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  • Inflammation
  • This raises the possibility that the ERK pathway may play a role in regulating expression of CRE-containing genes, such as prodynorphin and NK-1, in the dorsal horn after inflammation and in this way contribute to altered pain sensitivity. (jneurosci.org)
  • These results suggest that ICAM-1 cross-linking can contribute to inflammation in the lung via production of the chemokine RANTES. (biomedcentral.com)
  • Furthermore, our observations suggest that galectin-1 may be involved in chemoattraction at sites of inflammation in vivo and may contribute to disease processes such as atherosclerosis. (sussex.ac.uk)
  • antibody
  • Following ICAM-1 upregulation, ICAM-1 was ligated with a murine anti-human ICAM-1 antibody and subsequently cross-linked with a secondary antibody (anti-mouse IgG(ab') 2 ) in the presence or absence of the MAP kinase inhibitors. (biomedcentral.com)
  • Galectin-1-induced monocyte chemotaxis is blocked by lactose and inhibited by an anti-galectin-1 antibody but not by nonspecific antibodies. (sussex.ac.uk)
  • Signaling
  • MAP kinase plays an important role in the Ras signaling pathway because it can activate downstream substrates that directly mediate the cellular response to growth factors, suggesting that MAP kinase acts near or at the end of this signaling pathway (reviewed in T reisman 1996 ). (genetics.org)
  • Glucocorticoids inhibit the proinflammatory activities of transcription factors such as AP‐1 and NF‐κB as well as that of diverse cellular signaling molecules. (embopress.org)
  • However, the MAP kinase signaling cascade has never been studied in fungi with respect to in aspirin-induced apoptosis. (idhinhibitor.com)
  • Interestingly, it has not been determined whether ICAM-1 functions as a signaling molecule to transmit biochemical signals in airway epithelial cells. (biomedcentral.com)
  • 1 Although paracrine autacoids as well as transcription factors and signaling cascades have been identified to be involved in adipocyte differentiation and insulin signaling, these complex processes are still incompletely understood. (ahajournals.org)
  • induce
  • Intensive Dimethylenastron studies have been conducted to uncover how aspirin induce apoptosis in mammals and these have targeted p38 MAP kinase . (idhinhibitor.com)
  • Our recent findings have also revealed that ROS and UV-B radiation are able to induce GA production and Hog-1 phosphorylation in G. lucidum . (idhinhibitor.com)
  • MEKK1
  • The MAP3 kinase 1 (MAP3K1, also known as MEKK1), an """"""""eyelid closure factor"""""""", is responsible for transmission morphogenetic activin B signals to Jun N-terminal kinases (JNKs). (grantome.com)
  • degradation
  • In NIH‐3T3 fibroblasts, although glucocorticoids up‐regulate the MKP‐1 level, they do not attenuate the proteasomal degradation of this protein and consequently they are unable to inhibit Erk‐1/2 activity. (embopress.org)
  • epithelial cells
  • Intercellular adhesion molecule 1 (ICAM-1) is an immunoglobulin-like cell adhesion molecule expressed on the surface of multiple cell types, including airway epithelial cells. (biomedcentral.com)
  • however, the effect of cross-linking ICAM-1 on the surface of airway epithelial cells is currently unknown. (biomedcentral.com)
  • mutants
  • Finally, mpk-1 may act together with let-60 ras in multiple developmental processes, as mpk-1 mutants exhibit nearly the same range of developmental phenotypes as let-60 ras mutants. (genetics.org)
  • We are currently creating the genetic mutants of G. lucidum that are deficient in Hog-1 to clarify the gene's role in controlling GA biosynthesis in G. lucidum. (idhinhibitor.com)
  • promotes
  • Previous studies from our laboratory have shown ET-1 treatment promotes apoptosis of cultured rat retinal ganglion cells. (arvojournals.org)
  • nuclear
  • In addition to nuclear targets, some MAP kinase substrates are located in the cytoplasm, e.g. , the guanine nucleotide exchange factor SOS and the protein kinase pp90Rsk (reviewed in F errell 1996 ). (genetics.org)
  • spinal cord
  • 1.We found the immunohistochemical colocalization of endoplasmic reticulum (ER) chaperone, glucose regulated protein 78 (GRP78), with the mutant SOD1 within Lewy body-like hyaline inclusions (LBHIs) in the lumbar spinal cord from G93A transgenic mice. (nii.ac.jp)
  • cells
  • First, a signal from the anchor cell induces the nearest Pn.p cell (P6.p) to adopt the 1° cell fate, which is to divide three times and generate eight descendant cells that form the inner portion of the vulva. (genetics.org)
  • Virally transformed rat retinal ganglion cells (RGC5) were treated with 100nM ET-1 for 5, 10 and 15 min. (arvojournals.org)
  • Phosphorylation of p38 MAP kinase has been shown to be significantly enhanced by aspirin in colorectal cancer cells. (idhinhibitor.com)
  • However, in Y/F2 cells both basal and insulin-stimulated MKP-1 mRNA levels were more than 60% lower than that observed in cells transfected with the wild-type receptors. (semanticscholar.org)
  • Cyclic AMP analog (8-Br-cAMP)/inducer (Forskoline) increased MKP-1 mRNA levels in both cell lines, and to a lesser extent in Y/F2 cells. (semanticscholar.org)
  • The overexpression of MKP-1 in Y/F2 cells inhibited insulin stimulated DNA synthesis. (semanticscholar.org)
  • Transfection of wild type insulin receptors into Y/F2 cells increased basal levels of MKP-1. (semanticscholar.org)
  • Pathological investigation of the recipients revealed that transplanted cells migrated into the spinal cords and a subset of these cells expressed Iba-1, a marker of microglia. (nii.ac.jp)