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Identification of Gene Expression-Based Prognostic Markers in the Hematopoietic Stem Cells of Patients With Myelodysplastic Syndromes. (stembook.org)
Strong ALDH1 expression correlates with higher stage of lung carcinoma making it a prognostic marker needing in-depth study. (ijpmonline.org)

These cells are defined as tumor-initiating cells or rare cells with indefinite potential for self-renewal that drives tumorigenesis [ 15 ]. (hindawi.com)

The finding is the first evidence of cancer stem cells in head and neck tumors. (innovations-report.com)
The sorted cells were then implanted into immune-deficient mice to grow tumors. (innovations-report.com)
The cells that expressed CD44 were able to grow new tumors, while the cells that did not express CD44 did not grow new tumors. (innovations-report.com)
The tumors that grew were found to be identical to the original tumors and to contain cells that expressed CD44 as well as cells that did not express the marker. (innovations-report.com)
The current finding in head and neck tumors does not pinpoint the exact stem cells, the researchers believe, but rather narrows down the field. (innovations-report.com)
One crucial ability of the CSCs is to form tumors already at low cell numbers. (atlasantibodies.com)
On the other hand, in brain tumors, such as glioma and glioblastoma, CSCs have instead been identified using cell surface markers, including SSEA-1 20 , EGFR 21 , and CD44 22 . (atlasantibodies.com)
In the next tables, we have selected our CSC markers for solid (Table 1) and hematological (Table 2) tumors. (atlasantibodies.com)
Recent research demonstrates that tumors originate from the Cancer S tem Cells (CSCs) or Tumor Initiated Cells (TIC) [ 1 ], which are called breast cancer stem cells in breast cancer. (omicsonline.org)
Here, we report that microRNA-584-3p (miR-584-3p) is up-regulated in hypoxic glioma cells and in high-grade human glioma tumors (WHO grades III-IV) relative to normoxic cells and to low-grade tumors (WHO grades I-II), respectively. (oncotarget.com)
Although Hürthle cell carcinoma was previously considered a variant of follicular cell neoplasms, which are generally less aggressive, the 2017 World Health Organization (WHO) classification of endocrine tumors reclassified it as a distinct entity. (medscape.com)
[ 5 ] The 2022 WHO classification of endocrine tumors has replaced the term Hürthle cell carcinoma with oncocytic carcinoma. (medscape.com)
Overall, only about 33% of Hürthle cell tumors demonstrate signs of that invasive growth that indicates malignancy and the possibility of metastasis. (medscape.com)
On balance, Hürthle cell tumors may be considered to be more likely to metastasize than follicular tumors. (medscape.com)
Permissive histologic interpretation may result in the designation of some non-neoplastic Hürthle cell lesions as malignant tumors. (medscape.com)

To investigate the involvement of stem cells in Epstein-Barr virus infection-related nasopharyngeal carcinoma (NPC), we used double immunofluorescence staining to examine several cancer stem/progenitor cell markers (CD44v6, CD24, and ALDH1A1) in NPC tissues and NPC cell lines. (hindawi.com)
Moreover, study of progenitor cells purified with Ep-CAM antibodies from D-galactosamine injured rat liver, a noncarcinogenic model of progenitor cell activation, verified that progenitor cells expressed these markers. (elsevierpure.com)
Our studies also reveal the mesenchymal/epithelial phenotype of these cells and the existence of species diversity in the hepatic progenitor cell identity. (elsevierpure.com)

Flow cytometry can discriminate CD34+CD38- LSC and normal haematopoietic stem cells (HSC) by using aberrant expression of markers and scatter properties. (eur.nl)

Retinal regeneration is known to occur in teleost fish, amphibians, and birds, due to the proliferation and differentiation of retinal stem cells located within the ciliary marginal zone. (rndsystems.com)
Müller stem cells have unlimited proliferation capacity in vivo , express stem-like markers (SOX2 and Notch-1), and are capable of generating retinal neurons. (rndsystems.com)
Wang G, Fang X, Han M, Wang X and Huang Q: MicroRNA-493-5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2. (spandidos-publications.com)
Hu D, Hu Y, Xu W, Yu H, Yang N, Ni S and Fu R: miR-203 inhibits the expression of collagen-related genes and the proliferation of hepatic stellate cells through a SMAD3-dependent mechanism. (spandidos-publications.com)
The breast cancer stem cells have the ability of infinite proliferation and multi-directional differentiation by themselves. (omicsonline.org)
Downregulation of CDCA5 Can Inhibit Cell Proliferation, Migration, and Invasion, and Induce Apoptosis of Prostate Cancer Cells. (nih.gov)
Hepatic progenitor/oval cells appear in injured livers when hepatocyte proliferation is impaired. (elsevierpure.com)

Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells. (cdc.gov)
P-selectin (marker for endothelial cell func- instructions. (who.int)

We detect mutational signatures in cancer cell line exomes (where matched healthy tissues are not available) by adjusting for the confounding germline mutation spectra across ancestries. (nature.com)
The staining intensity of 8-nitroguanine was significantly higher in cancer cells and inflammatory cells in the stroma of NPC tissues than in chronic nasopharyngitis tissues. (hindawi.com)
Expression levels of CD44v6 and ALDH1A1 were significantly increased in cancer cells of primary NPC specimens in comparison to chronic nasopharyngitis tissues. (hindawi.com)
8-Nitroguanine was detected in both CD44v6- and ALDH1A1-positive stem cells in NPC tissues. (hindawi.com)
Alternatively, NPCs can be isolated from fresh nervous tissues using cell sorting with NPC markers (PMID: 11121071). (sanbio.nl)
Among all cancerous cells, a few act as stem cells that reproduce and sustain the tumor, much like stem cells normally renew and sustain our organs and tissues. (atlasantibodies.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

A subset of NSCs is present in the developed nervous system and acts as a reservoir of cells for cell replacement and nervous tissue regeneration (PMID: 20110496). (sanbio.nl)
Figure 3) or PSA-NCAM are markers frequently used for intermediate progenitor cells and early immature neurons (PMID: 29625071). (sanbio.nl)
NPCs can be differentiated from embryonic stem cells (ESCs) but also from induced pluripotent stem cells (iPSCs) (PMID: 11731782). (sanbio.nl)
NPCs can additionally be obtained by direct reprogramming of somatic cells from different cell lineage (PMID: 22445518). (sanbio.nl)

CRISPR/Cas9 mediated knock-out of VPREB1 gene induces a cytotoxic effect in myeloma cells. (nih.gov)
Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway. (nih.gov)

The workflow quantifies nuclear and cytoplasmic markers and computes marker translocation between these compartments. (jove.com)
Historically, the Islet cell (cytoplasmic) autoantibodies (ICAs) and islet cell surface autoantibodies (ICSAs) [2] - [6] were initially described in the 1970s. (scirp.org)

Furthermore, these techniques rely upon irreversible antibody binding, potentially altering cell properties, including gene expression and regenerative capacity. (ca.gov)
The following product was used in this experiment: PAX8 (Renal Cell Marker) Recombinant Rabbit Monoclonal Antibody (ZR-1) from Thermo Fisher Scientific, catalog # 7849-RBM9-P1ABX. (thermofisher.com)
GL7 high-expressing B cells show higher antibody production and antigen presenting capacity. (biolegend.com)

Association studies implied specific oncogenic mutations in malignant cells as determinants of PC status. (lu.se)

Cancer precision medicine draws on the presence of somatically acquired changes in the tumor, which serve as predictive markers of response to drugs and other therapies. (nature.com)
It is paramount to identify predictive markers that are associated with failures of DNA maintenance in cancer cells. (nature.com)
We also aimed to determine the predictive strengths of both autoantibodies in the development of type-1 diabetes mellitus, and which of the two autoantibodies is a better predictive marker of type-1 diabetes mellitus among Nigerian adults. (scirp.org)
Using the response function, we could predict the morphological change from molecular activity and its predictive performance provides a new quantitative measure of how much the Rho GTPases participate in the cell migration. (nature.com)
Thus, our proposed predictive approach enabled us to uncover the hidden information processing rules of Rho GTPases in the cell migration. (nature.com)

Because of the above, other types of molecular markers may be more useful to infer about failed DNA repair. (nature.com)
NPCs are distinct from differentiated cells of the nervous system at the molecular level. (sanbio.nl)
CD45RA-positive LSC tended to represent more favourable cytogenetic/molecular markers. (eur.nl)
This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. (nih.gov)
In this approach, we performed FRET time-lapse imaging of Rac1 and Cdc42, members of Rho GTPases which are responsible for cell motility and quantitatively identified the response functions that describe the conversion from the molecular activities to the morphological changes. (nature.com)
To examine this issue, we focused on cell migration as a model biological system, because both molecular activity (as input signal) and morphological changes (as output signal) during cell migration can be monitored by FRET imaging. (nature.com)
Many studies have extensively investigated the molecular mechanisms involved in cell migration and have recognized the Rho small GTPases as key regulators of actin dynamics 7 , 8 . (nature.com)

Procedures are provided for perturbation of cells using siRNA and reliable methodology for marker detection by indirect immunofluorescence in 96-well formats. (jove.com)
In conclusion, CD45RA contributes to more accurate LSC detection and is recommended for inclusion in stem cell tracking panels. (eur.nl)
T. Twellmann, T.W. Nattkemper, W. Schubert, H. Ritter, Cell detection in micrographs of tissue sections using support vector machines, in: Proceedings of the ICANN: workshop on Kernel & Subspace Methods for Computer Vision, Vienna, Austria, 2001, pp. 79–88. (crossref.org)
Paraffin blocks were taken and stained by hematoxylin and eosin (Sigma) to make the histopathological diagnosis and immunohistochemistry was done for detection of CSC marker ALDH1 (Daco). (ijpmonline.org)

We also studied expression of the identified novel cell surface markers in fetal rat liver progenitor cells and FAO-1 hepatoma cells. (elsevierpure.com)
From the panel of 21 cell surface markers, 9 were overexpressed in fetal progenitor cells, 6 in FAO-1 cells and 6 are unique for the adult progenitors (CD133, claudin-7, cadherin 22, mucin-1, ros-1, Gabrp). (elsevierpure.com)

B cell- and BAFF-induced collagen secretion was highly reduced by anti-TGF-β1 antibodies. (ox.ac.uk)

Similarly, more intense staining of CD44v6 and ALDH1A1 was detected in an NPC cell line than in an immortalized nasopharyngeal epithelial cell line. (hindawi.com)
In addition, epithelial cell cycle G2/M arrest and production of profibrotic cytokines were both attenuated. (holyexperiment.org)

CD markers are cell surface proteins often used to determine the identity of various cell types. (cellsignal.com)
Novel cell surface markers in adult progenitor cells included tight junction proteins, integrins, cadherins, cell adhesion molecules, receptors, membrane channels and other transmembrane proteins. (elsevierpure.com)

NPC markers are also useful in establishing and monitoring in vitro NPC culture differentiation. (sanbio.nl)
For in vitro studies, a cardiomyocyte cell line of human origin, AC16, was treated with palmitate and the PPARβ/δ agonist GW501516. (nih.gov)
Additionally, miR‑197‑3p markedly inhibited the metastasis of HCC cells in vitro and in vivo. (spandidos-publications.com)
We aim to examine the in vitro algal cell response under specific stress conditions (variation of salinity and heavy metals). (irb.hr)

Neural stem cells (NSCs) are undifferentiated neural cells with the capacity for long-term self-renewal and for differentiation into all types of neuronal and glial cells. (sanbio.nl)
The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. (nih.gov)
therefore, definitive differentiation of Hürthle cell carcinoma from Hürthle-cell adenoma is based on vascular invasion and/or capsular invasion, as well as on permanent histologic sections or extrathyroidal tumor spread and lymph node and systemic metastases. (medscape.com)

Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. (wikipedia.org)
Below is a list of genes/protein products that can be used to identify various types of stem cells, or functional assays that do the same. (wikipedia.org)
Commonly these markers are individual genetic changes, such as driver mutations affecting oncogenes or tumor suppressor genes, or copy-number alterations thereof. (nature.com)
This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. (thermofisher.com)

They are commonly expressed in pluripotent embryonic stem cells, germ cells, certain committed progenitors, and cancer cells 18 . (atlasantibodies.com)

The CD44-positive cells contain the tumorigenic cells, but we don't think that's a pure population of cancer stem cells. (innovations-report.com)
The use of CD133 (PROM1) to identify CSCs in glioma is still in question because tumorigenic cells are equally found in both CD133+ and CD133− cells in some gliomas, while some CD133+ brain tumor cells may not possess tumor-initiating capacity 23 . (atlasantibodies.com)
It has been seen that ALDH1 expression in non-small cell lung cancer (NSCLC) and the presence of marker was linked to a more tumorigenic potential in the in vivo assessment and shorter disease-free survival in NSCLC patients with platinum treatment. (ijpmonline.org)

Applications such as flow cytometry can enable phenotypic characterization of cells based on cell surface protein expression. (cellsignal.com)
Multipotent retinal stem cells can be identified by the expression of transcription factors such as Pax6 and CRX. (rndsystems.com)
To address these challenges, we have developed a novel, label-free stem-cell analysis and sorting platform capable of quantifying cell-surface marker expression of single functional organ stem cells directly isolated from their micro-anatomical niche. (ca.gov)
Using our unique platform, we have discovered a remarkable heterogeneity in both the regenerative capacity and expression of CXCR4, beta1-integrin, Sca-1, M-cadherin, Syndecan-4, and Notch-1 in freshly isolated muscle stem (satellite) cells residing on different, single myofibers and have identified a small population of Sca-1(+)/Myf5(+) myogenic satellite cells. (ca.gov)
We will look into cell surface mechanical properties (linked to adhesion dynamics and motility), as well as the membrane protein expression and cell autofluorescence. (irb.hr)
ALDH1 was expressed in a few cells in most samples except in a few cases of ADH, UDH and normal ducts, in which ALDH1 expression showed extensive distribution. (omicsonline.org)
We evaluated the semiquantitative expression of ALDH1 using a score based on positive cells rate and staining density in benign lesions. (omicsonline.org)
The score of ALDH1 in luminal epithelial cytoplasm expression is 3, 2, and 1 while myoepithelial cells and stroma expression are 3, 2, and 2 in ADHÃ¯Â¼ÂŒUDH and normal ducts respectively. (omicsonline.org)
Here we demonstrate that aberrant PROM1/CD133 expression is essential for leukemic cell growth, mediated by direct binding of MLL-AF4. (iric.ca)
We find that in PROM1/CD133 non-expressing cells, the PROM1 locus is repressed by polycomb repressive complex 2 (PRC2) binding, associated with reduced expression of TAPT1, partially due to loss of interactions with the PROM1 locus. (iric.ca)
B lymphocytes and B-cell activating factor promote collagen and profibrotic markers expression by dermal fibroblasts in systemic sclerosis. (ox.ac.uk)
We therefore investigated the involvement of B cells and BAFF in the expression of collagen and profibrotic markers by dermal fibroblasts. (ox.ac.uk)
RESULTS: Coculture of blood B cells and dermal fibroblasts isolated from SSc patients induced IL-6, TGF-β1, CCL2, and collagen secretion, as well as Alpha-SMA, TIMP1, and MMP9 expression in dermal fibroblasts. (ox.ac.uk)
Expression of stem cell marker ALDH1 with the staging of the tumor was observed in 62.5% of Stage I, 80% of Stage II, 94.1% of Stage III, and 100% of Stage IV cases. (ijpmonline.org)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)

Cancer stem cells (CSCs) are small cells, 1% to 3% of all cells in a tumor, that drive the tumor's initiation, growth, and metastasis and may cause relapse. (atlasantibodies.com)
Perivascular cells (PC) were recently implied as regulators of metastasis and immune cell activity. (lu.se)

Although flow cytometric immunophenotyping is a highly complex technology, methodology for performing CD4+ T-cell determinations has become more standardized between laboratories. (cdc.gov)

They can be used as NPC markers for immunohistochemistry and flow cytometry analysis. (sanbio.nl)
The CDC guidelines concerning CD4+ T-cell determinations (33) were first published in the MMWR in 1992 to provide laboratorians with the most complete information about how to measure CD4+ T-lymphocytes in blood from HIV-infected persons by using flow cytometry. (cdc.gov)

What are neural stem cells (NSCs), neural progenitors, and neural precursors (NPCs)? (sanbio.nl)
Neural progenitors are precursor cells able to further differentiate into various neuronal and glial cells. (sanbio.nl)

Depending on the cell type, an individual marker alone or in combination with others can be used to isolate defined cell populations. (cellsignal.com)
The ability to identify and modulate adult retinal stem cell populations may allow researchers to establish models of stem cell-facilitated retinal regeneration. (rndsystems.com)
Traditional cell-screening techniques such as FACS and MACS are better suited for large numbers of cells isolated from bulk tissue and cannot easily screen stem or progenitor cells from minute populations found in their physiological niches. (ca.gov)

In conclusion, CD44v6 and ALDH1A1 are candidate stem cell markers for NPC, and the increased formation of DNA lesions by inflammation may result in the mutation of stem cells, leading to tumor development in NPC. (hindawi.com)
Conclusion: The present study indicated a greater risk of autoimmune destruction of the insulin producing beta cells of the pancrease of the type-1 relatives and newly diagnosed type-1 patients and suggests the need for periodic recruitment of individuals in the general population, siblings and relatives of type-1 diabetic patients for planned intervention trials. (scirp.org)
Conclusion: We identified novel cell surface markers specific for hepatic progenitor/oval cells, which offers powerful tool for their identification, isolation and studies of their physiology and pathophysiology. (elsevierpure.com)

Replication analyses across independent drug and CRISPR genetic screening data sets reveal hundreds of robust associations, which are provided as a resource for drug repurposing guided by mutational signature markers. (nature.com)
In this work, we studied progenitor/oval cell surface markers in the liver of rats subjected to 2-acetylaminofluorene treatment followed by partial hepatectomy (2-AAF/PH) by using rat genome 230 2.0 Array chips and subsequent RT-PCR, immunofluorescent (IF), immunohistochemical (IHC) and in situ hybridization (ISH) analyses. (elsevierpure.com)
The specificity of progenitor/oval cell surface markers was confirmed by ISH and double IF analyses. (elsevierpure.com)
Perivascular heterogeneity in clinical samples, and associations with other tumor features and outcome, remain largely unknown.Here we report a novel method for digital quantitative analyses of vessel characteristics and PC, which was applied to two collections of human metastatic colorectal cancer (mCRC).Initial analyses identified marker-defined subsets of PC, including cells expressing PDGFR-β or α-SMA or both markers. (lu.se)

Using CD133 (PROM1) as a positive marker for colon CSCs also generated conflicting results 24 . (atlasantibodies.com)
For lung cancers, CSC markers include CD44 and CD133 (PROM1), but also CD117 (KIT), CD90 (or THY1), CD166, EpCAM for non-small-cell lung carcinoma (NSCLC), and PODXL-1, PTCH, and CD87 for small-cell lung carcinoma (SCLC) 25 . (atlasantibodies.com)
H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells. (iric.ca)
CD133 is a pentaspan transmembrane glycoprotein that represents a potential pan-cancer target as it is found on multiple cancer stem cells. (iric.ca)

Hence, our objective was to detect association of cancer stem cell (CSC) marker aldehyde dehydrogenase 1 (ALDH1) with clinicopathological profile in lung carcinoma patients. (ijpmonline.org)

these are as numerous as associations with established genetic markers such as driver gene alterations. (nature.com)
The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. (nih.gov)
Mutational Analysis of the VPREB1 Gene of Pre-BCR Complex in a Cohort of Sporadic Pediatric Patients With B-Cell Acute Lymphoblastic Leukemia. (nih.gov)
These cells can differentiate into hepatocytes and cholangiocytes and could be useful for cell and gene therapy applications. (elsevierpure.com)

Our previous study was the first to demonstrate 8-nitroguanine formation in the cancer cells of NPC patients via iNOS activation [ 14 ], showing that inflammation is an important risk factor for NPC development. (hindawi.com)
Researchers at the U-M Comprehensive Cancer Center and Stanford University School of Medicine took tumor samples from patients undergoing surgery for head and neck squamous cell carcinoma, including cancers of the tongue, larynx, throat and sinus. (innovations-report.com)
Riazalhosseini B, Mohamed R, Apalasamy YD, Langmia IM and Mohamed Z: Circulating microRNA as a marker for predicting liver disease progression in patients with chronic hepatitis B. Rev Soc Bras Med Trop. (spandidos-publications.com)
CD45RA is expressed on leukaemic cells in the majority of AML patients. (eur.nl)
Aim: We demonstrated the risk of developing islet autoantibodies-Insulin Autoantibodies (IAAs) and Islets cell Autoantibodies (ICAs)-in type-1 diabetic relatives and newly diagnosed type-1 patients compared to non-diabetic controls. (scirp.org)
B-cell activating factor (BAFF), a key cytokine for B-cell activation, is increased in the serum and the skin of patients with SSc. (ox.ac.uk)
Circulating Tumour Cells (CTCs) and circulating tumour DNA (ctDNA) represent a non-invasive liquid biopsy approach for the follow-up and therapy management of cancer patients. (oncotarget.com)
During the same liest markers in patients with atherogenic period, 20 healthy age- and sex-matched risk factors (e.g. male sex, ageing, hyper- personnel whose medical records showed tension, diabetes mellitus, smoking, fam- total cholesterol and triglycerides were ily history) in the absence of angiographic within normal levels and who had no car- evidence of atherosclerosis [1]. (who.int)

Work plan: characterization of mechanical properties of algal cells in stress and comparison with adhesion based study and AFM imaging. (irb.hr)

Cancer stem cells (CSCs) are generated by a combination of DNA mutations, epigenetic events, and tissue microenvironment factors from normal stem cells or precursor/progenitor cells, to which they are closely related and share many of the behaviors and features 1 . (atlasantibodies.com)
In addition, CSCs might give rise to metastases, acting as a reservoir of cancer cells, causing relapse after the surgery or treatment has eliminated the visible signs of cancer. (atlasantibodies.com)
CSCs were first identified in hematological cancer such as acute myeloid leukemia in the late '90s when scientists isolated a subpopulation of leukemia cells that expressed the surface marker CD34 but not CD38. (atlasantibodies.com)

You can also find a list of our extracellular CSC/CD markers (Table 3), extracellular CSC/not- CD markers (Table 4), and intracellular CSC markers (Table 5). (atlasantibodies.com)

Because cancer therapeutics often target DNA synthesis or repair, we asked if mutational signatures make useful markers of drug sensitivity. (nature.com)
Therefore, the altered capacity of cancer cells to repair and/or replicate DNA is the basis of many classical therapies, such as platinum-based agents, and also recently introduced or upcoming therapies, such as PARP inhibitors or ATR inhibitors (reviewed in refs. (nature.com)
Because mutational signatures describe the state of the DNA repair machinery of a cancer cell, they may be able to serve as a drug sensitivity marker. (nature.com)
rather, this property is limited to a subset of cells termed "cancer stem cells" [ 15 , 16 ]. (hindawi.com)
Moreover, several studies have shown that cancer cells have genetic instability, epigenetic changes, and an accumulation of mutations, suggesting that cancer is a genetic disease [ 16 ]. (hindawi.com)
Cancer stem cells are the small number of cancer cells that replicate to drive tumor growth. (innovations-report.com)
Researchers believe current cancer treatments sometimes fail because they are not attacking the cancer stem cells. (innovations-report.com)
Stem cells have been identified in several other cancer types, including breast, brain, central nervous system and colon cancers, as well as leukemia. (innovations-report.com)
U-M researchers in 2003 were the first to report the existence of stem cells in a solid tumor, finding them in breast cancer. (innovations-report.com)
CD44 was also found to play a role in breast cancer stem cells. (innovations-report.com)
This work gives more evidence that the cancer stem cell theory is valid," Prince says. (innovations-report.com)
That theory suggests that a small subpopulation of cancer cells are the critical cells in cancer growth and progression, and the key to treating it is to kill the stem cells. (innovations-report.com)
Researchers suspect cancer recurs because the treatments are not killing the stem cells. (innovations-report.com)
Studies in other cancer types have found the stem cell population to be smaller than 5 percent. (innovations-report.com)
Funding for the study was from the U-M Specialized Program of Research Excellence (SPORE) grant in head and neck cancer and from an anonymous gift fund for cancer stem cell research at Stanford University. (innovations-report.com)
The existence of stem cells in hematological tissue prompted research in other tissue cancer types. (atlasantibodies.com)
Tumor markers are substances that are often made by cancer cells or by normal cells in response to cancer. (medlineplus.gov)
An AFP tumor marker test cannot be used by itself to screen for or diagnose cancer. (medlineplus.gov)
So, an AFP tumor marker test can't rule out cancer for sure. (medlineplus.gov)
An AFP tumor marker test may be used during the diagnosis and/or treatment of cancer of the liver, ovaries, or testicles that make high levels of AFP. (medlineplus.gov)
In certain cases, results from an AFP tumor marker test may be used to guide treatment choices for specific types of cancer. (medlineplus.gov)
You may need an AFP tumor marker test from time to time to check whether your cancer is coming back. (medlineplus.gov)
But, some health care providers may still use an AFP tumor marker test with other tests to watch for liver cancer. (medlineplus.gov)
Hürthle cell carcinoma of the thyroid gland is an unusual and relatively rare type of differentiated thyroid cancer. (medscape.com)

Our results demonstrate the utility of our single-cell platform for uncovering and functionally characterizing stem-cell heterogeneity in the organ microniche. (ca.gov)
Our results demonstrate that palmitate induced ER stress in AC16 cells, a fact which was prevented after PPARβ/δ activation with GW501516. (nih.gov)
Thus, these results demonstrate a new pathogenic role of B cells and BAFF in fibrosis and systemic sclerosis. (ox.ac.uk)

Inflammation-associated tissue injury may activate stem/progenitor cells, and mutagenic stimuli from inflammation can accumulate multiple mutations and epigenetic changes in stem/progenitor cells [ 3 , 10 ]. (hindawi.com)

TBARS value according to the method of (pro-inflammatory cytokine) as markers of Mitsura and Midori. (who.int)

We investigated the role of CAL-101 (GS-1101, Idelalisib) TGF-1 in inducing profibrotic signaling from epithelial cells to activate pericyte-myofibroblast transition. (holyexperiment.org)

Here we provide an overview of the most prominent CSC markers, focusing on solid cancers (lung, stomach, liver, breast, and colorectal cancers) and hematological cancers (acute and chronic myeloid leukemia). (atlasantibodies.com)
AFP is a protein that the liver makes when its cells are growing and dividing to make new cells. (medlineplus.gov)

Accurate and reliable measures of CD4+ T-lymphocytes (CD4+ T-cells) are essential to the assessment of the immune system of human immunodeficiency virus (HIV)-infected persons (1-3). (cdc.gov)
and the percentage of lymphocytes that are CD4+ T-cells. (cdc.gov)

Studies suggest that Müller glia may be a relevant mammalian retinal stem cell population. (rndsystems.com)

Cells from the samples were separated based on whether they expressed a marker on their surface called CD44. (innovations-report.com)
The percent of cells within a tumor expressing CD44 varied from one sample to the next, with one sample composed of as high as 40 percent of these cells. (innovations-report.com)

Therefore, since several studies have shown that peroxisome proliferator-activated receptor (PPAR)β/δ inhibits ER stress, the main goal of this study consisted in investigating whether activation of this nuclear receptor was able to prevent lipid-induced ER stress in cardiac cells. (nih.gov)
Our results have demonstrated a tumor suppressive function of miR-584-3p in glioma, in which it inhibits the migration and invasion of tumor cells by antagonizing hypoxia-induced, ROCK1-dependent stress fiber formation. (oncotarget.com)

We still need to drill down further to find the subpopulation of those cells that is the pure version," Prince says. (innovations-report.com)

Sorting single satellite cells from individual myofibers reveals heterogeneity in cell-surface markers and myogenic capacity. (ca.gov)
Physicochemical and structural characterizations of single algal cell surface are of key importance to interpret, rationalize and predict the behavior and fate of the cell under stress in vivo. (irb.hr)

Acute (AML) and chronic (CML) myeloid leukemia are cancers of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. (atlasantibodies.com)
But when used with other tests and exams, AFP tumor marker testing can help diagnose and monitor cancers that cause high AFP levels. (medlineplus.gov)

Hürthle cells are observed in both neoplastic and nonneoplastic conditions of the thyroid gland (eg, Hashimoto thyroiditis , nodular and toxic goiter ). (medscape.com)

Immunofluorescent staining of PAX6 ( 12323-1-AP , 1:250 dilution) with 4% PFA fixed control human-induced pluripotent stem cell (hiPSC)-derived NPCs. (sanbio.nl)
The present invention relates to the use of one or more type 7 long terminal repeat (LTR7) nucleic acid sequences of type H human endogenous retroviruses (HERVH) ("LTR7/HERVH nucleic acid sequences") for identifying primate naive pluripotent stem cells. (bath.ac.uk)
The invention is directed to the use of LTR7/HERVH nucleic acid sequences as a marker, wherein LTR7/HERVH-associated transcription is used as a marker for primate naive pluripotent stem cells. (bath.ac.uk)
The invention also relates to a reporter construct comprising LTR7/HERVH nucleic acid sequences in addition to the use of said reporter, in particular for optimizing culture conditions for naïve primate pluripotent stem cells. (bath.ac.uk)
The invention also relates to a cell growth medium for cultivation of primate naive pluripotent stem cells that preferably exhibit elevated levels of LTR7/HERVH-associated transcription in comparison to control cells. (bath.ac.uk)

The most striking result of this study is that GW501516 treatment also upregulated the protein levels of beclin 1 and LC3II, two well-known markers of autophagy. (nih.gov)

The existence of mammalian retinal stem cells in vivo remains an active area of investigation. (rndsystems.com)

Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma. (nih.gov)

mmc9.pdf (66K) GUID:?55F9BD4F-0F85-40B3-99F0-75E20D3D96BC Supplemental Physique?S10 Silencing p21 reversed cell cycle G2/M arrest of TGF-1Ctreated proximal tubular epithelial cells. (holyexperiment.org)
B: Silencing p21 reversed cell cycle G2/M arrest of TGF-1Ctreated PTECs. (holyexperiment.org)

Hürthle cell carcinoma. (medscape.com)
Obviously, this factor has a major impact in interpreting the natural history of this disease and adds to the controversy about the aggressiveness of Hürthle cell carcinoma. (medscape.com)

The GL7 antigen is expressed by pre-B and immature B cells, activated T and B cells, and about 20% of TCR-bright thymocytes. (biolegend.com)

Anatomy29

Organisms7

Diseases18

Chemicals and Drugs65

Analytical, Diagnostic and Therapeutic Techniques and Equipment72

Phenomena and Processes73

Disciplines and Occupations4

Information Science6

Health Care24

Prognostic2

Tumor-initi1

Tumors15

Progenitor cell3

Haematopoietic stem cells1

Proliferation7

Endothelial2

Tissues7

PMID4

Induces2

Cytoplasmic2

Antibody3

Malignant1

Predictive5

Molecular7

Detection4

Fetal2

Antibodies1

Epithelial cell2

Proteins2

Vitro4

Differentiation3

Genes4

Embryonic1

Tumorigenic3

Expression15

Metastasis2

Methodology1

Flow cytometry2

Progenitors2

Populations3

Conclusion3

Analyses4

CD1334

ALDH11

Gene4

Patients8

Characterization1

CSCs3

Extracellular1

Cancer24

Demonstrate3

Mutations1

Cytokine1

Profibrotic1

Liver2

Lymphocytes2

Stem cell population1

CD442

Inhibits2

Subpopulation1

Surface2

Cancers2

Neoplastic1

Pluripotent5

Protein1

Vivo1

Apoptosis1

Silencing2

Carcinoma2

Immature1