Marrow graft rejection in mice. Medical search. Frequent questions

Progenitor cells derived from bone marrow have been shown to respond following lung injury in both mice and humans. (rotrf.org)

Bone Marrow Transplantation, 2013. (nih.gov)
It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (lookformedical.com)
Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the stimulation of total T cell populations with defined allogeneic antigen-presenting cells (APCs) under conditions that lead to the generation or expansion of donor-reactive, adaptive T(regs). (lu.se)
Treatment of mice with a single donor-specific transfusion plus a brief course of anti-CD154 mAb uniformly induces donor-specific transplantation tolerance characterized by the deletion of alloreactive CD8+ T cells. (palomid529.com)
00:00:27.07 So, the field of transplantation is limited by drug treatment-related complications, 00:00:33.20 chronic rejection, and the availability of organs. (ibiology.org)
00:00:37.15 So, one solution that would overcome all of these problems would be xenotransplantation, 00:00:43.22 meaning transplantation of organs from another species, with induction of tolerance to avoid 00:00:51.11 the drug treatment-related complications and chronic rejection. (ibiology.org)
A new study challenges long-held theories of why a common virus -- cytomegalovirus, or CMV -- can reactivate and become a life-threatening infection in people with a compromised immune system, including blood cancer patients undergoing bone marrow transplantation. (sciencedaily.com)
This is a big deal for the bone marrow transplantation field," said Dr. Geoffrey Hill, the paper's senior co-author and director of Hematopoietic Stem Cell Transplantation at Fred Hutchinson Cancer Research Center. (sciencedaily.com)
CMV infection is the most common complication of bone marrow transplantation. (sciencedaily.com)
investigated that music therapy mitigated pain and nausea, the two most common side effects of transplantation, in patients undergoing bone marrow transplantation. (e-lub.net)
London, Canada -Antibody-mediated acute vascular rejection (AVR) is a major problem in organ transplantation. (stemcellpatents.com)
In comparison to recipients with TDD pretreatment 28 times, individuals with shorter intervals of preparation had been still draining many lymphocytes within the last 5 times preceding transplantation, maintained a solid capability to create warm antibodies, and got a high occurrence of rejection (Fig. 3). (onlycoloncancer.com)
The introduction of CsA in the early 1970's significantly improved the outcome of organ and bone marrow allograft transplantation and advanced therapeutic options in autoimmune diseases. (ox.ac.uk)
Islets prepared for transplantation into type 1 diabetes patients are exposed to compromising intrinsic and extrinsic factors that contribute to early graft failure, necessitating repeated islet infusions for clinical insulin independence. (researchgate.net)
Early diagnosis and early implementation of bone marrow transplantation (BMT) are crucial to minimize neurodevelopmental complications and ensure productive adult life in patients with PNP deficiency. (medscape.com)

MSCs were initially isolated from bone marrow but are now known to exist in a wide range of tissues in the human adult, including brain, thymus, lung, liver, spleen, kidney, and dental pulp [ 11 , 12 ]. (hindawi.com)
Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
To illustrate exactly how big this request was, earlier in the conversation, the actors told Farrell that they were interested in obtaining liver-thymus pairs from the same donor, which would then be supplied to a laboratory that was hoping to create humanized mice. (traditioninaction.org)
Y-chromosome-specific sequence (Sry) of male SD rats could be detected in the bone marrow, spleen and thymus of female recipients at 15 d after bone marrow infusion . (zju.edu.cn)
Following discussion touched on possible next steps for their company, like developing a much cheaper growth hormone alternative, possibility of prolonging the lifespan of kidney transplants or reprogramming thymus with grafts to completely solve transplant rejections and autoimmune diseases. (foresight.org)

Mouse colon impacted by acute graft-versus-host disease. (wikipedia.org)
In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)
In the classical sense, acute graft-versus-host disease is characterized by selective damage to the liver , skin (rash), mucosa , and the gastrointestinal tract . (wikipedia.org)
Indeed, DPPI deficient mice were protected against acute arthritis induced by passive transfer of monoclonal antibodies against type II collagen (Adkison et al. (justia.com)
Infusion of nonmyeloablative bone marrow alleviates acute rejection reaction in liver allotransplantation[J]. Journal of Zhejiang University Science B, 2005, 6(12): 1188-1194. (zju.edu.cn)
Results: No signs of rejection were found in Group I. Acute rejection occurred in both Group II and the short-term CsA treated group. (zju.edu.cn)
Diagnosis of renal allograft rejection and acute tubular necrosis by 99mTc-mononuclear leukocyte imaging. (shengsci.com)
We have developed a quantitative method to diagnose rejection and acute tubular necrosis (ATN) by comparing regions of interest drawn on allograft scintigraphs at different. (shengsci.com)
Nuclear factor κB (NF-κB) activation is a deleterious molecular mechanism that drives acute kidney injury (AKI) and manifests in transplanted kidneys as delayed graft function. (researchgate.net)

To address this challenge, researchers have been trying to develop reliable, lab-based methods for making the vital, blood-producing component of bone marrow: hematopoietic stem cells (HSCs). (nih.gov)
Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)

METHODS: Tolerance to transplanted skin and bone marrow, mismatched for multiple minor histocompatibility antigens, was induced in Fas mutant and control mice using anti-CD4 and anti-CD8 monoclonal antibodies. (ox.ac.uk)
or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
00:05:08.18 In the 1980s, immunoabsorption procedures were developed to get rid of natural antibodies, 00:05:15.16 and that prolonged graft survivals to hours. (ibiology.org)
But Hill and his research team found that strain-specific antibodies made from B cells are responsible for keeping CMV suppressed in mice, without the need for any other immune cells. (sciencedaily.com)
A future therapy could work by collecting the CMV-thwarting antibodies from patients who have been exposed to the virus and who are undergoing bone marrow transplant. (sciencedaily.com)
That is, transplanted mice that had no pre-existing B cells and thus lacked antibodies saw CMV spring back to life within 10 days of the transplant. (sciencedaily.com)

An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
Conduct studies using novel recombinant proteins to modulate the immune response to prevent cell, tissue, and solid organ graft rejection. (postdocjobs.com)
White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
[6] Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands . (wikipedia.org)
This immune reaction leads to rejection, the greatest problem in successful tissue and organ grafting. (britannica.com)
Importantly, Rafii's team showed they could infuse the lab-derived HSCs, nurtured on the endothelial tissue, directly into a mouse, just as a person would now receive a bone marrow transplant. (nih.gov)
Scientists painstakingly removed tissue from one embryo and grafted it into another embryo (3). (the-scientist.com)
In the lengthy video, Farrell is seen looking over her e-mail when she finds a message from an immune-biology laboratory that was requesting fetal tissue to create humanized mice. (traditioninaction.org)
The purpose of the request was to obtain cadavers and fetal tissue to generate humanized mice for immune-deficiency experimentation and the development of pharmaceuticals. (traditioninaction.org)
Around the year 2000, a line of mice created through breeding and genetic alteration to suppress the immune response that prompts rejection of foreign tissue. (traditioninaction.org)
With the rodents' immune systems suppressed, human fetal cells or tissue could be transplanted or grafted into the mice where it would grow. (traditioninaction.org)
MSCs are stem cells that can be isolated from bone marrow, adipose and other tissue sources. (stemcellsportal.com)
He predicted that an organism could be prepared for the introduction of foreign tissue thereby preventing an immune response and rejection. (oxsci.org)
Peter Medawar, Rupert Billingham and Leslie Brent provided evidence to support Burnet's prediction through their work with skin grafts in twin cattle and the inoculation of mice embryos with foreign tissue. (oxsci.org)

GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
Bone marrow transplants offer a way to cure leukemia, sickle cell disease, and a variety of other life-threatening blood disorders.There are two major problems, however: One is many patients don't have a well-matched donor to provide the marrow needed to reconstitute their blood with healthy cells. (nih.gov)
Just over 8,000 people in the United States received allogenic transplants in 2017 for blood cancers, including leukemias and lymphomas, and other blood disorders, according to the Center for International Blood & Marrow Transplant Research. (sciencedaily.com)
These drugs have been used to prevent rejection of transplants and these are used as chemotherapy for cancers. (aao.org)

While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. (lookformedical.com)
Another is even with a well-matched donor, rejection or graft versus host disease can occur, and lifelong immunosuppression may be needed. (nih.gov)

The program has developed various novel biologics and targeted delivery biomaterial platforms with demonstrated efficacy for tolerance induction to allogeneic bone marrow cells and islets for the treatment of diabetes. (postdocjobs.com)
Here we demonstrate that stimulation of mouse CD4(+) T cells by immature allogeneic dendritic cells combined with pharmacological inhibition of phosphodiesterase 3 (PDE) resulted in a functional enrichment of Foxp3(+) T cells. (lu.se)

Mesenchymal stem cells (MSCs) are adult stem cells that can be isolated from most adult tissues, including bone marrow, adipose, liver, amniotic fluid, lung, skeletal muscle and kidney. (myradiary.com)

Expression of KLRB1C/NKR-P1C protein is correlated with the ability to lyse tumor cells in vitro and to mediate rejection of bone marrow allografts. (bdbiosciences.com)
this system we analyzed the maintenance of H-2b allografts in tolerized mice. (palomid529.com)
Rejection of healed-in allografts in tolerized mice appears to be a dynamic process dependent on the level of residual costimulation blockade CD4+ L-Thyroxine regulatory cells and triggered alloreactive CD8+ thymic emigrants that have repopulated the periphery after tolerization. (palomid529.com)
Combined therapy consisting of anti-CD154 mAb plus a L-Thyroxine solitary donor-specific transfusion (DST)5 in mice is definitely even more effective than anti-CD154 mAb monotherapy in prolonging the survival of islet pores and skin and heart allografts (5 6 15 The mechanism by which DST enhances graft survival appears in part to involve the deletion of recipient CD8+ alloreactive T cells (15). (palomid529.com)
Most skin allografts placed on mice treated with any of these protocols are eventually rejected (23) unless recipients are thymectomized (18). (palomid529.com)
With this system we studied the immune response to H-2b allografts in tolerized mice. (palomid529.com)

The ability of splenocytes from tolerant animals to suppress graft rejection was assessed by transfer into partially immunocompromised recipients. (ox.ac.uk)
Splenocytes from these and control tolerant animals when transferred into partially immunocompromised Fas mutant or control recipients, induced antigen-specific suppression of graft rejection. (ox.ac.uk)
Advances in immunosuppressive therapy have put increasing pressure on the supply of donor organs, and medical personnel sometimes find themselves having to determine who among the potential recipients should receive a lifesaving graft. (britannica.com)
To test this hypothesis more directly and to analyze L-Thyroxine the underlying mechanisms in detail we established a new analytical system based on allo-TCR transgenic hemopoietic chimeric graft recipients. (palomid529.com)
Strikingly, the depletion of CD8 + cells did not further enhance engraftment in anti-CD154 mAb-treated recipients in a model in which rejection is mediated by both CD4 + and CD8 + T cells. (umn.edu)
Additionally, the administration of either anti-CD28 mAb or anti-CD152 (anti-CTLA-4) mAb or the use of CD28 deletional recipients abrogated engraftment in anti-CD154 mAb-treated mice suggesting that balanced CD28/CD152:B7 interactions are required for the engraftment-promoting capacity of anti-CD154 mAb. (umn.edu)
When recipients are given a course of the conventionally used immune suppressant agent cyclosporin A, grafts survive 15 days. (stemcellpatents.com)
Conclusion: Mild preconditioning nonmyeloablative donor specific bone marrow infusion can enhance chimerism formation in recipients, alleviate the rejection of liver allotransplantation and prolong survival of liver allotransplantation. (zju.edu.cn)

Participate in the generation and use of humanized mouse models to assess the efficacy of lead immunomodulatory protocols to prevent rejection of human islets or stem-cell-derived beta cells in humanized mice as a prelude to clinical translation. (postdocjobs.com)

Three months later, the researchers gave the mice a bone marrow transplant, effectively wiping away their immune systems and replacing them with new donor marrow. (sciencedaily.com)
This can range from the relatively pedestrian, such as a person who received a bone marrow transplant, to creatures that seem more at home in science fiction, such as animals containing cells or tissues belonging to other species. (the-scientist.com)

However, anti-CD154 mAb did facilitate engraftment in a model in which only CD8 + T cells mediate rejection. (umn.edu)

In mice it prolongs islet (3-5) and cardiac (6) allograft survival. (palomid529.com)

Using mice models, Dr. Fitzhugh et al showed for the first time that sirolimus and post-transplant cyclophosphamide work synergistically to induce tolerance (Fitzhugh CD et al. (nih.gov)
One of the 3 patients engrafted but lost the graft at 7 months post-transplant. (nih.gov)
Based on the three patients losing their grafts, stopping rules were met and the study moved to the 2nd cohort where 1 dose of Cy was given at 50mg/kg on day 3 post-transplant. (nih.gov)
These cells inhibited T cell proliferation in a standard in vitro mixed lymphocyte assay and, moreover, attenuated the development of vasculopathy mediated by autologous peripheral blood mononuclear cells in a functionally relevant humanized mouse transplant model. (lu.se)
00:03:11.16 And what those can do, if you do a transplant from a pig to an old-world primate, 00:03:18.28 is they can immediately bind to the endothelial cells at the graft, fix complement, and cause 00:03:25.15 hyperacute rejection, or a more delayed form of rejection called delayed xenograft rejection. (ibiology.org)

The FcgammaRIIa polymorphism in patients with chronic kidney graft rejection. (shengsci.com)

Graft-versus-host disease ( GvHD ) is a syndrome , characterized by inflammation in different organs. (wikipedia.org)
GvHD can also occur after a blood transfusion , known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
Micrographs of grades of skin graft-versus-host disease: Ranging from grade I GvHR (with minimal vacuolization in the epidermis) to grade II GvHR (with vacuolization and dyskeratotic bodies) to grade III GvHR (with sub epidermal cleft formation) and finally to grade IV GvHR (with separation of the dermis from the epidermis). (wikipedia.org)

We documented that alloreactive CD8+ T cells were deleted during tolerance induction but slowly returned toward pretreatment levels in euthymic mice. (palomid529.com)

Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. (stemcellpatents.com)
2009 Aug 15;57(11):1192-203) asked the question of whether human mesenchymal stem cells may be useful in the treatment of the mouse model of multiple sclerosis, experimental. (stemcellpatents.com)
Münster, Germany -G-CSF is widely used as a stem cell mobilizer, inducing complement-dependent exit of CD34 and mesenchymal stem cells from the bone marrow . (stemcellpatents.com)

To test for linked suppression, animals were transplanted with a second graft-bearing tolerated and third party antigens. (ox.ac.uk)
Additionally, tolerant Fas mutant mice accepted grafts bearing tolerated and third party antigens. (ox.ac.uk)
Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (lookformedical.com)

The researchers used eight different strains of CMV and found mice given the antibody from the same strain of the virus that they were exposed to previously were protected completely from CMV coming back. (sciencedaily.com)

This rejection is caused by natural killer (NK) cells of the recipient. (wikipedia.org)
The rejection of parental (P) BM graft by F1 generation is caused by NK cells as was said. (wikipedia.org)
The activity of these cells (NK cells) is inhibited, if there is cell signaling through inhibitory receptors (Ly49 - mouse, KIR- human). (wikipedia.org)
Deficient Growth of C57Bl Marrow Cells Transplanted in F1 Hybrid Mice. (wikipedia.org)
In addition we will examine the effect of immunosuppressive drugs on lung progenitor cell mobilization from the bone marrow using both clinical patient data and animal models of drug delivery, with the aim of determining specific protocols that optimize the patients own regenerative cell capacity and minimize the contribution of fibrotic cells. (rotrf.org)
Without further manipulation or selection, the resultant population delayed skin allograft rejection mediated by polyclonal CD4(+) effectors or donor-reactive CD8(+) T cell receptor transgenic T cells and inhibited both effector cell proliferation and T cell priming for interferon-γ production. (lu.se)
and 3) activation of the alloreactive CD8+ T cells during graft rejection following deliberate depletion of regulatory CD4+ T cells. (palomid529.com)
Chimeras were normal CBA (H-2k) mice that were irradiated and given small numbers of syngeneic TCR-transgenic KB5 bone marrow cells. (palomid529.com)
These mice subsequently circulated a self-renewing trace population of anti-H-2b alloreactive CD8+ T L-Thyroxine cells L-Thyroxine that matured in a normal microenvironment. (palomid529.com)
Using this new model system we also tested the hypotheses that 1) declining concentrations of anti-CD154 mAb in the circulation 2 deletion of CD4+ regulatory cells and 3) activation of allo-reactive CD8+ cells would correlate with eventual graft rejection. (palomid529.com)
In the second, researchers employed another approach to convert mature mouse endothelial cells, which line the inside of blood vessels, directly into self-renewing HSCs. (nih.gov)
When these HSCs were transplanted into mice, they fully reconstituted the animals' blood systems with healthy red and white blood cells. (nih.gov)
Those HSCs ultimately find their way into the bone marrow, where they produce a lifetime supply of blood cells. (nih.gov)
In the parallel study, Raphael Lis and Shahin Rafii from Weill Cornell Medicine, New York, began with readily accessible endothelial cells taken from the organs of adult mice. (nih.gov)
Daley's team matured those human HSC-like cells by transplanting them directly into the bone marrow of living mice. (nih.gov)
Lis and Rafii instead grew the emerging mouse HSCs on a layer of endothelial cells in a dish, where they acquired the attributes of fully functional HSCs, and later were transplanted into mice. (nih.gov)
In the mice, stem cells generated using both approaches took up residence in the bone marrow as expected. (nih.gov)
since the new organs would be made from their own cells, they wouldn't have to worry about organ rejection. (the-scientist.com)
The study demonstrates how injecting mice with early outgrowth cells (EOCs), after first treating the cells with chemicals to activate a type of protein called liver x receptor (LXR), slows the development of this disease. (stemcellsportal.com)
This rejection is due to the body's immune system labeling the cells as "foreign invaders" and setting in motion a series of strategies intended to ward off what it deems an attack - leaving researchers scrambling for a way around this protective measure. (stemcellsportal.com)
What is radically new and is causing a change in the way we view health and wellness is the discovery that adult stem cells in the bone marrow have the ability to become virtually any kind of cell types in the body. (myradiary.com)
B cells in the bone marrow divide to create new cells, but what's special here is that each daughter cell is different from its parent as well as from all its siblings. (oxsci.org)

In a case of hybrid resistance, the parental bone marrow (BM) graft is rejected by F1 generation in murine model. (wikipedia.org)

These data establish a method for the ex vivo generation of graft-reactive, functional mouse and human T(regs) that uses a clinically approved agent, making pharmacological PDE inhibition a potential strategy for T(reg)-based therapies. (lu.se)
Using an in vivo skin graft model, we evaluated DCs tolerogenicity. (uandes.cl)
In vivo, skin-grafted mice treated with Rapa-mDCs show high allograft survival, accumulation of Foxp3 + Tregs and cytokine pattern modification. (uandes.cl)

Overall, no association was establish between the IL-10 gene polymorphism and graft rejection endanger. (upb.ro)

RESULTS: Monoclonal antibody therapy rendered Fas mutant mice tolerant of minor disparate skin and bone marrow. (ox.ac.uk)
Furthermore, CD154 deletional mice irradiated with 200 cGy irradiation were not tolerant of grafts, suggesting that engraftment promotion by anti-CD154 mAb may not simply be the result of CD154:CD40 blockade. (umn.edu)

Farrell made it clear that Planned Parenthood had been involved in the selling of aborted baby parts for some time and was very familiar with the use of fetal remains in the production of humanized mice. (traditioninaction.org)
VM), showed that the recovery of motor functions induced implanted either (1) as a solid piece in the lateral ven- by the grafted fetal dopamine neurons was well cor- tricle6 or a cortical cavity8 adjacent to the denervated related with the extent of graft-derived reinnervation caudate-putamen, or (2) as a crude cell suspension of the host caudate-putamen. (lu.se)

Such studies eldepryl wikiarms 308 communique used an isogenic manful-into-femasculine bone marrow reconstitution after mortal irradiation, and engraftment was followed using analysis of Y-chromosome-specific DNA probes during in situ hybridisation (ISH), whether chromogenic or fluorescent (FISH). (upb.ro)

The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)
External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. (medscape.com)

The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host. (lookformedical.com)

The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin. (lookformedical.com)

Researchers in Jun Wu's lab compare normal mouse embryos (left) to horse-mouse chimeric embryos (right) to identify barriers to interspecies chimerism. (the-scientist.com)

C57BL/6NHsd splenocytes were incubated simultaneously with PE-conjugated anti-mouse CD3e mAb 145-2C11 (Cat. (bdbiosciences.com)
Materials and Methods Animals CBA/JCr (H-2k) C57BL/6 (H-2b) and BALB/c (H-2d) mice were obtained from the National Cancer Institute (Frederick MD). (KB5 × CBA/JCr)F1 TCR-transgenic mice were obtained from a colony maintained in our facility (28). (palomid529.com)

100 d), the histological grade of rejection was significantly lower than that of Group II, so did the expression level of IL-2 and IFN-γ in both peripheral blood and grafted liver. (zju.edu.cn)

In order to understand why rejection occurs and how it may be prevented, it is necessary to know something of the operations of the immune system. (britannica.com)

Obstruction of flow in biological or prosthetic vascular grafts. (lookformedical.com)

In group II, seen as a removal of intermediate amounts of lymphocytes with this pretransplantation period, 6/17 individuals got rejections and 3 grafts had been dropped. (onlycoloncancer.com)

Objective: To study the effect and implication of nonmyeloablative donor specific bone marrow (DSBM) infusion on the immunoreaction of liver allotransplantation. (zju.edu.cn)

They infected mice with CMV so that the animals experienced the primary infection followed by virus dormancy, as a person would. (sciencedaily.com)

Another group of short-term CsA treatment preoperatively without bone marrow infusion was also set as control. (zju.edu.cn)

Abstract Mice expressing the immunoglobulin (Ig) heavy (H) chain variable (V) region from a rearranged V H 12 gene inserted into the IgH locus genetariff predominantly B-1 apartments, whereas countenance of two buy eldepryl (selegiline) online without prescription other V H region transgenes (V H B1-8 and V H glD42) leads to the all but exclusive generation of conventional, or B-2, stalls. (upb.ro)

Aim: To date, there is no human dendritic cell (DC) based therapy to prevent allograft rejection in transplanted patients. (uandes.cl)

Jun Wu helped create rat-mouse chimeras like those pictured above. (the-scientist.com)

Stopping rules were built into the study so that if too many patients either rejected their grafts or developed moderate to severe GVHD, the study would move to the 2nd cohort. (nih.gov)

The discovery, to be published in Science 's Jan. 18 issue, used a newly developed mouse model and could pave the way for cheaper, safer therapies to protect patients from CMV. (sciencedaily.com)

The studies discussed in this presentation have shown that CD8 T lymphocytes have a primary role in conferring resistance to MCMV in the immunocompetent BALB/c mouse. (shengsci.com)
The protective CTL response to MCMV, at least in BALB/c mice, is elicited by a single epitope encoded by the major ie 1 and expressed in protein pp89. (shengsci.com)

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