• Here we report a high-throughput method based on ion mobility spectrometry-mass spectrometry (IMS-MS) that is capable of rapidly detecting small molecules that bind to amyloid precursors, identifying the interacting protein species and defining the mode of inhibition. (ntnu.edu.tw)
  • The DNA binding of novel threading bis-intercalators V1, trans-D1, and cis-C1, which contain two naphthalene diimide (NDI) intercalation units connected by a scaffold, was evaluated using electrospray ionization mass spectrometry (ESI-MS) and DNAse footprinting techniques. (elsevier.com)
  • Journal of the American Society for Mass Spectrometry , 18 (2), 311-321. (elsevier.com)
  • We also demonstrate the ability of IMS-MS to screen for inhibitory small molecules in a 96-well plate format and use this to discover a new inhibitor of hIAPP amyloid assembly. (ntnu.edu.tw)
  • Students will avail of specialised tuition in the areas of film and screen media and digital filmmaking, and may also opt to get involved in voluntary work for cultural projects and film festivals, such as the Fastnet Film Festival, Schull, offered during the programme year. (ucc.ie)
  • The MA in Film and Screen Media programme reflects the broad spectrum of research profiles and interests of our staff and is designed to provide our students with advanced knowledge of the history, theory, and aesthetics of international film and the emerging field of screen media. (ucc.ie)
  • With its combination of theory and practice , as well as its interface with the Industry, the MA offers students a programme of study that is simultaneously extensive, eclectic and in-depth. (ucc.ie)
  • MA Screen: Acting breaks away from the traditional stage-focused training by providing a specific programme directly relevant to film and television. (arts.ac.uk)
  • Delivered in close working partnership with MA Screen: Directing, it features an extended programme of acting skills, two film projects which are professionally produced and shot on location and in CSM's film Studio and then edited and screened. (arts.ac.uk)
  • Asymptomatic breast cancer in non-participants of the national screening programme in Norway: a confounding factor in evaluation? (arctichealth.org)
  • To evaluate the extent and histopathological characteristics of asymptomatic breast cancer detected outside the Norwegian Breast Cancer Screening Program (NBCSP) in women targeted by the programme. (arctichealth.org)
  • In 2008, with emergence of new genomic technologies, the WHO synthesised and modified these with the new understanding as follows: Synthesis of emerging screening criteria proposed over the past 40 years The screening programme should respond to a recognized need. (wikipedia.org)
  • There should be scientific evidence of screening programme effectiveness. (wikipedia.org)
  • The programme should promote equity and access to screening for the entire target population. (wikipedia.org)
  • In January 2015, Sussex Police began a voluntary mass DNA screening programme in Bosham, asking men aged 17 and over to give samples. (wikipedia.org)
  • And in a recent Bloomberg report Napolitano said the screening mandate "is an easy thing to say, but it's probably not the best way to go. (logisticsmgmt.com)
  • At the time, strong opposition from the shipping industry, the U.S. Chamber of Commerce, and other business interests prevented the inclusion of a screening mandate for all-cargo planes. (logisticsmgmt.com)
  • The film, which won eight Academy Awards including Best Picture, will look wonderful again when it is shown at movie theaters across the country as part of the 2020 TCM Big Screen Classics Series with Fathom Events. (telegram.com)
  • Indonesian medical staff take part in a mass test for the COVID-19 coronavirus at Patriot stadium in Bekasi, West Java on March 25, 2020. (timesofisrael.com)
  • Limpopo Provincial health official gives a thumbs up after conducting a screening test on a traveller carrying a baby while making her way from Gauteng to Limpopo ahead of the nationwide lockdown at Mantsole Weighbridge near Hammanskraal on March 25, 2020. (timesofisrael.com)
  • In a preferred embodiment, the synthesis, screening, and/or characterization steps are carried out in a highly parallel fashion, where more than one compound is synthesized, screened, and/or characterized at the same time. (google.com)
  • The array is easily interchangeable between different analytical instruments, and in an embodiment, the invention relates to an automated workstation, where the array is transferred between different synthesis, screening, and characterization stations. (google.com)
  • Alden Research Laboratory, Inc. working on behalf of the Massachusetts Department of Environmental Protection (MassDEP) and the Massachusetts Clean Energy Center (MassCEC) developed a screening tool for in-conduit (inside the pipe or channel) hydropower technologies with a focus on water infrastructure opportunities managed by municipalities or districts. (mass.gov)
  • The purpose of this study was to compare performance metrics of postanalytical interpretive tools of the Region 4 Stork collaborative project to the actual outcome based on cutoff values for amino acids and acylcarnitines selected by the California newborn screening program. (nih.gov)
  • It is our hope that - as screening for PPD becomes increasingly common across the U.S. and globally - easy-to-use tools like the MGHPDS, which can be readily used on smartphones and other digital devices, will lead to more accurate screening of perinatal mood and anxiety disorders and to improved clinical outcomes for patients. (eurekalert.org)
  • According to the panel's statement, the effectiveness of lung cancer screening is associated with clinical settings with high rates of accuracy in interpreting LDCTs, appropriate follow-up protocols for positive results, and clear criteria for undertaking invasive procedures. (massgeneral.org)
  • educator and guide for patients and their families enrolled in the Lung Cancer Screening Program and will serve as a clinical resource and liaison across the disciplines while coordinating and tracking patients through the process. (theladders.com)
  • Anticancer drug development guide: preclinical screening, clinical trials, and approval. (wikipedia.org)
  • Use these frequently asked questions (FAQ) to learn more about lung cancer screening and access resources to help support patients. (massgeneral.org)
  • Who should be screened for lung cancer? (massgeneral.org)
  • A low-dose CT scan (LDCT) is the only screening test for lung cancer recommended by the US Preventive Services Task Force. (massgeneral.org)
  • Referrals to the Mass General Lung Screening and Pulmonary Nodule Clinic can be made by emailing [email protected] or via CRMS (for clinicians within Partners). (massgeneral.org)
  • This week, the U.S. Preventive Services Task Force published its final recommendation on lung cancer screening based on a comprehensive review of available evidence. (massgeneral.org)
  • Citing smoking as the biggest risk factor for lung cancer (accounting for about 85 percent of cases in the U.S.), the panel stressed that screening is not an alternative to quitting smoking. (massgeneral.org)
  • For patients at high risk of lung cancer, screening with LDCT has the potential to find even the smallest cancers at an early stage when they are most treatable," said Jo-Anne Shepard, MD , director of Thoracic Imaging and Intervention in the Mass General Department of Radiology. (massgeneral.org)
  • LDCT for lung cancer is available at Mass General for patients with a doctor's order who meet the recommended criteria. (massgeneral.org)
  • LDCT is the only recommended screening test for lung cancer. (massgeneral.org)
  • Mass-screening for lung cancer is rather a unique system in Japan. (spandidos-publications.com)
  • Among the 517 patients with lung cancer who were admitted to our hospital over a 10-year period up to December 2001, 83 (16.1%) were detected by mass-screening. (spandidos-publications.com)
  • Lung cancer screening refers to cancer screening strategies used to identify early lung cancers before they cause symptoms, at a point where they are more likely to be curable. (wikipedia.org)
  • Screening studies for lung cancer have only been done in high risk populations in the U.S., such as smokers and workers with occupational exposure to certain substances. (wikipedia.org)
  • Results from large randomized studies have recently prompted a large number of professional organizations and governmental agencies in the U.S. to now recommend lung cancer screening in select populations. (wikipedia.org)
  • Research has not found two other clinically available tests - sputum cytology or chest radiograph (CXR) screening tests - to reduce the overall number of people who die from lung cancer. (wikipedia.org)
  • In the 2010s recommendations by medical authorities are turning in favour of lung cancer screening, which is likely to become more widely available in the advanced economies. (wikipedia.org)
  • Currently multiple professional organizations as well as the United States Preventive Services Task Force (USPSTF) and the Centers for Medicare and Medicaid Services (CMS) concur and endorse low-dose, computerized tomographic screening for individuals at high-risk of lung cancer. (wikipedia.org)
  • It has been estimated that radiation exposure from repeated screening studies could induce cancer formation in a small percentage of screened subjects, so this risk should be mitigated by a (relatively) high prevalence of lung cancer in the population being screened. (wikipedia.org)
  • The National Lung Screening Trial found that screening people who were between 55 and 74 years who had smoked for a long time, and had quit smoking no more than 15 prior to being screened, allows timely intervention to the extent that 16% fewer people died from lung cancer, compared to people who were not screened. (wikipedia.org)
  • Based on this study, the U.S. Preventive Services Task Force recommends annual screening for lung cancer with low-dose computed tomography in adults aged 55 to 80 years who have a 30 pack-year smoking history and currently smoke or have quit within the past 15 years. (wikipedia.org)
  • Screening should be discontinued once a person has not smoked for 15 years or develops a health problem that substantially limits life expectancy or the ability or willingness to have curative lung surgery. (wikipedia.org)
  • Included in this endeavor is TSA's Certified Cargo Screening Program (CCSP), which enables Indirect Air Carriers (IAC's), shippers, and Independent Cargo Screening Facilities (ICSF's) to screen cargo for flights originating in the U.S. According to TSA, most shippers involved in CCSP have readily incorporated physical search into their packing/shipping operation at minimal cost without needing to invest in screening equipment. (logisticsmgmt.com)
  • Virtual screening (VS) is a computational technique used in drug discovery to search libraries of small molecules in order to identify those structures which are most likely to bind to a drug target, typically a protein receptor or enzyme. (wikipedia.org)
  • Once formed, a peptide-mass fingerprint can be used to search in databases for related protein or even genomic sequences, making it a powerful tool for annotation of protein-coding genes. (wikipedia.org)
  • While it can be analyzed to some degree on its own, in forming a peptide-mass fingerprint, the peak list is run through a database search to find homologous peptide sequences. (wikipedia.org)
  • This screening is intended to detect inborn disorders that can result in early mortality or lifelong disability. (cdc.gov)
  • They can be used to screen healthy individuals to predict predisposition to disease or to detect the presence of asymptomatic disease ( e.g. prostate-specific antigen for prostate cancer). (mcponline.org)
  • When a woman has both first and second trimester screening tests done, the ability of the tests to detect an abnormality is greater than using just one screening independently. (ahealthyme.com)
  • Cancer screening aims to detect cancer before symptoms appear. (wikipedia.org)
  • Results: When individuals ranked in the top 10% of the HRA-F risk score was screened, the sensitivity was 57.9% and positive predictive value was 0.93% or 2.12% according to the above assumptions, respectively. (aacrjournals.org)
  • For these reasons, a test used in a screening program, especially for a disease with low incidence, must have good sensitivity in addition to acceptable specificity. (wikipedia.org)
  • Because of this sensitivity, sample preparation is likely the most important step in forming a peptide-mass fingerprint. (wikipedia.org)
  • Screening a small compound library with this approach led to the rapid discovery of an antagonist for the 5-HT receptor and four positive allosteric modulators for GLP-1 receptor that were not previously reported. (rsc.org)
  • 5,6 Finally, while surface plasma resonance and NMR have recently been employed in the identification of GPCR ligands, 7-9 they require highly purified and stabilized receptors, which are not feasible for a number of targets and their current throughput is not amenable to large-scale compound library screening. (rsc.org)
  • A painless, non-invasive procedure, an abdominal aortic aneurysm screening requires you to lie on your back while a technician uses ultrasound to take images and measurements of your abdominal aorta. (lifelinescreening.com)
  • In the United States, screening with abdominal ultrasound is recommended for males between 65 and 75 years of age with a history of smoking. (wikipedia.org)
  • Focused assessment with sonography for trauma (commonly abbreviated as FAST) is a rapid bedside ultrasound examination performed by surgeons, emergency physicians and certain paramedics as a screening test for blood around the heart (pericardial effusion) or abdominal organs (hemoperitoneum) after trauma. (wikipedia.org)
  • But since WHtR is not routinely used for screening children today, more research is needed specifically focusing on this age group before these findings can be implemented," she says. (springer.com)
  • There'll be opportunities to network with other future creative leaders, working alongside students on our other postgraduate screen courses. (uwe.ac.uk)
  • With a strong emphasis on practice and production-based work running through the course, you'll learn about the industrial and business context of film and TV, and build valuable enterprise skills, working with students on our other postgraduate screen MAs. (uwe.ac.uk)
  • The first City of Cambridge/Community Legal Services and Counseling Center (CLSACC) Immigration Legal Screening Clinic will be held on Wednesday, Dec.13, from 5:15-7:15 p.m., at the offices of Community Legal Services and Counseling Center (CLSACC), 47 Thorndike St (lower level) in East Cambridge. (cambridgema.gov)
  • He died in Cambridge, Massachusetts. (wikipedia.org)
  • Cambridge, Massachusetts: De Capo Press. (wikipedia.org)
  • Cambridge, MA: Harvard University Press. (wikipedia.org)
  • In 1638, Massachusetts Bay Governor John Winthrop and Lt. Governor Thomas Dudley were granted land along the Concord River in the area, and roughly a dozen families from Cambridge and Charlestown Village had begun to occupy Shawshin by 1652. (wikipedia.org)
  • As a supplement to these proposals, this report contains synopses of selected presentations made at the 2000 workshop regarding integration of MS/MS technology into newborn screening programs. (cdc.gov)
  • The following table shows the growth in wind power installed nameplate capacity in MW for Massachusetts since 2000. (wikipedia.org)
  • The MGHPDS app blends together digital versions of perinatal depression screening tools such as the Edinburgh Postpartum Depression Scale, a 10-question self-rating scale which is the most common tool for identifying women at risk for PPD, with other instruments that measure symptoms associated with perinatal psychiatric illness - such as sleep disturbance, anxiety and perceived stress. (eurekalert.org)