• We develop proteomic tools for dissecting cellular function, with a special emphasis on the mass spectrometry (MS) of peptides and proteins. (rockefeller.edu)
  • Mass spectrometry imaging (MSI) (also known as imaging mass spectrometry) is a technique used in mass spectrometry to visualize the spatial distribution of chemical compositions e.g. compounds, biomarkers , metabolites , peptides or proteins by their molecular masses. (wikipedia.org)
  • The ability of mass spectrometry to identify and, increasingly, to precisely quantify thousands of proteins from complex samples can be expected to impact broadly on biology and medicine. (nih.gov)
  • We have here investigated the proteome of urinary exosomes by using mass spectrometry to identify proteins differentially expressed in prostate cancer patients compared to healthy male controls. (urotoday.com)
  • In this way, simple and directly interpretable mass spectra were obtained from immunoglobuline M (ca. 1 MDa) and from von Willebrand factor, a group of proteins that play an important role in coagulation of blood (signals at 0.5, 1, 1.5 and 2 MDa). (innovations-report.com)
  • Mass spectrometry-based proteomics. (nih.gov)
  • Recent successes illustrate the role of mass spectrometry-based proteomics as an indispensable tool for molecular and cellular biology and for the emerging field of systems biology. (nih.gov)
  • Mass spectrometry differs from the types of spectroscopy previously discussed because the molecular information that the technique provides does not depend on absorption of electromagnetic radiation. (britannica.com)
  • The foundation of mass spectroscopy was laid in 1898, when Wilhelm Wien, a German physicist, discovered that beams of charged particles could be deflected by a magnetic field . (britannica.com)
  • The use of the term mass spectroscopy is now discouraged due to the possibility of confusion with light spectroscopy . (wikipedia.org)
  • Mass spectroscopy based measurement of the rate and/or extent of the hydrogen/deuterium exchange. (ebi.ac.uk)
  • These capabilities include advanced sample preparation combined with both LC-MS and GC-MS. High resolution accurate mass (HRAM) hyphenated with both GC and LC separation, enhanced-resolution triple quadrupole hyphenated with GC instrument and triple quadrupole LC systems for routine quantitation. (intertek.com)
  • The Thermo Scientific Exactive GC (HRAM with 60,000 resolution and sub ppm mass accuracy, CI capability without vacuum venting) with SPME, static headspace (SHS) and multiple liquid injection capabilities supports component identification, elemental composition confirmation and MS quantitation. (intertek.com)
  • Wilhelm Wien found that strong electric or magnetic fields deflected the canal rays and, in 1899, constructed a device with perpendicular electric and magnetic fields that separated the positive rays according to their charge-to-mass ratio ( Q/m ). (wikipedia.org)
  • Wien found that the charge-to-mass ratio depended on the nature of the gas in the discharge tube. (wikipedia.org)
  • The multiply charged species are detected by their mass-to-charge ratio. (edu.au)
  • Since electrical detectors are now most commonly used, the field is typically referred to as mass spectrometry. (britannica.com)
  • The Warwick Mass Spectrometry community includes scientists with a wide range of technical and applications expertise. (warwick.ac.uk)
  • The principles behind mass spectrometry are somewhat abstract, so let's start with a concrete mental exercise. (howstuffworks.com)
  • The mass spectrometry process normally requires a very pure sample while gas chromatography using a traditional detector (e.g. (wikipedia.org)
  • SIMS is widely regarded as one of the most sensitive forms of mass spectrometry as it can detect elements as small as 10 −6 -10 −9 . (wikipedia.org)
  • In Mass Spectrometry of Glycoproteins: Methods and Protocols, expert researchers in the field detail many of the methods that are now commonly used for glycoproteomics. (springer.com)
  • Authoritative and practical, Mass Spectrometry of Glycoproteins: Methods and Protocol is an essential resource for those who work at the interface of glycobiology and mass spectrometry. (springer.com)
  • The Mass Spectrometry Unit, part of the Central Analytical Facilities of Stellenbosch University, serves as a resource offering contemporary mass spectrometric techniques and the 'state-of-the-art' instrumen-tation needed for the diversity of research interests on- and off-campus. (sun.ac.za)
  • This permits compounds to be assigned to the Δ 4 or Δ 5 series on the basis of mass-spectrometric data. (springer.com)
  • A mass spectroscope configuration was used in early instruments when it was desired that the effects of adjustments be quickly observed. (wikipedia.org)
  • Mass spectrometry is one of the most important techniques of an analytical chemist. (howstuffworks.com)
  • Modern techniques of mass spectrometry were devised by Arthur Jeffrey Dempster and F.W. Aston in 1918 and 1919 respectively. (wikipedia.org)
  • independent data processing can also be accomplished using the Automated Mass Spectral Deconvolution and Identification System (AMDIS) developed at NIST. (umsl.edu)
  • This method is based in the covalent attachment of an isobaric mass tag to all the samples, depending on the choice of tag 4-10 samples can be quantified. (sun.ac.za)
  • ME-SIMS has been so effective that it has been able to detect low mass chemicals at sub cellular levels that was not possible prior to the development of the ME-SIMS technique. (wikipedia.org)
  • Using this technique has resulted in an increase of sensitivity for larger mass samples. (wikipedia.org)