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  • acute myocardial
  • Cells extracted from umbilical cord, also known as Human Umbilical Cord PeriVascular Cells, were more effective in restoring heart function following acute myocardial infarction. (medindia.net)
  • TORONTO, Ontario (13 November, 2012) - A study published this month by researchers at the University of Toronto and Toronto's Princess Margaret Hospital has shown that cells derived from the umbilical cord, "Human Umbilical Cord PeriVascular Cells" (HUCPVCs), are more effective in restoring heart function after an acute myocardial infarction (in common parlance, a heart attack) in a pre-clinical model than a similar cell population derived from bone marrow. (bio-medicine.org)
  • autologous
  • Beginning in 2001, a phase-1 equivalent feasibility and safety evaluation of intramyocardial injection of autologous CD133+ bone marrow cells during elective CABG surgery was conducted at Rostock University. (clinicaltrials.gov)
  • A total of 60 patients will therefore be enrolled in the study and will be randomized to undergo either CABG surgery and injection of placebo or in conjunction with intramyocardial injection of autologous CD133+ enriched bone marrow cells. (clinicaltrials.gov)
  • Mitotic
  • MarrowMAX™ medium far outperforms commercially available formulations supplemented with giant cell tumor (GCT) conditioned media (Figure 1), providing consistent lot-to-lot performance (Figure 2) with a higher mitotic index and superior chromosome morphology. (thermofisher.com)
  • Mitotic cells were assayed 24 hrs after plating. (thermofisher.com)
  • Irvine Scientific's CHANG Marrow ® and CHANG BMC ® are optimized for short-term bone marrow culture, and provide consistent mitotic cells that are suitable for karyotyping and a more accurate cytogenetic analysis. (irvinesci.com)
  • umbilical
  • He is also interested in conducting further research with the umbilical cord cells to overcome the damaging effects of chemotherapy on heart tissue, an agonizing problem for some patients who may be cured of their cancer only to confront heart failure as a result of treatment. (healthcanal.com)
  • But the new study, headed by Dr. Armand Keating, now suggests that umbilical cord cells outperform bone marrow cells in improving heart muscle function. (bio-medicine.org)
  • scientists
  • Scientists have discovered a new way to replicate the regenerative power of stem cells in the lab, which could lead to powerful treatments for injuries and diseases. (phys.org)
  • Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have made a major advance in understanding how the cells of an organism, which all contain the same genetic information, come to be so diverse. (phys.org)
  • Scientists have long assumed that once the inflammatory response concludes, the white blood cells mostly either then die or go into circulation in the bloodstream. (innovations-report.com)
  • Now, scientists have combined stem cells and other cells from bone marrow to promote a drug-free organ tolerance. (zdnet.com)
  • This, say the scientists, is proof that circulating bone marrow stem cells do not normally produce new eggs. (ivf.net)
  • placebo
  • In the study, 50 patients who were ineligible for conventional revascularization received the bone marrow cell injections or received a placebo. (thefreedictionary.com)
  • Sixty patients who had myocardial infarction in the past and now need bypass surgery for ongoing coronary artery disease will undergo either bypass surgery and placebo treatment or bypass surgery and injection of CD133 bone marrow cells directly in the heart muscle. (clinicaltrials.gov)
  • The study will be fully blinded, i.e. neither the patient nor the surgeon knows what substance is injected (placebo or cell product). (clinicaltrials.gov)
  • Bone marrow will be harvested one day prior to surgery and a CD133-enriched cell product (or placebo) will be prepared on-campus. (clinicaltrials.gov)
  • Random allocation will be performed in the cell production facility, so that neither the patient nor the surgeon nor any of the persons involved in follow-up examinations will know whether the cell product or placebo was administered. (clinicaltrials.gov)
  • findings
  • The findings will be published in the Sept. 3 issue of Stem Cells. (innovations-report.com)
  • If these findings can be confirmed, bone marrow cells might clearly play a role in the adaptive increase in β-cell mass that occurs physiologically during, for example, obesity and pregnancy. (diabetesjournals.org)
  • Conclusions: These findings provide novel evidence that alterations to the bone marrow play a role in the anti-tumor activity of ZOL and suggest possibilities for capitalizing on the beneficial effects of ZOL in reducing breast cancer development and progression. (harvard.edu)
  • tissues
  • This research uses bone marrow cells to fuse with a patient tissues so that nothing transplanted is rejected by our immune systems, and brings universal graft survival closer to reality. (redorbit.com)
  • Rejection
  • Although more work is necessary to determine the exact clinical outcomes, the discovery raises the possibility that bone marrow cells could be fused to transplant organs to reduce the likelihood of rejection. (redorbit.com)
  • A mix of bioengineered cells can mean that transplant recipients no longer need to take a lifetime of anti-rejection drugs. (zdnet.com)
  • Cytogenetic Effects
  • In the present study, cytogenetic effects of Indian chrysotile asbestos in rat bone marrow cells after 290 days of intratracheal inoculation, when it develops massive pulmonary fibrosis, were investigated. (osti.gov)
  • organ
  • These observations are compelling, as circulating myo-miRs are not only a bio-marker, but also a functional constituent of the intricate crosstalk between the ischemic heart and the remote bone marrow organ. (infowars.com)
  • Chromatid
  • Chromatid and chromosome aberrations were investigated in 100 metaphase cells per animal and percent micronuclei frequencies were investigated in 1,000 metaphase cells per animal. (mdpi.com)
  • therapy
  • The study used standard heart function tests to measure the effect of the therapy after the cells were injected. (healthcanal.com)
  • Keating, director of the Cell Therapy Program at the Princess Margaret Cancer Centre and University Health Network (UHN), said he hopes to begin clinical trials of the HUCPVC cells on patients within the next 12 to 18 months. (healthcanal.com)
  • However, until this controversy has been resolved, bone marrow cells continue to be promoted as a candidate source for cell replacement therapy for diabetes ( 31 ). (diabetesjournals.org)
  • Standard heart function tests measured the effect of the therapy after the cells were injected. (bio-medicine.org)
  • transplant
  • The team made those stem cells more 'transplant-friendly' by enriching them with graft-facilitating cells and removing GvHD-causing cells. (zdnet.com)
  • We may actually be able to use a person's own bone marrow cells and get them to differentiate into [liver cells} and then transplant them back into [the person's] own liver without having to go through the trauma of a liver transplant," said Bryon Petersen of the University of Pittsburgh, Penn. (thefreedictionary.com)
  • Some transplant recipients have been found to have cells in their uterus that come from the donor. (clinicaltrials.gov)
  • Hematologic pre-transplant conditioning information will be correlated with these research studies to identify factors that may assist with the understanding of adult endometrial stem cell biology. (clinicaltrials.gov)
  • study
  • Nov. 26 (UPI) -- Breast cancer tumors can grow by recruiting other cells from bone marrow, lowering the chances of a patient's survival, a new study says. (upi.com)
  • A study published in the Journal of Experimental Medicine found that cells found in breast cancer tumors can strengthen themselves by pulling in non-cancerous fibroblasts originally formed in bone marrow called mesenchymal stromal cells, or MSCs. (upi.com)
  • Our study shows that the recruitment of bone marrow-derived fibroblasts is important for promoting tumor growth, likely by enhancing blood vessel formation," Neta Erez, researcher at Sackler School of Medicine, Tel Aviv University, said in a press release. (upi.com)
  • The Heeschen study demonstrates that the Harvest BMAC System is, in fact, capable of producing a bone marrow cell composition that is equal to, and may in fact be clinically superior to, the cell composition prepared by the gold standard. (thefreedictionary.com)
  • Left ventricular function and exercise capacity increased, while the area of the heart muscle damaged shrank, in 18 patients given infusions of their own bone marrow cells up to eight years after a heart attack, according to a new study. (thefreedictionary.com)
  • The purpose of this study is to evaluate the safety and effectiveness of a gene transfer procedure in generating new, healthy cells in individuals with FA. (clinicaltrials.gov)
  • Participants will be required to have the initial bone marrow transfer procedure performed at Cincinnati Children's Hospital, but will be allowed to see their own doctor for the majority of study visits. (clinicaltrials.gov)
  • To collect cells from the uterus to study how stem cells work in the reproductive tract. (clinicaltrials.gov)
  • To study if endometiral stem cells are different in normal and disease states. (clinicaltrials.gov)
  • The results of that study indicate that the additional cell injection yields a better left ventricular contractility than CABG alone (LVEF = 47.1±8% vs. 41.3±9% at 6 months). (clinicaltrials.gov)
  • functional
  • Although a number of studies do suggest the existence of subpopulations of B-cells, a system of functional markers analogous to the Lyt system of T-cells has not yet been defined. (springer.com)
  • abnormal
  • Chapters cover methods of culture, observation and evaluation of cell cultures, cultures of normal and abnormal blood and bone marrow cells, and effect of nutrients and stimulants and of cytotoxic therapeutic agents. (annals.org)
  • adhesion
  • Also disclosed is a method for detecting binding between cell adhesion membrane proteins and cells having a potential to be bound to such proteins. (google.com)
  • examining the stained cells adhering to the blotting material for indications of adhesion of the cell adhesion molecule proteins to the applied cells, wherein said subjecting and/or said contacting is effective to clear lithium dodecyl sulfate from the cell adhesion molecule proteins. (google.com)
  • growing cells bound to cell adhesion molecule proteins on the blotting material, prior to said staining. (google.com)
  • 7. A method according to claim 1, wherein the cell adhesion molecule proteins have an unknown identity and the cells have a known identity. (google.com)
  • The present invention relates to bone marrow cell adhesion molecules and a method for detecting adherence between cell adhesion molecules and cells. (google.com)
  • Effect of surface roughness of hydroxyapatite on human bone marrow cell adhesion, proliferation, differentiation and detachment strength. (nih.gov)
  • Cell adhesion, proliferation and differentiation (evaluated with the expression of ALP activity) were determined following various incubation periods. (nih.gov)
  • Cell adhesion, proliferation and detachment strength were surface roughness sensitive and increased as the roughness of HA increased. (nih.gov)
  • function
  • So, to create an environment where two bone marrow systems exist and function in one person , a team led by Suzanne Ildstad the University of Louisville looked to bioengineered versions of cells from donor bone marrow. (zdnet.com)
  • Nerve cells that have not merged with the insulin-producing bone marrow cells remain intact and function normally. (innovations-report.com)
  • Understanding the function of these cancer-associated fibroblasts could form the basis of developing novel therapeutic manipulations that co-target bone marrow-derived fibroblasts as well as the cancer cells themselves," Erez said. (upi.com)
  • The percentage of the adherent cells decreased in a sigmoidal mode as a function of the applied shear stress. (nih.gov)