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  • collagen
  • In their study, researchers used microtubes of spun of silk (the biomaterial component that is a nonactivating agent for platelets), collagen, and fibronectin, which were surrounded by a porous silk sponge. (fool.com)
  • The mineralised matrix of bone tissue has an organic component of mainly collagen called ossein and an inorganic component of bone mineral made up of various salts. (wikipedia.org)
  • The matrix is made up of between 90 and 95% collagen fibers, and the remainder is ground substance. (wikipedia.org)
  • Its matrix is mostly made up of a composite material incorporating the inorganic mineral calcium phosphate in the chemical arrangement termed calcium hydroxylapatite (this is the bone mineral that gives bones their rigidity) and collagen, an elastic protein which improves fracture resistance. (wikipedia.org)
  • The abnormal megakaryocytes stimulate other cells, the fibroblasts, to produce collagen in the bone marrow. (wikipedia.org)
  • Production of cytokines such as fibroblast growth factor by the abnormal hematopoietic cell clone (particularly by megakaryocytes) leads to replacement of the hematopoietic tissue of the bone marrow by connective tissue via collagen fibrosis. (wikipedia.org)
  • elements of note are: the D'/D3 domain, which binds to factor VIII (Von Willebrand factor type D domain) the A1 domain, which binds to: platelet GPIb-receptor heparin possibly collagen the A2 domain, which must partially unfold to expose the buried cleavage site for the specific ADAMTS13 protease that inactivates vWF by making much smaller multimers. (wikipedia.org)
  • Vascular
  • Decades of continued studies have identified many of the components and mechanisms that make platelets so sensitive to stimulation but, at the same time, have recognized the many ways in which their uncontrolled activation compromises vascular integrity, as seen in several of the most prevalent and deadly syndromes, from strokes and heart attacks to venous thromboses. (rupress.org)
  • The vascular system is made up of two parts: 1) Blood vasculature 2) Lymphatic vessels Both parts consist of ECs that show differential expression of various genes. (wikipedia.org)
  • Infection
  • In many cases this may follow a viral infection or vaccination during which time the immune system attacks the virus but the immune system then goes on to think that the platelets are part of the virus and starts to attack the platelets. (itpsupport.org.uk)
  • While they normally produce digestive fluids for the stomach, they can revert into stem cells to make temporary repairs to stomach injuries, such as a cut or damage from infection. (wikipedia.org)
  • leukemia
  • A classic example of such a disease is chronic myelogenous leukemia, a neoplasm commonly caused by a mutation that creates the BCR-ABL1 fusion gene (see Philadelphia chromosome). (wikipedia.org)
  • If the patient has leukemia, the morphology and immunophenotype check is needed to make sure the type of leukemia. (wikipedia.org)
  • blood clot formation
  • Fibrinogen and its Aα fibrin chain have several functions in this process: Blood clotting: fibrinogen concentration is the rate-limiting factor in blood clot formation and along with blood platelets is critical to this formation (see Coagulation). (wikipedia.org)
  • Low-dose aspirin is used to reduce the risk of blood clot formation unless the platelet count is very high, where there is a risk of bleeding from the disease and hence this measure would be counter-productive (as they increase one's risk for bleeds). (wikipedia.org)
  • protein
  • Silk protein possesses a unique molecular structure that enables it to be modeled in a wide variety of forms and stiffnesses, characteristics that have been shown to affect platelet formation and release. (eurekalert.org)
  • The Kupfer laboratory is currently involved in work engineering a viral protein to be used in concert with standard therapy to make chemotherapy more effective. (yale.edu)
  • This aberrant Notch signal may cause a failure of the tumor suppressor protein Rb and result in uncontrolled growth of immature megakaryocytes. (yale.edu)
  • All mutations (insertions or deletions) affected the last exon, generating a reading frame shift of the resulting protein, that creates a novel terminal peptide and causes a loss of endoplasmic reticulum KDEL retention signal. (wikipedia.org)
  • successfully generates
  • According to researchers at Tufts University School of Engineering and the University of Pavia, whose work was pre-published in the journal Blood , they've developed the first three-dimensional tissue system capable of producing human bone marrow that successfully generates platelets. (fool.com)
  • MEDFORD/SOMERVILLE, Mass. (February 18, 2015) - A team led by researchers at Tufts University School of Engineering and the University of Pavia has reported development of the first three-dimensional tissue system that reproduces the complex structure and physiology of human bone marrow and successfully generates functional human platelets. (eurekalert.org)
  • nucleus
  • The megakaryoblast matures into the megakaryocyte, which has a nucleus with many lobes and a large cytoplasmic volume. (ubc.ca)
  • The most obvious morphological difference between the mammalian platelet and the nonmammalian thrombocyte is the lack of a nucleus in the platelet. (rupress.org)
  • Thus, the lack of a nucleus in the platelet, together with other factors, such as its humble size and production method, has led to controversy over its formal recognition as a cell ( Garraud and Cognasse, 2015 ). (rupress.org)
  • As a result, the nucleus of the megakaryocyte can become very large and lobulated, which, under a light microscope, can give the false impression that there are several nuclei. (wikipedia.org)
  • After budding off platelets, what remains is mainly the cell nucleus. (wikipedia.org)
  • immune
  • ITP commonly results from the immune system mistaking platelets as being foreign and attacking them. (itpsupport.org.uk)
  • Additional blood tests may be taken at this time to rule out rare problems with making blood clots and rare problems of the immune system that can look like ITP. (itpsupport.org.uk)
  • ITP (Immune Thrombocytopenic Purpura) is a condition caused by the body's formation of antibodies that attack platelets. (medicalassessmentonline.com)
  • Many decades after these observations were made, however, researchers began to notice striking correlations between platelet numbers and activation states with the onset of immune and inflammatory responses. (rupress.org)
  • We discuss here aspects of platelet biology not usually described in textbooks and other recent reviews, specifically how platelets appear to be designed for their hemostatic and immune functions. (rupress.org)
  • proteins
  • The gene regulator, miR-125b-2, belongs to a class of molecules known as microRNAs, which silence gene expression by halting the manufacturing of different proteins. (bio-medicine.org)
  • production
  • More importantly, it provides a means for studying the process of platelet production and diseases that arise from a lack of platelet production. (fool.com)
  • There are many diseases where platelet production or function is impaired," says Alessandra Balduini, M.D., research associate professor in the Department of Biomedical Engineering at Tufts, associate professor at the Department of Molecular Medicine at the University of Pavia and co-corresponding author on the paper. (eurekalert.org)
  • The need for platelet production systems to treat patients with related diseases is significant. (eurekalert.org)
  • Megakaryocytopoiesis is the cellular development process that leads to platelet production. (wikipedia.org)
  • researchers
  • Find out what bioprinting recently helped researchers at two universities create, and how this breakthrough could wind up saving lives. (fool.com)
  • Researchers were also able to confirm that these platelets functioned normally and led to clotting. (fool.com)
  • Specifically, researchers hope the additional platelets produced by their model could one day be used to help support bone tissue regeneration or help heal ulcers or burns. (fool.com)
  • fibrin
  • These processes may overlap: the spectrum is from a predominantly platelet plug, or "white clot" to a predominantly fibrin clot, or "red clot" or the more typical mixture. (wikipedia.org)
  • William Addison in 1842 drew pictures of a platelet-fibrin clot. (wikipedia.org)