely activation of autophagy induces localized cell death that prevents fungal establishment during its brief biotrophic phase. (informationalwebs.com)
  • Beyond fungal resistance, this work also informs on the key role of proteases in the execution of plant cell death regimes. (informationalwebs.com)
  • To define the whole panel of fungal complement-evasion molecules, C. albicans cell extract was absorbed to a factor H-coupled matrix. (leibniz-hki.de)
  • Cysteinyl residues in proteins are important for many cellular processes and unregulated modification of the cysteine thiol group can have negative effects on cell vitality and viability. (wgtn.ac.nz)
  • Therefore, our results provide evidence that PepEST is involved in hydrolysis of the outmost layer of the fungal cell walls and that DTD has antifungal activity, suggesting an alternative strategy to control agronomically important phytopathogens. (inra.fr)
  • Among these patients, three were found to have pan-resistant C. auris that developed after receipt of antifungal medications, including echinocandins, a class of drugs that targets the fungal cell wall. (cdc.gov)
  • Differences were found in the expression of glucosidase II, beta-glucosidase PYK10, two glutathione- S -transferases and several so-far uncharacterized proteins. (ufz.de)
  • This meant some BGCs were consistently present or absent, or showed differences in the proteins they produce. (eurekalert.org)
  • Clinicians gain insights into individual variations and disease states through detailed analyses of protein profiles in patient samples. (aurorabiomed.com)
  • Blackman LM, Arikawa M, Yamada S, Suzaki T, Hardham AR (2011) Identification of a mastigoneme protein from Phytophthora nicotianae . (springer.com)
  • Identification of emerging fungal latency period [6, 7]. (cdc.gov)
  • This classification is fundamental to the type of marketing authorization (MA), and therefore to the controls to be performed, from preclinical stages through clinical trials to pharmacovigilance, to meet the safety requirements for patients. (frontiersin.org)