Loading...
  • tumor
  • For example, 2-alkylimidazole 2 , the analog of LN950 , inhibits both the p38α MAP kinase as well as the LPS-stimulated tumor necrosis factor-α release from human whole blood in the low double-digit nanomolar range. (mdpi.com)
  • Mek1
  • No group x time interactions were observed for MEK1 or SHP-2. (tdl.org)
  • MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAF amplification whereas KRAS amplification promotes EMT-chemoresistance. (babraham.ac.uk)
  • mice
  • Gstp1/2 −/− mice exhibited a significant increase in the number of S -glutathionylated proteins compared with wild-type animals. (aspetjournals.org)
  • Furthermore, we found that S -glutathionylation of the rate-limiting glutathione-synthesizing enzyme, glutamate cysteine ligase, was markedly increased in Gstp1/2 −/− mice in response to APAP. (aspetjournals.org)
  • vivo
  • In vitro and in vivo metabolism studies revealed that 2-alkylsulfanylimidazole ML3403 (4-(5-(4-fluorophenyl)-2-(methylthio)-1 H -imidazol-4-yl)- N -(1-phenylethyl)pyridin-2-amine) undergoes rapid oxidation to the sulfoxide. (mdpi.com)
  • They display a 4-fold increased binding affinity towards the target kinase as well as similar in vitro potency and ex vivo efficacy relative to their 2-alkylsulfanylimidazole counterparts ML3403 and LN950 . (mdpi.com)
  • cell
  • Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. (genecards.org)
  • Eukaryotic Cell, 2 , 351-361. (springer.com)
  • human
  • The 2-alkylimidazole analogs 1 and 2 showed 20% and 10% biotransformation after 4 h of incubation with human liver microsomes, respectively. (mdpi.com)
  • sensitivity
  • In addition, disruption of CgPBS 2 led to sensitivity to hyperosmosis and high salt concentration as well as resistance to the fungicide fludioxonil. (springer.com)