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  • antigens
  • Limiting dilution analysis was used to assess helper-T-lymphocyte reactivity to donor antigens. (harvard.edu)
  • MHC-Restricted cytotoxic T-Cell: studies on the biological role of polymorphic major transplantation antigens determining t-cell restriction specificity, function, and responsiveness. (springer.com)
  • HLA-identical siblings or HLA-identical unrelated donors often have genetically different proteins (called minor histocompatibility antigens) that can be presented by Major histocompatibility complex (MHC) molecules to the donor's T-cells, which see these antigens as foreign and so mount an immune response. (wikipedia.org)
  • donation
  • The eligibility criteria for a stem cell donor are essentially the same as for blood donation. (medscape.com)
  • However, certain donors with these diseases may still be considered for donation on a case-to-case basis. (medscape.com)
  • Accordingly, all donors should be evaluated for the possibility of general anesthesia during the donation process. (medscape.com)
  • 56% of donors stated they benefited from donation. (aappublications.org)
  • 13 - 15 Across these studies, both positive and negative psychosocial consequences of typing and donation are reported, including sibling donors' lack of choice, lack of appropriate information, and need for greater support. (aappublications.org)
  • Before donation, a drug is injected into the donor, which increases the number of stem cells into their body. (wikipedia.org)
  • clinical
  • A number of clinical trials have proved the superiority of this method over collection from the bone marrow. (medscape.com)
  • John Raymond Hobbs MRCS, FRCP, FRCPath, FRCPaed (17 April 1929 - 13 July 2008) was a professor who was at the forefront of the techniques of clinical immunology, protein biochemistry and bone marrow transplantation, specifically in child health. (wikipedia.org)
  • adults
  • As for the children who were treated by Professor Hobbs's bone marrow team at the Westminster hospital, most of these children now enjoy full lives as adults. (wikipedia.org)
  • Bone marrow failure in both children and adults can be either inherited or acquired. (wikipedia.org)
  • siblings
  • We recommend education for all siblings before typing, comprehensive education for the donor by a health care provider pretransplant, and systematic donor follow-up after transplantation. (aappublications.org)
  • One barrier to determining appropriate stringency for a donor protection policy is the relative lack of empirical data regarding the experience of families and specifically siblings who are typed and/or serve as donors. (aappublications.org)
  • Research
  • Early research in bone marrow transplantation by E. Donnall Thomas and colleagues demonstrated that this process of splitting TBI into multiple smaller doses resulted in lower toxicity and better outcomes than delivering a single, large dose. (wikipedia.org)