MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor (MRGA, MAS, MGRA""), is a protein that in humans is encoded by the MAS1 gene. (wikipedia.org)
A protein that is encoded by the MAS1 gene. (bvsalud.org)
Receptors3
The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. (wikipedia.org)
Recent cancer genome deep sequencing efforts have revealed an unanticipated high frequency of mutations in G proteins and G-protein-coupled receptors (GPCRs) in most tumour types. (nature.com)
Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are frequently associated with tumorigenesis. (nature.com)
Angiotensin1
Intrinsic brain RAS is an enzyme-neuropeptide system having functional components (angiotensinogen, peptidases, angiotensin, and specific receptor proteins) with important biological and neurobiological activities in the brain. (hindawi.com)
Metastasis1
These alterations may arise from cancer-specific changes in gene copy number, as well as from other genetic, epigenetic and post-translational changes resulting in higher protein expression, thereby enhancing tumour progression and metastasis. (nature.com)
Kinase2
Deletions at the C-terminus of the proto-oncogene protein c-Src kinase are found in the viral oncogene protein v-Src as well as in some advanced human colon cancers. (nih.gov)
Endothelial adenosine monophosphate-activated protein kinase (AMPK) plays a critical role in the regulation of vascular tone through stimulating nitric oxide (NO) release in endothelial cells. (bvsalud.org)
Cellular2
Genome-wide transcriptome analysis revealed that c-Src(mt) de-regulated the expression levels of approximately 430 mRNAs whose gene products are mainly involved in the cellular processes of migration and adhesion, apoptosis and protein synthesis. (nih.gov)
Introduction of the identified PMPCB variants into the homologous S. cerevisiae Mas1 protein resulted in a severe growth and MPP processing defect leading to the accumulation of mitochondrial precursor proteins and early impairment of the biogenesis of iron-sulfur clusters, which are indispensable for a broad range of crucial cellular functions. (regenerativemedicine.net)
Therapeutic2
G proteins, GPCRs and their linked signalling circuitry represent novel therapeutic targets for cancer prevention and treatment. (nature.com)
These studies indicate that G proteins, GPCRs and their linked signalling circuitry represent novel therapeutic targets for cancer prevention and treatment. (nature.com)
Human1
Here, we analyzed the mRNA expression signature of a constitutively active C-terminal mutant of c-Src, c-Src(mt), in comparison with its wild-type protein, c-Src(wt), in the human non-transformed breast epithelial cell line MCF-10A. (nih.gov)
Expression1
Aberrant expression, overexpression or signal reprogramming of GPCRs and G proteins in tumour cells can contribute to cancer development and progression. (nature.com)
Encodes3
A similar disorder of the mouse, "dominant white spotting" (W), results from mutations of the c-kit proto-oncogene, which encodes the cellular tyrosine kinase receptor for the mast/stem cell growth factor. (nih.gov)
Its vector encodes the SARS-CoV-2 Spike protein. (nih.gov)
This gene encodes a class I seven-transmembrane G-protein-coupled receptor. (nih.gov)
Receptor6
Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism. (nih.gov)
The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects. (wikipedia.org)
The findings indicated that diminazene significantly reduced the levels of inflammatory factors including tumor necrosis factor-α and interleukin-6, suppressed the protein expression of cytochrome c oxidase subunit 2 (COX-2) and inducible nitric oxide synthase (iNOS), and activated angiotensin-converting enzyme 2 (ACE2), angiotensin II receptor type 1 (AT1R) and MAS1 proto-oncogene, G protein-coupled receptor (MasR) protein expression in AMI model rats. (archive.org)
Protease-activated receptor-2 (PAR2) is a G-Protein Coupled Receptor (GPCR) activated by proteolytic cleavage to expose an attached, tethered ligand (SLIGRL). (nih.gov)
1.3-3.4 nM) with improved selectivity for PAR2 over Mas1 related G-protein coupled receptor type C11, a GPCR that can be activated by the PAR2 peptide agonist, SLIGRL-NH2. (nih.gov)
The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. (nih.gov)
20223
HN - 2022 BX - Adolescent Motherhood BX - Teen Mothers BX - Teenage Mothers FX - Pregnancy in Adolescence MH - ADP-Ribosylation Factor 6 UI - D000089982 MN - D8.811.277.40.330.300.400.100.50 MN - D12.776.157.325.515.100.550 MN - D12.776.476.338.400.100.50 MS - A member of GTP-binding protein of the large ras superfamily involved in regulation of membrane trafficking by modulating ENDOCYTOSIS and ACTIN CYTOSKELETON remodeling. (nih.gov)
HN - 2022 BX - ADP Ribosylation Factor 6 BX - ARF6 Protein MH - Aerosolized Particles and Droplets UI - D000088342 MN - D20.65 MS - A suspension of tiny particles or liquid droplets ( (nih.gov)
HN - 2022 FX - Quality of Health Care MH - AMP-Activated Protein Kinase Kinases UI - D000091162 MN - D8.811.913.696.620.682.700.74 MN - D12.776.476.563.74 MS - Protein Serine-threonine kinases that phosphorylate the 63-kDa subunit of AMP-ACTIVATED PROTEIN KINASES. (nih.gov)
Kinase3
Ca2+ ions acting as secondary messengers initiate protein kinase C activation, phospholipase C and nitric oxide synthetase production, and proto-oncogene expression. (nih.gov)
This action results in reactivation of AMP-ACTIVATED PROTEIN KINASE activity and downstream signaling aimed at decreased metabolism. (nih.gov)
Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. (nih.gov)
Endogenous1
Co-IP assay confirmed mutual interaction between endogenous KIF15 and DEK (encoded by DEK proto-oncogene). (nih.gov)
Subunit1
Protein Serine-threonine kinases that phosphorylate the 63-kDa subunit of AMP-ACTIVATED PROTEIN KINASES. (nih.gov)
Overexpression1
Predominantly expressed in the nucleus in PDA cells, HuR translocates to the cytoplasm in response to hypoxic stress and stabilizes the PIM1 mRNA transcript, resulting in PIM1 protein overexpression. (nih.gov)
Inhibitors1
A class of intracellular signaling proteins that were originally identified as inhibitors of ANGIOSTATIN activity. (nih.gov)
Regulation1
A reverse-phase protein array revealed that HuR-mediated regulation of PIM1 protects cells from hypoxic stress through phosphorylation and inactivation of the apoptotic effector BAD and activation of MEK1/2. (nih.gov)
Cell2
In conclusion, this study revealed a novel mechanism that KIF15 enhances LMS cell proliferation via preventing DEK protein from degradation by increasing USP15 mediated deubiquitylation. (nih.gov)
They play a role in cell signaling pathways such as those involving G-PROTEINS and the HIPPO-SIGNALING PATHWAY. (nih.gov)
Present2
In addition, the present study investigated whether ACE2 signaling was involved in the effects of diminazene on protein function. (archive.org)
Antibodies against non-structural viral proteins were present in more than 50% of the convalescent subjects. (bvsalud.org)
Function2
The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. (nih.gov)
Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
Results1
RESULTS: Immunization with CoronaVac induced higher levels of antibodies against the viral membrane (M) protein compared to convalescent subjects both, after primary vaccination and a booster dose. (bvsalud.org)
Member1
The first member of the Angiopoietin-like protein family to be discovered. (nih.gov)
Levels1
Breakthrough cases produced the highest antibody levels against the N and M proteins. (bvsalud.org)