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  • hypercellular
  • These patients tend to have a normocellular to hypercellular bone marrow with erythroid hyperplasia, an elevated reticulocyte count, a large population of PNH cells (usually greater than 60% PNH granulocytes), and an LDH (lactate dehydrogenase) that is two to ten times the upper limit of normal. (thecardiologyadvisor.com)
  • clonal
  • We propose the term clonal hematopoiesis of indeterminate potential (CHIP) to describe individuals with a hematologic malignancy-associated somatic mutation in blood or marrow, but without other diagnostic criteria for a hematologic malignancy. (bloodjournal.org)
  • hematopoiesis
  • Pathology is primarily due to accumulation of blasts, replacing healthy marrow and leading to failure of normal hematopoiesis and the humoral and mechanical complications of large numbers of these immature cells in the peripheral circulation and/or tissues. (clinicaladvisor.com)
  • leukemia
  • As the disease progresses and converts into leukemia, further gene mutation occurs, and a proliferation of leukemic cells overwhelms the healthy marrow. (medscape.com)
  • Adult
  • Figure 8:T1w sagittal image demonstrates a poorly circumscribed central area of low signal intensity (arrows) which might mimic a pathologic lesion in this adult male. (amazonaws.com)
  • Adult marrow does not appreciably enhance to visual inspection after intravenous gadolinium contrast is administered. (amazonaws.com)
  • elderly
  • Figure 12:This T1w sagittal image demonstrates the Ricci Pattern 3 consisting of a speckled marrow pattern in a normal elderly woman. (amazonaws.com)
  • Figure 13:This T1w sagittal image in an elderly woman demonstrates normal marrow with large round areas of yellow marrow consistent with Ricci pattern 4. (amazonaws.com)
  • cause
  • Because mutations are frequently observed in healthy older persons, detection of an MDS-associated somatic mutation in a cytopenic patient without other evidence of MDS may cause diagnostic uncertainty. (bloodjournal.org)
  • disease
  • The T2w FSE sequence is substantially less reliable in assessing spinal marrow, particularly in diffuse disease, as comparison with adjacent normal tissues is more variable than on T1w images13. (amazonaws.com)
  • lack
  • Allogeneic bone marrow transplantation offers the opportunity for cure in younger patients, but most are not suitable candidates for transplantation due to advanced age or lack of a histocompatible donor. (centerwatch.com)