Markers macrophages. Medical search. Frequent questions

When there are lipopolysaccharide (LPS), tumor necrosis factor (TNF)-α, or interferon (IFN)-γ, macrophages adopt M1 phenotype and produce cytokines, such as IFN-γ, TNF-α, interleukin (IL)-6, IL-12, and reactive oxygen species (ROS). (creative-biolabs.com)
In the context of acute kidney injury, M-CSF has been implicated in promoting repair following injury, but also been described in an opposing role, driving proliferation of a pro-inflammatory macrophage phenotype. (wikipedia.org)
In this work, we demonstrate a consistent down-regulation of TSPO mRNA and protein in macrophages activated to a pro-inflammatory, or 'M1' phenotype. (ox.ac.uk)
Conversely, stimulation of macrophages to an M2 phenotype with IL-4, dexamethasone or TGF-β1 did not alter TSPO expression, regardless of MDM source. (ox.ac.uk)
For example, organs like the lung and the liver are exposed to pathogen components from the air or from the gut barrier, respectively, which explains the predominance of a macrophage phenotype that has a higher capacity for phagocytic clearance of pathogen components. (hindawi.com)
The present in vitro research work studied the interactions between expanded Tregs and activated monocytes and macrophages, and the ability of immunomodulatory drugs and other Treg-enhancing therapies to increase Treg anti-inflammatory function and suppress the pro-inflammatory function of the M1 phenotype of activated monocytes and macrophages. (businesswire.com)
Low AKR1B10 expression induced M2 macrophage polarization and promoted the malignant phenotype of GC. (portlandpress.com)
The primary aim of the present study was to determine the immunological phenotype of NSCLC-associated macrophages. (ersjournals.com)
CD68 + macrophages expressing markers of a cytotoxic M1 phenotype or a noncytotoxic M2 phenotype were identified in the islets and stroma of surgically resected tumours from 20 patients with extended survival (median 92.7 months) and 20 with poor survival (median 7.7 months), using immunohistochemistry. (ersjournals.com)
Macrophages infiltrating the tumour islets in nonsmall cell lung cancer were predominantly of the M1 phenotype in patients with extended survival. (ersjournals.com)
The M1 phenotype (classically activated) macrophages are thought to be induced by interferon-γ, with or without lipopolysaccharide and tumour necrosis factor (TNF)-α, and exert a cytotoxic effect against cancer cells. (ersjournals.com)
Additionally, M2 macrophages have been traditionally thought of as being the predominant macrophage phenotype in solid tumours (tumour-associated macrophages). (ersjournals.com)
Alternative polarization with interleukin-4 and IL-13 led to a macrophage phenotype characterized by increased tissue factor (TF) production and release and by an increase in extracellular vesicle production. (haematologica.org)
In conclusion, we provide evidence that proinflammatory polarization of macrophages does not lead to enhanced procoagulatory function, whereas alternative polarization of macrophages leads to an increased expression of TF and increased production of TF bearing extracellular vesicles by these cells suggesting a procoagulatory phenotype of alternatively polarized macrophages. (haematologica.org)
This macrophage polarization can be simulated in vitro using lipopolysaccharide (LPS) and interferon (IFN)-γ stimulation for a proinflammatory subset termed classical activation and stimulation with interleukin (IL)-4 and IL-13 for an alternative polarization phenotype. (haematologica.org)
4 Upon polarization, macrophages react to the respective stimulus with the expression of a distinct phenotype. (haematologica.org)

In the present study, increased infiltration of macrophages into the tumor microenvironment (TME) was significantly associated with shorter overall survival and increased resistance to chemotherapeutic drugs, particularly DTX, in patients with HNSCC. (nih.gov)
Arsenic trioxide (ATO) reduced macrophage infiltration into the TME and impaired IL-1β secretion by macrophages. (nih.gov)
Results: Macrophage polarization was the main immune infiltration pattern in GC, and the state of macrophage polarization was closely related to the pathological grading of GC and the clinical stage of patients. (portlandpress.com)
Conclusion: M2 macrophage polarization is the main immune infiltration pattern in GC. (portlandpress.com)
The survival advantage conferred by islet macrophage infiltration may be related to their cytotoxic antitumour activity. (ersjournals.com)
The present study revealed that obese OA patients and Apoe −/− mice showed a more pronounced synovitis and enhanced macrophage infiltration in synovial tissue, accompanied by dominant M1 macrophage polarization. (elifesciences.org)
In this study, the authors demonstrated that patients with obese-OA and mice with ApoE deficiency showed phenotypes of synovitis and enhanced macrophage infiltration in synovial tissues. (elifesciences.org)
This effect was correlated with reduced glucose intolerance, body weight gain, fat mass development, lower inflammation, oxidative stress, and macrophage infiltration marker mRNA expression in visceral adipose tissue. (diabetesjournals.org)
The number and diameter of lung vessels and macrophage infiltration were assessed using immunofluorescence staining. (spandidos-publications.com)

In vivo , there is a spectrum of macrophage phenotypes exists, and in vitro , there is low or non-selective M2 marker protein expression. (creative-biolabs.com)
This study aims to explore the energy metabolism of macrophages under either inflammatory or anti-inflammatory conditions by adding LPS and Met, respectively, using an in vitro and an in vivo model. (nature.com)
To delineate the molecular target of Karanjin, in vitro study on LPS induced macrophages were performed at calibrated non toxic doses (4-μg/mL and 6-μg/mL). (caluniv.ac.in)
Results of the in vitro study in samples from ALS patients highlight the deleterious role of M1 pro-inflammatory monocytes and macrophages in the ability of Tregs to maintain their immunomodulatory anti-inflammatory function and achieve immune homeostasis. (businesswire.com)
30% of untreated, human derived macrophages in vitro, while slightly downregulating SR expression. (escholarship.org)
A soluble form of CD206 is generated by cleavage of the full-length protein, and it can be detected in in vitro macrophage cell culture supernatants and in mouse serum. (fishersci.com)

Here, we have further characterized the process of PCMO generation with respect to markers of monocyte-to-macrophage transition and pluripotency. (uni-luebeck.de)
The N-glycome showed a dramatic change during human monocyte-to-macrophage transition ( 17 ) and murine macrophage polarization ( 18 ). (frontiersin.org)

Subject: [Histonet] Macrophage marker mouse tissue In my experience, Serotec's CD68 clone FA-11 is a much better tissue macrophage marker than F4/80, which is not expressed on all macs (i.e. lung). (utsouthwestern.edu)
Messenger RNA levels of CD68, a marker of endocytosis, were increased 1.4 to 2.4-fold in lungs that contained alveolar macrophage accumulations. (hw.ac.uk)
Cytoplasmic immunostaining related to the CD68 protein was increased 1.43 to 5.66-fold when the alveolar macrophage accumulations were numerous, large and associated with neutrophils and lymphocytes. (hw.ac.uk)
General Description of CD68 (Macrophage Marker). (enquirebio.com)
enQuire Bio's product, CD68 (Macrophage Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). (enquirebio.com)
In conjunction, there was a reduction in IBA1-positive macrophages in the outer retina compared to the WT mice and a decrease in the number of CD68-positive cells in the outer nuclear layer and the subretinal space. (molvis.org)

M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell cytotoxicity. (wikipedia.org)
Macrophage abundance and phagocytosis were assessed with immunolabeling for pan-macrophage and phagocytic markers, in conjunction with TUNEL staining in cohorts of C3 KO and WT mice. (molvis.org)
Intra-articular injection of GAS6 restored the phagocytic capacity of macrophages, reduced the accumulation of local ACs, and decreased the levels of TUNEL and Caspase-3 positive cells, preserving cartilage thickness and preventing the progression of obesity-associated OA. (elifesciences.org)
Intra-articular injection of GAS6 restored the phagocytic capacity of macrophages, decreased synovial cell apoptosis, and prevented OA progression in obese-OA mice. (elifesciences.org)

The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which causes hematopoietic stem cells to differentiate into macrophages or other related cell types. (wikipedia.org)
Macrophage colony-stimulating factor has been shown to interact with PIK3R2. (wikipedia.org)
In macrophage-colony stimulating factor (MCSF) generated macrophages, Sia + IgG induced increased production of numerous cytokines/ chemokines including IL-6, TNFα, CXCL1, and IL-10, and the expression of the macrophage surface marker CD163. (scirp.org)

There is a spectrum of macrophage phenotypes and functions, due to the diversity and overlap of cues in the microenvironment. (creative-biolabs.com)
As a consequence of the immunosuppressive tumor microenvironment, tumor-associated macrophages (TAMs) are reported to be M2-like macrophages, playing a critical role in tumor growth, invasion, and metastasis. (creative-biolabs.com)
Macrophages, which are functional plasticity cells, have the ability to phagocytize and digest foreign substances and acquire pro-(M1-like) or anti-inflammatory (M2-like) phenotypes according to their microenvironment. (frontiersin.org)
Recent evidence, however, supports a dual role for macrophages in the regulation of tumour proliferation and immune control 10 , 16 , and indicates that the local tissue microenvironment plays a critical role in determining cell phenotypes. (ersjournals.com)
The present study found that synovial macrophages infiltrated and polarized in the obesity microenvironment and identified the essential role of M1 macrophages in impaired macrophage efferocytosis using pathology analysis of obesity-associated OA. (elifesciences.org)
In the local tumour microenvironment, elevated glucose levels, the presence of tumour-associated stellate cells and macrophages are hypothesised to promote the tumour progression and invasion. (lu.se)

Overexpression of macrophage migration inhibitory factor (MIF) was identified in human GBM specimens that were MGMT methylated but showed poor survival. (nature.com)

Lysozyme is an inducible marker of macrophage activation in murine tissues as demonstrated by in situ hybridization. (ox.ac.uk)
It stains macrophages in a wide variety of human tissues, including Kupffer cells and macrophages in the red pulp of the spleen, in lamina propria of the gut, in lung alveoli, and in bone marrow. (enquirebio.com)
Most tissues harbor resident mononuclear phagocytes, that is, dendritic cells and macrophages. (hindawi.com)
Mononuclear phagocytes are a group of phenotypic distinct members, often referred to as either macrophages or dendritic cells (DC), that derive from myeloid precursors and that contribute to the functions of peripheral tissues [ 1 ]. (hindawi.com)
All solid organs and most other tissues harbor a network of DC or macrophages (Table 1 ). (hindawi.com)
Tumor markers are soluble glycoproteins that are found in the blood, urine, or tissues of patients with certain types of cancer. (medscape.com)
Macrophages are phagocytes found in tissues and maintain tissue homeostasis, regulate inflammation, and play a significant role in host protection. (frontiersin.org)
Traditionally, CSCs are identified through a combination of surface markers, however, there is a lack of consensus among the scientific community, especially as these combinations appear to be specific to the corresponding tissues and tumors. (springer.com)
Macrophages reside in all tissues of the body and each population of macrophages within a tissue can take on specialized functions that are tuned to the developmental and functional requirements of that tissue. (haematologica.org)

Soluble CD163 (sCD163) is a macrophage specific protein known to be up-regulated in serum from patients with multiple sclerosis (MS). (nih.gov)
We noted direct coculturing increased stemness among CSC populations and induced both M1 (CD80 and HLA-DR) and M2 (CD163) tumor associated macrophage polarization. (springer.com)

Our data extended prior observations of Sia + IgG on DC function and showed that Sia + IgG was able to differentially modulate multiple pathways in monocytes and macrophages. (scirp.org)
D. Bruder, E. , O. Richards, J. , M. Michel, K. and Oaks, M. (2016) Differential Effects of Alternative Glycoforms of IgG on Human Monocytes and Macrophages: Sialylated IgG Induces Novel Expression Signatures of Cell Surface Markers, Cytokines, and Chemokines. (scirp.org)
M1 activated monocytes and macrophages reduce Treg viability and upregulate apoptosis markers. (businesswire.com)

Macrophage secretion of IL-1β was found to induce tumor expression of ICAM1. (nih.gov)
We have previously shown that the sialic acid-containing (Sia + ) fraction of intravenous immune globulin (IVIG) influences cell surface marker expression and cytokine/ chemokine secretion during the differentiation and maturation of human dendritic cells (DC). (scirp.org)
The present study examined the effects of Sia + IgG on human peripheral blood mononuclear cell (PBMC)-derived monocyte and macrophage surface marker expression and cytokine/chemokine secretion. (scirp.org)
We designed a new class of composite AScMs incorporating lithocholic acid (LCA), a natural agonist for the TGR5 receptor that is known to counteract atherosclerotic inflammation, with two complementary goals: to simultaneously decrease lipid uptake and inhibit pro-inflammatory cytokine secretion by macrophages. (escholarship.org)
Enhanced M1-polarized macrophages in obese synovium decreased growth arrest-specific 6 (GAS6) secretion, resulting in impaired macrophage efferocytosis in synovial ACs. (elifesciences.org)
GAS6 secretion is decreased during M1 macrophage polarization during obese-OA, leading to impaired macrophage efferocytosis in synovial apoptotic cells. (elifesciences.org)

Therefore, studying the correlation between inflammation and macrophage mitochondrial function could lead to a better understanding of the link between inflammation and diseases. (nature.com)

Sia + IgG also increased the expression of cell surface markers associated with macrophage polarization (e.g. (scirp.org)
Low AKR1B10 expression induces M2 macrophage polarization and promotes the malignant transformation of GC. (portlandpress.com)
These studies suggest that there is a bi-directional crosstalk between macrophages and CSCs that promotes stemness renewal and tumor associated macrophage polarization. (springer.com)
To understand if polarization of macrophages can lead to a procoagulant macrophage subset we polarized human monocyte derived macrophages to a proinflammatory and an alternative activation state. (haematologica.org)

In addition, also TF activity was enhanced in extracellular vesicles of alternatively polarized macrophages. (haematologica.org)

M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. (wikipedia.org)
During a 6-day culture period, various monocyte/macrophage differentiation markers were down-regulated being indicative of a process of partial dedifferentiation. (uni-luebeck.de)
Expression of the pluripotency-associated OCT4A isoform was paralleled by a global rise in histone H3 methylation on Lys-4, a marker of active chromatin, and coincided with peak sensitivity to tissue-specific differentiation. (uni-luebeck.de)
In summary, co-culture with TPSCs induced molecular changes associated with EMT in pancreatic cancer cells, regardless of differentiation status, and the organotypic model demonstrated the influence of microenvironmental factors, such as glucose, stellate cells and macrophages, on pancreatic cancer cell invasion. (lu.se)

This study demonstrates the induction of lysozyme mRNA expression in situ in tissue macrophages (M phi) of mice following in vivo stimulation. (ox.ac.uk)
1 Some tissue macrophages and precursors are already established embryonically in the yolk sac and fetal liver before the onset of definitive hematopoiesis. (haematologica.org)

Messenger RNA levels of inducible nitric oxide synthase, a marker of classical (M1) activated macrophages was found to be increased 4.1-fold when neutrophils and lymphocytes were present amongst the accumulated alveolar macrophages. (hw.ac.uk)
Treatment of human alveolar macrophages (AMs) with the synthetic GC dexamethasone (Dex) did not alter the expression of TLRs −1, −4, and −6. (frontiersin.org)
Alveolar macrophages (AMs) are the tissue-resident macrophages in the lung alveolar space. (frontiersin.org)

Fig.1 Macrophage signature in classically activated M1 and alternatively activated M2 macrophages. (creative-biolabs.com)

Therefore, by leveraging the wealth of knowledge that we have on macrophage marker development, Creative Biolabs performs the most comprehensive analysis of the transcriptional signature of M1 and M2 macrophages in humans and mice. (creative-biolabs.com)
The markers identified could be used to distinguish between M1 and M2 macrophage, and better characterize TAM as well as other macrophage populations collected from humans and mice. (creative-biolabs.com)
In addition, the engulfment of TUNEL-positive and -negative photoreceptors by macrophages was significantly lower in the C3 KO mice cohort following photo-oxidative damage compared to the WT cohort. (molvis.org)

Novel markers to delineate murine M1 and M2 macrophages. (creative-biolabs.com)
In this study, murine peritoneal macrophages were isolated and then activated by LPS, HSV and VSV. (frontiersin.org)

urinary hydroxyproline and glucosamine, respectively, serum lysosomal enzymes responsible for articular cartilage damage, and major proinflammatory cytokine TNFα, secreted by macrophages involved in articular inflammation and destruction. (caluniv.ac.in)
Our data indicate that the Sia + fraction of IVIG possesses the ability to influence inflammatory processes in multiple immune cell types and induces novel signatures in cell surface marker expression and cytokine/chemokine production. (scirp.org)

Thus, organ- and disease phase-specific microenvironments determine macrophage and dendritic cell heterogeneity in a temporal and spatial manner, which assures their support to maintain and regain homeostasis in whatever condition. (hindawi.com)

The role of macrophage phenotypes in tumour progression has been extensively reviewed 6 - 10 . (ersjournals.com)

The macrophage marker translocator protein (TSPO) is down-regulated on pro-inflammatory 'M1' human macrophages. (ox.ac.uk)
Immunoflourescence images of expression of Nrf2 and HO-1 showing thealteration of key protein markers of antioxidant gene expression, read more in 'Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model' from Saha et al, in this edition of Bioscience Reports. (portlandpress.com)
Myeloid related protein (MRP) 8/14 expression by macrophages is associated with the release of TNF-α 12 . (ersjournals.com)

The interaction of GCs with macrophages in the immunosuppressive resolution phase upon prolonged TLR activation is widely unknown. (frontiersin.org)

Classically (M1) and alternatively activated (M2) macrophages exhibit distinct functions. (creative-biolabs.com)
M2 (alternatively activated) macrophages are thought to be modulated by IL-4 and -13 and associated with tumour formation. (ersjournals.com)
7 In contrast, alternatively activated macrophages are characterized by increased expression of IL-10 and of scavenger receptors. (haematologica.org)
Besides scavenging debris, promoting angiogenesis, tissue remodeling and repair, alternatively activated macrophages are able to fine tune inflammatory responses. (haematologica.org)

The same applies to the bone marrow that requires macrophages for the clearance of the nuclei that get expelled from erythroblasts during their maturation towards erythrocytes [ 8 ]. (hindawi.com)

Macrophage coculture induced expression of intercellular adhesion molecule 1 (ICAM1), which promotes stemness and the formation of polyploid giant cancer cells, thereby reducing the efficacy of DTX. (nih.gov)

Macrophages help maintain homeostasis. (creative-biolabs.com)

In summary, our data show that sTLR2 and full-length TLR2 are released by macrophages under anti-inflammatory conditions, which may contribute to GC-induced immunosuppression. (frontiersin.org)

On the other hand, M2 macrophages are induced by IL-4, IL-10, IL-13, or glucocorticoids, which produce anti-inflammatory cytokines, such as transforming growth factor (TGF)-β and IL-10. (creative-biolabs.com)
Macrophages play a significant role in many processes, such as the human immune function, parasite infection, and tissue remodeling by secreting cytokines and producing reactive oxygen and nitrogen intermediates. (frontiersin.org)

Messenger RNA levels of pro-inflammatory genes (such as E selectin) were found to be increased 2.2 to 4.4-fold in samples of lungs that contained alveolar macrophage accumulations but only when neutrophils and lymphocytes were visible amongst the accumulated macrophages in histological lung sections. (hw.ac.uk)

Supernatants of LPS/Dex-primed macrophages contained sTLR2, as demonstrated by Western blot analysis. (frontiersin.org)
EVs from macrophage supernatants were isolated by sequential centrifugation. (frontiersin.org)
These vesicles were identified as the source of full-length TLR2 in macrophage supernatants by Western blot and mass spectrometry. (frontiersin.org)

Macrophages have different activation states in different microenvironments ( 15 ) and pathogenic stimulation ( 16 ). (frontiersin.org)
In contrast to monocytes, human macrophages did not show increased tissue factor expression upon stimulation with lipopolysaccharide and interferon-γ. (haematologica.org)

Due to their considerable plasticity and heterogeneity, the tissue-based DC and macrophage populations have been defined as mononuclear phagocytes [ 1 , 6 , 7 ]. (hindawi.com)

The expression of markers of alveolar macrophage endocytosis, alveolar macrophage activation and lung inflammation were investigated by means of reverse transcriptase-polymerase chain reaction, immunohistochemistry and in situ hybridisation in samples of formalin fixed paraffin embedded lungs from male rats. (hw.ac.uk)

This slightly different perspective may somewhat shape our understanding of macrophage heterogeneity and tissue pathology but certainly also raise new questions for future research. (hindawi.com)

IL-1β neutralization and IL-1 receptor blockade reversed DTX resistance induced by macrophage coculture. (nih.gov)
Following verification of a stem-like signature (upregulated expression of stemness markers, resistance to chemotherapy, increased spheroid formation, and tumorigenesis capabilities despite inoculation of a small number of cells), we analyzed the interaction of these cells with macrophages via direct and indirect coculture assays. (springer.com)

The inability of proinflammatory activated macrophages to respond to lipopolysaccharide and interferon-γ with an increase in TF production seems to be due to an increase in TF promoter methylation and was reversible when treating these macrophages with a demethylation agent. (haematologica.org)
6 In addition, these cells are present during early wound healing and proinflammatory macrophages are characterized by a pronounced ability to degrade tissue. (haematologica.org)

Creative Biolabs has extensive experience in employing RNAseq and microarrays to evaluate how gene expression changes throughout the process of M1/M2 macrophage activation. (creative-biolabs.com)
This assay is also used to determine the expression kinetics of previously established markers as well as novel markers identified by this strategy. (creative-biolabs.com)
Its purported high expression on activated macrophages, has lent utility to TSPO targeted molecular imaging in the form of positron emission tomography (PET), as a means to detect and quantify inflammation in vivo. (ox.ac.uk)
However, existing literature regarding TSPO expression on human activated macrophages is lacking, mostly deriving from brain tissue studies, including studies of brain malignancy, and inflammatory diseases such as multiple sclerosis. (ox.ac.uk)
Here, we utilized three human sources of monocyte derived macrophages (MDM), from THP-1 monocytes, healthy peripheral blood monocytes and synovial fluid monocytes from patients with rheumatoid arthritis, to undertake a detailed investigation of TSPO expression in activated macrophages. (ox.ac.uk)
Differential expression of monocyte/macrophage-selective markers in human idiopathic pulmonary fibrosis. (sutterhealth.org)
M1 macrophages are associated with the expression of interleukin (IL)-1, -12, TNF-α and inducible nitric oxide synthase (iNOS) 7 . (ersjournals.com)

Toll-like receptors (TLRs) enable innate immune cells, such as macrophages, to recognize a wide variety of microbial ligands, thereby promoting inflammation. (frontiersin.org)
Macrophages are important immune cells that participate in both innate and adaptive immune responses, such as phagocytosis, recognition of molecular patterns, and activation of the immune response. (frontiersin.org)
Macrophages are immune cells widely distributed throughout the body and are components of innate immunity. (frontiersin.org)
Macrophages are cells of the innate immune system which play numerous and vastly different functions within the body. (haematologica.org)

While macrophage-induced inflammation is crucial for the response to pathogen infection, excessive or sustained inflammation can cause tissue damage and may lead to different conditions such as diabetes, cardiovascular diseases, and tumors 2 . (nature.com)
On the other hand, phagosomes are formed when the pathogen is engulfed by macrophages and fuse with lysosomes to release enzymes and toxic substances, resulting in killing or having cytotoxic effects on bacteria and tumor cells. (frontiersin.org)

Glycans are one of the four fundamental macromolecular components of all cells and are highly regulated in immune cells, including macrophages. (frontiersin.org)

Subject: [Histonet] Macrophage marker mouse tissue Hello, I am in need of a good macrophage marker on FFPE tissue. (utsouthwestern.edu)
Measuring the markers in FFPE lung samples can potentially help investigators discriminate adverse from nonadverse drug-induced alveolar macrophage accumulations with greater clarity and scientific rigour. (hw.ac.uk)

The two faces of tumor-associated macrophages and their clinical significance in colorectal cancer. (creative-biolabs.com)
Tumor markers are not elevated in all cancer patients, particularly patients with early-stage cancer. (medscape.com)
Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
Because pathologic diagnosis of ovarian cancer is difficult without laparotomy, tumor markers such as CA-125, in addition to diagnostic imaging, are useful in preoperative evaluation for ovarian cancer. (medscape.com)
No tumor markers with high sensitivity and high specificity for endometrial cancer are known at present, although CA-125 is often used in clinical practice. (medscape.com)
There is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC) expressing high numbers of macrophages in their tumour islets. (ersjournals.com)
The present authors have previously shown that the anatomical microlocalisation of macrophages in NSCLC strongly predicts patient survival, regardless of cancer stage 4 . (ersjournals.com)
After co-culture with tumour-associated pancreatic stellate cells (TPSCs), pancreatic cancer cells displayed up to 8-fold reduction in levels of epithelial-mesenchymal transition (EMT) markers E-cadherin and ZO-1, while β-catenin and vimentin levels were increased. (lu.se)
High glucose conditions further enhanced changes in EMT markers as well as the cancer cell invasion. (lu.se)

An intense signal was observed in cells in the red pulp in spleen and macrophages in lung. (enquirebio.com)
More moderate antibody staining intensity was present in cells in the red pulp in spleen and macrophages in lung. (enquirebio.com)

The various tumor markers differ in their usefulness for screening, diagnosis, prognosis, assessing therapeutic response, and detecting recurrence. (medscape.com)
Thus, increasing numbers of macrophages within the tumour islets conferred a marked survival advantage, while increased numbers of macrophages in the tumour stroma were associated with worse prognosis. (ersjournals.com)
The association between prognosis and islet macrophage count has been confirmed recently by others in an independent cohort of patients 5 but the stromal macrophage counts in that study were not associated with survival. (ersjournals.com)

It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. (bvsalud.org)

Many new tumor markers have been discovered since the development of monoclonal antibodies, and most tumor markers are now detected with them. (medscape.com)

We investigate the effect of C3 ablation on macrophage activity and phagocytosis by outer retinal macrophages during photo-oxidative damage. (molvis.org)
The results show that the absence of C3 mitigates the phagocytosis of photoreceptors by macrophages in the outer retina, and the net impact of C3 depletion is neuroprotective in the context of photo-oxidative damage. (molvis.org)

Macrophage activation syndrome--what's in a name! (jrheum.org)

The reasons for this are uncertain, but our study findings add some supporting evidence for recent investigations concluding that TSPO may be involved in negative regulation of inflammatory responses in macrophages. (ox.ac.uk)

It also reacts with plasmacytoid T cells, which are supposed to be of monocyte/macrophage origin. (enquirebio.com)
We also noted that CD11c positive dendritic cells but not F4/80 positive macrophages retained SWCNT in the lungs 9 days after pharyngeal aspiration. (cdc.gov)
In this paper we apply the tissue-centric perspective to discuss the role of resident and infiltrating macrophages and dendritic cells in different organs. (hindawi.com)
PCMOs expressed various markers of human embryonic stem cells with early induction of NANOG and OCT4. (uni-luebeck.de)
The large number of macrophages in the intestinal tract, play a significant role in maintaining the homeostasis of microorganisms on the surface of the intestinal mucosa and in the continuous renewal of intestinal epithelial cells. (frontiersin.org)
In addition, the effects of macrophages in the occurrence and development of inflammatory bowel disease (IBD), and their role in inducing fibrosis, activating T cells, reducing colitis, and treating intestinal inflammation were also reviewed in this paper. (frontiersin.org)
The lamina propria of the small intestine is the main site of the intestinal immune system, which contains a large number of macrophages, CD4 T cells, and dendritic cells. (frontiersin.org)
CD206 is a 175-kDa, type 1 integral membrane glycoprotein receptor that is present in macrophages, some dendritic cells, as well as liver and lymphoid endothelial cells. (fishersci.com)
Although CD4 T cells are the main targets of HIV infection, macrophages also become infected and resist the cytopathic effects of infection, contributing potentially to HIV reservoir persistence. (nih.gov)
Macrophages are versatile cells that can be polarized by the tissue environment to fulfill required needs. (haematologica.org)
The combined presence of TPSCs and M2-like macrophages induced invasion of the non-invasive BxPC-3 cells. (lu.se)

In order to be able to respond to multiple tasks, macrophages can adapt to the environment when exposed to specific cues. (haematologica.org)

A panel will discuss research gaps and priorities related to human macrophage reservoirs and inflammation/comorbidities and treatment strategies for HIV remission and cure. (nih.gov)

The sCD163 CSF/serum ratio was significantly increased in patients with MS and may reflect macrophage activation in MS lesions. (nih.gov)
In the extended survival group, M1 islet density was significantly increased compared with M2 density, 70% of islet macrophages were positive for M1 markers versus 38% for M2, and the islet:stromal ratio of M1 macrophages was markedly increased compared with M2. (ersjournals.com)

MRP 8/14 is enhanced by interferon-γ and lipopolysaccharide 13 , 14 , a characteristic of M1 macrophages, and also has bacteriostatic properties 15 . (ersjournals.com)

Anatomy36

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CD686

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