Marker genetic heterogeneity. Medical search. Frequent questions

To assess if the behavioral difference between the family and kenneled dogs could be due to genetic divergence of these two populations and/or to lower genetic diversity of the kenneled dogs, we analyzed their genetic structure using 11 microsatellite markers. (frontiersin.org)
The main focus was to test different genera for the phenomenon via microsatellite markers and to distinguish which underlying process caused the genetic heterogeneity. (datadryad.org)
We performed a genome-wide linkage scan using highly polymorphic microsatellite markers. (duke.edu)
We have analyzed genetic data for 326 microsatellite markers that were typed uniformly in a large multiethnic population-based sample of individuals as part of a study of the genetics of hypertension (Family Blood Pressure Program). (blogspot.com)
Genetic cluster analysis of the microsatellite markers produced four major clusters, which showed near-perfect correspondence with the four self-reported race/ethnicity categories. (blogspot.com)
We identified six regions on chromosomes 2, 3, 4, 7, 11 and 14 as candidates to contain genes involved in breast cancer susceptibility, and additional fine mapping genotyping using microsatellite markers around linkage peaks confirmed five of them, excluding the region on chromosome 3. (biomedcentral.com)
Genomewide linkage scans have traditionally been performed using low-density maps of microsatellite markers with a spacing of about 10 cM across the genome [ 1 ]. (biomedcentral.com)
We show the existence of different candidate regions linked to a small number of families, and a power improvement by using SNPs instead of microsatellite markers. (biomedcentral.com)
Methods: GWS was performed using 811 microsatellite markers providing about five centiMorgan (cM) resolution. (lu.se)

Six genetic loci for long QT syndrome have been identified. (medscape.com)
Variation at 4 polymorphic loci, including the diagnostic creatine kinase (CK-A2*) locus, indicated that 19 populations were of southern origin, 5 of northern origin, and 32 of mixed genetic origin. (intechopen.com)
After the exclusion of type II collagen and vitamin D receptor genes and the recessive loci for HSPs, a genome wide search was performed with about 500 fluorescent markers. (bmj.com)
From a genetic point of view, little information has so far been available on possible susceptibility loci. (bmj.com)
Genetic loci implicated in hereditary, familial, and sporadic breast cancer susceptibility. (hindawi.com)
In addition, we identified several loci with P value for interaction <5 x 10(-7) in gender-specific analyses (P for heterogeneity between genders <0.001) including those mapping to the genes LRRTM4, ATF3 and DCLRE1C in women and POTEA in men. (harvard.edu)
Two recent studies by Veterinary Genetics Laboratory researchers and collaborators investigated equine recurrent uveitis (ERU) risk factors and genetic loci of interest in Appaloosas, including leopard complex (LP) and Appaloosa pattern-1 (PATN1), finding evidence that LP has an additive effect on ERU risk. (ucdavis.edu)
In the families studied here, close linkage (θ max = 0.09 at Z max = 2.32) was also observed between the marker and disease loci. (uni-luebeck.de)
In the families studied here, close linkage (θmax= 0.09 at Zmax= 2.32) was also observed between the marker and disease loci. (uni-luebeck.de)
The applica tion of new genetic tools also led to the discovery of an important familial neuroblastoma cancer gene, ALK , which is mutated in approximately 8% of sporadic tumors, and genome-wide association studies have unveiled loci with risk alleles for neuroblastoma development. (biomedcentral.com)
In a genetic association study of severe disease, we identified putative complement and coagulation-associated loci including missense, eQTL and sQTL variants of complement and coagulation regulators. (cdc.gov)
To follow up suggestive loci, an additional 13 families from other Nordic countries were genotyped for selected markers. (lu.se)
The heterogeneity LOD (HLOD) at the 6q, 2p and 14q loci in all families was 3.27, 1.66 and 1.24, respectively. (lu.se)

The newly identified structural variants will facilitate genetic improvement of tomato through both marker-assisted selection and genomic selection. (nature.com)
Recently, the growing availability of Single Nucleotide Polymorphism (SNP) markers and high-throughput parallel genotyping has facilitated genome-wide association studies (GWAS) as well as genomic selection. (usda.gov)
The study, titled "Intra-patient genomic heterogeneity of single circulating tumor cells (CTCs) associated to phenotypic CTC heterogeneity in metastatic castrate resistant prostate cancer (mCRPC)," was conducted in collaboration with clinical investigators at Memorial Sloan Kettering Cancer Center. (epicsciences.com)
In the study, 337 CTCs from 17 patients were individually isolated and characterized for cell morphology, molecular and genomic markers. (epicsciences.com)
Genome wide association studies, fluorescence in situ hybridization, comparative genomic hybridization, and candidate gene studies have enumerated genetic contributors to cancers in women. (hindawi.com)
Based on the heterogeneity within a specific tumor type, a combination of genomic alterations defines the cancer subtype, biologic behavior, and in some cases, response to therapeutics. (hindawi.com)

We found no significant difference between the populations in their genetic diversity (i.e., heterozygosity, level of inbreeding), nor any evidence that the family and kenneled populations originated from different genetic pools. (frontiersin.org)
The study revealed that late stage patients have heterogeneous clonal CTC populations harboring separate genetic alterations. (epicsciences.com)
Conclusion : Une étude des marqueurs Y-STRs (Short Tandem Repeat) sur notre cohorte a permis d'extraire un haplotype majoritaire retrouvé en Irlande et au sein de populations méditerranéennes (Espagne, Italie, Portugal). (blogspot.com)
In order to determine this differentiation, established allozyme markers were used to classify 56 southwest Virginia populations as southern, northern, or introgressed. (intechopen.com)
The results show that the populations of T. sordida are highly structured genetically, and that the wing morphology shows heterogeneity in the wing shape, which allows to conclude that even if genetically structured, there is no speciation process occurring for this species. (usp.br)
A new study reveals that the genetic uniqueness of the Basque population is not due to its external origin in respect of other Iberian populations, but reduced contacts as of the Iron Age. (eurekalert.org)
Now, an international research team led by UPF has confirmed that the Basques' genetic uniqueness is the result of genetic continuity since the Iron Age, characterized by periods of isolation and scarce gene flow, and not its external origin in respect of other Iberian populations. (eurekalert.org)
The results show that the Basques' genetic makeup is similar to other populations of Western Europe but with slight differences. (eurekalert.org)
This has drawn attention to possible benefits of studying populations where genetic heterogeneity might be reduced. (lu.se)
Mathematical constraints on FST: multiallelic markers in arbitrarily many populations. (who.int)
The frequencies exhibit considerable variation in different geographic locations, reflecting the underlying genetic and ethnic diversity of human populations [3]. (who.int)

Moreover, by resolving allelic and locus heterogeneity, structural variants improve the power to identify genetic factors underlying agronomically important traits leading to, for example, the identification of two new genes potentially contributing to soluble solid content. (nature.com)

This syndrome, once diagnosed by clinical profile, has been more clearly defined by specific genetic defects that cause ion channel abnormalities, resulting in a syndrome that predisposes to lethal cardiac arrhythmias. (medscape.com)
The recognition of these two subtypes, one maintaining a cone-differentiated state, and the other, more aggressive, associated with cone dedifferentiation and expression of neuronal markers, opens up important biological and clinical perspectives for retinoblastomas. (nih.gov)
Clinical response to hormonal treatment was documented using prostate specific antigen as the marker into responders (good, fair, stable) and non-responders. (bmj.com)
Autism is a neurodevelopmental disorder characterized by clinical, etiologic and genetic heterogeneity. (neurotransmitter.net)
A Symposium on 'Multimodal Markers of disease expression in mental disorders: results from large clinical and general population cohorts' will be given by various partners from the IMAGEMEND consortium. (imagemend.eu)
The clinical heterogeneity of neuroblastoma mirrors the biological and genetic heterogeneity of these tumors. (biomedcentral.com)

The maximum multipoint lod score of 3.28 was obtained in only one interval, between markers D6S1699 and D6S314. (bmj.com)
Evidence for linkage was supported by linkage analysis with the two SNPs, with a maximal multipoint nonparametric linkage score of 1.57 and a maximal multipoint heterogeneity lod score of 2.11. (neurotransmitter.net)

To categorise the immunostaining heterogeneity of androgen receptors in metastatic carcinoma of the prostate using a pattern oriented approach and to correlate the results with response to hormonal treatment. (bmj.com)

The candidate gene approach to conducting genetic association studies focuses on associations between genetic variation within pre-specified genes of interest, and phenotypes or disease states. (wikipedia.org)
in contrast, molecular markers accurately represent the underlying genetic variation and become an important tool in maintaining germplasm collections, understanding relationships between taxa, and in elucidating genetic diversity. (usda.gov)
Genetic material from each individual cell was sequenced and analyzed for genome wide copy number variation (CNV). (epicsciences.com)
The contributions of any single genetic variation or mutation in a population depend on its frequency and penetrance as well as tissue-specific functionality. (hindawi.com)
Host genetic variation is also a critical source of transmission heterogeneity, and this is an area research developed by Mike Stear and Louise Matthews (ovine nematodes), and Barbara Mable (effects of MHC on host-pathogen interactions). (gla.ac.uk)
13 ] focused on the marker heterogeneity by detecting the genes that showed different variation between healthy and disease samples. (biomedcentral.com)

The establishment of a long QT syndrome registry and the discovery of genetic mutations that cause long QT syndrome have greatly contributed to the understanding of this condition. (medscape.com)
Since the first report in 1991 of a deoxyribonucleic acid (DNA) marker in the short arm of chromosome 11, numerous studies have reported genetic mutations and molecular descriptions of ion channel abnormalities in long QT syndrome. (medscape.com)
However, the genetic heterogeneity of this condition has made using genetic mutations to screen for it difficult. (medscape.com)
There is strong evidence that inherited genetic factors (mutations plus single nucleotide polymorphisms) can play a major role in breast cancer susceptibility [ 1 ]. (hindawi.com)
The genes/mutations could act alone or interact with other genetic and/or epigenetic or environmental factors, causing autism or related disorders. (neurotransmitter.net)

They express markers of less differentiated cone together with neuronal/ganglion cell markers with marked inter- and intra-tumor heterogeneity. (nih.gov)
The existence of distinct molecular subtypes of glioblastoma and possibility for intra-tumoral heterogeneity present significant therapeutic challenges. (cns.org)
In this study, single-cell microfluidic genetic profiling of primary human glioblastoma was performed to characterize intra-tumoral BTIC heterogeneity, identify unique surface markers of BTIC subsets, and associate BTIC subsets with clinically-relevant bulk tissue molecular subtypes. (cns.org)
Microfluidic genetic profiling of BTICs at the single-cell level was performed to characterize intra-tumoral BTIC heterogeneity. (cns.org)
These data support BTIC subpopulation heterogeneity as an underlying source of intra-tumoral bulk tissue molecular heterogeneity. (cns.org)
Genetic analysis of single circulating tumor cells shows high intra-patient heterogeneity. (epicsciences.com)

Worldwide, there are approximately 16 national genebanks that contain important genetic diversity collections of Pisum. (usda.gov)
We analysed the dependency of habitat specialist diversity to climate, topographic heterogeneity and geographical distance to potential refugia. (muni.cz)
For genetic analysis, we sampled three or four habitat specialists of each steppe type and used cpDNA markers to investigate intraspecific diversity and geographical distribution of haplotypes. (muni.cz)
To date it was thought that they were formed from the Middle Ages but we postulate that they may have arisen much earlier and are therefore related to the genetic structure", explains David Comas, head of the Human Genome Diversity research group of the IBE. (eurekalert.org)
A collaborative study involving Veterinary Genetics Laboratory researchers and other researchers at UC Davis used 33 autosomal short tandem repeat (STR) markers to evaluate genetic heterogeneity and diversity in a large sample of purebred Golden Retrievers. (ucdavis.edu)

Hereditary gingival fibromatosis (HGF) is a rare inherited condition with fibromatoid hyperplasia of the gingival tissue that exhibits great genetic heterogeneity. (nature.com)
Each BTIC subtype was characterized by distinct surface markers, and single-cell molecular profiles relating to distinct bulk tissue molecular subtypes. (cns.org)
The promise and attractiveness of this approach is the small amount of tissue needed for analysis in the face of increasing numbers of prognostic and predictive markers, and the possibility of quantifying tumor genetic heterogeneity," said Dr. William Yong, a Jonsson Cancer Center physician-scientist who led the pathology aspects of the research. (nanowerk.com)
For selected markers and cases, tumour tissue was compared to normal tissue to look for allelic loss indicative of a tumour suppressor gene. (lu.se)
But while interventions can be tailored to some extent to these domains, or phenotypes, there are limitations without an understanding of the different pathophysiology and mechanisms driving the heterogeneity in tissue involvement. (medscape.com)

Data -- More than one genotype: How common is intracolonial genetic variability in scleractinian corals? (datadryad.org)
Intracolonial genetic variability describes the occurrence of more than a single genotype within an individual colony. (datadryad.org)

immunotherapeutics being a prime example of the latter) with the potential to eliminate all cancer cells, despite their clonal heterogeneity and their surrounding microenvironment. (nih.gov)

It harbors few genetic alterations other than the initiating RB1 inactivation and corresponds to differentiated tumors expressing mature cone markers. (nih.gov)
By contrast, subtype 2 tumors harbor frequent recurrent genetic alterations including MYCN-amplification. (nih.gov)

Among them, it has usually been suggested that a genetic factor or a familial predisposition may be of relevance to the development of disc herniation. (bmj.com)

Identification of cell surface markers of distinct BTIC subpopulations will support future study of glioblastoma cancer stem cells, and the potential development of BTIC subpopulation-specific therapeutic strategies. (cns.org)
2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)

4 On immunostaining, prostate carcinoma specimens show heterogeneity of androgen receptors in contrast to homogeneous staining of androgen receptors in normal prostate epithelium. (bmj.com)
Genetic markers indicate a distinction between specimens with a continuous orange line in the connexivum of those with triangular orange spots. (usp.br)

This is the first demonstration of cancer stem cell heterogeneity in glioblastoma at the single-cell level, and particularly as it relates to prospective isolation and bulk tumor subtypes. (cns.org)
Our data show that the disease heterogeneity frequently present in late stage mCRPC patients may contain multiple CTC subtypes driven by multiple, and sometimes rare genetic alterations, which would likely be missed by analytical methods that only look at cell free DNA or other bulk measures of allelic frequency versus those examining single cells. (epicsciences.com)
Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes. (who.int)

Next generation sequencing (NGS) is revolutionizing molecular ecology by simplifying the development of molecular genetic markers, including microsatellites. (datadryad.org)

This is in contrast to genome-wide association studies (GWAS), which is a hypothesis-free approach that scans the entire genome for associations between common genetic variants (typically SNPs) and traits of interest. (wikipedia.org)
To overcome these bottlenecks, an exhaustive and precise catalogue of genetic variants is required. (nature.com)
Thus, the behavior difference between the groups more likely reflects a G × E interaction, that is, the influence of specific genetic variants manifesting under specific environmental conditions (kennel life). (frontiersin.org)
The first stage involved identifying, in unrelated subjects showing linkage to 2q24-q33, genetic variants in exons and flanking sequence within candidate genes and comparing the frequency of the variants between autistic and unrelated nonautistic subjects. (neurotransmitter.net)

To minimize genetic heterogeneity, we focused on sibpairs meeting the strict diagnosis of autism. (duke.edu)
An analysis, of the joint segregation of these two markers in RA sibpairs, confirmed the previously described effect of HLA in RA but did not provide evidence of an independent effect of Gm alone or in interaction with HLA. (ox.ac.uk)

Quasi-linear scores combine such heterogeneity and have a better predictive ability compared with linear scores. (biomedcentral.com)

Our case report illustrates marked phenotype variability in two siblings with an identical genetic mutation of SMARD1, one of whom died of fulminant respiratory failure aged 6 months, whereas the other shows limb weakness but, only mild sleep hypoventilation aged 12 years. (nih.gov)
On the other hand, dogs bred and kept solely for breeding or research purposes ("kenneled dogs") are kept and handled under standardized conditions, and are usually of the same breed, thus the effects of environmental and breed-specific genetic variability on their individual behavioral variability is small. (frontiersin.org)
In recent years, a few colonial marine invertebrates have shown intracolonial genetic variability, a previously unreported phenomenon. (datadryad.org)
We investigate the occurrence of intracolonial genetic variability in five scleractinian corals: Acropora florida, Acropora hyacinthus, Acropora sarmentosa, Pocillopora species complex and Porites australiensis. (datadryad.org)
Our results show that intracolonial genetic variability was common (between 46.6% for A. sarmentosa and 23.8% for P. species complex) in all tested corals. (datadryad.org)
This suggests that intracolonial genetic variability is widespread in scleractinian corals and could challenge the view of a coral colony as an individual and therefore a unit of selection. (datadryad.org)
The present work had as objective to verify the genetic and morphological variability of these two species, through the geometric morphometry of the head and mitochondrial molecular markers. (usp.br)

Surface markers of distinct BTIC subpopulations were validated in fluorescence-activated cell sorting (FACS) and colony forming assays. (cns.org)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)

Many causes of sudden death in the pediatric population are due to genetic heart disorders, which can lead to structural abnormalities (eg, hypertrophic cardiomyopathy) and arrhythmogenic abnormalities (eg, familial long QT syndrome ). (medscape.com)
In this study we describe the phylogenetic relationships of 384 accessions of the USDA PSP population as well as describe associations between important agronomic and quality traits and previously published gene-anchored SNP markers. (usda.gov)
To identify the genetic defect in a Hutterite population from northern Alberta with Usher syndrome type I. (molvis.org)
Ainsi, l'haplogroupe I, défini par le marqueur M170 et observé majoritairement dans les pays de l'Est de l'Europe, en particulier les pays scandinaves, est représenté à 6,03 % dans la population finistérienne. (blogspot.com)
In total, our study of genetics of this population is based on an analysis of 19 Y-SNP markers. (blogspot.com)
Thus, I haplogroup, defined by the M170 marker and observed mostly in countries of Eastern Europe, especially Scandinavian countries, is represented by 6.03% in the population Finistérienne. (blogspot.com)
Population genetic evidence suggests differentiation among evolutionarily significant units of southern and northern Appalachian brook trout, with the zone of contact in southwestern Virginia. (intechopen.com)
Thus, ancient geographic ancestry, which is highly correlated with self-identified race/ethnicity-as opposed to current residence-is the major determinant of genetic structure in the U.S. population. (blogspot.com)
The study, led by David Comas, principal investigator at UPF and at the Institute of Evolutionary Biology (IBE: CSIC-UPF), has involved the most comprehensive geographic sampling to date of the Basque population, with over 600,000 genetic markers throughout the genome for each individual. (eurekalert.org)
Their study revealed that in order to understand biodiversity, the heterogeneous structure of the targeted population must be considered, and that such heterogeneity can be clarified by the clustering method. (biomedcentral.com)
Such heterogeneity may have unexpected effects on a therapy or treatment which is considered as best practice, and lead to an unfavorable risk in one part of the population. (biomedcentral.com)
CSIC-UPF), has involved the most comprehensive geographic sampling to date of the Basque population, with over 600,000 genetic markers throughout the genome for each individual. (upf.edu)
They are also well-defined genetic markers em-ployed in population genetic and anthropological studies [1,2]. (who.int)

In addition, the availability of genetic information through online databases enables researchers to mine existing data and web-based resources for new candidate gene targets. (wikipedia.org)
Here, we describe two Hutterite families from northern Alberta with Usher syndrome type I who did not carry a mutation in exon 10 of PCDH15 but did carry a mutation in exon 3 of the myosin VIIA ( MYO7 A) gene, providing evidence of genetic heterogeneity in Alberta Hutterites with Usher syndrome type I. (molvis.org)
In 1999, Kawaguchi et al 1 chose a polymorphism (VNTR) in exon 12 of the aggrecan gene as a candidate marker for lumbar disc disease. (bmj.com)
Consideration of tumor heterogeneity is therefore important in the critical analysis of gene associations in cancer. (hindawi.com)
To identify common genetic markers that may modify this association, we tested gene-caffeine intake interaction on BCC risk in a genome-wide analysis. (harvard.edu)
Ploidy and MYCN amplification have been used as genetic markers for risk stratification and therapeutic decision making, and, more recently, gene expression profiling and genome-wide DNA copy number analysis have come into the picture as sensitive and specific tools for assessing prognosis. (biomedcentral.com)
Genetic analysis of the G4.5 gene in families with suspected Barth syndrome. (lu.se)

These methods studied genetic linkage and positional cloning through the use of a genetic screen, and were effective at identifying relative risk genes in Mendelian diseases. (wikipedia.org)

In summary, these results demonstrate ZNF513 + KIF3C as an important genetic combination in HGF manifestation and suggest that ZNF513 mutation may be a major risk factor for HGF. (nature.com)
The finding of a MYO7A mutation in two related Hutterite families from northern Alberta provides evidence of genetic heterogeneity in Hutterites affected by Usher syndrome type I. (molvis.org)

Missing heritability in genome-wide association studies defines a major problem in genetic analyses of complex biological traits 1 , 2 . (nature.com)

Because heterogeneity can be captured by a clustering method, integrating different information from different clusters should yield better predictions. (biomedcentral.com)
Genetic heterogeneity, suggested by clusters of patients with the same human leukocyte antigen or autoimmune markers, may predispose to inflammatory bowel disease (IBD). (northwestern.edu)

As a result, different samples in different subgroups may have different intrinsic characteristics in their environmental and genetic factors as demonstrated by the motivated example in the " Methods " section. (biomedcentral.com)
Despite the prognostic contribution of molecular profiling, the heterogeneity of long-term outcomes among AML subgroups remains profound, and there is a pressing need for the development of new prognostic tools. (ascopost.com)

Other contributors to genetic susceptibility, for example, polymorphisms, may have a higher relative contribution to risk, but their lower penetrance makes identification more difficult. (hindawi.com)

We observed that two shrinkage methods worked well: ridge shrinkage for estimating the quasi-linear score, and lasso shrinkage for selecting markers within each cluster. (biomedcentral.com)

The heterogeneity of the depression concept seems to play a differentiating role: metabolic syndrome and inflammation up-regulations appear more specific to the atypical depression subtype, whereas hypercortisolemia appears more specific for melancholic depression. (biomedcentral.com)

Thus, more and more studies have considered heterogeneous structure and reflected this heterogeneity in their predictions. (biomedcentral.com)

5 Prins et al have shown that this heterogeneity is a useful indicator of tumour behaviour. (bmj.com)

The theoretical advantage of a minimal residual disease-based prognostic marker relies on the assumption that relapses arise from submicroscopic disease reservoirs remaining after initial treatment and that minimal residual disease is the result of a combination of factors that underlie an individual's response to therapy (including leukemic stem cell biology, mechanisms of leukemogenesis, and drug-resistance mechanisms). (ascopost.com)

In order to evaluate the power improvement provided by using SNP markers in a real situation, we have performed a whole genome screen of 19 non-BRCA1/2 breast cancer families using 4720 genomewide SNPs with Illumina technology (Illumina's Linkage III Panel), with an average distance of 615 Kb/SNP. (biomedcentral.com)

Successful treatment of cancer depends on understanding the heterogeneity of the patient's tumor burden and the driving genetic alterations behind their disease progression," said Murali Prahalad, Ph.D., president and CEO of Epic Sciences. (epicsciences.com)

There was no gender difference for this interaction (P = 0.64 for heterogeneity). (harvard.edu)
For genetic counselling it would seem important to resolve the mode of genetic interaction. (lu.se)

Several species showed a strong geographical differentiation, suggesting migration waves from multiple refugia with only limited subsequent genetic intermixture. (muni.cz)
On the other hand, we detected only modest genetic differentiation between different current geographic locales within each race/ethnicity group. (blogspot.com)

Here we summarize the results of the large scale development of microsatellites for 54 non-model species using NGS and show there are clear differences amongst plants, invertebrates and vertebrates for the number and proportion of motif types recovered that are able to be utilised as markers. (datadryad.org)
Results: In Western Europe, the majority haplogroup is the haplogroup R1, defined by the M173 marker. (blogspot.com)
These results provide no evidence for genetic heterogeneity of ADPKD in families with early and adult onset. (uni-luebeck.de)

An integrated understanding of the genetic and non-genetic mechanisms involved in treatment resistant relapse is necessary to identify novel treatment regimens. (lu.se)

Consideration may be given to ordering multiple tumor markers because of the heterogeneity in cell composition of each tumor. (medscape.com)

identify molecular markers that can meaningfully predict responses or resistance to anticancer therapies and develop algorithms that can be applied to predict responses to treatments and/or define more precise treatment modalities. (nih.gov)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)

2021) Life-history trade-offs and the genetic basis of fitness in Arabidopsis thaliana. (oeaw.ac.at)

In the history of pea genetic studies, many types of molecular markers have been used with various levels of success. (usda.gov)
Data compiled among genetic studies of brook trout in the southern Appalachians showed that the southern/northern break is sharp, occurring at the New/Roanoke-James watershed divide. (intechopen.com)
As far as upper spinal disc herniations and related paraplegia are concerned, similar genetic studies have not yet been reported, in spite of considerable information collected about hereditary spastic paraplegia (HSP). (bmj.com)
Implications of this genetic structure for case-control association studies are discussed. (blogspot.com)
The correct diagnosis of a cleft anomaly is fundamental for treatment, for further genetic and etiopathologic studies, and for preventive measures correctly targeting the category of preventable orofacial clefts. (medscape.com)

The additional hypothesis that the previously described correlation between RA and autoimmune thyroid disease is due to genetic factors, was also investigated in relation to HLA and Gm. (ox.ac.uk)
The effect of thyroid disease on HLA segregation suggests that the familial association between RA and autoimmune thyroid disease is at least partially due to genetic factors. (ox.ac.uk)

There is a great deal of tumor heterogeneity in late stage cancer and identifying the individual clones and the genetic alterations driving their continued growth may help guide treatment selection and accelerate or better enable drug development. (epicsciences.com)

What we hope might be neutral genetic differences in pathogens are useful as tracers of pathogen movement, but non-neutral genetic differences are increasingly appreciated to play a critical role in transmission heterogeneity. (gla.ac.uk)
The ELLIPSS project will utilize the host of -omics tools and technologies (for proteomics, metabolomics, and genomics, for instance) that are making it increasingly possible to dissect the heterogeneity of single diseases and achieve more precision with treatments. (medscape.com)

In addition to providing evidence that complement function modulates outcome, the data point to putative transcriptional genetic markers of susceptibility. (cdc.gov)
Genetic analysis in patients with left ventricular noncompaction and evidence for genetic heterogeneity. (lu.se)

The recent successes in unraveling the genetic basis of neuroblastoma are now opening opportunities for development of targeted therapies. (biomedcentral.com)

Interactive effect of HLA and Gm and genetic heterogeneity tested in 79 rheumatoid arthritis families. (ox.ac.uk)

Genetic characteristics are merely one facet of complex disease biology that is likely better assessed by evaluation of disease response via a reliable and validated minimal residual disease tool. (ascopost.com)

This analysis showed significant heterogeneity in HLA segregation (P = 0.02) with an HLA effect restricted only to sibships without thyroid disease. (ox.ac.uk)

Anatomy27

Diseases48

Chemicals and Drugs23

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Psychiatry and Psychology4

Phenomena and Processes82

Disciplines and Occupations6

Anthropology, Education, Sociology and Social Phenomena4

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Health Care13

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Microsatellite markers9

Loci13

Genomic6

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Locus1

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Multipoint2

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Variation6

Mutations5

Intra6

Diversity5

Tissue5

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Clonal1

Tumors2

Predisposition1

Cell surface markers2

Specimens2

Subtypes3

Molecular genetic markers1

Variants4

Sibpairs2

Predictive1

Variability7

Distinct2

Population13

Gene7

Genes1

Mutation2

Analyses1

Clusters2

Subgroups2

Identification1

Methods1

Subtype1

Heterogeneous1

Tumour1

Prognostic1

Evaluate1

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Interaction2

Differentiation2

Results3

Mechanisms1

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Identify2

20211

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Neuroblastoma1

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Analysis1