Mass spectrometry analysis gas chromatography mass spectrometry. Medical search. Frequent questions

In this study, the qualitative identification of 34 designer drugs, mainly synthetic cannabinoids and synthetic cathinones, was performed by gas chromatography-triple quadrupole-tandem mass spectrometry with two different ionization techniques, including electron ionization (EI) and chemical ionization (CI), focusing only on qualitative seized-drug analysis, not from the toxicological point of view. (ojp.gov)
Recently, we introduced a heated nebulizer microchip and showed its potential to interface liquid microseparation techniques and GC with API-MS. This study demonstrates the feasibility of GC-microchip atmospheric pressure photoionization-tandem mass spectrometry (GC-μAPPI-MS/MS) in the analysis of underivatized anabolic steroids in urine. (aalto.fi)

Title : Quantitative Analysis of Menthol in Human Urine Using Solid Phase Microextraction and Stable Isotope Dilution Gas Chromatography/Mass Spectrometry Personal Author(s) : Huang, Wenlin;Blount, Benjamin C.;Watson, Clifford H.;Watson, Christina;Chambers, David M. (cdc.gov)
In the present study, for the first time, a reliable solid-phase microextraction-gas chromatography-mass spectrometry (SPME-GC-MS) method was developed and validated for the ultra-trace analysis of MF released in growth medium by Daphnia pulex maintained in presence of crowding w/o MK801, a putative upstream inhibitor of MF endogenous production. (unipr.it)
The regular purge and trap extraction followed by analysis with gas chromatography-mass spectrometry (GC-MS) usually involve a complicated assembly of facilities, more working space, long sample preparation time, and headspace solid-phase microextraction (SPME). (hindawi.com)
Moreover, the trapped residues usually undergo enrichment before GC-MS analysis [ 23 ] such as solid-phase microextraction [ 24 ]. (hindawi.com)

Using two-dimensional gas chromatography coupled to time-of-flight mass spectrometry, they measured a total 851 metabolites, 43 of which differed significantly in expression patterns between TBI cases and controls. (medscape.com)

It is possible to distinguish precious vanillin from Vanilla species (planifolia or tahitensis) from much less expensive synthetic and nature-identical vanillin on the basis of the stable isotope ratios of H and C ( 2 H/ 1 H, 13 C/ 12 C). Analysis is usually performed using GC-IRMS (Gas Chromatography - Isotope Ratio Mass Spectrometry) after solvent extraction of vanillin from the sample. (unitn.it)
Established isotope ratio mass spectrometry methods for analyzing urinary steroids for doping control purposes consist of up to two time-consuming HPLC purification steps to achieve the required purity of all analytes. (uni-koeln.de)
Detection was performed simultaneously by isotope ratio mass spectrometry and a single quadrupole mass spectrometer for analyte identity confirmation and assessment of peak purity. (uni-koeln.de)

Conifer seed oils from European Larch (Larix decidua), Norway Spruce (Picea abies) and European Silver Fir (Abies alba) have been analyzed by non-aqueous reversed-phase high-performance liquid chromatography (NARP-HPLC) with atmospheric pressure chemical ionisation (APCI)-MS detection. (unboundmedicine.com)
MDMA and MDA were determined in plasma and urine by reversed-phase high-performance liquid chromatography with diode array detection (HPLC-DAD) after solid-phase extraction on cation-exchange columns. (erowid.org)

The potential of pyrolysis gas chromatography-mass spectrometry (Py-GCMS ) as a tool for the estimation of post-mortem age of bones has been investigated. (uc.pt)

Results obtained from HPLC/MS analyses are supported by validated GC/FID analyses of fatty acid methyl esters after the transesterification. (unboundmedicine.com)
A High Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) Qualitative Detection Method Developed for In Vivo Analyses of Toxin Orellanine from the Cortinarius orellanus Fr. (hindawi.com)
The high-performance liquid chromatography-mass spectrometry (HPLC-MS) qualitative analysis method in negative mode of detection was used to record the presence of orellanine in the stomach contents of rats after ingestion of Cortinarius orellanus . (hindawi.com)

In 1964, Electronic Associates, Inc. (EAI), a leading U.S. supplier of analog computers, began development of a computer controlled quadrupole mass spectrometer under the direction of Robert E. Finnigan. (wikipedia.org)
The most common type of mass spectrometer (MS) associated with a gas chromatograph (GC) is the quadrupole mass spectrometer, sometimes referred to by the Hewlett-Packard (now Agilent) trade name "Mass Selective Detector" (MSD). (iitk.ac.in)
The platform, which includes the new Thermo Scientific Quantiva triple-stage quadrupole mass spectrometer and the new Thermo Scientific Endura triple-stage quadrupole mass spectrometer , made its debut at the ASMS Conference on Mass Spectrometry and Allied Topics. (labmate-online.com)
The TSQ Quantiva triple quadrupole mass spectrometer employs Active Ion Management (AIM) to optimise ion creation and transmission from the source to the detector, resulting in extreme sensitivity. (labmate-online.com)
The TSQ Endura triple quadrupole mass spectrometer shares much of the advanced technology of the TSQ Quantiva MS, but was designed to deliver higher uptime than any competitive triple quadrupole instrument. (labmate-online.com)

Applications of GC-MS include drug detection, fire investigation, environmental analysis, explosives investigation, food and flavor analysis, and identification of unknown samples, including that of material samples obtained from planet Mars during probe missions as early as the 1970s. (wikipedia.org)
Like liquid chromatography-mass spectrometry, it allows analysis and detection even of tiny amounts of a substance. (wikipedia.org)
Applications of GC-MS include drug detection, environmental analysis, explosives investigation, and identification of unknown volatile samples. (iitk.ac.in)
It has a three way splitter which enables the simultaneous detection by three detectors for analysis, i.e Micro ECD, NPD with EPC and MS. (iitk.ac.in)
Gas chromatography/mass spectrometry (GC/MS) is a well-known instrumental technique used for the analysis of fire debris for accelerant detection. (astm.org)
The common method used is gas chromatography (GC) coupled with electron capture detection (ECD) followed by identification using GC/mass spectrometry (MS). Since evidence indicates that heptachlor is metabolized to heptachlor epoxide in mammals, exposure to heptachlor is usually measured by determining levels of heptachlor epoxide in biological media. (cdc.gov)
Detection and quantification of amyloid β protein and variants by immunoprecipitation-mass spectrometry. (eanso.org)
The feasibility of GC-μAPPI-MS/MS in the analysis of six selected anabolic steroids in urine samples was studied with respect to intra-batch repeatability, linearity, linear range, and limit of detection (LOD). (aalto.fi)
The analysis of Pelargonium graveolens essential oil is reported using comprehensive two-dimensional gas chromatography with quadrupole mass spectrometric detection (GC×GC-qMS). (edu.au)

For the analysis of volatile compounds, a purge and trap (P&T) concentrator system may be used to introduce samples. (wikipedia.org)
Gas chromatography coupled with mass spectrometry (GC-MS) was used to analyze for phytochemicals and bioactive compounds in three species of Apocynacae, Gongronema latifolium , Vincetoxicum rossicum and Marsdenia edulis commonly found in tropical rainforest vegetation and used as food and traditional medicine by locals. (phcogj.com)
These bioactive compounds revealed by GC-MS analysis in crude extracts of A. quisqualis had a stronger antifungal and antibacterial activity against E. necator . (ansfoundation.org)
Sixty unique chemical features representative of exogenous chemicals and endogenous compounds, including single-ring aromatics, polynuclear aromatic hydrocarbons, volatile sulfur-containing compounds, aldehydes, alkanes, and alkenes were identified using the nontargeted analysis workflow. (cdc.gov)
It can be used for analysis of high-molecule compounds and storage of biological specimens. (memphis.edu)

The first on-line coupling of gas chromatography to a mass spectrometer was reported in the late 1950s. (wikipedia.org)
The GC-MS is composed of two major building blocks: the gas chromatograph and the mass spectrometer. (wikipedia.org)
The molecules are retained by the column and then elute (come off) from the column at different times (called the retention time), and this allows the mass spectrometer downstream to capture, ionize, accelerate, deflect, and detect the ionized molecules separately. (wikipedia.org)
The mass spectrometer does this by breaking each molecule into ionized fragments and detecting these fragments using their mass-to-charge ratio. (wikipedia.org)
Sometimes two different molecules can also have a similar pattern of ionized fragments in a mass spectrometer (mass spectrum). (wikipedia.org)
Combining the two processes reduces the possibility of error, as it is extremely unlikely that two different molecules will behave in the same way in both a gas chromatograph and a mass spectrometer. (wikipedia.org)
The molecules take different amounts of time (called the retention time) to come out of (elute from) the gas chromatograph, and this allows the mass spectrometer downstream to capture, ionize, accelerate, deflect, and detect the ionized molecules separately. (iitk.ac.in)
Another relatively common detector is the ion trap mass spectrometer. (iitk.ac.in)
The prevalent methods are carried out on gas chromatography-mass spectrometer, regardless of the water or fish flesh. (hindawi.com)

The GC-MS analysis of flower extracts was performed using a GC and MS JEOL GC mate system and Interpretation on mass spectrum GC-MS was conducted using the database of National Institute Standard and Technology (NIST). (scialert.net)
This study describes the use of the GERSTEL MPS robotic with automated liquid option for the analysis of pesticide residues in hemp oil samples by direct liquid injection gas The number of cannabis containing products, such as extracts, tinctures, edibles, waxes and oils, available in the United States have increased significantly due to changes in state law and the 2018 Farm Bill. (gerstelus.com)
Using GPC with methylene chloride and cyclohexane as solvents, individual organochlorine contaminants can be separated from adipose tissue to produce extracts clean enough for direct GC analysis. (cdc.gov)

The gas chromatograph utilizes a capillary column whose properties regarding molecule separation depend on the column's dimensions (length, diameter, film thickness) as well as the phase properties (e.g. 5% phenyl polysiloxane). (wikipedia.org)

Essential oil was obtained by hydrodistillation and analyzed by the Gas Chromatography-Mass Spectrometry (GC-MS) method. (bvsalud.org)

The polymer-like organic material in the Orgueil (Cl) chondrite was analyzed by high vacuum pyrolysis/gas chromatography/mass spectrometry, a new technique specially developed for this type of polymer analysis. (arizona.edu)

To evaluate the variations on the global volatile signature (chromatographic profile and m/z pattern of fragmentation in each scan) of beer during thermal deterioration, a non-supervised multivariate analysis method, Principal Component Analysis (PCA), was applied to the GC-MS data. (ua.pt)

Sample preparation steps for adipose tissue vary but, in general, involve a lipid extraction step followed by a clean-up procedure involving gel permeation chromatography (GPC) and/or Florisil column clean-up. (cdc.gov)
This method is suitable for large-scale determination of 2-MIB and GSM in fish samples, owing to the use of simple facility and easy-to-operate procedure, rapid sample preparation, and shorter time for GC-MS analysis without SPME. (hindawi.com)
Cotinine levels were measured using a gas chromatography-mass spectrometry procedure. (who.int)

The mass spectrometry process normally requires a very pure sample while gas chromatography using a traditional detector (e.g. (wikipedia.org)

Currently, the qualitative seized-drug analysis is mainly performed by gas chromatography-electron ionization-mass spectrometry (GC-EI-MS) in which most of these emerging designer drug derivatives are extensively fragmented, not presenting a molecular ion in their mass spectra. (ojp.gov)
Analysis incorporated an ion preparation method (IPM) that manipulates the ion population in the ion trap following ionization but prior to ion analysis. (astm.org)

All the samples were subjected to HS-SPME-GC-IRMS analysis and most of them to GC-IRMS analysis after solvent extraction of vanillin. (unitn.it)
The SPME method developed for 2 H/ 1 H analysis guarantees the absence of isotopic fractionation, repeatability and reproducibility standard deviation of below 7‰ and savings in terms of time (from 30 to 5 min) and solvent. (unitn.it)

Pre-professional preparation requiring one term of quantitative analysis is satisfied by Chemistry 220. (beloit.edu)

Mass spectrometers equipped with atmospheric pressure ion sources (API-MS) have been designed to be interfaced with liquid chromatographs (LC) and have rarely been connected to gas chromatographs (GC). (aalto.fi)

Gas chromatography-mass spectrometry (GC-MS) is an analytical method that combines the features of gas-chromatography and mass spectrometry to identify different substances within a test sample. (wikipedia.org)
The targeted method successfully differentiated 50 cannabinoids based on either retention time differences or mass spectral dissimilarity - determined using a newly developed spectral comparison test. (ojp.gov)
This paper describes a method of analyzing arson accelerants using gas chromatography coupled with ion trap mass spectrometry/mass spectrometry (GC/MS/MS). Petrol was investigated as an accelerant. (astm.org)
The method should be generally suited to the analysis of similar essential oil samples. (edu.au)
The results demonstrate that the method is suitable for an application in routine doping control analysis. (uni-koeln.de)
In this work, a method with easier sample preparation, fewer and simplified facilities, and without SPME on GC-MS analysis is developed for the determination of 2-MIB and GSM in fish samples. (hindawi.com)
While mostly persistent organic pollutants are the center of interest, the aim of our study was to develop a method for the determination of different chemical classes of emerging pollutants (organophosphorus flame retardants, plastic additives such as phthalates, bisphenol A, insecticides, antimicrobials, preservatives and musk fragrances) in hair by gas chromatography-mass spectrometry. (ufz.de)

This study describes the use of the GERSTEL MPS robotic with automated liquid option for the analysis of pesticide residues in hemp oil samples by direct liquid injection gas chromatography/mass spectrometry (GC/MS). This technique is sensitive, accurate and precise and allows the quantification of pesticides of interest well below the established limits of quantification for the State of California. (gerstelus.com)
Thermo Fisher Scientific have introduced a new-generation triple quadrupole liquid chromatography-mass spectrometry (LC-MS) platform designed to transform quantitation experiments with extreme sensitivity, productivity, precision and usability. (labmate-online.com)

This paper describes a novel non-targeted methodology for monitoring the chemical changes occurring in a lager beer exposed to accelerated aging (induced by thermal treatment: 18 days at 45 degrees C), using gas chromatography-mass spectrometry in tandem with multivariate analysis (GC-MS/MVA). (ua.pt)
The authors then conducted univariate and multivariate analyses to investigate correlations between metabolic patterns and TBI severity, clinical descriptors of TBI, and extracranial injury. (medscape.com)

Multidimensional gas chromatography consists of two gas chromatographs connected by a pressure-controlled heart-cutting device. (uni-koeln.de)

Phytochemical analysis and GC-MS were carried out using leaf samples of the species following standard protocols. (phcogj.com)
Non-targeted GC/MS analysis of exhaled breath samples: exploring human biomarkers of exogenous exposure and endogenous response from professional firefighting activity. (cdc.gov)
A non-targeted analysis workflow was applied to analyze exhaled breath samples collected from firefighters pre- and post-structural fire suppression. (cdc.gov)
Serum samples from NHANES 2009-2010 were stored frozen before analysis. (cdc.gov)
Serum samples were processed, stored, and shipped to the Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA for analysis. (cdc.gov)

Journal of Chromatography & Separation Techniques, 06(01). (eanso.org)
JOURNAL OF CHROMATOGRAPHY A , 1217 (52), 8290-8297. (aalto.fi)
AU - Lísa,Miroslav, AU - Holcapek,Michal, AU - Rezanka,Tomás, AU - Kabátová,Nadezda, Y1 - 2007/02/06/ PY - 2006/09/04/received PY - 2007/01/23/revised PY - 2007/01/25/accepted PY - 2007/2/20/pubmed PY - 2007/5/1/medline PY - 2007/2/20/entrez SP - 67 EP - 77 JF - Journal of chromatography. (unboundmedicine.com)

The aim of collection of the leaves was to carry out the extraction and analysis of essential oils from S. manii. (eanso.org)
Gas Chromatography-Mass Spectrometry Analysis of Photosensitive Characteristics in Citrus and Herb Essential Oils. (eanso.org)

Currently, non-invasive biomonitoring of human exposure to organic pollutants bases upon the analysis mainly of urine and human breast milk. (ufz.de)

In addition, CI mass spectra and MRM mass spectra of these designer drug derivatives can be used as a potential supplemental database along with EI mass spectral database. (ojp.gov)
Very high quality mass spectra were obtained, which facilitated accurate library matching, without the need for background correction. (edu.au)
TGs containing Delta5-UPIFAs have a higher retention in comparison with common TGs found in plant oils with single methylene interrupted Delta6(9)-FAs and also significantly changed relative abundances of fragment ions in APCI mass spectra. (unboundmedicine.com)

Bioactive constituents of n-hexane and methanol fractions of Vernonia calvoana (VC) leaves were evaluated using Gas chromatography-Mass spectrometry. (phcogj.com)
The paste (251.8g) was subjected to column chromatography over silica gel (mesh 60 - 120μm) and eluted with 1.5L of n-hexane and methanol respectively. (phcogj.com)

A spectral acquisition rate of 20 Hz was achieved by using a reduced mass scan range of 188 u. 65 components were identified within the two-dimensional separation space based upon retention index and mass spectral matching with literature data. (edu.au)

This paper outlines a six-step, data-driven, framework to develop and evaluate gas chromatography mass spectrometry (GC-MS) methods for targeted classes of drugs. (ojp.gov)
Rather, the intention is to identify well-established methods that are used as the standard methods of analysis. (cdc.gov)
NHANES uses several methods to monitor the quality of the analyses performed by the contract laboratories. (cdc.gov)

The preparation step used for measuring heptachlor epoxide in blood and serum involves lipid extraction, clean-up with column chromatography, and elution with acetonitrile, hexane, and methylene chloride (Burse et al. (cdc.gov)

Fatty acid composition of the extract was identified by gas chromatography-mass spectrometry with their relative concentrations. (biomedjournal.com)

Our labs are equipped for the analysis of a range of bulk and trace, natural and pollutant organic constituents in sediments, oils, bitumens, rocks, waters and many more applications. (ucalgary.ca)
Our lab provides organic geochemistry analysis services including: GC-MS, FTICR-MS, Wet lab procedures. (ucalgary.ca)
GC-MS analysis was also used to determine the antagonistic potential and efficacy of volatile organic chemicals produced by several Ampelomyces spp. (ansfoundation.org)

Therefore, when an identifying mass spectrum appears at a characteristic retention time in a GC-MS analysis, it typically increases certainty that the analyte of interest is in the sample. (wikipedia.org)

We analyzed associations, in a univariable and multivariable analysis, between socio-demographic variables and proportions of urinary cotinine =1 Âµg/l (Limit of Quantification = LOQ) or =4 Âµg/l. (who.int)

10%), and linearity (regression coefficient ≥ 0.9995) and, therefore, high potential for the analysis of anabolic steroids. (aalto.fi)

GC/MS analysis and antimicrobial activity of diethyl ether fraction of methanolic extract from the stem bark of Annona senegalensis Pers. (ansfoundation.org)

The fractions were analyzed for bioactive constituents using Gas chromatography-Mass spectrometry (GC-MS) (30m x 0.25mm ID x 0.25μm film thickness). (phcogj.com)

In this article, the odor characteristics of AF from three different habitats were investigated and analyzed using gas chromatography-mass spectrometry (GC-MS) and an electronic nose (E-nose). (phcog.com)

In order to accelerate the sample preparation, multidimensional gas chromatography was applied. (uni-koeln.de)

Final determination of target analytes was performed by isotope dilution gas chromatography high-resolution mass spectrometry GC/IDHRMS. (cdc.gov)

Parent ions of selected mass-to-charge ( m/z ) values, characteristic for petrol, are stored within the ion trap. (astm.org)

Anatomy13

Organisms9

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment59

Phenomena and Processes43

Disciplines and Occupations6

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture2

Information Science8

Health Care11

Tandem Mass Spectro2

Solid-phase microextr4

Time-Of-Flight Ma1

Isotope Ratio Mass S3

Reversed-phase high-performance li2

GCMS1

HPLC3

Quadrupole mass spectrometer5

Detection9

Compounds5

Spectrometer9

Extracts3

Capillary1

Hydrodistillation1

Pyrolysis1

Chromatographic1

Procedure3

Detector1

Ionization2

Solvent2

Chemistry1

Atmospheric pressure1

Method7

Liquid2

Multivariate2

Chromatographs1

Samples5

Journal3

Essential oils2

Urine1

Spectra3

Methanol2

Separation1

Methods3

Extraction1

Fatty1

Organic3

Analyte1

Urinary1

Steroids1

Extract1

Fractions1

Characteristics1

Sample preparation1

High1

Characteristic1