• Bone marrow adipose tissue (BMAT), sometimes referred to as marrow adipose tissue (MAT), is a type of fat deposit in bone marrow. (wikipedia.org)
  • Since BMAT is increased in the setting of obesity and is suppressed by endurance exercise, or vibration, it is likely that BMAT physiology, in the setting of mechanical input/exercise, approximates that of white adipose tissue (WAT). (wikipedia.org)
  • Visceral abdominal fat (VAT) is a distinct type of WAT that is "proportionally associated with negative metabolic and cardiovascular morbidity", regenerates cortisol, and recently has been tied to decreased bone formation Both types of WAT substantially differ from brown adipose tissue (BAT) as by a group of proteins that help BAT's thermogenic role. (wikipedia.org)
  • Interestingly, these tissues display the well-established pattern of increased adipose tissue typically observed in the marrow compartment throughout the skeleton with increasing age. (medscape.com)
  • In this study we compared MSCs derived from three different sources (iliac crest bone marrow (ICBM), adipose tissue (AT), and (RIA)) regarding the morphology, the success rate of isolating MSCs, colony frequency, expansion potential, osteogenic and chondrogenic differentiation capacity. (cellmolbiol.org)
  • Mesenchymal stem cells (MSC) produced from bone tissue marrow stem cells (BMSC) and adipose tissue stem cells (ASC) of individuals and rhesus macaques were evaluated because of their cell cycle properties during protracted culture around 50 cumulative population doublings, and the cultures stop dividing (7). (bio2009.org)
  • Mechanisms of benzene-induced hematotoxicity and leukemogenicity: cDNA microarray analyses using mouse bone marrow tissue. (nih.gov)
  • Cyclophosphamide-induced cytogenetic effects in mouse bone marrow and spleen cells in in vivo and in vivo/in vitro assays. (cdc.gov)
  • The comparative cytogenetic results of in-vivo and in-vivo/in-vitro studies in mouse bone marrow and spleen cells were evaluated after treatment with varying doses of cyclophosphamide (50180) (CPA). (cdc.gov)
  • Further, experiments using an indirect technique to measure the sensitivity of normal mouse bone marrow indicated that these cells have a radiation sensitivity of similar magnitude ( 6 ). (bioone.org)
  • The relationship between the number of cells injected and the number of colonies appearing in the spleen has been determined and used to study the sensitivity to radiation of the proliferative capacity in vivo of normal adult mouse bone marrow cells irradiated in vitro . (bioone.org)
  • The results show that normal mouse bone marrow cells have a similar radiation sensitivity to other mammalian cells tested by very different methods. (bioone.org)
  • Furthermore, in a NMRI mouse bone marrow micronucleus assay 1-Ethinyl-1-cyclohexanol did not exert a cytotoxic effect in the bone marrow. (europa.eu)
  • Presence of a mounted immune response, as evidenced by seropositivity, might have contributed to negative culture results in all specimens other than spleen tissue. (cdc.gov)
  • Antimony(III) trioxide has low solubility in water, but absorption and distribution results in increased excretion with higher levels of exposure by inhalation in workers and by distribution to tissues in animals, particularly to organs rich in reticuloendothelial cells, e.g., spleen, liver, bone marrow. (nih.gov)
  • While no organ difference was seen in-vivo, spleen cells were more sensitive than bone marrow in the in-vivo/in-vitro condition. (cdc.gov)
  • Bone tissue marrow (BM)-derived fibrocytes are a human population of CD45+ and collagen Type I-expressing cells that migrate to the spleen and to target injured organs such as pores and skin lungs kidneys and liver. (cancer-ecosystem.com)
  • 89 Zr-Df-IAB22M2C accumulated in tumors and CD8-rich tissues (e.g., spleen, bone marrow, nodes), with maximum uptake at 24-48 h after injection and low background activity in CD8-poor tissues (e.g., muscle and lung). (snmjournals.org)
  • In addition to spleen size, scar tissue from previous operations may lead your surgeon to choose the open approach. (clevelandclinic.org)
  • Designed to work like human organs, tissue chips mimic living human tissues and cells. (nih.gov)
  • The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
  • In June 2018, the Secretariat established the WHO Task Force on Donation and Transplantation of Human Organs and Tissues as an advisory group composed of experts from all WHO regions. (who.int)
  • Some cancers can also start in these organs and then spread to the bone marrow, but these cancers are not leukemia. (cancer.org)
  • While leukemias like ALL mainly affect the bone marrow and the blood, lymphomas mainly affect the lymph nodes or other organs (but may also involve the bone marrow). (cancer.org)
  • In humans, cells build tissues, tissues form organs, and organs work together to keep the body alive. (medicalnewstoday.com)
  • During this week, each day we focused on a specific type of donation : blood, platelets, bone marrow, organs, plasma and cord blood. (ifmsa.org)
  • A zoonotic disease that can affect various organs, tissues, and systems. (bmj.com)
  • A blood chemistry test measures the amounts of certain substances that are released into the blood by the organs and tissues of the body. (cancer.gov)
  • Microchimeric fetal cells are found in various maternal tissues and organs including blood, bone marrow, skin and liver. (snopes.com)
  • Results- According to our observations, MSCs from ovine marrow appeared to be fibroblastic in appearance. (ivsajournals.com)
  • A comparison of the colonogenic ability in different tissues by CFU-F assay after 10 days showed that more colonies are formed from RIA-MSCs than from ICBM-MSCs, and AT-MSCs. (cellmolbiol.org)
  • recommended that individual MSCs produced from the marrow might become senescent during protracted lifestyle, as indicated by their reduced differentiation potential, shortening from the mean telomere duration, and morphologic modifications (9). (bio2009.org)
  • They have previously been reported by our group that civilizations of MSCs produced from the bone tissue marrow and adipose tissues underwent morphologic alteration, a drop in multilineage differentiation potential, and a proclaimed reduction in telomerase activity in steadily raising passages of MSCs (4). (bio2009.org)
  • As MSCs from bone tissue marrow adipose tissues and cord bloodstream are being looked into because of their potential as healing interventions for many diseases, it is vital to comprehend the biological properties of the distinct MSC populations fully. (bio2009.org)
  • The data shown herein display that bone tissue marrowC and adipose tissueCderived MSCs regularly cultured for protracted intervals have changed cell cycle development, leading to both cellular senescence and turmoil. (bio2009.org)
  • However, this requires the homing and migration of MSCs to a target tissue. (wjgnet.com)
  • Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
  • An estimate of the relationship between benzene exposure (up to 10 ppm) and fraction metabolized in the bone marrow is obtained and is shown to be linear for the subjects studied. (nih.gov)
  • At levels approaching occupational inhalation exposure (continuous 1 ppm exposure), the estimated quantity metabolized in the bone marrow ranges from 2 to 40 mg/day. (nih.gov)
  • Red blood cells bring oxygen to the body's tissues. (nih.gov)
  • If the lymphatic system didn't drain the excess fluid, the lymph fluid would build up in the body's tissues, making them swell. (kidshealth.org)
  • Bone marrow adipocytes (BMAds) originate from mesenchymal stem cell (MSC) progenitors that also give rise to osteoblasts, among other cell types. (wikipedia.org)
  • Objectives- To isolate, culture-expand and differentiate mesenchymal stem cells from ovine bone marrow and determine their culture requirements for high expansion rate. (ivsajournals.com)
  • Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs / F. Collino, M.C. Deregibus, S. Bruno, L. Sterpone, G. Aghemo, L. Viltono, C. Tetta, G. Camussi. (unimi.it)
  • This study discussed the effect of extracellular vesicles (EVs) released from bone marrow mesenchymal stem cells (BMSCs) on ALL cells and the mechanism. (karger.com)
  • Extracellular vesicles from human bone marrow mesenchymal stem cells repair organ damage caused by cadmium poisoning in a medaka model. (karger.com)
  • Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue. (nih.gov)
  • Wakitami, S., Saito, T. and Caplan, A.I. (1995) Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. (scirp.org)
  • Bone marrow aspiration is not the same as bone marrow biopsy . (medlineplus.gov)
  • A biopsy removes a core of bone tissue for examination. (medlineplus.gov)
  • Bates I, Burthem J. Bone marrow biopsy. (medlineplus.gov)
  • Bone marrow aspiration analysis -- specimen (biopsy, bone marrow iron stain, iron stain, bone marrow). (medlineplus.gov)
  • Bone marrow aspiration and biopsy. (medlineplus.gov)
  • CNS tissue is not accessible to biopsy during life, and the use of post-mortem CNS tissue is necessary for the sophisticated morphometrical and molecular biological approaches required to identify the underlying mechanisms responsible for HIV-induced motor/cognitive dysfunction. (nih.gov)
  • This includes: Blood, urine, heart, and imaging tests For NAFLD participants only: A needle-like device will remove a small biopsy of the liver and fatty tissue. (nih.gov)
  • Bone marrow biopsy collects tissue. (ohsu.edu)
  • Biopsy samples from sacroiliac joints (SIJs) of five patients with AS, two with early, three with advanced changes and samples from age matched controls from one necropsy SIJ and two iliac bone marrow (BM) biopsies were studied. (bmj.com)
  • Inside the bone marrow, blood stem cells divide and mature to make new blood cells. (cancer.org)
  • Differentiation potential cell therapy stem cells regenerative medicine orthopedic tissue engineering. (cellmolbiol.org)
  • Individual adipose tissues stem cells (hASCs) go through immortalization and spontaneous change after protracted intervals of enlargement (10). (bio2009.org)
  • Components and Strategies Cell Lifestyle and Differentiation Individual and rhesus bone tissue marrow stem cells (BMSCs) and ASCs had been obtained and prepared as previously AKAP7 referred to (4). (bio2009.org)
  • Stem cells or progenitor cells are defined by a capacity for self-renewal and the ability to generate different types of cells (multipotentiality) that are involved in the formation of mature tissues. (intechopen.com)
  • Despite the successful isolation and characterization of stem cells from various tissues, relatively few animal studies have been done to investigate the efficacy of stem cell transplantation. (intechopen.com)
  • Prockop, D.J. (1997) Marrow stromal cells as stem cells for nonhematopoietic tissues. (scirp.org)
  • Stem cells are essentially blank slates that have ability to turn into a variety of different tissues and, as such, play a big role in the development of a fetus. (snopes.com)
  • Reduced intensity conditioning (RIC) was used with either unrelated double umbilical cord blood (dUCB) or HLA-haploidentical related donor bone marrow (Haplo-marrow) transplantation. (nih.gov)
  • During aging, bone quantity declines and fat redistributes from subcutaneous to ectopic sites such as bone marrow, muscle, and liver. (wikipedia.org)
  • A liver tissue sample is taken. (nih.gov)
  • Stained cells were counted over one entire high power field (×400) per section in BM, cartilage, and other connective tissue (CT). (bmj.com)
  • Bone marrow is the soft tissue inside bones that helps form blood cells. (medlineplus.gov)
  • Leukemia occurs in bone marrow which is a soft tissue. (medgadget.com)
  • Most sarcomas develop in the muscles, blood vessels or other soft tissues of the body, and are known as soft tissue sarcomas. (moffitt.org)
  • Within these two categories, there are more than 70 unique types of sarcoma , each one indicating wherein the bone or soft tissue the cancer developed. (moffitt.org)
  • Blood cells are made in the bone marrow. (cancer.org)
  • Red blood cells carry oxygen from the lungs to all other tissues in the body, and take carbon dioxide back to the lungs to be removed. (cancer.org)
  • Having too few red blood cells (anemia) can make you feel tired, weak, and short of breath because your body tissues aren't getting enough oxygen. (cancer.org)
  • Lymphocytes are mature, infection-fighting cells that develop from lymphoblasts , a type of blood stem cell in the bone marrow. (cancer.org)
  • Lymphocytes are the main cells that make up lymphoid tissue, a major part of the immune system. (cancer.org)
  • Hematopoietic cells (also known as blood cells) reside in the bone marrow along with BMAds. (wikipedia.org)
  • HSC renewal occurs in the marrow stem cell niche, a microenvironment that contains cells and secreted factors that promote appropriate renewal and differentiation of HSC. (wikipedia.org)
  • [ 29 , 30 ] Tissues from male patients were collected because our initial observations, generated during another line of experimentation, revealed that ER+ breast cancer cells were preferentially sustained in tissues from male and female patients. (medscape.com)
  • However, an experiment performed using bone fragments from a 50-year old female patient (THR 151) revealed that ER+ MCF-7, ZR-75, and T-47D breast cancer cells exhibited dramatically greater BLI signal, reflecting higher numbers of viable cells, following co-culture on bone tissue fragments vs. plastic, as shown in Figure 2b. (medscape.com)
  • Red blood cells provide oxygen to body tissues. (nih.gov)
  • Antimony is generally highest in tissues with reticuloendothelial cells. (nih.gov)
  • Thrombocythemia occurs when faulty cells in your bone marrow make too many platelets. (nih.gov)
  • Procedures- In this study, ovine marrow cells were plated and culture expanded through 3 successive subcultures. (ivsajournals.com)
  • Doctors analyze bone marrow, where white blood cells are made, to understand the stage and extent of leukemia. (ohsu.edu)
  • Hormones given as pills or shots can stimulate your bone marrow to create more red blood cells and platelets. (ohsu.edu)
  • While individual fibroblastic cells interface with a greater number of cells, inflammatory cells have the largest contact area suggesting a role in establishing intercellular electrical connections in scar tissue. (edu.sa)
  • A major obstacle to using bone marrow cell-based therapies for ischemic cardiovascular disease is that transplanted cells must survive in an ischemic microenvironment characterized by low oxygen, glucose, and pH. (elsevierpure.com)
  • We demonstrate that treatment of bone marrow-derived angiogenic cells (BMDACs) with dimethyloxalylglycine, an α-ketoglutarate antagonist that induces hypoxia-inducible factor 1 (HIF-1) activity, results in metabolic reprogramming of these cells, with increased glucose uptake, decreased O 2 consumption, increased lactate production, decreased reactive oxygen species, and increased intracellular pH. (elsevierpure.com)
  • ALL starts in the bone marrow (the soft inner part of certain bones, where new blood cells are made). (cancer.org)
  • Evidence is accumulating that the proliferative capacity of mammalian cells has a uniformly high radiation sensitivity regardless of the species and tissue of origin. (bioone.org)
  • The method is based on the fact that the intravenous injection of an appropriate number of marrow cells into isologous hosts previously exposed to supralethal total-body irradiation leads to the formation of colonies of proliferating cells in the spleens of these animals. (bioone.org)
  • Marrow cells were obtained from the femora of normal mice, suspended in Puck's saline A, and the nucleated cells were counted in a hemacytometer as previously described ( 6 ). (bioone.org)
  • Although MSC homing has been described, this process does not appear to be highly efficacious because only a few cells reach the target tissue and remain there after systemic administration. (wjgnet.com)
  • Non-reproducible treatment outcomes or even absence of treatment effects in comparison to control groups challenges the potential of these cells for routine application both in tissue engineering and in regenerative medicine. (frontiersin.org)
  • The major function of bone marrow is to produce new blood cells. (medlineplus.gov)
  • Leukemia develops by the uncontrolled growth of blood cells in the bone marrow. (medgadget.com)
  • In MDS, the bone marrow does not make enough healthy blood cells. (epnet.com)
  • Rat BMSCs could be differentiated into cardiomyocytes-like cells, which have a good biocompatibility with acellular bovine pericardium, and myocardium-like tissue could be engineered with BMSCs and acellular bovine pericardium in vitro . (scirp.org)
  • Fetal microchimeric cells (fmcs) engraft the maternal bone marrow and are able to migrate through the circulation and to reach tissues. (snopes.com)
  • Here, we show that Bone Marrow (BM) adipocytes dynamically evolve during ALL pathogenesis and therapy, transitioning from cellular depletion in the primary leukaemia niche to a fully reconstituted state upon remission induction. (nature.com)
  • Bone marrow is the sponge-like tissue inside the bones. (nih.gov)
  • Shwachman-Diamond syndrome is an inherited condition that affects many parts of the body, particularly the bone marrow, pancreas, and bones. (medlineplus.gov)
  • Bone marrow is tissue found in the bones. (epnet.com)
  • These advances create opportunities to draw parallels to examine similarities and differences with the tissues in the oral environment, such as OoCs representing tonsils, tongue, lip, alveolar bone, suture, temporomandibular joint, and periodontal ligament. (nih.gov)
  • To determine if removing an ovary for ovarian tissue cryopreservation (OTC) increased rates of primary ovarian insufficiency (POI) in girls undergoing bone marrow transplantation (BMT). (nih.gov)
  • In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
  • The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
  • Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (who.int)
  • Thus, the availability of and access to human tissues for transplantation remains essential. (who.int)
  • The 1-year probabilities of overall and progression-free survival were 54% and 46%, respectively, after dUCB transplantation (n = 50) and 62% and 48%, respectively, after Haplo-marrow transplantation (n = 50). (nih.gov)
  • The day +56 cumulative incidence of neutrophil recovery was 94% after dUCB and 96% after Haplo-marrow transplantation. (nih.gov)
  • The 100-day cumulative incidence of grade II-IV acute GVHD was 40% after dUCB and 32% after Haplo-marrow transplantation. (nih.gov)
  • The 1-year cumulative incidences of nonrelapse mortality and relapse after dUCB transplantation were 24% and 31%, respectively, with corresponding results of 7% and 45%, respectively, after Haplo-marrow transplantation. (nih.gov)
  • The study is to investigate BMSCs ability to differentiate cardiomyocytes, especially discussed cell generations and 5-Aaz concentration influence on BMSCs capability of proliferation and differentiation into cardiomyocytes during constructing the engineered myocardium-like tissue in vitro . (scirp.org)
  • Different generations and different 5-Aza density have influence on the rate of increase of BMSCs, and the engineered myocardium-like tissue could be constructed with BMSCs and acellular bovine pericardium in vitro . (scirp.org)
  • Vascularized microtumors have recreated physiologically-relevant vascularized tumorigenesis in vitro, dynamic interactions between tissues and tumors, and effects of chemotherapeutics on healthy and cancerous tissues. (nih.gov)
  • The evidence derives from experiments on fresh explants and established cell lines in tissue culture ( 1 - 2 3 4 ), and on transplantable tumors in vivo ( 5 ) where single-cell techniques have been applied. (bioone.org)
  • Ishii, O., Shin, M., Sueda, T. and Vacanti, J.P. (2005) In vitro tissue engineering of a cardiac graft using a degradable scaffold with an extracellular matrix-like topography. (scirp.org)
  • Per the FDA definition, OoC is a subset class of microphysiological systems (MPS) consisting of a miniaturized physiological environment engineered to yield and/or analyze functional tissue units capable of modelling specified/targeted organ-level responses. (nih.gov)
  • Pantomics Array Description: 33 types of normal tissues in duplicates based on the FDA recommendation for antibody. (delos.info)
  • Platelets are actually cell pieces made by a type of bone marrow cell called the megakaryocyte. (cancer.org)
  • Non-Hodgkin's lymphoma usually originates in the lymph nodes and other lymph tissue, although the skin may also be affected. (medicinenet.com)
  • Those germs are filtered out in the lymph nodes, small clumps of tissue along the network of lymph vessels. (kidshealth.org)
  • Another launch, currently planned for March 2019, also from Cape Canaveral, will send kidney chip s, bone and cartilage chip s, and chips modeling the blood-brain barrier , which is a protective mesh of blood vessels and tissue that can stymie therapies from reaching the brain, to the ISS-NL. (nih.gov)
  • Blood-brain barrier platforms have successfully modelled the interface between vascular and brain tissues. (nih.gov)
  • These pathologic conditions do not typically involve the trabecular bone tissue located in the neck of the femoral head used in our co-culture model, as outlined in Figure 1a, Figure 1b, Figure 1c, Figure 1d and Figure 1e. (medscape.com)
  • To study the responses of breast cancer cell lines during short-term co-culture with human bone tissue fragments, cell suspensions prepared from six breast cancer cell lines were seeded at low density into tissue culture wells vs. directly onto trabecular bone tissue fragments isolated from a given THR specimen, as illustrated in Figure 2a, and monitored with BLI to compare relative cell numbers over time. (medscape.com)
  • Analytical methods have been developed to measure benzene levels in exhaled breath, blood, and various body tissues. (cdc.gov)
  • Usually, if at least 20% of the bone marrow is made up of cancerous lymphocytes (called lymphoblasts, or just blasts ), the disease is considered leukemia. (cancer.org)
  • The Blood and Marrow Transplant Clinical Trials Network conducted 2 parallel multicenter phase 2 trials for individuals with leukemia or lymphoma and no suitable related donor. (nih.gov)
  • These multicenter studies confirm the utility of dUCB and Haplo-marrow as alternative donor sources and set the stage for a multicenter randomized clinical trial to assess the relative efficacy of these 2 strategies. (nih.gov)
  • To better understand the relevance of the astronauts' experience to human health - both on the ground and beyond - NIH's National Center for Advancing Translational Sciences (NCATS) partnered with the International Space Station U.S. National Laboratory (ISS National Lab) to send tissue chips , a research technology that reflects the human body, into space. (nih.gov)
  • Wednesday, a set of tissue chips that model aspects of the human immune system will launch on SpaceX's 16th commercial resupply mission (awarded by NASA) from Cape Canaveral, Florida, to the ISS National Lab. (nih.gov)
  • While the development of xenografts (products of animal origin) and bioengineered alternatives is advancing, to date they cannot fully mimic or replace all human-sourced tissues on an equivalent basis. (who.int)
  • But it may also be done on other body fluids or tissue samples. (cancer.gov)
  • The bone marrow fluid is sent to a laboratory and examined under a microscope. (medlineplus.gov)
  • Bone marrow aspiration collects fluid. (ohsu.edu)
  • One of the lymphatic system's major jobs is to collect extra lymph fluid from body tissues and return it to the blood. (kidshealth.org)
  • Cytogenetic analysis looks for changes in chromosomes in samples of tissue, blood, bone marrow , or amniotic fluid . (cancer.gov)
  • Paraffin sections of tissues from mice perfused with 4% paraformaldehyde or buffered formalin are also available upon request, contact technical service for availability. (delos.info)
  • Combined HIF-1α-based gene and cell therapy reduced tissue necrosis even when BMDAC donors and ischemic recipient mice were 17 months old, suggesting that this approach may have therapeutic utility in elderly patients with critical limb ischemia. (elsevierpure.com)
  • Tissues are fixed in 10% neutral buffered formalin, embedded in paraffin blocks, sectioned at a thickness of 5 microns and mounted on positively charged slides (2 sections per slide). (delos.info)
  • Paraffin tissue sections are prepared in RNase-, protease-free environment and are ideal for immunohistochemistry and in situ hybridization. (delos.info)
  • Leukemia is a type of cancer which is formed in blood tissues. (medgadget.com)
  • After irradiation and injection of marrow they were housed 3 to 4 animals per cage and allowed food (Ralston Purina Mills mouse diet) and water as desired. (bioone.org)
  • Dimethyloxalylglycine-treated BMDACs have a significant survival advantage under conditions of low O 2 and low pH ex vivo and in ischemic tissue. (elsevierpure.com)
  • Red blood cell indices do not become abnormal for several months after tissue stores are depleted of iron. (medscape.com)
  • This project analyzes the distribution and function of newly discovered fat cell subtypes in brown, bone marrow, and dermal fat. (ohio.edu)