Marker of neuroendocrine. Medical search. Frequent questions

A histological evaluation of any breast tumor will routinely check for the presence of estrogen and progesterone receptors, the HER2/neu protein, also the GCDFP-15 protein , but for neuroendocrine breast tumors additional markers, uniquely associated with neuroendocrine cells, are considered. (breast-cancer.ca)
It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. (neobiotechnologies.com)
Determination of chromogranin A (marker of neuroendocrine tumors). (rezus.lt)
Chromogranin A (a marker of neuroendocrine tumors) is one of the most important indicators in the diagnosis of carcinoid tumors. (rezus.lt)
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. (neobiotechnologies.com)
It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors. (neobiotechnologies.com)
PanNETs are a type of neuroendocrine tumor, representing about one-third of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). (wikipedia.org)
The World Health Organization (WHO) classification scheme places neuroendocrine tumors into three main categories, which emphasize the tumor grade rather than the anatomical origin. (wikipedia.org)
Relative incidence is given as percentage of all functional pancreatic neuroendocrine tumors. (wikipedia.org)
The new 2019 WHO classification and grading criteria for neuroendocrine tumors of the digestive system grades all the neuroendocrine tumors into three grades, based on their degree of cellular differentiation (from well-differentiated NET grade (G)1 to G3, and poorly-differentiated neuroendokrina cancer, NEC G3), morphology, mitotic rate and Ki-67 index. (wikipedia.org)
Pancreatic neuroendocrine tumor staging (AJCC) Stage T1 Stage T2 Stage T3 Stage T4 Involvement of nearby lymph nodes - Stage N1 Metastasis - stage M1 In general, treatment for PanNET encompasses the same array of options as other neuroendocrine tumors, as discussed in that main article. (wikipedia.org)
Recently, insulinoma-associated protein 1 (INSM1) has been identified as a novel neuroendocrine marker that is more sensitive than chromogranin, synaptophysin, and CD56 in pulmonary neuroendocrine tumors. (gastrores.org)
Conventional neuroendocrine markers, such as chromogranin and synaptophysin, however, are often negative or focally positive in these tumors [ 2 , 3 ]. (gastrores.org)
Background and study aims Endoscopic resection of duodenal neuroendocrine tumors (DNETs) remains controversial, and its indications are still unclear. (thieme-connect.com)
Differential diagnoses include poorly differentiated adenocarcinomas, solid pseudopapillary tumors, pancreatic carcinoma, pancreatic neuroendocrine tumors and autoimmune pancreatitis. (orpha.net)
Streptozocin chemotherapy for advanced/metastatic well-differentiated neuroendocrine tumors: an analysis of a multi-center survey in Japan. (cancerindex.org)
Neuroendocrine tumors (NETs) are believed to be relatively rare and to follow a generally indolent course. (cancerindex.org)
Carcinoid tumors arise from neuroendocrine cells, which are widespread in the human body, especially in the organs derived from the primitive intestine (see the image below). (medscape.com)
Scintigraphy with indium-111 diethylenetriamine pentaacetic acid (DTPA) octreotide (In-111 DTPA Octr), or OctreoScan, localizes the primary carcinoid and eventual recurrences, as well as other neuroendocrine tumors, with high sensitivity and specificity. (medscape.com)
Therapeutic options in patients with advanced-stage gastroenteropancreatic (GEP) neuroendocrine tumors are limited. (snmjournals.org)
Therapeutic options in patients with progressive and disseminated metastatic neuroendocrine gastroenteropancreatic (GEP) tumors are often limited, and prognosis is often poor ( 1 , 2 ). (snmjournals.org)
Multiple endocrine neoplasia type 1 is a rare genetic syndrome, characterized by the co-occurrence, in the same individual or in related individuals of the same family, of hyperparathyroidism, duodenopancraetic neuroendocrine tumors, pituitary adenomas, adrenocortical tumors, and neuroendocrine tumors (carcinoids) in the thymus, the bronchi, or the stomach. (nih.gov)
In MEN1 patients, special attention should be paid to evaluate the progression duodenopancraetic neuroendocrine tumors because of their malignant potential. (nih.gov)
Also, thymic neuroendocrine tumors should be detected as soon as possible because they represent the most lethal tumor. (nih.gov)
A pancreatic neuroendocrine tumor (NET) is a type of cancer that forms tumors in the pancreas. (hopkinsmedicine.org)
This cellular compartmentalization of PTEN was investigated in lung neuroendocrine tumors (lung NET). (biomedcentral.com)
Lung neuroendocrine tumors (NET) comprise the four histotypes typical carcinoid (TC), atypical carcinoid (AC), large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC). (biomedcentral.com)
It is also a marker for cells of the diffuse neuroendocrine system and their tumors. (neuromics.com)
A wide variety of neuroendocrine tumors stain positive for chromogranin A. (medscape.com)
Chromogranin A is a reliable serum diagnostic biomarker for pancreatic neuroendocrine tumors but not for insulinomas. (medscape.com)
Chromogranin A, Ki-67 index and IGF-related genes in patients with neuroendocrine tumors. (medscape.com)
Although most tumors release detectable antigenic macromolecules into the circulation, no tumor marker has all the requisite characteristics to provide enough specificity or sensitivity to be used in early diagnosis or mass cancer screening programs. (msdmanuals.com)

In order to be identified as ductal carcinoma with a neuroendocrine differentiation, positive neuroendocrine markers should be found on at least 50% of malignant cells . (breast-cancer.ca)
The ENO2 protein will certainly be found in neuroendocrine cells, but its presence alone is generally considered insufficient to confirm neuroendocrine differentiation in breast carcinoma. (breast-cancer.ca)
Carcinoid carcinoma, which is a cancer of simple stem cells of neuroendocrine origin and tends to develop in the gut wall or appendix, is also diagnosed in part through the use of neuroendocrine markers. (breast-cancer.ca)
In fact, neuroendocrine carcinoma of the breast has only recently been classified as a unique ductal carcinoma , having previously been subsumed as a subset of carcinoid carcinoma . (breast-cancer.ca)
For further reading, I suggest you visit this page on neuroendocrine carcinoma, go to this page on hormone receptor statuses of breast cancer, as well as this page for a brief overview of breast cancer treatments. (breast-cancer.ca)
Neuroendocrine differentiation in pure type mammary mucinous carcinoma is associated with favorable histologic and immunohistochemical parameters. (breast-cancer.ca)
Until now, squamous cell carcinoma (SQC) and adenocarcinoma (ADC) markers have not been thoroughly analyzed for pulmonary neuroendocrine carcinomas (NECs). (elsevierpure.com)
A study by Sokolova et al of 9 genetic markers for detecting urothelial carcinoma showed that polysomy of chromosomes 3, 7, and 17 and deletion of 9p21 were the most sensitive and specific markers, detecting 95% of recurrent urothelial carcinomas. (medscape.com)
In MEN2, calcitonin and carcinoembryonic antigen (CEA) serve as excellent tumor markers for medullary thyroid carcinoma. (nih.gov)
Large cell neuroendocrine carcinoma (LCNEC) is now recognized as a histologically high grade non small cell carcinoma showing histopathological features of neuroendocrine differentiation as well as immunohistochemical neuroendocrine markers. (ersjournals.com)
As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
In addition of the categories of squamous dysplasia and carcinoma in situ , two additional lesions were added to the group of pre-invasive lesions: atypical adenomatous hyperplasia (AAH) and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). (ersjournals.com)
with non-MCC high-grade neuroendocrine carcinomas (5 and Pierre Coursaget small-cell lung carcinomas and 3 well-differentiated in- testinal carcinomas) and an FFPE tissue specimen from a We investigated whether Merkel cell carcinoma (MCC) patient with high-grade neuroendocrine carcinoma of the patients in France carry Merkel cell polyomavirus (MCPyV) and then identified strain variations. (cdc.gov)

Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. (neobiotechnologies.com)
The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. (neobiotechnologies.com)
Pancreatic neuroendocrine tumours (PanNETs, PETs, or PNETs), often referred to as "islet cell tumours", or "pancreatic endocrine tumours" are neuroendocrine neoplasms that arise from cells of the endocrine (hormonal) and nervous system within the pancreas. (wikipedia.org)
Appendiceal goblet cell carcinoid (GCC) and adenocarcinoma ex-goblet cell carcinoid (AdexGCC) have previously been described as two entities in a spectrum of neoplasms showing both glandular/mucinous and neuroendocrine differentiation [ 1 ]. (gastrores.org)
Molecular and proteomics profiling of neuroendocrine neoplasms have identified several proteins that play a pivotal role in neuroendocrine differentiation. (gastrores.org)
Streptozocin-Based Chemotherapy in Patients with Advanced Neuroendocrine Neoplasms--Predictive and Prognostic Markers for Treatment Stratification. (cancerindex.org)
Chemotherapy with streptozocin (STZ) in combination with 5-FU or doxorubicin (Dox) represents a standard of care for patients with metastatic pancreatic neuroendocrine neoplasms (pNEN). (cancerindex.org)
STZ-based chemotherapy is an effective and well-tolerated treatment option in patients with well differentiated neuroendocrine neoplasms. (cancerindex.org)
There was evidence of perineural invasion and the synaptophysin (marker protein for neuroendocrine cells and neoplasms) was focally positive. (hpathy.com)
Pulmonary carcinoids are well differentiated low to intermediate grade lung neuroendocrine tumours (LNETs), that belong to the group of lung neuroendocrine neoplasms which also include highly aggressive lung neuroendocrine carcinomas (LNECs). (who.int)
These data have been combined with previously published LNET data to perform integrative analysis using multi-omics factor analysis (MOFA), resulting in a molecular map of lung neuroendocrine neoplasms for exploration. (who.int)

Histologically, this malignant epithelial pancreatic neoplasm of the exocrine cells is characterized by multiple lines of differentiation (acinar, ductal, mesenchymal, neuroendocrine) and the presence of squamoid nests. (orpha.net)
It shows significant acinar cell differentiation but also ductal, mesenchymal and neuroendocrine differentiation. (orpha.net)
Acinar adenocarcinoma with focal neuroendocrine differentiation. (hpathy.com)

Chromogranin and synaptophysin , for example, are two proteins commonly secreted by neuroendocrine cells. (breast-cancer.ca)
Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. (neobiotechnologies.com)
Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. (neobiotechnologies.com)
Adenocarcinoma ex-goblet cell carcinoid (AdexGCC) was considered a neuroendocrine adenocarcinoma, despite majority of tumor cells being negative for conventional neuroendocrine markers such as chromogranin and synaptophysin. (gastrores.org)
We studied this marker in conjunction with chromogranin, synaptophysin, and CD56 in 36 appendiceal AdexGCCs (21 primaries, 15 metastatic). (gastrores.org)
Clinico-pathologic data including overall survival, proliferation rate and diagnostic markers (synaptophysin, chromogranin A, Mib-1, TTF-1) were recorded. (biomedcentral.com)
No change was detected in the expression level of neuroendocrine markers: MAP-2 and chromogranin. (viamedica.pl)
Chromogranin A is a secretory protein, composed of 439 amino acids, found in the large dense-core vesicles of the neuroendocrine cells. (medscape.com)
Chromogranin A (CgA) is a secretory protein, composed of 439 amino acids, found in the large dense-core vesicles of the neuroendocrine cells. (medscape.com)

Prognostic Value of Lymphatic and Blood Vessel Invasion in Neuroendocrine Tumours of the Lung," The American Journal of Surgical Pathology, Vol. 29, 2005, pp. 324-328. (scirp.org)
Role of pre-operative inflammatory markers as predictors of lymph node positivity and disease recurrence in well-differentiated pancreatic neuroendocrine tumours. (lu.se)

The multicentre cohort included 58 typical carcinoids (TC), 42 atypical carcinoids (AC), 32 large cell neuroendocrine carcinomas (LCNEC) and 60 small cell lung carcinomas (SCLC). (biomedcentral.com)

It is a high-grade and poorly differentiated neuroendocrine tumor, usually diagnosed in advanced stages, with a poor prognosis and few therapeutic options in that setting. (mdpi.com)

Although our investigated markers have been reported useful for differentiating between SQC and ADC, some of them were also present in a portion of pulmonary NECs. (elsevierpure.com)
Effects of pulmonary exposure to chemically-distinct welding fumes on neuroendocrine markers of toxicity. (cdc.gov)
atypical adenomatous hyperplasia and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. (ersjournals.com)
While progress has been made in recent years in the characterisation of pulmonary carcinoids, little is known about the underlying biology or developmental origins of these molecular groups, hampering efforts to identify predictive markers and suitable therapeutic options. (who.int)

Another neuroendocrine marker is neuron specific enolase . (breast-cancer.ca)

Cancer precision medicine draws on the presence of somatically acquired changes in the tumor, which serve as predictive markers of response to drugs and other therapies. (nature.com)
It is paramount to identify predictive markers that are associated with failures of DNA maintenance in cancer cells. (nature.com)
However, predictive markers for patient selection are still missing. (cancerindex.org)

The authors assessed associations between positive affect, cortisol sampled over the day, and inflammatory markers (C-reactive protein and interleukin-6) among 2,873 healthy members of the Whitehall II study. (nih.gov)

neuroendocrine cells are full of these ' amine-based ' proteins, and if they are present in the tumor, they will be clearly revealed by the argyrophil stain . (breast-cancer.ca)
Neuroendocrine markers help identify the origin of mutated cancer cells , not just in the breast, but in other parts of the body. (breast-cancer.ca)
this observation demonstrates that vesicle-free miRNAs are secreted from neuroendocrine cells, in a manner similar to hormone secretion. (frontiersin.org)
This review focuses on the mechanisms by which vesicle-free miRNAs are secreted from neuroendocrine cells and will discuss potential functions of vesicle-free miRNAs and how vesicle-free miRNAs regulate cell-to-cell communication. (frontiersin.org)
Recently, miRNA exocytosis by vesicle fusion in response to stimulation was observed in chromaffin cells, which are neuroendocrine cells in the sympathetic nervous system ( 24 ). (frontiersin.org)
The objective of this review is to discuss how miRNAs are released by active exocytosis and to examine the physiological functions of vesicle-free miRNAs in neuroendocrine cells. (frontiersin.org)
It is present in neurons and in cells of the diffuse neuroendocrine system. (neuromics.com)
CgA is co-stored with a tissue-specific peptide hormone or neuropeptide and exerts an autocrine and paracrine effect on secretory activity of the neuroendocrine cells. (medscape.com)

Pejorative events were defined as side effects due to therapy, relapse in clinical symptoms, tumor progression, tumor laboratory marker increase, and death. (snmjournals.org)
Serum CgA can be used to monitor neuroendocrine tumor progression after a surgical intervention as well as medical therapy, with the only exception being somatostatin analogs that inhibit tumor secretion rather than causing tumor reduction. (medscape.com)

These results confirm findings from smaller studies relating cortisol with positive affect while suggesting that in women, positive affect is associated with reduced levels of inflammatory markers. (nih.gov)
Risk factors include metabolic changes such as signs of the metabolic syndrome, increased inflammatory markers as well as neuroendocrine alterations. (karger.com)

A ' marker ' is a positive finding on a kind of diagnostic ' tally-sheet ', which indicates the presence of various proteins, hormones, unique cell-types, and other biological agents. (breast-cancer.ca)

these are as numerous as associations with established genetic markers such as driver gene alterations. (nature.com)
Commonly these markers are individual genetic changes, such as driver mutations affecting oncogenes or tumor suppressor genes, or copy-number alterations thereof. (nature.com)
The research will mainly focus on four biological processes including possible alterations of the epigenome, neuroendocrine system, inflammatome, and the gut microbiome. (plos.org)

How neurochemistry and neuroendocrine markers may aid in classification of anxiety disorders. (appi.org)
This study uses a cohort sample of 12,644 to 13,832 mother-child pairs from the UK Born in Bradford Study to examine the associations between maternal metabolic syndrome classification (MetS) and child development outcomes at age 5, using cord blood markers as candidate mediators. (biomedcentral.com)
After adjusting for maternal, child, and environmental covariates, maternal metabolic syndrome classification during pregnancy was associated with children's LIT domain through direct effects of maternal metabolic health and indirect effects of cord blood markers (total effects), and COM and PSE domains via changes only in a child's cord blood markers (total indirect effects). (biomedcentral.com)
There has been substantial evolution of concepts in neuroendocrine lung tumour classification. (ersjournals.com)

We studied tumour lymphangiogenesis and lymphatic invasion using D2-40 endothelial marker in 35 breast cancer patients treated by primary surgery and correlated it with various clinico-pathological prognostic parameters. (scirp.org)

Because of the above, other types of molecular markers may be more useful to infer about failed DNA repair. (nature.com)
Molecular markers would improve differential diagnosis, but none are available at present. (bvsalud.org)

However, I have created a new page with more up-to-date information on Rare Breast Cancers including Neuroendocrine Markers in Breast Cancer. (breast-cancer.ca)

This case shows that vascular markers should be done in front of an aggressive sellar lesion with unexpected histologic features. (medscape.com)
MCPyV was detected by nested PCR by using a first rare, aggressive primary cutaneous neuroendocrine carci- PCR amplification with the LT1 and VP1 primer sets noma. (cdc.gov)

Because cancer therapeutics often target DNA synthesis or repair, we asked if mutational signatures make useful markers of drug sensitivity. (nature.com)
Because mutational signatures describe the state of the DNA repair machinery of a cancer cell, they may be able to serve as a drug sensitivity marker. (nature.com)

The aim of this study was a retrospective evaluation of the clinicopathological characteristics of pNEN patients receiving STZ-based chemotherapies and to identify predictive and prognostic markers. (cancerindex.org)
M. A. Ansari, V. Pandey, V. Srivastava, M. Kumar, R. Mishra and A. Kumar, "Lymphangiogenesis as a Prognostic Marker in Breast Cancer Using D2-40 as Lymphatic Endothelial Marker-A Preliminary Study," Journal of Cancer Therapy , Vol. 3 No. 5A, 2012, pp. 814-821. (scirp.org)

This funding opportunity announcement (FOA) solicits research grant applications from applicant organizations that propose to identify neurodevelopmental and neuroendocrine mechanisms that impact emotional and cognitive development and emerging psychopathology during adolescence, uti lizing animal models and human studies. (nih.gov)

There are many ways of testing for markers, but those most commonly used for neuroendocrine breast cancer include blood-serum levels, staining of tissue samples, chemical reactions, and even electron-microscope images. (breast-cancer.ca)

Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers. (neuromics.com)

Functional markers for these pathways in animal models as well as in humans are available and allow an indirect assessment of NTS function. (karger.com)

These markers can be used not only to assist the development of new treatment compounds, but also for a personalized approach to treat patients with depression and related disorders by individual dose titration with an active medication, which targets this system. (karger.com)
Even tumor markers can be elevated in patients with chronic pancreatitis. (medscape.com)
in these patients with low or absent titer of CA 19-9, monitoring disease with this tumor marker will not be possible. (medscape.com)
The epigenetic markers can be developed to be used to predict common complications of type 2 diabetes, which would allow for tailored treatments of patients. (lu.se)

These markers are recommended for diagnosis of poorly differentiated non-small cell lung cancer. (elsevierpure.com)
Based on our experience PRAME is a helpful marker for making the diagnosis of PM, and PD-L1 can predict the success of the immunotherapy. (bvsalud.org)
Vascular markers allowed us in this case to make the unusual diagnosis of primary epithelioid angiosarcoma. (medscape.com)

Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries: Podoplanin as a Specific Marker for Lymphatic Endothelium," American Journal of Pathology, Vol. 154, 1999, pp. 385-394. (scirp.org)

Anatomy37

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